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Determination of the Concentration of Heavy Metals and Their Assessment of Related Potential Health Risk for Dry Black Teas in Kashan, Iran 伊朗卡山干红茶重金属浓度测定及潜在健康风险评价
Q4 Medicine Pub Date : 2020-05-01 DOI: 10.22034/JCHR.2020.1891622.1094
Nedasadat Seyyedi Bidgoli, G. Mostafaii, H. Akbari, E. Chimehi, M. Miranzadeh
1 MA,Department of Environmental Health Engineering, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran 2 Associate Professor in Department of Environmental Health Engineering, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran 3 Associate Professor in Department of Biostatistics and Public Health, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran 4 Full Professor in Department of Environmental Health Engineering, Faculty of Health, Kashan University of Medical Sciences, Kashan, Iran (Received: 23 January 2020 Accepted: 13 April 2020)
1伊朗卡尚医科大学卫生学院环境卫生工程系硕士2伊朗卡尚医科大学卫生学院环境卫生工程系副教授3伊朗卡尚医科大学卫生学院生物统计与公共卫生系副教授4伊朗卡尚医科大学卫生学院环境卫生工程系正教授伊朗卡尚医科大学(收稿日期:2020年1月23日)
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引用次数: 1
Lactobacillus paracasei Impact on Myocardial Hypertrophy in Rats with Heart Failure 副干酪乳杆菌对心力衰竭大鼠心肌肥大的影响
Q4 Medicine Pub Date : 2020-02-26 DOI: 10.22034/JCHR.2020.1888659.1080
Zohreh Hesari, Khatereh Kafshdoozan, M. Barati, P. Kokhaei, S. Andalib, Fatemeh TalebiKiassari, M. Darban, A. Abdolshahi, B. Bagheri
Cardiac hypertrophy and cardiac dysfunction are important complications of heart failure. Cardiovascular, immunological, and hormonal players are involved in the pathogenesis of heart failure. Current evidence suggests that probiotics may have fruitful effects on the heart function. This was our aim. To this end, effects of oral administration of Lactobacillus paracasei subsp. paracasei 8700:2 on isoproterenol-induced heart failure were investigated. Forty male Wistar rats weighing 200 g were randomly assigned to five groups; the control group (saline-treated group), probiotic-treated group, heart failure group (isoproterenol-introduced group), pretreatment group (treating them by probiotic for 20 days then induced heart failure) and treatment group (following heart failure-induced, treating them by probiotic for 20 days). The groups were studied for 30 days. Serum levels of atrial natriuretic peptide (ANP) and chemerin were measured by ELISA. Finally, the hearts were removed for histopathological evaluation. Compared to the control group, isoproterenol caused cardiac hypertrophy and increased ANP (P < 0.05) and chemerin levels. Treatment with Lactobacillus paracasei significantly reduced the levels of ANP (P < 0.01) and decreased the pathological damages to the myocardium. It caused a small reduction in chemerin level, as well. Pretreatment with probiotics had no positive effects on cardiac hypertrophy and related parameters. Our findings indicate that treatment with Lactobacillus paracasei subsp. paracasei 8700:2 reduces cardiac hypertrophy in rats. In addition, this probiotic reduces the serum levels of chemerin and ANP.
