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Treatments for age-related macular degeneration and novel options using CCR3 antagonists 利用 CCR3 拮抗剂治疗老年性黄斑变性和新方案
Pub Date : 2024-07-24 DOI: 10.54097/d1jyyr11
Jie Xu
As global ageing increases, more and more people are suffering, or will soon suffer, from the inconvenience of living with a degenerative disease. One of these degenerative diseases is age-related macular degeneration (AMD), a degenerative disease closely related to the eye and millions of elderly people are suffering from it. This article will explain the primary pathophysiology of age-related macular degeneration.and focuses on the conventional treatment of Wet AMD, for example anti-VEGF drugs and surgery, and describes the mechanism of treatment with the shortcomings therein.  In addition to this, this paper will present a novel therapeutic approach for wet age-related macular degeneration, via the G protein-coupled receptor CCR3. At the same time, this paper will compare the CCR3 therapy with the traditional therapy using chemical drugs, and explain the superior points and shortcomings of the CCR3 therapy. CCR3 antagonists were found to have better selectivity and affinity compared to anti-vascular endothelial growth factor drugs. CCR3 antagonists are expected to become another new class of drugs for the treatment of AMD, if novel, low-cost CCR3 antagonists are developed to replace the expensive CCR3 antibodies.
随着全球老龄化的加剧,越来越多的人正遭受或即将遭受退行性疾病带来的生活不便。老年性黄斑变性(AMD)就是其中一种退行性疾病,它是一种与眼部密切相关的退行性疾病,目前有数百万老年人正深受其害。本文将解释老年性黄斑变性的主要病理生理学,重点介绍湿性AMD的传统治疗方法,如抗血管内皮生长因子药物和手术,并介绍治疗机制及其不足之处。 此外,本文还将介绍一种通过 G 蛋白偶联受体 CCR3 治疗湿性老年黄斑变性的新方法。同时,本文还将比较 CCR3 疗法和使用化学药物的传统疗法,并解释 CCR3 疗法的优缺点。研究发现,与抗血管内皮生长因子药物相比,CCR3 拮抗剂具有更好的选择性和亲和性。如果开发出新型、低成本的 CCR3 拮抗剂来取代昂贵的 CCR3 抗体,那么 CCR3 拮抗剂有望成为治疗老年黄斑病变的又一类新药。
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引用次数: 0
Role of Lactic Acid Bacteria and Their Exosomes in Anti-Food Allergy 乳酸菌及其外泌体在抗食物过敏中的作用
Pub Date : 2024-07-24 DOI: 10.54097/tz00nb72
Xinyun Cui
Food allergies, a pressing health concern with worldwide ramifications, have attracted immense attention in recent decades. A promising solution to this enduring issue lies in the prophylactic and therapeutic benefits offered by lactic acid bacteria (LAB) fermented products. These bacteria exhibit remarkable abilities, not only assisting in alleviating allergy symptoms but also in reducing the likelihood of allergies by intricately regulating the host's immune system. Through the process of fermentation hydrolysis, LAB modifies the antigenicity of food proteins, altering their linear epitopes and higher structural configurations. Additionally, they secrete epigenome modulators, release anti-inflammatory cytokines, and fortify the intestinal barrier, collectively contributing to the reduction of allergic reactions. The emerging role of LAB and their exosomes in combating food allergies presents an innovative and intriguing path for future research endeavors and therapeutic applications.This review summarizes the research achievements of lactic acid bacteria products in combating food allergies through two main approaches.
