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Osteoporosis screening using X-ray assessment and osteoporosis self-assessment tool for Asians in hip surgery patients.
IF 2.4 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-10 DOI: 10.1007/s00774-024-01569-5
Ryo Higuchi, Keisuke Uemura, Sotaro Kono, Hirokazu Mae, Kazuma Takashima, Hirohito Abe, Takashi Imagama, Takashi Sakai, Seiji Okada, Hidetoshi Hamada

Objectives: As many patients with osteoporosis remain undiagnosed, we aimed to develop a simple method to efficiently screen for osteoporosis using a combination of anteroposterior hip X-ray assessment and the Osteoporosis Self-Assessment Tool for Asians (OSTA), which is calculated as (body weight - age) × 0.2.

Methods: One hundred Japanese women (age: 73 ± 11 years, body weight: 54.4 ± 11.1 kg) who underwent hip surgery, anteroposterior hip X-ray, and DXA were included. Based on the DXA results of the total proximal femur, 35 cases were diagnosed with osteoporosis. Fifteen orthopaedic surgeons visually inspected the hip X-ray images and scored the suspicion of osteoporosis on a scale of 1-4 (1: very unlikely, 4: very suspicious), which is referred to as "pred-score." In addition, OSTA was calculated as a continuous variable (OSTA score). Osteoporosis was screened using the pred-score and OSTA score, and both scores were analyzed using the receiver operating characteristic curves.

Results: The area under the curves (AUCs) of the pred-score and OSTA score were 0.626-0.875 and 0.817 across surgeons, respectively. When both scores were used, the AUC for screening osteoporosis ranged from 0.821 to 0.915 across surgeons. Significant improvement from AUCs calculated with the pred-score or OSTA score was found in 11 surgeons (73.3%).

Conclusion: The combination of X-ray assessment and OSTA can be used to screen for osteoporosis and has the potential to be used as a new simple screening tool in daily clinical practice.

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引用次数: 0
Responders and non-responders to romosozumab treatment.
IF 2.4 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-07 DOI: 10.1007/s00774-024-01570-y
Ayako Tominaga, Keiji Wada, Yoshiharu Kato, Ken Okazaki

Introduction: Romosozumab is an anti-sclerostin antibody drug with potent bone formation-promoting and bone resorption-inhibiting properties. It enhances bone mineral density and has a novel effect in preventing fractures. However, there have been reports of non-responders to romosozumab.

Findings: If the least significant change is defined as 3%, only 2-12% of patients with spine osteoporosis are non-responders, and romosozumab is highly effective in this population. Low-type 1 amino-terminal propeptide (P1NP) levels during the early treatment phase are associated with non-responders early in treatment. The researchers found a cutoff value of 50.3 μg/L of P1NP in the first month of treatment. In contrast, hip osteoporosis does not respond (54-57% of the time). Low P1NP levels at the start of treatment increase the risk of non-responders. The cutoff value for P1NP was reported as 53.7 μg/L at the beginning of treatment. However, failure to meet these cutoff values does not necessarily indicate that the patient is a non-responder and does not justify a change in drug administration.

Conclusions: In spine osteoporosis, romosozumab demonstrates high effectiveness, with approximately 2-12% of patients showing no response. However, in hip osteoporosis, approximately 54-57% do not respond to the treatment with romosozumab.

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引用次数: 0
Multiple thyroid disorders and risk of osteoporosis: a two-sample Mendelian randomization study.
IF 2.4 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-06 DOI: 10.1007/s00774-024-01559-7
Guang Shi, Zhao Lin, Qixiao Shen, Wei Jin, Zhuowen Hao, Junwu Wang, Tianhong Chen, Jiayao Chen, Xin Wang, Jingfeng Li

Introduction: Previous research has demonstrated that even minor changes in thyroid function are associated with an increased risk of osteoporosis (OP). However, the causal relationship between thyroid disorders and the development of OP remains unclear. To address this, we aim to investigate the connection between genetic predispositions to various thyroid disorders and OP using a two-sample Mendelian randomization (MR) approach.

Materials and methods: Instrumental variables (IVs) for multiple thyroid disorders were sourced from a large genome-wide association study (GWAS) meta-analysis dataset. Summary-level data for OP were obtained from the FinnGen consortium. Inverse variance weighting (IVW) methods served as the primary approach for MR analysis. Sensitivity analyses included MR-Egger regression, heterogeneity testing, multiple validity tests, and leaFve-one-out sensitivity tests.