心脏肥厚和心功能障碍是心力衰竭的重要并发症。心血管、免疫和激素因素参与心力衰竭的发病机制。目前的证据表明,益生菌可能对心脏功能有有益的影响。这就是我们的目标。为此,口服副干酪乳杆菌亚种的效果。Paracasei 8700:2对异丙肾上腺素诱发心力衰竭的影响。体重200 g的雄性Wistar大鼠40只,随机分为5组;对照组(盐水处理组)、益生菌处理组、心力衰竭组(异丙肾上腺素引入组)、预处理组(益生菌治疗20 d后诱发心力衰竭)、治疗组(心力衰竭后益生菌治疗20 d)。各组试验期为30 d。ELISA法测定血清房钠肽(ANP)和趋化素水平。最后,取出心脏进行组织病理学评估。与对照组相比,异丙肾上腺素引起心肌肥厚,ANP和趋化素水平升高(P < 0.05)。副干酪乳杆菌显著降低了ANP水平(P < 0.01),减轻了心肌病理损伤。它也导致了趋化素水平的小幅下降。益生菌预处理对心肌肥厚及相关指标无显著影响。我们的研究结果表明,用副干酪乳杆菌处理。Paracasei 8700:2减少大鼠心脏肥厚。此外,该益生菌可降低血清趋化素和ANP水平。
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引用次数: 1
Cardiovascular Disease risk Factors in Male Cigarette Smokers in Calabar, Southern Nigeria 尼日利亚南部卡拉巴尔男性吸烟者心血管疾病危险因素
Q4 Medicine Pub Date : 2020-02-01 DOI: 10.22034/JCHR.2020.1869928.1032
I. Bassey, U. Akpan, I. Okafor, I. Inyang, O. Eze
Cigarette smoking has been linked to atherosclerosis, coronary artery disease, peripheral vascular disorders and various malignancies. However, the mechanism by which smoking increases the risk of cardiovascular diseases is still controversial. One hundred and forty one apparently healthy male cigarette smokers and sixty apparently healthy non-smokers aged 18 to 65 years were enrolled into the study. The smokers were sub-divided into light ( 30 pack years) smokers. Anthropometric indices and blood pressure were measured. Fasting plasma glucose, total cholesterol (TC), triglycerides and High density lipoprotein-cholesterol (HDL-C) were estimated using colorimetric test methods while low density lipoprotein-cholesterol (LDL-C) and very low density lipoprotein were calculated using Friedewald’s equation. Serum insulin was estimated using ELISA. Data was analyzed using SPSS version 20.0; level of significance was set at p<0.05. The smokers had significantly higher diastolic BP (p=0.0001), TC (p= 0.008) and LDL-C (p = 0.0001) and significantly lower HDL-C (p = 0.0001) compared to the non-smokers. There was a significant higher fasting plasma glucose in the light smokers (p=0.001) than in the moderate and heavy smokers whereas, serum TC and LDL-C levels were significantly increased in heavy smokers (p=0.001) than in the light and moderate smokers. There was a negative correlation between BMI and smoking pack years. Dyslipidaemia was observed to be the most prevalent cardiovascular disease risk factor. It is concluded that the alterations in lipid profile and blood pressure observed in this study may contribute to higher risk of cardiovascular disease.
吸烟与动脉粥样硬化、冠状动脉疾病、外周血管疾病和各种恶性肿瘤有关。然而,吸烟增加心血管疾病风险的机制仍然存在争议。141名明显健康的男性吸烟者和60名年龄在18至65岁之间的明显健康的非吸烟者被纳入了这项研究。吸烟者被分为轻度吸烟者(30包年)。测量人体测量指标和血压。用比色法测定空腹血糖、总胆固醇(TC)、甘油三酯和高密度脂蛋白胆固醇(HDL-C),用弗里德瓦尔德方程计算低密度脂蛋白(LDL-C)和极低密度脂素。用ELISA法测定血清胰岛素。数据使用SPSS 20.0版进行分析;显著性水平设定为p<0.05。与非吸烟者相比,吸烟者的舒张压(p=0.0001)、TC(p=0.008)和LDL-C(p=0.001)显著较高,HDL-C(p=.0001)显著较低。轻度吸烟者的空腹血糖显著高于中度和重度吸烟者(p=0.001),而重度吸烟者的血清TC和LDL-C水平显著高于轻度和中度吸烟者(p=0.0001)。BMI与吸烟年限呈负相关。血脂异常被认为是最常见的心血管疾病危险因素。结论是,本研究中观察到的血脂和血压的变化可能会导致心血管疾病的风险增加。
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引用次数: 0
Effects of Process Parameter on Crude Oil Biodegradation of Palm Oil Mill Effluent using Response Surface Optimization 响应面优化研究工艺参数对棕榈油厂废水原油生物降解的影响
Q4 Medicine Pub Date : 2019-04-25 DOI: 10.22034/JCHR.2019.664497
Ani Kingsley Amechi, Eze Felix
Crude oil; Contaminated soil; Palm oil mill effluent; First order kinetics; second order kinetics; Error analysis; RSM ABSTRACT: The aim of this study was to investigate the effects of process parameter on crude oil (CO) biodegradation of palm oil mill effluent (POME) by using response surface optimization. Physiochemical characterization of the uncontaminated soil (UCS), crude oil contaminated soils (COCS), and POME were investigated. Further characterization on the POME was done employing the scanning electron microscope (SEM) and Fourier transform infrared (FT-IR). First and second order kinetics models were used to estimate the kinetic parameters. Results obtained indicated that POME contained valuable soil nutrient as it showed a stimulatory effect on the physiochemical properties of the COCS. However, POME was able to degrade 51% of CO with an initial CO concentration of 130 g/L. The first order kinetics proved a better model with a high rate constant, lower biological half-life and R2 greater than 0.96. From the optimization process, the quadratic model with 78.8% contribution and R2 of 0.993 satisfactorily explained the interactions between the independent variable and the response. The FT-IR spectrum revealed the presence of nitrogen and phosphorous on the surface of POME, while SEM indicated a smooth surface of POME.
