The COVID-19 pandemic has impacted eye health;however, innovations that address this disruption may present opportunities to improve eye health even after the pandemic is under control. HT 6:30am - 7:45amH08 - ANZGS Morning Symposium Sponsored by Allergan Title: The Functional Consequences of Glaucoma and Why They Matter Dr Pradeep Yammanuru Ramulu Chair: Prof Keith Martin Venue: M4 Synopsis: That we see glaucoma patients every day, we may not understand the profound ways in which visual field damage and the treatment of disease impacts our patients on a daily basis. The introduction of affordable intraocular lenses for patients in developing countries, as championed by Professor Fred Hollows, is an example of a disruptive innovation that has had a profound impact on eye health globally. [Extracted from the article] Copyright of Clinical & Experimental Ophthalmology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
{"title":"Tuesday 1 March Speakers","authors":"P. Ramulu","doi":"10.1111/ceo.14012","DOIUrl":"https://doi.org/10.1111/ceo.14012","url":null,"abstract":"The COVID-19 pandemic has impacted eye health;however, innovations that address this disruption may present opportunities to improve eye health even after the pandemic is under control. HT 6:30am - 7:45amH08 - ANZGS Morning Symposium Sponsored by Allergan Title: The Functional Consequences of Glaucoma and Why They Matter Dr Pradeep Yammanuru Ramulu Chair: Prof Keith Martin Venue: M4 Synopsis: That we see glaucoma patients every day, we may not understand the profound ways in which visual field damage and the treatment of disease impacts our patients on a daily basis. The introduction of affordable intraocular lenses for patients in developing countries, as championed by Professor Fred Hollows, is an example of a disruptive innovation that has had a profound impact on eye health globally. [Extracted from the article] Copyright of Clinical & Experimental Ophthalmology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75137900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Ferreira, J. Furtado, Jason Charng, M. Franchina, A. Molan, Michael, Hunter, D. Mackey, Shi-bang Ma, M. Wilsher, Noor Ali, J. Sims, O. Tomkins-Netzer, Sue, Lightman
8:30am 9:00am L03 – REFRACTIVE UPDATE LECTURE Chair: Dr Jacqueline Beltz Venue: Great Hall 1 & 2 Title: Artificial Intelligence: Applications for Pathologies of the Anterior Segment of the Eye Dr Damien Gatinel Synopsis: The use of artificial intelligence (AI) provides a better understanding of data collected through biometric and imaging techniques. It can increase the accuracy or the effectiveness of solutions intended to correct certain optical defects of the eye caused by structural alterations responsible for a reduction in the transparency of the ocular media and/or refractive errors. This work has been mainly applied to the study of corneal topography and imaging, description of the ocular wavefront, ocular biometry and improving the accuracy of the power calculation of intraocular lenses. We used AI techniques to carry out studies to characterise the alterations observed during the evolution of keratoconus, as well as the spatial distribution of corneal oedema through the use of neural networks to tomographic image analysis. Using artificial intelligence and the results from the description of the ocular wavefront on a new basis, we were able to estimate the real impact of high degree aberrations on subjective refraction. From a thick lens paraxial eye model, we established an analytical formula to calculate the position of the principal planes of an implant based on its geometry and the main biometric constants. This work made it possible to train an algorithm to predict the effective position of an implant, taking into account its geometry and establishing an original biometric calculation formula combining principles of paraxial optics and artificial intelligence algorithms applied to an eye model made up of thick lenses.