Results: IVW analysis revealed a direct causal effect of hypothyroidism (OR = 1.105, 95% CI 1.023-1.194, P 0.011) and Hashimoto's thyroiditis (OR = 1.142, 95% CI 1.026-1.271, P 0.015) on OP. However, no direct causal association was found between hyperthyroidism (OR = 1.030, 95% CI 0.944-1.123, P 0.508) or thyroid cancer (OR = 0.971, 95% CI 0.898-1.051, P 0.469) and OP.

Conclusion: Our MR analysis revealed a causal association between hypothyroidism, Hashimoto's thyroiditis, and OP. This highlights the significant impact of thyroid function on bone health. However, further longitudinal studies are needed to confirm these findings conclusively.

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引用次数: 0
Histological assessments for anabolic effects in teriparatide/abaloparatide administered rodent models.
IF 2.4 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-04 DOI: 10.1007/s00774-024-01562-y
Tomoka Hasegawa, Tomomaya Yamamoto, Mai Haraguchi-Kitakamae, Hiromi Hongo, Yan Shi, Jiaxin Cui, Xuanyu Liu, Qi Yao, Miki Abe, Haruhi Maruoka, Ayako Yokoyama, Tamaki Sekiguchi, Akito Makino, Norio Amizuka

Parathyroid hormone (PTH) is thought to induce remodeling-based bone formation by promoting osteoclastic activity, a process known as cellular coupling. Our research has shown that the frequency of PTH administration affects trabecular number and thickness. High-frequency PTH administration induced remodeling-based bone formation, while less frequent administration induced both remodeling-based and modeling-based bone formation. Additionally, we found that specific bone sites influence whether remodeling-based or modeling-based bone formation is more likely to occur. Additionally, while PTH significantly increases trabecular bone, it also causes cortical porosis. Our research on the femoral diaphysis showed that PTH administration resulted in the invasion of blood vessels and osteoclasts into the cortical bone. Abaloparatide acts similarly to teriparatide through the parathyroid hormone receptor type 1 (PTH1R) but may have a wider anabolic window due to its lesser impact on bone resorption. Our mouse studies with abaloparatide showed similar results to those seen in human patients, with increased preosteoblastic cell populations and wider anabolic windows when compared with teriparatide. Abaloparatide-induced bone formation cannot be explained solely by remodeling-based bone formation, indicating the need for further research into modeling-based bone formation.

{"title":"Histological assessments for anabolic effects in teriparatide/abaloparatide administered rodent models.","authors":"Tomoka Hasegawa, Tomomaya Yamamoto, Mai Haraguchi-Kitakamae, Hiromi Hongo, Yan Shi, Jiaxin Cui, Xuanyu Liu, Qi Yao, Miki Abe, Haruhi Maruoka, Ayako Yokoyama, Tamaki Sekiguchi, Akito Makino, Norio Amizuka","doi":"10.1007/s00774-024-01562-y","DOIUrl":"https://doi.org/10.1007/s00774-024-01562-y","url":null,"abstract":"<p><p>Parathyroid hormone (PTH) is thought to induce remodeling-based bone formation by promoting osteoclastic activity, a process known as cellular coupling. Our research has shown that the frequency of PTH administration affects trabecular number and thickness. High-frequency PTH administration induced remodeling-based bone formation, while less frequent administration induced both remodeling-based and modeling-based bone formation. Additionally, we found that specific bone sites influence whether remodeling-based or modeling-based bone formation is more likely to occur. Additionally, while PTH significantly increases trabecular bone, it also causes cortical porosis. Our research on the femoral diaphysis showed that PTH administration resulted in the invasion of blood vessels and osteoclasts into the cortical bone. Abaloparatide acts similarly to teriparatide through the parathyroid hormone receptor type 1 (PTH1R) but may have a wider anabolic window due to its lesser impact on bone resorption. Our mouse studies with abaloparatide showed similar results to those seen in human patients, with increased preosteoblastic cell populations and wider anabolic windows when compared with teriparatide. Abaloparatide-induced bone formation cannot be explained solely by remodeling-based bone formation, indicating the need for further research into modeling-based bone formation.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
List of reviewers 2024.
IF 2.4 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-04 DOI: 10.1007/s00774-024-01565-9
{"title":"List of reviewers 2024.","authors":"","doi":"10.1007/s00774-024-01565-9","DOIUrl":"https://doi.org/10.1007/s00774-024-01565-9","url":null,"abstract":"","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrient foramina of human fibula: morphometric analysis and clinical relevance.
IF 2.4 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-12-02 DOI: 10.1007/s00774-024-01568-6
N Roshini, Maria Francis Yuvaraj, Sankaran Ponnusamy Kasirajan, Balaji Karunakaran, Lakshmanan Govindan, John T D Caleb, Azhagu Madhavan Sivalingam, T Siva, Sathish Kumar

Background: The fibula, situated laterally in the leg, receives vital nutrition through nutrient arteries during embryonic bone growth and early ossification. This study aims to assess the direction, distance, location, number, and foraminal index of nutrient foramina in dry fibulae from the South Indian population.