近几十年来,食物过敏这一影响全球的紧迫健康问题引起了人们的极大关注。乳酸菌(LAB)发酵产品具有预防和治疗作用,是解决这一持久问题的可行办法。这些细菌表现出非凡的能力,不仅能帮助缓解过敏症状,还能通过复杂地调节宿主的免疫系统来降低过敏的可能性。通过发酵水解过程,LAB 可改变食物蛋白质的抗原性,改变其线性表位和高级结构配置。此外,它们还能分泌表观基因组调节剂,释放抗炎细胞因子,强化肠道屏障,共同为减少过敏反应做出贡献。乳酸菌及其外泌体在抗击食物过敏中的新兴作用为未来的研究工作和治疗应用提供了一条创新且引人入胜的道路。本综述通过两种主要方法总结了乳酸菌产品在抗击食物过敏方面的研究成果。
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引用次数: 0
Impact of sex ratio on ecosystem stability: a Lotka-Volterra model considering sex ratio 性别比对生态系统稳定性的影响:考虑性别比的 Lotka-Volterra 模型
Pub Date : 2024-07-24 DOI: 10.54097/24146420
Rui Xu, Rui Zhu, Meng-Ting Sun
This study examined the effects of sex ratio on ecology, using Lamprey as the study population. It was found that there was a close relationship between sex ratio and food availability, with a higher proportion of female Lamprey when food availability was adequate and an increase in the proportion of males when food was scarce.The relationship between sex ratio and population dynamics of Lamprey was established by logistic growth model and Lotka-Volterra predator-prey model, and it was found that the change of sex ratio had a significant effect on the population size of Lamprey, which will affect the number of prey as well as the ecological factors such as water temperature and pH value.These discoveries reveal the important role of gender ratio in the ecosystem, and provide new perspectives and methods to solve the dynamics and resource utilization in the ecosystem.
这项研究以灯笼鱼为研究种群,探讨了性别比例对生态的影响。研究发现,性别比例与食物供应之间存在密切关系,当食物充足时,雌性灯鱼的比例较高,而当食物稀缺时,雄性灯鱼的比例会增加。这些发现揭示了性别比例在生态系统中的重要作用,为解决生态系统的动态和资源利用问题提供了新的视角和方法。
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引用次数: 0
Preface: 3rd International Conference on Food Engineering, Nutriology and Biological Chemistry (FENBC 2024) 前言:第三届国际食品工程、营养学和生物化学会议(FENBC 2024)
Pub Date : 2024-07-24 DOI: 10.54097/0kcaph16
Arlen Penn, Kai Jiang
2024 3rd International Conference on Food Engineering, Nutriology and Biological Chemistry (FENBC 2024) has been successfully held during June 29-30, 2024, in Wellington, New Zealand. FENBC 2024 mainly focuses on food engineering, nutrition, agricultural biotechnology, diet, public health, and biological chemistry, aiming at providing a platform for experts, scholars, engineers, and technical researchers. The major audiences of the proceedings include academic staff and scholars at universities and research institutes, researchers and developers in the R&D departments of companies. Our attendees are delighted to share scientific research achievements and cutting-edge technologies, understand academic development trends, broaden research ideas, strengthen academic research, and promote cooperation in industrialization of academic achievements. Experts, scholars, business people, and other relevant personnel from universities and research institutions are cordially invited to attend and exchange. During the FENBC 2024 conference, the conference model was divided into three sessions, including oral presentations, keynote speeches, and Q&A discussion. In the first part, some scholars, whose submissions were selected as the excellent papers, were given about 10-15 minutes to perform their oral presentations one by one. Then in the second part, keynote speakers were each allocated 30-40 minutes to hold their speeches. FENBC 2024 Scientific Committee Wellington, New Zealand