原油受污染的土壤;棕榈油厂废水;一阶动力学;二阶动力学;误差分析;RSM摘要:本研究的目的是通过响应面优化研究工艺参数对棕榈油磨废水(POME)原油(CO)生物降解的影响。研究了未污染土壤(UCS)、原油污染土壤(COCS)和聚甲醛的理化性质。采用扫描电子显微镜(SEM)和傅立叶变换红外光谱(FT-IR)对POME进行了进一步的表征。使用一阶和二阶动力学模型来估计动力学参数。结果表明,聚甲醛对COCS的理化性质具有刺激作用,含有宝贵的土壤养分。然而,当初始CO浓度为130g/L时,POME能够降解51%的CO。一阶动力学证明是一个更好的模型,具有较高的速率常数、较低的生物半衰期和大于0.96的R2。从优化过程来看,贡献率为78.8%、R2为0.993的二次模型很好地解释了自变量与响应之间的相互作用。FT-IR光谱显示POME表面存在氮和磷,SEM显示POME的表面光滑。
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引用次数: 0
Synthesis and Cytotoxic Evaluation of 2-Pyrazoline Derivative on Leukemia Cancer Cell Line K562 2-吡唑啉衍生物的合成及其对白血病癌症细胞株K562细胞毒性的评价
Q4 Medicine Pub Date : 2018-12-26 DOI: 10.22034/JCHR.2018.545324
M. Shaabanzadeh, M. Torbati
The 2-pyrazoline derivatives have a wide range of biological effects, such as anti-viral, anti-bacterial, anti-fungal, anti-depressant and anti-cancer effects. Studies have shown that compounds containing 2-pyrazoline along with another heterocycles may show more effective biological properties. In this study, a 2-pyrazoline derivative with a spiro-indenoquinoxaline ring at C3 position was synthesized by one-pot microwave-assisted method and its chemical structure was confirmed by 1H NMR spectroscopy. The cytotoxic effects of the compound were evaluated on the K562 cell line and phytohemagglutinin-activated peripheral blood mononuclear cells (PHA+PBMC) by MTT assay. Additionally, the cytotoxic effects of cisplatin on these cells were investigated and compared with those of 2-pyrazoline. The IC50 values ​​obtained from the 2-pyrazoline derivative effects on the K562 cell line and PHA+PBMC cells were 45 and 55 μg/mL respectively, while cisplatin inhibited proliferation of the same cells with IC50 value 1.71 and 7.8 µg/mL respectively. The results of this study showed that the synthesized derivative had a cytotoxic activity on the K562 cancer cell line at higher concentrations than cisplatin.