Materials and methods: A descriptive cross-sectional analysis involved 63 dry adult human fibulae sourced from the Department of Anatomy, Saveetha Medical College and Hospital, Thandalam. Parameters like fibula length, location, number, and direction of vascular foramina were recorded. Statistical analyses were performed on morphometric data and foraminal index.

Results: The mean fibula length was 34.68 ± 2.11 cm. Among the fibulae, 88.88% had a single nutrient foramen, 4.76% had dual foramina, and 6.34% lacked nutrient foramina. Most single foramina were found on the medial crest (66.66%), followed by between the medial crest and posterior border (20.63%). Nutrient foramina were primarily located in Zone II (87.30%), followed by Zone III (11.11%) and Zone I (1.58%). Directionally, 85.71% pointed downward, while 14.28% pointed upward. The mean foraminal index was 40.85 ± 6.78, ranging from 32.57 to 56.25.

Conclusion: Zone II, particularly on the medial crest, was the most prevalent location for vascular foramina in the fibula. Dual foramina occurred in 6.34% of cases. This precise anatomical knowledge is valuable for various medical professionals, including anthropologists, forensic experts, radiologists, plastic surgeons, and orthopedic surgeons, especially in procedures involving vascularized fibular bone grafts.

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引用次数: 0
Journal of Bone and Mineral Metabolism Best Paper Award 2024.
IF 2.4 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-30 DOI: 10.1007/s00774-024-01566-8
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引用次数: 0
Meclozine and growth hormone ameliorate bone length and quality in experimental models of achondroplasia. 美克洛嗪和生长激素可改善软骨发育不全实验模型的骨长度和骨质量。
IF 2.4 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-08 DOI: 10.1007/s00774-024-01563-x
Kenta Sawamura, Masaki Matsushita, Ryusaku Esaki, Kenichi Mishima, Yasunari Kamiya, Kinji Ohno, Hiroshi Kitoh, Shiro Imagama

Introduction: Achondroplasia (ACH) is a common skeletal dysplasia associated with short-limbed short stature caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. Meclozine was found to inhibit FGFR3 signaling using a drug repositioning strategy. In some countries, growth hormone (GH) has been employed to ameliorate short stature in children with ACH. This study aims to investigate the effects of meclozine and GH on bone growth and quality using an experimental model of ACH.

Materials and methods: Meclozine (2 mg/kg/day) and/or GH (0.35 mg/kg/day) were administered to a mouse model of ACH from the age of 7 to 56 days. Body length and body weight of each mouse were measured during these treatments. At the end of treatments, these mice were subjected to micro-computed tomography scans to measure the lengths of long bones and bone mineral density (BMD). The width of the growth plate was quantified by histological analysis.

Results: The body and bone length of transgenic mice significantly increased after treatment with meclozine and GH, although there was no additive effect of the combination therapy on promoting bone growth. In contrast, BMD was additively increased by the combination therapy. The width of the growth plate in transgenic mice was significantly increased by both treatments, although the hypertrophic zone was enlarged by meclozine but not by GH.

Conclusion: Meclozine or GH may be an option for treating children with ACH to ameliorate bone length and quality, but the additive effect would be limited.