2024 第三届食品工程、营养学和生物化学国际会议(FENBC 2024)于 2024 年 6 月 29-30 日在新西兰惠灵顿成功举办。FENBC 2024 主要关注食品工程、营养学、农业生物技术、饮食、公共卫生和生物化学,旨在为专家、学者、工程师和技术研究人员提供一个平台。论文集的主要受众包括大学和研究机构的学术人员和学者、企业研发部门的研究人员和开发人员。与会者乐于分享科研成果和前沿技术,了解学术发展趋势,拓宽研究思路,加强学术研究,促进学术成果产业化合作。诚邀高校、科研机构的专家、学者、企业界人士及其他相关人员参会交流。FENBC 2024会议期间,会议模式分为口头报告、主题演讲、问答讨论三个环节。在第一环节中,部分入选优秀论文的学者在10-15分钟左右的时间内逐一进行口头报告。在第二部分,主旨发言人每人有 30-40 分钟的发言时间。FENBC 2024 科学委员会 新西兰惠灵顿
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引用次数: 0
Research on the Sex Ratio Variation of Sea Lampreys and Its Ecological Impact Based on the Lotka-Volterra Competition Model 基于洛特卡-伏特拉竞争模型的海灯笼鱼性别比例变异及其生态影响研究
Pub Date : 2024-07-24 DOI: 10.54097/vam80834
BoWen Tang, JingYu Wang
Changes in sex ratio are a common adaptive phenomenon in biodiversity-rich ecosystems, which is reflected in many species, and the adjustment of the sex ratio of sea lampreys reflects its response to resource constraints and is critical for maintaining ecosystem stability. In this study, the population of sea lampreys was taken as an example, and the Lotka-Volterra competition model was used to explore the changes in the sex ratio of sea lampreys with environmental resource conditions. We found that the sex ratio of sea lampreys could reach 78% of the total population in an environment with a low food supply rate. In environments where food is more readily available, males make up about 56% of the population, which means that the population size of sea lampreys can have a significant impact on the changes in the population of competing species, affecting the time of extinction of the species and the population size in the early competition. Finally, we explore the ecological effects of sex ratio and resource availability.
性别比例的变化是生物多样性丰富的生态系统中常见的适应现象,在许多物种中都有体现,海灯鱼性别比例的调整反映了其对资源约束的响应,对维持生态系统的稳定至关重要。本研究以海灯鱼种群为例,利用 Lotka-Volterra 竞争模型探讨了海灯鱼性别比随环境资源条件的变化。我们发现,在食物供应率较低的环境中,海灯鱼的性别比例可达总种群的 78%。而在食物供应较为充足的环境中,雄性海灯鱼约占种群的56%,这意味着海灯鱼的种群数量会对竞争物种的种群数量变化产生重大影响,影响物种灭绝的时间和早期竞争中的种群数量。最后,我们探讨了性别比例和资源可用性的生态效应。
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引用次数: 0
Potential Application of Mediterranean Diet and DASH Diet and Plant-Based Diet in Solving the Problem of Hypertension in Women 地中海饮食、DASH 饮食和植物性饮食在解决女性高血压问题中的潜在应用
Pub Date : 2024-07-24 DOI: 10.54097/f212pd59
Yuan Liu
The food industry is thriving due to economic prosperity. People's food requirements have expanded beyond mere sustenance to include a desire for diversity. However, long-term pressure from heavy work or family responsibilities may cause women to develop irregular dietary habits, leading to obesity and related health issues. As hypertension is a significant contributor to cardiovascular disease, this paper compares the advantages and disadvantages of three popular diets: the Mediterranean diet, the DASH diet, and the plant- based diet. The paper discusses the pros and cons of each diet to determine which one is more suitable for the female to prevent and alleviate hypertension symptoms. By comparing the regional, quantitative, nutritional value and public acceptance of three different diets, it is concluded that the plant-based diet which consists of fruits and vegetables in addition to nuts, seeds, whole grains, and legumes, is more suitable as a daily diet for women to alleviate hypertension symptoms.