2-吡唑啉衍生物具有广泛的生物作用,如抗病毒、抗菌、抗真菌、抗抑郁和抗癌作用。研究表明,含有2-吡唑啉和其他杂环的化合物可能显示出更有效的生物特性。本研究采用一锅微波辅助法合成了一种C3位具有螺茚基喹喔啉环的2-吡唑啉衍生物,并通过1H NMR光谱证实了其化学结构。用MTT法评价该化合物对K562细胞系和植物血凝素活化的外周血单个核细胞(PHA+PBMC)的细胞毒作用。此外,还研究了顺铂对这些细胞的细胞毒性作用,并与2-吡唑啉的细胞毒性进行了比较。IC50值​​2-吡唑啉衍生物对K562细胞系和PHA+PBMC细胞的作用分别为45和55μg/mL,而顺铂抑制相同细胞的增殖的IC50值分别为1.71和7.8μg/mL。本研究的结果表明,合成的衍生物在比顺铂更高的浓度下对K562癌症细胞系具有细胞毒性活性。
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引用次数: 1
Distribution and Toxicological Risk Evaluation of Pb, Cd, As and Zn from Surface Soils of Selected Marts in Port Harcourt, Rivers State, Nigeria 尼日利亚河流州哈科特港部分火星表层土壤中Pb、Cd、As和Zn的分布和毒理学风险评估
Q4 Medicine Pub Date : 2018-12-01 DOI: 10.22034/JCHR.2018.544142
J. O. Osuoha, Chidiebere Uchenna Iheka, P. Amadi, I. Archibong, O. Adeoti
It is very pertinent to carry out environmental studies for the assessment of human health risks associated with heavy metal accumulation of frequently visited environments. By Atomic Absorption Spectrophotometry, Lead (Pb), Zinc (Zn), Cadmium (Cd) and, Arsenic (As) were analyzed in top soil samples from Rumuokoro mart (RUM), Choba mart, Mile 3 mart, Mile 1 mart , Town mart (TM), Trans-Amadi mart (TRANS), Boundary mart (BOUND), Oil mill mart (OIL M), Eleme mart (ELE). The concentration of zinc was highest in the mart sites among the other metals. There was pollution with some of the heavy metals at some mart sites. The highest I geo was found for cadmium at TRANS. The study further established contamination with some of the metals in some of the mart sites as very high contamination with arsenic was observed in RUM. The enrichment factor result obtained revealed that all the metals in all the mart sites occurred as a result of anthropogenic origin except that of lead in MILE 3 that was from natural activities. The levels of average daily intake of all the metals in all the sites were found to be below their respective reference doses. The highest average daily intake of all the metals investigated was observed in zinc at BOUND. No significant health hazard could result from the levels of the metals deposited in the study sites as they did not exceed the reference level at 1.0. RUM is observed as the likely mart site vulnerable to significant health hazards of all sites assessed. Regular environmental assessment should be performed in order monitor and regulate these metals in order to minimize health risks.
开展环境研究以评估与经常访问的环境中重金属积累相关的人类健康风险是非常有意义的。采用原子吸收分光光度法对鲁莫科罗集市(RUM)、乔巴集市(Choba mart)、Mile 3集市、Mile 1集市、Town mart(TM)、Trans Amadi集市(Trans)、Boundary mart(BOUND)、Oil mill mart(Oil M)、Eleme mart(ELE)的表层土壤样品中的铅(Pb)、锌(Zn)、镉(Cd)和砷(As)进行了分析。在其他金属中,锌在集市上的浓度最高。一些商场的一些重金属污染了。在TRANS发现镉含量最高的I geo。该研究进一步确定了一些集市场所的一些金属污染,因为在RUM中观察到砷的污染非常高。所获得的富集因子结果表明,除MILE 3中来自自然活动的铅外,所有集市场地中的所有金属都是人为来源的。发现所有部位的所有金属的平均每日摄入量水平均低于其各自的参考剂量。在BOUND的锌中观察到所有研究金属的最高平均日摄入量。研究地点沉积的金属水平不会对健康造成重大危害,因为它们没有超过1.0的参考水平。在所有评估的场所中,RUM被视为可能易受重大健康危害的集市场所。应定期进行环境评估,以监测和监管这些金属,从而将健康风险降至最低。