导言:软骨发育不全症(ACH)是一种常见的骨骼发育不良症,由于成纤维细胞生长因子受体 3(FGFR3)基因的功能增益突变而导致短肢矮身材。研究发现,美克洛嗪可通过药物重新定位策略抑制 FGFR3 信号传导。在一些国家,生长激素(GH)被用于改善ACH患儿的身材矮小。本研究旨在通过ACH实验模型,研究美克洛嗪和GH对骨骼生长和质量的影响:给7至56天大的ACH小鼠模型注射美克洛嗪(2毫克/千克/天)和/或GH(0.35毫克/千克/天)。在治疗期间测量每只小鼠的体长和体重。治疗结束后,对这些小鼠进行微型计算机断层扫描,以测量长骨的长度和骨矿物质密度(BMD)。生长板的宽度通过组织学分析进行量化:结果:使用美克洛嗪和 GH 治疗后,转基因小鼠的体长和骨长明显增加,但联合疗法对促进骨生长没有叠加效应。与此相反,联合疗法可增加骨密度。两种疗法都能显著增加转基因小鼠生长板的宽度,但美克洛嗪能扩大肥厚区,而 GH 却不能:结论:美克洛嗪或 GH 可用于治疗 ACH 儿童,以改善骨长度和骨质量,但其叠加效应有限。
{"title":"Meclozine and growth hormone ameliorate bone length and quality in experimental models of achondroplasia.","authors":"Kenta Sawamura, Masaki Matsushita, Ryusaku Esaki, Kenichi Mishima, Yasunari Kamiya, Kinji Ohno, Hiroshi Kitoh, Shiro Imagama","doi":"10.1007/s00774-024-01563-x","DOIUrl":"https://doi.org/10.1007/s00774-024-01563-x","url":null,"abstract":"<p><strong>Introduction: </strong>Achondroplasia (ACH) is a common skeletal dysplasia associated with short-limbed short stature caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. Meclozine was found to inhibit FGFR3 signaling using a drug repositioning strategy. In some countries, growth hormone (GH) has been employed to ameliorate short stature in children with ACH. This study aims to investigate the effects of meclozine and GH on bone growth and quality using an experimental model of ACH.</p><p><strong>Materials and methods: </strong>Meclozine (2 mg/kg/day) and/or GH (0.35 mg/kg/day) were administered to a mouse model of ACH from the age of 7 to 56 days. Body length and body weight of each mouse were measured during these treatments. At the end of treatments, these mice were subjected to micro-computed tomography scans to measure the lengths of long bones and bone mineral density (BMD). The width of the growth plate was quantified by histological analysis.</p><p><strong>Results: </strong>The body and bone length of transgenic mice significantly increased after treatment with meclozine and GH, although there was no additive effect of the combination therapy on promoting bone growth. In contrast, BMD was additively increased by the combination therapy. The width of the growth plate in transgenic mice was significantly increased by both treatments, although the hypertrophic zone was enlarged by meclozine but not by GH.</p><p><strong>Conclusion: </strong>Meclozine or GH may be an option for treating children with ACH to ameliorate bone length and quality, but the additive effect would be limited.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum albumin as a biomarker of (nutritional status in) sarcopenia. 血清白蛋白作为(肌肉疏松症营养状况的)生物标志物。
IF 2.4 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-08 DOI: 10.1007/s00774-024-01557-9
Kübra Erdoğan, Murat Kara, Fatıma Edibe Şener, Mahmut Esad Durmuş, Beyza Nur Çıtır Durmuşoğlu, Ahmad J Abdulsalam, Semih Sezer, Özgür Kara, Bayram Kaymak, Levent Özçakar

Introduction: To explore the possible associations between blood markers including albumin, hemoglobulin, creatinine and 25 OH vitamin D with sarcopenia using the ISarcoPRM algorithm.

Materials and methods: A total of 2094 community-dwelling males and postmenopausal females (495 males, 1599 females)aged ≥ 50 years were recruited and their demographic data along with all comorbidities and laboratory evaluations were noted. Functional measurements were also quantified and the ISarcoPRM algorithm was used for the diagnosis/confirmation of the participants into sarcopenic and non-sarcopenic categories.

Results: Sarcopenia was detected in 434 (20.7%) participants and low albumin level in 578 (27.6%) of them. While sarcopenia was detected in 193 (33.4%) of 578 subjects with low albumin levels, and in 241 (15.9%) of 1516 subjects with normal albumin levels (p < 0.001). In the binary logistic regression analysis, among the blood parameters; only albumin levels [OR: 0.932 (95% CI 0.876-0.992) in males (p = 0.026), OR: 0.901 (95% CI 0.862-0.941) in females (p < 0.001)were found to be independently associated with sarcopenia in each gender. After adjusting for sociodemographic and other clinical factors, having low albumin levels(≤ 4.0 g/dL) were independently associated with sarcopenia i.e. 2.368 times (95% CI 1.424-3.939) in males and 2.026 times (95% CI 1.520-2.699) in females (both p < 0.001).