{"title":"Sunday 27 February Speakers","authors":"L. Ferreira, J. Furtado, Jason Charng, M. Franchina, A. Molan, Michael, Hunter, D. Mackey, Shi-bang Ma, M. Wilsher, Noor Ali, J. Sims, O. Tomkins-Netzer, Sue, Lightman","doi":"10.1111/ceo.14010","DOIUrl":"https://doi.org/10.1111/ceo.14010","url":null,"abstract":"8:30am 9:00am L03 – REFRACTIVE UPDATE LECTURE Chair: Dr Jacqueline Beltz Venue: Great Hall 1 & 2 Title: Artificial Intelligence: Applications for Pathologies of the Anterior Segment of the Eye Dr Damien Gatinel Synopsis: The use of artificial intelligence (AI) provides a better understanding of data collected through biometric and imaging techniques. It can increase the accuracy or the effectiveness of solutions intended to correct certain optical defects of the eye caused by structural alterations responsible for a reduction in the transparency of the ocular media and/or refractive errors. This work has been mainly applied to the study of corneal topography and imaging, description of the ocular wavefront, ocular biometry and improving the accuracy of the power calculation of intraocular lenses. We used AI techniques to carry out studies to characterise the alterations observed during the evolution of keratoconus, as well as the spatial distribution of corneal oedema through the use of neural networks to tomographic image analysis. Using artificial intelligence and the results from the description of the ocular wavefront on a new basis, we were able to estimate the real impact of high degree aberrations on subjective refraction. From a thick lens paraxial eye model, we established an analytical formula to calculate the position of the principal planes of an implant based on its geometry and the main biometric constants. This work made it possible to train an algorithm to predict the effective position of an implant, taking into account its geometry and establishing an original biometric calculation formula combining principles of paraxial optics and artificial intelligence algorithms applied to an eye model made up of thick lenses.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87639868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aanchal Gupta, Marco, Abbondanza, L. Sullivan, A. Apel, Himal, Kandel, C. Kong, Andrew, White, C. Samarawickrama
Synopsis: Treatment of specific cancers was revolutionised through the use of immune checkpoint blockade (ICI) which unleashes the body's own immune surveillance and mechanisms to kill tumour cells. This innovative treatment strategy induces remission for many patients with treatment-resistant cancers. Unintended consequences of ICI result from disrupting tolerance, therefore creating autoimmune consequences which can affect the eye and central nervous system. Following ICI therapy, case reports and series document dry eye, uveitis and multiple neuro-ophthalmic complications involving the optic nerve, cranial nerves, neuromuscular junction and extraocular muscles. The majority of patients with uveitis or optic nerve disease respond to discontinuing the ICI or to systemic or local corticosteroid therapy. Clinical improvement is however variable for patients with other types of neuro-ophthalmic sequelae. Case series provide insights about specific disease sequelae but do not help us understand the incidence or prevalence of complications following ICI therapy. Two big data studies provide additional complementary information, one using the IRIS database developed by the American Academy of Ophthalmology, and the other using the Kaiser Permanent Medical Record system. Using big data, cancer patients were identified to have a higher rate of uveitis and neuro-ophthalmic disease, even without the use of ICI. Patients with a prior history of immune-mediated ocular disease, uveitis or other, had a higher rate of recurrent disease following ICI therapy. Coordination of care between ophthalmologists and oncologists is suggested for patients in which ICI therapy is indicated.
{"title":"Monday 28 February Speakers","authors":"Aanchal Gupta, Marco, Abbondanza, L. Sullivan, A. Apel, Himal, Kandel, C. Kong, Andrew, White, C. Samarawickrama","doi":"10.1111/ceo.14011","DOIUrl":"https://doi.org/10.1111/ceo.14011","url":null,"abstract":"Synopsis: Treatment of specific cancers was revolutionised through the use of immune checkpoint blockade (ICI) which unleashes the body's own immune surveillance and mechanisms to kill tumour cells. This innovative treatment strategy induces remission for many patients with treatment-resistant cancers. Unintended consequences of ICI result from disrupting tolerance, therefore creating autoimmune consequences which can affect the eye and central nervous system. Following ICI