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引用次数: 1
Effect of Sulfur Application on Growth, Photosynthetic Pigments, Antioxidant Activity and Arsenic Accumulation in Coriander (Coriandrum sativum) under Arsenic Stress 施硫对砷胁迫下香菜生长、光合色素、抗氧化活性及砷积累的影响
Q4 Medicine Pub Date : 2018-12-01 DOI: 10.22034/JCHR.2018.544686
Hosein Asadi Ghalehni, V. Poozesh
Soils polluted with toxic elements are one of the major environmental problems in human societies. Sulfur (S), an essential element for the growth and development plants, plays an important role in reducing the toxicity of toxic elements as arsenic. In this study, the role of Sulfur different regimes (0, 50, 100 and 150 mg per kg) in reducing arsenic (As) toxicity in coriander (Coriandrum sativum) was investigated.  The obtained results indicated that Sulfur application increased the activities of antioxidant enzymes and photosynthetic pigments, but it’s decreased the arsenic induced oxidative stress. Reduction of shoot and root biomass occurred in presence of sulfur different regimes and As various concentrations. S supplement under high As concentration increased protein content of shoot. Different S regimes resulted in enhanced both shoot and root As accumulation. Meanwhile, different treatments of sulfur allowed high translocation of As quantities from root to shoot.  It is well illustrated that phytoextraction is one of the best methods for toxic metals phytoremediation. Thus from present study it is evident that the phytoremediation ability of plants for accumulates toxic metals may be enhanced through exogenous sulfur application.
有毒元素污染的土壤是人类社会的主要环境问题之一。硫是植物生长发育的必需元素,在降低砷等有毒元素的毒性方面发挥着重要作用。在本研究中,研究了不同硫浓度(0、50、100和150 mg/kg)在降低香菜中砷(As)毒性方面的作用。结果表明,施硫提高了抗氧化酶和光合色素的活性,但降低了砷诱导的氧化应激。不同硫浓度和不同砷浓度下,地上部和根部生物量减少。高砷浓度下补硫可提高地上部蛋白质含量。不同的硫处理使地上部和根部砷的积累增加。同时,不同的硫处理允许As从根到地上部的高迁移量。这充分说明了植物提取是有毒金属植物修复的最佳方法之一。因此,从目前的研究来看,外源硫的施用可以增强植物对积累的有毒金属的修复能力。
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引用次数: 2
Removal of Heavy Metal Ions from Polluted Waters by Using of Low Cost Adsorbents: Review 低成本吸附剂对污染水中重金属离子的去除研究进展
Q4 Medicine Pub Date : 2018-10-29 DOI: 10.22034/JCHR.2018.544016
M. Ghaedi
Adsorption is a fundamental process in the physicochemical treatment of wastewaters which industries employ to reduce hazardous organic and inorganic wastes in effluents. In recent years the use of low-cost adsorbents has been widely investigated as a replacement for the currently costly methods of removing heavy metal ions from wastewater. It is well-known that cellulosic waste materials can be obtained and employed as cheap adsorbents and their performance to remove heavy metal ions can be affected upon chemical treatment. In this study, the use of some of low cost adsorbents for the removal of heavy metals from wastewater has been reviewed.