由于经济繁荣,食品工业蓬勃发展。人们对食物的要求也从单纯的温饱扩展到对多样性的追求。然而,长期繁重的工作或家庭责任压力可能会使女性养成不规律的饮食习惯,导致肥胖和相关的健康问题。由于高血压是心血管疾病的重要诱因,本文比较了三种流行饮食的优缺点:地中海饮食、DASH 饮食和植物性饮食。本文讨论了每种饮食的优缺点,以确定哪种饮食更适合女性预防和缓解高血压症状。通过比较三种不同饮食的地区、数量、营养价值和公众接受度,得出结论认为,植物性饮食(除坚果、种子、全谷物和豆类外,还包括水果和蔬菜)更适合作为女性缓解高血压症状的日常饮食。
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引用次数: 0
Uric Acid Plays a Key Role in Hypertension and its Long-term Risk 尿酸在高血压及其长期风险中发挥着关键作用
Pub Date : 2024-07-24 DOI: 10.54097/9hcmxc60
Yue Wang, Ziyou Li
Hypertension is a chronic disease now prevalent in modern societies and is a separate heart failure threat. If leave unattended a lengthy amount duration, it may lead to long-term risks such as stroke or heart attack, kidney damage, osteoporosis, and even death. Human metabolism of purines results in uric acid, which may have a significant impact on the onset and subsequent risk of pressure. The connection that exists among uric acid and hypertension was found to be progressively observable in Mendelian randomization studies, but no further strong subsequent studies have been conducted as of 2021 to illustrate the relationship. Meta-analysis studies have shown a potential link between elevated uric acid levels and an increased risk of hypertension, However, there is still a need to investigate the potential benefits of uric acid-lowering medications in reducing the risk of hypertension. Previous studies involving large sample sizes have indicated a positive association between uric acid levels and the likelihood of developing hypertension, but there is some geographic variation in the studies and the conclusions are limited and difficult to generalize. Multiple studies have given possible mechanisms at the mechanistic level for uric acid triggering hypertension or long-term risk, but the evidence-based value is low, giving no strong proof in terms of its relevance and continuity. This paper summarizes the existing evidence in the above points, puts forward its own insights, and looks forward to the future direction of scientific research, with a view to providing some references for future researcht.
高血压是现代社会普遍存在的一种慢性疾病,也是一种独立的心力衰竭威胁。如果长期任其发展,可能会导致中风或心脏病发作、肾脏损伤、骨质疏松症甚至死亡等长期风险。人体对嘌呤的新陈代谢会产生尿酸,而尿酸可能会对压力的发生和后续风险产生重大影响。在孟德尔随机研究中发现,尿酸与高血压之间存在的联系是可以逐步观察到的,但截至 2021 年,还没有进一步的强有力的后续研究来说明这种关系。元分析研究表明,尿酸水平升高与高血压风险增加之间存在潜在联系,但仍有必要研究降尿酸药物在降低高血压风险方面的潜在益处。以往涉及大量样本的研究表明,尿酸水平与罹患高血压的可能性呈正相关,但这些研究存在一定的地域差异,得出的结论也很有限,很难一概而论。多项研究从机理层面给出了尿酸引发高血压或长期风险的可能机制,但证据价值较低,在相关性和持续性方面没有给出有力的证明。本文就以上几点总结了现有证据,提出了自己的见解,并展望了未来科学研究的方向,以期为今后的研究提供一些参考。
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引用次数: 0
Study on the Impact of Sex Ratio Changes in Lamprey on the Ecosystem and Its Stability 研究灯鱼性别比例变化对生态系统及其稳定性的影响
Pub Date : 2024-07-24 DOI: 10.54097/ehb8ay64
Bin Shen, Ruiqi Li
Different species adopt different survival strategies. For lampreys, adaptive changes in sex ratio are crucial for their survival and reproduction. Then, we aim to find out how the change of lampreys’ sex ratio affect the ecosystem. Firstly, by expanding the Lotka-Volterra equations to three species and species competition models, we find that an increase in the male-female ratio of lampreys under different food resources leads to higher peaks of population, more pronounced fluctuations, and greater threats to their prey. Secondly, applying a method to calculate stability index with species’ biomass, we discussed the impact of lampreys’ sex ratio changes on ecosystem stability with species that are ranked by PageRank algorithm. When male-female ratio increases, the ecosystem tends to become unstable. In conclusion, adaptive changes in lampreys’ sex ratio has a great effect on their survival and reproduction. Therefore, studying the effects of lamprey sex ratio changes on ecosystems will contribute significantly to addressing the current issues.