therapy, case reports and series document dry eye, uveitis and multiple neuro-ophthalmic complications involving the optic nerve, cranial nerves, neuromuscular junction and extraocular muscles. The majority of patients with uveitis or optic nerve disease respond to discontinuing the ICI or to systemic or local corticosteroid therapy. Clinical improvement is however variable for patients with other types of neuro-ophthalmic sequelae. Case series provide insights about specific disease sequelae but do not help us understand the incidence or prevalence of complications following ICI therapy. Two big data studies provide additional complementary information, one using the IRIS database developed by the American Academy of Ophthalmology, and the other using the Kaiser Permanent Medical Record system. Using big data, cancer patients were identified to have a higher rate of uveitis and neuro-ophthalmic disease, even without the use of ICI. Patients with a prior history of immune-mediated ocular disease, uveitis or other, had a higher rate of recurrent disease following ICI therapy. Coordination of care between ophthalmologists and oncologists is suggested for patients in which ICI therapy is indicated.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86227834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-09DOI: 10.9734/BPI/HMMR/V6/1751F
L. Mondal, Subhasish Pramanik, Sriparna De, Suman K Paine, G. Bhaduri
Unutilized, enormous intracellular glucose in insulin-nondependent tissues, including retina, leads to several consequences: (i) increased formation of advanced glycation end products, (ii) activation of polyol pathway, (iii) anaerobic glycolysis, (iv) glutamate toxicity, (v) lipid peroxidation and oxidative stress, and all of these, finally, resulting in convergence to up regulation of antigenic VEGF and VEGFR2, the crucial player in the development of DR. The purpose of the present pilot study is to assess the effects of one kind of intervention on the development of DR: supplementation of B-vitamins (B1, B2, B3, B5 and B6), vitamin C and vitamin E on amelioration of biochemical derangements related to development of DR. 400 diagnosed type 2 diabetic patients were identified for the study, of which subjects were randomised 1:1 to receive oral antidiabetic medication along with B-vitamins, vitamin C and vitamin E or only antidiabetic medication to give the study and controlled population in this unblended randomized trial since December 2004 to December 2017. The following preliminary tasks were completed: firstly, baseline detailed fundoscopic examinations were enough to exclude the presence of retinopathy. Secondly, had baseline biochemical parameters like bllod concentration of NAD+, NADH, advanced glycation end products (AGEs), malondialdehyde (MDA), VEGF and VEGFR2 determined? Lastly, yearly fundoscopic examinations were documented to detect the features of DR. These efforts revealed the following findings: 32 among 187 (17.11%) patients who received supplementation with B-vitamins, vitamin C and vitamin E developed very mild microangiopathy; whereas 92 patients among 200 (46%) controlled ones developed mild to moderate non proliferative diabetic retinopathy (NPDR). 13 patients of the study group who didn’t follow up were counted as lost from the observation of the study. The findings lead to this conclusion: Glycolysis and citric acid cycle should run uninterruptedly by supplementation of precursors of oxidized cofactors and antioxidants to prevent biochemical derangements which lead to increased expression of VEGF.
{"title":"Modification of Biochemical Derangements and VEGF Secretion May Prevent Diabetic Retinopathy (DR): An Advance Study","authors":"L. Mondal, Subhasish Pramanik, Sriparna De, Suman K Paine, G. Bhaduri","doi":"10.9734/BPI/HMMR/V6/1751F","DOIUrl":"https://doi.org/10.9734/BPI/HMMR/V6/1751F","url":null,"abstract":"Unutilized, enormous intracellular glucose in insulin-nondependent tissues, including retina, leads to several consequences: (i) increased formation of advanced glycation end products, (ii) activation of polyol pathway, (iii) anaerobic glycolysis, (iv) glutamate toxicity, (v) lipid peroxidation and oxidative stress, and all of these, finally, resulting in convergence to up regulation of antigenic VEGF and VEGFR2, the crucial player in the development of DR. The purpose of the present pilot study is to assess the effects of one kind of intervention on the development of DR: supplementation of B-vitamins (B1, B2, B3, B5 and B6), vitamin C and vitamin E on amelioration of biochemical derangements related to development of DR. \u0000400 diagnosed type 2 diabetic patients were identified for the study, of which subjects were