Conclusion: Independent of other factors, low albumin level is associated with sarcopenia i.e. at least two times in both genders. Older and obese adults at risk of malnutrition should be screened/diagnosed and treated early for sarcopenia. Prospective studies are needed for better/prompt management of relevant patients who are prone to significant morbidity and mortality.

导言利用 ISarcoPRM 算法探讨白蛋白、血红蛋白、肌酐和 25 OH 维生素 D 等血液指标与肌肉疏松症之间可能存在的关联:共招募了 2094 名年龄≥ 50 岁的社区男性和绝经后女性(男性 495 人,女性 1599 人),并记录了他们的人口统计学数据、所有合并症和实验室评估结果。此外,还对功能测量进行了量化,并使用 ISarcoPRM 算法将参与者诊断/确认为肌肉疏松症和非肌肉疏松症:结果:434 名参与者(20.7%)发现了肌肉疏松症,578 名参与者(27.6%)发现了白蛋白水平低。白蛋白水平低的 578 名受试者中有 193 人(33.4%)患有肌肉疏松症,白蛋白水平正常的 1516 名受试者中有 241 人(15.9%)患有肌肉疏松症:在不考虑其他因素的情况下,低白蛋白水平与肌肉疏松症有关联,即在男女两性中至少有两倍的关联。有营养不良风险的老年人和肥胖成人应及早筛查/诊断和治疗肌肉疏松症。我们需要进行前瞻性研究,以便更好地/及时处理易导致严重发病和死亡的相关患者。
{"title":"Serum albumin as a biomarker of (nutritional status in) sarcopenia.","authors":"Kübra Erdoğan, Murat Kara, Fatıma Edibe Şener, Mahmut Esad Durmuş, Beyza Nur Çıtır Durmuşoğlu, Ahmad J Abdulsalam, Semih Sezer, Özgür Kara, Bayram Kaymak, Levent Özçakar","doi":"10.1007/s00774-024-01557-9","DOIUrl":"https://doi.org/10.1007/s00774-024-01557-9","url":null,"abstract":"<p><strong>Introduction: </strong>To explore the possible associations between blood markers including albumin, hemoglobulin, creatinine and 25 OH vitamin D with sarcopenia using the ISarcoPRM algorithm.</p><p><strong>Materials and methods: </strong>A total of 2094 community-dwelling males and postmenopausal females (495 males, 1599 females)aged ≥ 50 years were recruited and their demographic data along with all comorbidities and laboratory evaluations were noted. Functional measurements were also quantified and the ISarcoPRM algorithm was used for the diagnosis/confirmation of the participants into sarcopenic and non-sarcopenic categories.</p><p><strong>Results: </strong>Sarcopenia was detected in 434 (20.7%) participants and low albumin level in 578 (27.6%) of them. While sarcopenia was detected in 193 (33.4%) of 578 subjects with low albumin levels, and in 241 (15.9%) of 1516 subjects with normal albumin levels (p < 0.001). In the binary logistic regression analysis, among the blood parameters; only albumin levels [OR: 0.932 (95% CI 0.876-0.992) in males (p = 0.026), OR: 0.901 (95% CI 0.862-0.941) in females (p < 0.001)were found to be independently associated with sarcopenia in each gender. After adjusting for sociodemographic and other clinical factors, having low albumin levels(≤ 4.0 g/dL) were independently associated with sarcopenia i.e. 2.368 times (95% CI 1.424-3.939) in males and 2.026 times (95% CI 1.520-2.699) in females (both p < 0.001).</p><p><strong>Conclusion: </strong>Independent of other factors, low albumin level is associated with sarcopenia i.e. at least two times in both genders. Older and obese adults at risk of malnutrition should be screened/diagnosed and treated early for sarcopenia. Prospective studies are needed for better/prompt management of relevant patients who are prone to significant morbidity and mortality.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of disease activity and gonadal status on bone mineral density and turnover in acromegaly. 疾病活动和性腺状态对肢端肥大症患者骨矿物质密度和骨转换的影响。
IF 2.4 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM Pub Date : 2024-11-07 DOI: 10.1007/s00774-024-01561-z
Fabiana Freire Silva, Maria de Lourdes Lima, Clarissa Carvalho Pedreira, Marcos Almeida Matos

Introduction: The purpose of this study was to evaluate the impact of disease activity and gonadal status on bone mineral density (BMD) and turnover markers (BTMs) in individuals with acromegaly.

