Journal of Cardiopulmonary Rehabilitation最新文献

Purpose: An exaggerated blood pressure (EBP) response to exercise has been shown to be a predictor of future hypertension and risk of cardiovascular mortality. Although EBP is associated with endothelial dysfunction and increased left ventricular hypertrophy, the underlying mechanisms are not fully understood. Inflammatory markers, C-reactive protein (CRP) and white blood cells (WBCs), were predictive of future hypertension. The objective of this study was to examine the hypothesis that increasing levels of CRP and WBCs would be related to an EBP response during exercise.

Methods: Inflammatory markers were compared in 43 males with an EBP (systolic blood pressure [SBP] >or=210 mm Hg) response during maximal treadmill testing to an age and resting SBP-matched group of 42 males with a normal blood pressure response to exercise.

Results: There were significant group differences in maximal SBP and diastolic blood pressure (DBP), exercise induced increases in SBP and DBP (P <.01), and WBCs (P <.01), but CRP did not differ between groups (P =.39). White blood cells were significantly associated with maximal SBP (r = 0.31), and the exercise-induced increase in SBP (r = 0.34). However, CRP did not correlate with the maximal blood pressure response to exercise (r = 0.11, P =.33). In a stepwise multiple regression analysis, WBC was independently associated with the exercise-induced increase in SBP (beta = 0.256, P =.011).

Conclusions: These results suggest that inflammation may be associated with an EBP response during exercise testing.

Purpose: Psychosocial factors, such as depression, have been identified as important predictors of morbidity and mortality in individuals with coronary heart disease; however, little research has been done examining hopelessness in this population. This investigation examined the frequency and severity of hopelessness and depression in the early recovery period after hospitalization for acute coronary syndrome (ACS), the relationship between hopelessness and depression, and patient characteristics leading to these 2 variables.

Methods: A total of 525 post-ACS patients at 5 hospitals in Michigan were interviewed. Measures included the cognitive expectations factor of the Beck Hopelessness Scale and the Center for Epidemiologic Studies-Depression Scale.

Results: Hopelessness symptoms were frequent and moderate to severe in 27% of the sample, whereas depression was frequent and moderate to severe in 36% of subjects. Hopelessness was moderately correlated with depression, yet a number of different patient characteristics were predictive of each. Lower educational level predicted hopelessness, but not depression. Patients who had coronary artery bypass surgery or coronary angioplasty were more hopeless, but not more depressed. Female gender predicted depression, but not hopelessness. Hopelessness and depression had a shared variance of 33%.

Conclusions: Hopelessness and depression were frequent and moderate to severe in a portion of patients in the early ACS recovery period. An association between hopelessness and depression exists, while different patient characteristics were more strongly associated with each. Longitudinal analysis is needed to examine hopelessness and depression in later phases of the ACS recovery period.

Background: Unsupported arm exercise tests have been used to evaluate the effects of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD), but the reliability and validity of these tests are not established.

Objective: We evaluated the test-retest reliability and validity of a 6-minute pegboard and ring test (PBRT) in 27 outpatients with COPD and 30 age-matched controls.

Methods: We evaluated a 6-minute PBRT, subject demographics, pulmonary function and disease-specific quality of life questionnaire, and the Pulmonary Functional Status Dyspnea Questionnaire-Modified version in 27 patients with COPD.

Results: Highly significant correlation coefficients (r = .91, P < .001) were found between test and retest of PBRT scores. Statistically significant correlation coefficients were found between PBRT scores and pulmonary function tests such as FEV1% pred and FVC% pred, and activity domain and subdomain of Pulmonary Functional Status Dyspnea Questionnaire-Modified (P

Conclusion: PBRT is a reliable and valid method to assess unsupported arm exercise endurance in patients with COPD.

Purpose: Use the meta-analytic approach to examine the effects of aerobic exercise on lipids and lipoproteins in adults with cardiovascular disease (CVD).

Methods: Studies were retrieved via electronic databases, review of reference lists from retrieved articles, including reviews, and hand searching. Inclusion criteria were: (1) randomized controlled trials, (2) aerobic exercise >or=4 weeks as an intervention, (3) studies published in English language only between January 1, 1955 and January 1, 2005, (4) studies published in journals or as dissertations or master's theses, (5) human subjects >or=18 years, (6) all subjects diagnosed with some type of CVD, and (7) pre and post data available for total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). Random-effects models were used for data analysis.

Results: Of the more than 3,000 studies reviewed, a total of 10 representing 1,260 subjects (580 exercise, 680 control) were included in our analysis. There was a statistically significant increase of 9% in HDL-C (mean +/- SEM, 3.7 +/- 1.3 mg/dL; 95% CI, 1.2 to 6.1 mg/dL) and a statistically significant decrease of 11% in TG (-19.3 +/- 5.4 mg/dL; 95% CI, -30.1 to -8.5 mg/dL), but no statistically significant decreases in TC or LDL-C (TC, -8.8 +/- 6.8 mg/dL; 95% CI, -22.3 to 4.7 mg/dL; LDL-C, -7.7 +/- 6.0 mg/dL; 95% CI, -19.5 to 4.2 mg/dL).

Conclusions: The present findings suggest that chronic aerobic exercise increases HDL-C and decreases TG in adults, especially men, with CVD.