randomised 1:1 to receive oral antidiabetic medication along with B-vitamins, vitamin C and vitamin E or only antidiabetic medication to give the study and controlled population in this unblended randomized trial since December 2004 to December 2017. The following preliminary tasks were completed: firstly, baseline detailed fundoscopic examinations were enough to exclude the presence of retinopathy. Secondly, had baseline biochemical parameters like bllod concentration of NAD+, NADH, advanced glycation end products (AGEs), malondialdehyde (MDA), VEGF and VEGFR2 determined? Lastly, yearly fundoscopic examinations were documented to detect the features of DR. \u0000These efforts revealed the following findings: 32 among 187 (17.11%) patients who received supplementation with B-vitamins, vitamin C and vitamin E developed very mild microangiopathy; whereas 92 patients among 200 (46%) controlled ones developed mild to moderate non proliferative diabetic retinopathy (NPDR). 13 patients of the study group who didn’t follow up were counted as lost from the observation of the study. \u0000The findings lead to this conclusion: Glycolysis and citric acid cycle should run uninterruptedly by supplementation of precursors of oxidized cofactors and antioxidants to prevent biochemical derangements which lead to increased expression of VEGF.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"23 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2021-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91524174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
RANZCO Fellows can claim CPD points by reading the following two articles which appear in this issue, and answering the five questions. Half an hour is awarded for each set of five questions answered. Please remember to claim your points. Lee SSY, Lingham G, Blaszkowska. Low-concentration atropine eyedrops for myopia control in a multi-racial cohort of Australian children: A randomised clinical trial (1001-1012)
{"title":"Continuing Professional Development","authors":"G. Watts, Norman Watts","doi":"10.1201/9780429353062-1","DOIUrl":"https://doi.org/10.1201/9780429353062-1","url":null,"abstract":"RANZCO Fellows can claim CPD points by reading the following two articles which appear in this issue, and answering the five questions. Half an hour is awarded for each set of five questions answered. Please remember to claim your points. Lee SSY, Lingham G, Blaszkowska. Low-concentration atropine eyedrops for myopia control in a multi-racial cohort of Australian children: A randomised clinical trial (1001-1012)","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"49 1","pages":"1116 - 1117"},"PeriodicalIF":0.0,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76800504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
1. Regarding the prevalence of epiretinal membrane (ERM), ... a. the peak prevalence for patients with epiretinal membrane is in the 5th decade. b. epiretinal membrane is more common in males. c. there is large variability in the overall prevalence of ERMs due to differences in classifications, imaging modalities, reading methodologies and retinal appearances across ethnic groups. d. the prevalence of ERM does not appear to vary with ethnicity. e. the reported prevalence of ERM in Australia is under 5%.
{"title":"Continuing professional development","authors":"A. Stevens","doi":"10.2307/j.ctt9qgnb4.8","DOIUrl":"https://doi.org/10.2307/j.ctt9qgnb4.8","url":null,"abstract":"1. Regarding the prevalence of epiretinal membrane (ERM), ... a. the peak prevalence for patients with epiretinal membrane is in the 5th decade. b. epiretinal membrane is more common in males. c. there is large variability in the overall prevalence of ERMs due to differences in classifications, imaging modalities, reading methodologies and retinal appearances across ethnic groups. d. the prevalence of ERM does not appear to vary with ethnicity. e. the reported prevalence of ERM in Australia is under 5%.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"28 1","pages":"319 - 321"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87999152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-11DOI: 10.29328/JOURNAL.IJCEO.1001034
T. Burak, Mercan Kadir, D. Nesrin, I. Nevin, Çatak Onur
1Department of Ophthalmology, Faculty of Medicine, Onsekiz Mart University, Çanakkale, Turkey 2Universal Eye Hospital, Malatya, Turkey 3Department of Immunology, Faculty of Medicine, Onsekiz Mart University, Çanakkale, Turkey 4Department of Biochemistry, Faculty of Medicine, Fırat University, Elazığ, Turkey 5Department of Ophthalmology, Faculty of Medicine, Fırat University, Elazığ, Turkey More Information
