Pub Date : 2022-08-01DOI: 10.1891/9781617051937.0002
Josef Jankovič, M. Hallett, M. Okun, C. Comella, Stanley Fahn, Jennifer Goldman
{"title":"Tremors","authors":"Josef Jankovič, M. Hallett, M. Okun, C. Comella, Stanley Fahn, Jennifer Goldman","doi":"10.1891/9781617051937.0002","DOIUrl":"https://doi.org/10.1891/9781617051937.0002","url":null,"abstract":"","PeriodicalId":148749,"journal":{"name":"Principles and Practice of Movement Disorders","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134262400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-01DOI: 10.1016/b978-0-323-31071-0.00018-4
Josef Jankovič, M. Hallett, Michael S. Okun, Cynthia Comella, Stanley Fahn, Jennifer Goldman
{"title":"Myoclonus","authors":"Josef Jankovič, M. Hallett, Michael S. Okun, Cynthia Comella, Stanley Fahn, Jennifer Goldman","doi":"10.1016/b978-0-323-31071-0.00018-4","DOIUrl":"https://doi.org/10.1016/b978-0-323-31071-0.00018-4","url":null,"abstract":"","PeriodicalId":148749,"journal":{"name":"Principles and Practice of Movement Disorders","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122016378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Josef Jankovič, M. Hallett, M. Okun, C. Comella, Stanley Fahn, Jennifer Goldman
He was diagnosed with Parkinson disease (Hoehn and Yahr grade 2) and administered levodopa at the maximum dose of 800 mg. However, his condition did not improve. While his symptoms were responsive to levodopa therapy, the sensitivity to the drug was poor. Brain MRI revealed atrophy of the upper vermis and cerebral hemispheres, and brain SPECT revealed low perfusion in both parietal lobes. I 123 -metaiodobenzylguanidine scintigraphy showed a decrease in the heart/mediastinum ratio. Striatal dopamine transporter (DAT) density was evaluated using I 123 -FP-CIT. The patient showed moderately reduced DAT density, which suggested nigrostriatal dopaminergic damage. His mother was found to have pure cerebellar ataxia without parkinsonism, and her two siblings also had celebellar type of multiple system atrophy (MSA-C) and progressive supranuclear palsy, respectively. Genetic testing revealed that the patient, his mother and the uncle with MSA-C had spinocerebellar ataxia type 6 (SCA6). SCA6 presenting parkinsonism without ataxia is very rare and important for the pathomechanism of disease.
{"title":"Ataxia","authors":"Josef Jankovič, M. Hallett, M. Okun, C. Comella, Stanley Fahn, Jennifer Goldman","doi":"10.32388/uen3p8","DOIUrl":"https://doi.org/10.32388/uen3p8","url":null,"abstract":"He was diagnosed with Parkinson disease (Hoehn and Yahr grade 2) and administered levodopa at the maximum dose of 800 mg. However, his condition did not improve. While his symptoms were responsive to levodopa therapy, the sensitivity to the drug was poor. Brain MRI revealed atrophy of the upper vermis and cerebral hemispheres, and brain SPECT revealed low perfusion in both parietal lobes. I 123 -metaiodobenzylguanidine scintigraphy showed a decrease in the heart/mediastinum ratio. Striatal dopamine transporter (DAT) density was evaluated using I 123 -FP-CIT. The patient showed moderately reduced DAT density, which suggested nigrostriatal dopaminergic damage. His mother was found to have pure cerebellar ataxia without parkinsonism, and her two siblings also had celebellar type of multiple system atrophy (MSA-C) and progressive supranuclear palsy, respectively. Genetic testing revealed that the patient, his mother and the uncle with MSA-C had spinocerebellar ataxia type 6 (SCA6). SCA6 presenting parkinsonism without ataxia is very rare and important for the pathomechanism of disease.","PeriodicalId":148749,"journal":{"name":"Principles and Practice of Movement Disorders","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114934546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1016/b978-0-323-31071-0.00004-4
Josef Jankovič, M. Hallett, M. Okun, C. Comella, Stanley Fahn, Jennifer Goldman
{"title":"Parkinsonism","authors":"Josef Jankovič, M. Hallett, M. Okun, C. Comella, Stanley Fahn, Jennifer Goldman","doi":"10.1016/b978-0-323-31071-0.00004-4","DOIUrl":"https://doi.org/10.1016/b978-0-323-31071-0.00004-4","url":null,"abstract":"","PeriodicalId":148749,"journal":{"name":"Principles and Practice of Movement Disorders","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128908815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1016/b978-0-323-31071-0.00009-3
J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, J. Goldman
{"title":"Atypical parkinsonism, parkinsonism-plus syndromes and secondary parkinsonian disorders","authors":"J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, J. Goldman","doi":"10.1016/b978-0-323-31071-0.00009-3","DOIUrl":"https://doi.org/10.1016/b978-0-323-31071-0.00009-3","url":null,"abstract":"","PeriodicalId":148749,"journal":{"name":"Principles and Practice of Movement Disorders","volume":"9 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128883696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1016/b978-0-323-31071-0.00015-9
J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, Jennifer Goldman
{"title":"Tics and Tourette syndrome","authors":"J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, Jennifer Goldman","doi":"10.1016/b978-0-323-31071-0.00015-9","DOIUrl":"https://doi.org/10.1016/b978-0-323-31071-0.00015-9","url":null,"abstract":"","PeriodicalId":148749,"journal":{"name":"Principles and Practice of Movement Disorders","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115162257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1016/b978-0-323-31071-0.00019-6
J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, Jennifer Goldman
{"title":"Gait disorders","authors":"J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, Jennifer Goldman","doi":"10.1016/b978-0-323-31071-0.00019-6","DOIUrl":"https://doi.org/10.1016/b978-0-323-31071-0.00019-6","url":null,"abstract":"","PeriodicalId":148749,"journal":{"name":"Principles and Practice of Movement Disorders","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133049877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1016/b978-0-323-31071-0.00026-3
J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, J. Goldman
{"title":"Peripheral movement disorders","authors":"J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, J. Goldman","doi":"10.1016/b978-0-323-31071-0.00026-3","DOIUrl":"https://doi.org/10.1016/b978-0-323-31071-0.00026-3","url":null,"abstract":"","PeriodicalId":148749,"journal":{"name":"Principles and Practice of Movement Disorders","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116249836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1016/b978-0-323-31071-0.00023-8
J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, J. Goldman
{"title":"Autoimmune movement disorders","authors":"J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, J. Goldman","doi":"10.1016/b978-0-323-31071-0.00023-8","DOIUrl":"https://doi.org/10.1016/b978-0-323-31071-0.00023-8","url":null,"abstract":"","PeriodicalId":148749,"journal":{"name":"Principles and Practice of Movement Disorders","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124657850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1016/b978-0-323-31071-0.00021-4
J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, Jennifer Goldman
{"title":"Stiffness syndromes","authors":"J. Jankovic, M. Hallett, M. Okun, C. Comella, S. Fahn, Jennifer Goldman","doi":"10.1016/b978-0-323-31071-0.00021-4","DOIUrl":"https://doi.org/10.1016/b978-0-323-31071-0.00021-4","url":null,"abstract":"","PeriodicalId":148749,"journal":{"name":"Principles and Practice of Movement Disorders","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130475222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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