不同的物种采取不同的生存策略。对于灯鱼来说,性别比例的适应性变化对其生存和繁殖至关重要。因此,我们希望了解灯鱼性别比例的变化对生态系统的影响。首先,通过将 Lotka-Volterra 方程扩展到三个物种和物种竞争模型,我们发现在不同食物资源条件下,灯鱼雌雄比例的增加会导致种群峰值更高、波动更明显以及对猎物的威胁更大。其次,运用物种生物量计算稳定性指数的方法,以PageRank算法排序的物种为对象,讨论灯鱼性别比变化对生态系统稳定性的影响。当雌雄比例增加时,生态系统趋于不稳定。总之,灯鱼性别比例的适应性变化对其生存和繁殖有很大影响。因此,研究灯鱼性别比变化对生态系统的影响,将对解决当前的问题做出重要贡献。
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引用次数: 0
Effects of changes in lamprey sex ratios on ecosystem stability: a Lotka-Volterra model-based study 灯鱼性别比例变化对生态系统稳定性的影响:基于 Lotka-Volterra 模型的研究
Pub Date : 2024-07-24 DOI: 10.54097/c9wqh624
Hanlu Yan, Shanghao Zhou
The aim of this study was to investigate the effects of external environmental factors on the sex ratio of lampreys and the possible changes in population size and structure as a result of such effects. We simulated the population dynamics of male and female lampreys separately by modeling the population dynamics of lampreys based on the Lotka-Volterra model, and considered the effects of human predation on the lamprey population. By adjusting model parameters, such as predation intensity, initial sex ratio and rate of change in sex ratio dynamics, we simulated changes in the sex ratio of lampreys under different conditions and observed the effects of such changes on the ecosystem. The results suggest that changes in the sex ratio of lampreys may lead to changes in the abundance and distribution of other species, which in turn may affect the stability of the ecosystem. In addition, we analyzed the model results and presented graphs showing changes in predator and prey population dynamics and changes in lamprey sex ratios, further illustrating the effects of changes in sex ratios on ecosystem dynamics, population size and stability.
本研究旨在探讨外部环境因素对灯鱼性别比例的影响,以及这种影响可能导致的种群数量和结构变化。我们根据 Lotka-Volterra 模型分别模拟了雌雄灯鱼的种群动态,并考虑了人类捕食对灯鱼种群的影响。通过调整捕食强度、初始性别比和性别比动态变化率等模型参数,模拟了不同条件下灯鱼性别比的变化,并观察了这些变化对生态系统的影响。结果表明,灯鱼性别比的变化可能会导致其他物种的数量和分布发生变化,进而影响生态系统的稳定性。此外,我们还对模型结果进行了分析,并展示了捕食者和猎物种群动态变化以及灯鱼性别比例变化的图表,进一步说明了性别比例变化对生态系统动态、种群数量和稳定性的影响。
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引用次数: 0
The Current Situation, Problems and Improvement Measures of Food Waste in China's Catering Industry 中国餐饮业食物浪费的现状、问题及改进措施
Pub Date : 2024-07-24 DOI: 10.54097/3appc482
Yixun Wang
  Food waste has become a very serious global problem that urgently requires the global attention and improvement. The promulgation of the Anti-Food Waste Law had a great impact on the China's catering industry, however,there are still many problems that need to be solved. Due to the advancement of information technology, online ordering services are gradually emerging, and the consumer online ordering behavior towards restaurants is increasing, leading to an increase in the degree of food waste in the catering industry. Due to many factors that affect food waste and some of them, such as personal consumer norms, it is difficult to change and limit the personal food waste behavior because it is controlled by subjective thoughts. This study proposes targeted suggestions based on not only the current situation but also the influencing factors in the Chinese catering industry, hoping to provide new ideas and ways to improve this situation.
食物浪费已经成为一个非常严重的全球性问题,亟待全球关注和改善。反食品浪费法》的颁布对中国餐饮业产生了巨大影响,但仍有许多问题亟待解决。由于信息技术的进步,网上订餐服务逐渐兴起,消费者对餐厅的网上订餐行为日益增多,导致餐饮业食物浪费程度增加。由于影响食物浪费的因素很多,其中一些因素如个人消费规范等,受主观思想的控制,很难改变和限制个人的食物浪费行为。本研究不仅根据中国餐饮业的现状,还根据其影响因素提出了有针对性的建议,希望能为改善这一现状提供新的思路和方法。
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引用次数: 0
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Highlights in Science, Engineering and Technology
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