{"title":"Circulating salusin-beta levels in the patients with age-related macular degeneration","authors":"T. Burak, Mercan Kadir, D. Nesrin, I. Nevin, Çatak Onur","doi":"10.29328/JOURNAL.IJCEO.1001034","DOIUrl":"https://doi.org/10.29328/JOURNAL.IJCEO.1001034","url":null,"abstract":"1Department of Ophthalmology, Faculty of Medicine, Onsekiz Mart University, Çanakkale, Turkey 2Universal Eye Hospital, Malatya, Turkey 3Department of Immunology, Faculty of Medicine, Onsekiz Mart University, Çanakkale, Turkey 4Department of Biochemistry, Faculty of Medicine, Fırat University, Elazığ, Turkey 5Department of Ophthalmology, Faculty of Medicine, Fırat University, Elazığ, Turkey More Information","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"115 1","pages":"001-004"},"PeriodicalIF":0.0,"publicationDate":"2021-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88081181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2155-9570.21.S12.002
Konstantina Bachtalia, Athina Plakitsi, A. Charonis, Georgios Charonis, Dimitrios Kyroudis, S. Palioura
Purpose: To evaluate how corneal epithelium thickness changes after myopic Photorefractive Keratectomy (PRK) relate to the magnitude of myopic correction, the diameter of the Optical Zone (OZ) and the incidence of regression in the early postoperative period. Setting: Tertiary referral center Design: Prospective longitudinal cohort study Methods: Twenty-two eyes of 11 patients with mean manifest spherical equivalent of -4.75 ± 1.69 D underwent PRK between November 2016 and March 2017. Epithelial thickness profiles were evaluated preoperatively and at 1, 3 and 6 month’s postoperatively using ultra-high resolution anterior segment OCT. The relationship between post-operative epithelial thickness changes and the magnitude of myopic correction, the OZ diameter and the refractive outcomes was investigated prospectively. Results: Central epithelial thickening progressed during the first three postoperative months (p=0.045, between first and third postoperative month) and stabilized thereafter (p=0.980, between third and sixth postoperative month). A corresponding myopic shift of 0.13 D and an increase in mean K by 0.65 D were observed at three months postoperatively, which remained stable thereafter and did not affect the final refractive outcomes (mean postoperative spherical equivalent 0.14 ± 0.40 D). Central epithelial thickness increased proportionally with the amount of myopia treated (r=0.41, p=0.04) and reversely with the ablation zone diameter (r=-0.39, p=0.04). Conclusion: Corneal epithelial hyperplasia after myopic PRK is dependent on the preoperative myopic error and ablation zone diameter. Epithelial hyperplasia-induced regression did not have a negative effect on the overall refractive outcome. Synopsis: The degree of epithelial thickening and hyperopic shift post-PRK depends on the preoperative refraction and the optical zone diameter. The subsequent regression does not negatively affect the refractive outcome.
{"title":"Compensatory Corneal Epithelial Thickness Changes after Myopic Photorefractive Keratectomy Imaged with Ultra High Resolution AnteriorSegment Optical Coherence Tomography","authors":"Konstantina Bachtalia, Athina Plakitsi, A. Charonis, Georgios Charonis, Dimitrios Kyroudis, S. Palioura","doi":"10.35248/2155-9570.21.S12.002","DOIUrl":"https://doi.org/10.35248/2155-9570.21.S12.002","url":null,"abstract":"Purpose: To evaluate how corneal epithelium thickness changes after myopic Photorefractive Keratectomy (PRK) relate to the magnitude of myopic correction, the diameter of the Optical Zone (OZ) and the incidence of regression in the early postoperative period. Setting: Tertiary referral center Design: Prospective longitudinal cohort study Methods: Twenty-two eyes of 11 patients with mean manifest spherical equivalent of -4.75 ± 1.69 D underwent PRK between November 2016 and March 2017. Epithelial thickness profiles were evaluated preoperatively and at 1, 3 and 6 month’s postoperatively using ultra-high resolution anterior segment OCT. The relationship between post-operative epithelial thickness changes and the magnitude of myopic correction, the OZ diameter and the refractive outcomes was investigated prospectively. Results: Central epithelial thickening progressed during the first three postoperative months (p=0.045, between first and third postoperative month) and stabilized thereafter (p=0.980, between third and sixth postoperative month). A corresponding myopic shift of 0.13 D and an increase in mean K by 0.65 D were observed at three months postoperatively, which remained stable thereafter and did not affect the final refractive outcomes (mean postoperative spherical equivalent 0.14 ± 0.40 D). Central epithelial thickness increased proportionally with the amount of myopia treated (r=0.41, p=0.04) and reversely with the ablation zone diameter (r=-0.39, p=0.04). Conclusion: Corneal epithelial hyperplasia after myopic PRK is dependent on the preoperative myopic error and ablation zone diameter. Epithelial hyperplasia-induced regression did not have a negative effect on the overall refractive outcome. Synopsis: The degree of epithelial thickening and hyperopic shift post-PRK depends on the preoperative refraction and the optical zone diameter. The subsequent regression does not negatively affect the refractive outcome.