Materials and methods: Subjects underwent laboratory tests for PTH, 25-hydroxyvitamin D, calcium, phosphorus, osteocalcin (OC) and C-telopeptide (CTX-1) and bone densitometry at the lumbar spine (LS), femoral neck (FN) and total hip (TH).

Results: Sixty participants (48.6 ± 11.0 years; 66,7% female) were included in this cross-sectional study. Phosphorus, OC, CTX-1, and LS BMD were greater in the active disease group than in the controlled/cured disease group (P = 0.025, P < 0.001, P = 0.007, and P = 0.016, respectively). When analyzing gonadal status, phosphorus, OC and CTX-1 were greater in the hypogonadal group than in the eugonadal group (P = 0.017, P = 0.015, and P = 0.033, respectively). Patients with hypogonadism had a higher prevalence of reduced bone mass compared to eugonadal patients (44 vs. 17%, P = 0.023).

Conclusion: This study revealed increased levels of phosphorus and BTMs in patients with active acromegaly. In this group, the greater LS BMD values are likely due to the anabolic effects of GH and IGF-1 and/or to the influence of LS arthropathy. Moreover, hypogonadism negatively impacts bone metabolism in acromegaly, leading to elevated BTMs and a higher prevalence of reduced bone mass in individuals affected by both conditions.

简介本研究旨在评估疾病活动和性腺状态对肢端肥大症患者骨矿物质密度(BMD)和骨转换标志物(BTMs)的影响:受试者接受了 PTH、25-羟维生素 D、钙、磷、骨钙素(OC)和 C-telopeptide (CTX-1)的实验室检测,以及腰椎(LS)、股骨颈(FN)和全髋(TH)的骨密度测量:这项横断面研究共纳入 60 名参与者(48.6 ± 11.0 岁;66.7% 为女性)。活动性疾病组的磷水平、OC 水平、CTX-1 水平和 LS BMD 水平均高于控制/治愈疾病组(P = 0.025,P 结论:该研究发现,活动性疾病组的磷水平、OC 水平、CTX-1 水平和 LS BMD 水平均高于控制/治愈疾病组:本研究显示,活动性肢端肥大症患者的磷和BTM水平升高。在该组患者中,LS BMD 值升高可能是由于 GH 和 IGF-1 的合成代谢作用和/或 LS 关节病的影响。此外,性腺功能减退症会对肢端肥大症患者的骨代谢产生负面影响,从而导致 BTMs 升高,这两种疾病患者的骨量降低率更高。
{"title":"Influence of disease activity and gonadal status on bone mineral density and turnover in acromegaly.","authors":"Fabiana Freire Silva, Maria de Lourdes Lima, Clarissa Carvalho Pedreira, Marcos Almeida Matos","doi":"10.1007/s00774-024-01561-z","DOIUrl":"https://doi.org/10.1007/s00774-024-01561-z","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to evaluate the impact of disease activity and gonadal status on bone mineral density (BMD) and turnover markers (BTMs) in individuals with acromegaly.</p><p><strong>Materials and methods: </strong>Subjects underwent laboratory tests for PTH, 25-hydroxyvitamin D, calcium, phosphorus, osteocalcin (OC) and C-telopeptide (CTX-1) and bone densitometry at the lumbar spine (LS), femoral neck (FN) and total hip (TH).</p><p><strong>Results: </strong>Sixty participants (48.6 ± 11.0 years; 66,7% female) were included in this cross-sectional study. Phosphorus, OC, CTX-1, and LS BMD were greater in the active disease group than in the controlled/cured disease group (P = 0.025, P < 0.001, P = 0.007, and P = 0.016, respectively). When analyzing gonadal status, phosphorus, OC and CTX-1 were greater in the hypogonadal group than in the eugonadal group (P = 0.017, P = 0.015, and P = 0.033, respectively). Patients with hypogonadism had a higher prevalence of reduced bone mass compared to eugonadal patients (44 vs. 17%, P = 0.023).</p><p><strong>Conclusion: </strong>This study revealed increased levels of phosphorus and BTMs in patients with active acromegaly. In this group, the greater LS BMD values are likely due to the anabolic effects of GH and IGF-1 and/or to the influence of LS arthropathy. Moreover, hypogonadism negatively impacts bone metabolism in acromegaly, leading to elevated BTMs and a higher prevalence of reduced bone mass in individuals affected by both conditions.</p>","PeriodicalId":15116,"journal":{"name":"Journal of Bone and Mineral Metabolism","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Bone and Mineral Metabolism
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