Pub Date : 2025-01-01DOI: 10.1016/j.jacbts.2024.08.003
Panagiota Efstathia Nikolaou PhD , Lara S.F. Konijnenberg MD, PhD , Ioannis V. Kostopoulos PhD , Marios Miliotis PhD , Nikolaos Mylonas MSc , Anastasios Georgoulis PhD , George Pavlidis MD, PhD , Carolien T.A. Kuster Msc , Vince P.A. van Reijmersdal Msc , Tom T.J. Luiken Msc , Anna Agapaki PhD , Rona Roverts PhD , Nikolaos Orologas PhD , Dimitris Grigoriadis PhD , Gaëtan Pallot PhD , Pierre Boucher MSc , Nikolaos Kostomitsopoulos PhD , Michael Paul Pieper PhD , Stéphane Germain PhD , Yannis Loukas PhD , Ioanna Andreadou PhD
Empagliflozin treatment before acute myocardial infarction mainly targets the endothelial cell transcriptome. Empagliflozin treatment before and after myocardial infarction decreased no reflow and microvascular injury, leading to reduced infiltration of inflammatory cells, reduced infarct size, and improved cardiac function in mice. In diabetic patients receiving empagliflozin after myocardial infarction, perfused boundary region, flow-mediated dilation, and global longitudinal strain were improved.
Pub Date : 2025-01-01DOI: 10.1016/j.jacbts.2024.09.006
Jean W. Wassenaar MD PhD , C. Duncan Smart MD PhD , Daniel J. Fehrenbach PhD , Vineet Agrawal MD PhD , Matthew M. Dungan BS , Niki L. Fortune , Lin Zhong MD PhD , Anna R. Hemnes MD , R. Stokes Peebles Jr. MD , Francis J. Miller Jr. MD , Amanda C. Doran MD PhD , Meena S. Madhur MD PhD
{"title":"Targeting IL-33/ST2 Signaling Alters Cardiac Structure and Function in Hypertensive Heart Disease","authors":"Jean W. Wassenaar MD PhD , C. Duncan Smart MD PhD , Daniel J. Fehrenbach PhD , Vineet Agrawal MD PhD , Matthew M. Dungan BS , Niki L. Fortune , Lin Zhong MD PhD , Anna R. Hemnes MD , R. Stokes Peebles Jr. MD , Francis J. Miller Jr. MD , Amanda C. Doran MD PhD , Meena S. Madhur MD PhD","doi":"10.1016/j.jacbts.2024.09.006","DOIUrl":"10.1016/j.jacbts.2024.09.006","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"10 1","pages":"Pages 107-109"},"PeriodicalIF":8.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143165280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.jacbts.2024.11.003
Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science)
{"title":"Where Comity in Science Goes to Die","authors":"Douglas L. Mann MD (Editor-in-Chief, JACC: Basic to Translational Science)","doi":"10.1016/j.jacbts.2024.11.003","DOIUrl":"10.1016/j.jacbts.2024.11.003","url":null,"abstract":"","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1440-1441"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.jacbts.2024.07.009
Heather Quiriarte MS , Robert C. Noland PhD , James E. Stampley PhD , Gregory Davis MS , Zhen Li PhD , Eunhan Cho PhD , Youyoung Kim MS , Jake Doiron BS , Guillaume Spielmann PhD , Sujoy Ghosh PhD , Sanjiv J. Shah MD , Brian A. Irving PhD , David J. Lefer PhD , Timothy D. Allerton PhD
Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a “2-hit” model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF. These results underscore the importance of skeletal muscle metabolism to improve exercise intolerance in HFpEF.
{"title":"Exercise Therapy Rescues Skeletal Muscle Dysfunction and Exercise Intolerance in Cardiometabolic HFpEF","authors":"Heather Quiriarte MS , Robert C. Noland PhD , James E. Stampley PhD , Gregory Davis MS , Zhen Li PhD , Eunhan Cho PhD , Youyoung Kim MS , Jake Doiron BS , Guillaume Spielmann PhD , Sujoy Ghosh PhD , Sanjiv J. Shah MD , Brian A. Irving PhD , David J. Lefer PhD , Timothy D. Allerton PhD","doi":"10.1016/j.jacbts.2024.07.009","DOIUrl":"10.1016/j.jacbts.2024.07.009","url":null,"abstract":"<div><div>Exercise intolerance, a hallmark of heart failure with preserved ejection fraction (HFpEF) exacerbated by obesity, involves unclear mechanisms related to skeletal muscle metabolism. In a “2-hit” model of HFpEF, we investigated the ability of exercise therapy (voluntary wheel running) to reverse skeletal muscle dysfunction and exercise intolerance. Using state-of-the-art metabolic cages and a multiomic approach, we demonstrate exercise can rescue dysfunctional skeletal muscle lipid and branched-chain amino acid oxidation and restore exercise capacity in mice with cardiometabolic HFpEF. These results underscore the importance of skeletal muscle metabolism to improve exercise intolerance in HFpEF.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"9 12","pages":"Pages 1409-1425"},"PeriodicalIF":8.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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