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"104 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78627088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2155-9570.21.12.867
A. Scott, Battiston Adrian, Bong Donna, Carrell Nathan, F. DamjiKarim
Objective: To investigate the validity of the 24-2 SITA fast Humphrey Visual Field (HVF) testing compared to the established parameters of Octopus Visual Field (OVF) for detecting and monitoring patients with neurologic pathology impacting visual fields Design: Retrospective chart review. Participants: 108 adult patients derived from the Eye Institute of Alberta (EIA) database. Methods: Study participants included adults with OVF testing, at the EIA between September 2015 to September 2017. Three blinded reviewers assessed if findings from each OVF would be identifiable on 24-2 SITA fast HVF testing based on established standardized degree of visual field cut-offs. Demographic data and level of agreement were measured using basic descriptive statistics. Results: In total, 211 individual eye OVFs were scored. Based on our established measurements the 24-2 SITA fast HVF would have identified clinically relevant findings on visual field testing in 197 (93.4%) participants. Of the 6.4% not detected, 64% were due to the patient being unable to fixate on a I2e or I4e isopter, with an additional 18% suffering from movement disorders resulting in exam difficulty (i.e. Parkinson’s disease). Conclusion: The 24-2 SITA fast HVF has potential to be an appropriate alternative test to OVF for detecting and monitoring patients with neurologic pathology impacting visual fields. However, patients with severe vision loss or those not able to fixate on isopters I4e and lower would benefit from more robust testing available in OVF formats. Further head to head comparison of the two visual field modalities is warranted in this group of patients
{"title":"Using the 24-2 Sita Fast Humphrey to Detect Visual Field Defects Noted in Patients with Neurological Lesions Impacting the Visual Field NormallyAssessed by Octopus Visual Field Testing","authors":"A. Scott, Battiston Adrian, Bong Donna, Carrell Nathan, F. DamjiKarim","doi":"10.35248/2155-9570.21.12.867","DOIUrl":"https://doi.org/10.35248/2155-9570.21.12.867","url":null,"abstract":"Objective: To investigate the validity of the 24-2 SITA fast Humphrey Visual Field (HVF) testing compared to the established parameters of Octopus Visual Field (OVF) for detecting and monitoring patients with neurologic pathology impacting visual fields Design: Retrospective chart review. Participants: 108 adult patients derived from the Eye Institute of Alberta (EIA) database. Methods: Study participants included adults with OVF testing, at the EIA between September 2015 to September 2017. Three blinded reviewers assessed if findings from each OVF would be identifiable on 24-2 SITA fast HVF testing based on established standardized degree of visual field cut-offs. Demographic data and level of agreement were measured using basic descriptive statistics. Results: In total, 211 individual eye OVFs were scored. Based on our established measurements the 24-2 SITA fast HVF would have identified clinically relevant findings on visual field testing in 197 (93.4%) participants. Of the 6.4% not detected, 64% were due to the patient being unable to fixate on a I2e or I4e isopter, with an additional 18% suffering from movement disorders resulting in exam difficulty (i.e. Parkinson’s disease). Conclusion: The 24-2 SITA fast HVF has potential to be an appropriate alternative test to OVF for detecting and monitoring patients with neurologic pathology impacting visual fields. However, patients with severe vision loss or those not able to fixate on isopters I4e and lower would benefit from more robust testing available in OVF formats. Further head to head comparison of the two visual field modalities is warranted in this group of patients","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"39 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84565360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：