吸附是工业废水物理化学处理的一个基本过程,用于减少废水中的有害有机和无机废物。近年来,利用低成本的吸附剂来替代目前昂贵的去除废水中重金属离子的方法得到了广泛的研究。众所周知,纤维素废料可以作为廉价的吸附剂使用,化学处理会影响其去除重金属离子的性能。本文综述了几种低成本吸附剂对废水中重金属的去除效果。
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引用次数: 15
The Phytochemical Changes of Violet Flowers (Viola cornuta) Response to Exogenous Salicylic Acid Hormone 紫罗兰(Viola cornuta)对外源水杨酸激素反应的植物化学变化
Q4 Medicine Pub Date : 2018-10-29 DOI: 10.22034/JCHR.2018.544042
N. Ghorbani, H. Moradi, V. Akbarpour, A. Ghasemnezhad
Violet is one of the ornamental plants with a good value in landscaping and herbal medicine. Salicylic acid is a signaling agent involving in secondary metabolite production. The aim of this study was to evaluate the physiological responses of violet flowers to exogenous salicylic acid. This experiment was conducted in the greenhouse, as a completely randomized design. Salicylic acid was sprayed on violet plants in four levels as , , , mM and three replications. Flower diameter, flower stem length, fresh weight and dry matter percentage of violet flower were measured as morphological parametes. In laboratory parameters like antioxidant activity and anthocyanin variation were recorded using spectrophotometery method. The quercetin and rutin values were determined by HPLC. Results showed that salicylic acid significantly affected on flower diameter, total antioxidant capacity, rutin and quercetin contents. Therefore data analysis provides that high levels of salicylic acid increased morphological parameters and improved chemical substance involving to secondary metabolism promotion. Furthermore, using different concentrations of the hormone is required, to achieve the best quality and quantity of plant biomass and it is also necessary to achieve the best traits of ornamental and medicinal value
紫罗兰是一种具有良好园林绿化和中药材价值的观赏植物。水杨酸是一种参与次级代谢产物产生的信号剂。本研究的目的是评估紫罗兰花对外源水杨酸的生理反应。这个实验是在温室里进行的,完全是随机设计。水杨酸以、、mM和三次重复的四个水平喷洒在紫色植物上。以紫罗兰花的花径、花茎长度、鲜重和干物质含量为形态参数。用分光光度法记录了抗氧化活性和花青素变化等实验室参数。采用高效液相色谱法测定槲皮素和芦丁的含量。结果表明,水杨酸对花径、总抗氧化能力、芦丁和槲皮素含量均有显著影响。因此,数据分析表明,高水平的水杨酸增加了形态参数,改善了参与二次代谢促进的化学物质。此外,需要使用不同浓度的激素,以实现植物生物量的最佳质量和数量,还需要实现最佳的观赏和药用价值
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引用次数: 5
Modeling the Chlorine Gas Dispersion in the Water Treatment Plant 水处理厂氯气扩散模拟
Q4 Medicine Pub Date : 2018-10-29 DOI: 10.22034/JCHR.2018.544205
Hadi Shamizadeh, R. A. Shahabi, M. Arjmand
An issue rose for industrial safety and successful address of crisis involves quick and pragmatic decision that would reduce losses and accidents. This will become practical when in addition to studying of past accidents the industrial executives create the necessary readiness to face risks through precise estimation of the consequences of eventual accidents. The present research concerns modeling the consequences of chlorine gas dispersion in the wastewater installations. The transfer of knowledge and information in this study were gained from modeling the dispersion of chlorine in the water treatment plants, useful for managers and executives. Detection and specifying the risks of chlorine for the public and especially the staff and those residing near the water treatment plant, would result in the appropriate action against this lethal substance, which is the subject of this study. Identification of risks related to foreign agents and their negative impacts on water treatment plants containing chlorine tanks is among the objectives of this study. The modeling and accurate specification of the scope and level of danger created following the dispersion of chlorine was done using the PHAST software, which allowed a clear identification of danger zones created by the dispersion of Chlorine. This text reports the radius of areas affected by chlorine dispersion as well as the results of different conditions after running the model for variable physical and process conditions, and given their availability, these results can be compared with each other.
工业安全问题日益突出,危机的成功解决需要快速和务实的决策,以减少损失和事故。如果工业管理人员除了研究过去的事故外,还能通过精确估计最终事故的后果,做好面对风险的必要准备,这一点就会变得切实可行。目前的研究是关于氯气在废水装置中分散的后果的建模。本研究中的知识和信息转移是通过对水处理厂中氯的分散进行建模获得的,这对管理人员和行政人员很有用。检测并明确氯对公众,特别是工作人员和居住在水处理厂附近的人的风险,将导致对这种致命物质采取适当行动,这是本研究的主题。本研究的目标之一是确定与外来物剂有关的风险及其对含氯水箱的水处理厂的负面影响。使用PHAST软件对氯分散后产生的危险范围和水平进行建模和准确规范,该软件可以清楚地识别氯分散造成的危险区域。本文报告了受氯分散影响的区域半径以及在不同物理和工艺条件下运行模型后的不同条件下的结果,并给出了它们的可用性,这些结果可以相互比较。
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引用次数: 0
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Journal of Chemical Health Risks
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