Journal of clinical trials最新文献

{"title":"Treatment of Chronic Constipation and Dysbiosis in Elderly Patients","authors":"Toshihiro Matsuura, K. Kyokane, S. Yamada, Y. Ku","doi":"10.35248/2167-0870.21.11.467","DOIUrl":"https://doi.org/10.35248/2167-0870.21.11.467","url":null,"abstract":"The Japanese population is aging at an accelerated rate, with people aged 65 and over encompassing nearly 25% of the total population [1]. One of the gastrointestinal symptoms characteristic of the elderly is abnormal bowel movements such as constipation, and there is no organic disease in the lower gastrointestinal tract. According to the statistics released by the Ministry of Health, Labor, and Welfare, the number of patients complaining about constipation increases rapidly after the age of 70 [2]. Abnormal bowel movements are always accompanied by abdominal discomfort and lead to a decreased Quality of Life (QOL) [3] as well as deterioration of nutritional status, especially in elderly people, due to decreased appetite and motivation.","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"46 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86438147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features of Heart Failure with Preserved Ejection Fraction in a Sub-Saharan Africa Population","authors":"M. Temgoua, J. Boombhi, J. Tochie, S. Kingue","doi":"10.35248/2167-0870.21.11.449","DOIUrl":"https://doi.org/10.35248/2167-0870.21.11.449","url":null,"abstract":"Copyright: © 2021 Temgoua MN, et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Clinical Features of Heart Failure with Preserved Ejection Fraction in a Sub-Saharan Africa Population Mazou N Temgoua, Jérôme Boombhi, Joel Noutakdie Tochie, Samuel Kingue Department of Internal Medicine and Sub-Specialties, Medicine and Biomedical Sciences, University of Yaoundé I, Yaounde, Cameroon; Department of Cardiology, Program of Heart Rhythm Disorders and Cardiac Stimulation, University of Clermont-Ferrand, Clermont-Ferrand, France; 3Department of Anesthesiology and Intensive Care Unit, Medicine and Biomedical Sciences, University of Yaoundé I, Yaounde, Cameroon","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"4 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88831651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State and Local Public Health Response to COVID-19 (USA)","authors":"P. Aaron","doi":"10.35248/2167-0870.21.S11.003","DOIUrl":"https://doi.org/10.35248/2167-0870.21.S11.003","url":null,"abstract":"","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"282 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77178664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Call to Redefine Undergraduate Medical Education: Fostering Scientific Research and Evidence driven Decision-Making among Future Physicians","authors":"Farah Otaki, A. Khamis, A. Azar","doi":"10.35248/2167-0870.21.11.464","DOIUrl":"https://doi.org/10.35248/2167-0870.21.11.464","url":null,"abstract":"Farah Otaki1, Amar Hassan Khamis2, Aida Joseph Azar3* 1Department of Strategy and Institutional Excellence, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates; 2Department of Dental Medicine, Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates; 3Department of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"7 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72828275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of Serum Tumor Markers for Epithelial Ovarian Cancer Stage I-II: A Retrospective Analysis","authors":"Q. Yi, Yu Ran, Cong Li","doi":"10.35248/2167-0870.21.11.462","DOIUrl":"https://doi.org/10.35248/2167-0870.21.11.462","url":null,"abstract":"Objective: Epithelial Ovarian Cancer (EOC) in early stage is difficult to diagnose. Serum indicators for stage I-II of epithelial ovarian cancer which confined to pelvic cavity were found through retrospective analysis, possible early detection methods might be found. Methods: 165 patients were diagnosed as epithelial ovarian cancer at stage I-II from January 1st, 2015 to December 31st, 2019. Data was collected including age, pathological type, serum D-dimer (D-D), Neutrophil to Lymphocyte ratio (N/L), the platelet to Lymphocyte ratio (P/L), Cancer Antigen 125 (CA125), Human Epididymis Protein 4 (HE4) and diameter of the ovarian mass by ultrasound. Results: D-D, CA125, HE4, ROMA, diameter, pathological type and age were significantly different in the different stage, age showed independent effect after logistical regression (P<0.05). D-D, CA125, HE4, ROMA, diameter, age and stage were significantly different in the different pathological type, and diameter showed significant independent influence on different pathological type after binary logistic regression (P<0.05). Conclusion: CA125, HE4, ROMA, diameter of tumor, D-dimer and age were found significantly different between stage I and stage II, with age shows good effect on the diagnosis for stage II and diameter of tumor shows diagnostic value for non-serous ovarian cancer. Combined diagnosis may improve the diagnosis rate of early ovarian cancer.","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"6 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90854274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attack of Acute Intermittent Porphyria in a 34-Year-Old Female Patient after a Lithotrypsy","authors":"Zuzanna Wardega, M. Donderska, Z. Czudy, Barbara Dominik","doi":"10.35248/2167-0870.21.11.471","DOIUrl":"https://doi.org/10.35248/2167-0870.21.11.471","url":null,"abstract":"A 34-old-female patient had acute intermittent porphyria. Rare diseases should be considered in the differential diagnosis, especially in young adults. It is hard to recognize the illness in a district hospital, where access to the specialist laboratory tests is difficult. Although non-specific symptoms and attributing them to prior surgical intervention delayed diagnosis, the maintained diagnostic, careful observation allowed for proper diagnosis of the disease.","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"127 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82105688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of COVID-19 Pandemic in day by day Life","authors":"S. Won","doi":"10.35248/2167-0870.21.S11.004","DOIUrl":"https://doi.org/10.35248/2167-0870.21.S11.004","url":null,"abstract":"","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"33 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82435317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TB prevalence and BCG Vaccinations Correlations to Multisystem Inflammatory Syndrome in Children","authors":"T. F. Raham","doi":"10.35248/2167-0870.21.11.465","DOIUrl":"https://doi.org/10.35248/2167-0870.21.11.465","url":null,"abstract":"Background: This study aims to examine the influence of BCG status and TB prevalence on variances among countries regarding the new Multisystem Inflammatory Syndrome in Children (MIS-C). Material and methods: We chose all countries which report MIS-C till 23/6/2020. The number of MIS-C cases for each 10 million inhabitants has been examined among 3 categories of countries classified according to BCG program status. TB prevalence, MIS-C no./10 million (M) population and COVID-19 deaths/M are taken as markers. Receiver Operation Characteristic-(ROC) curve, with some relative indicators such as (sensitivity and specificity rates), estimation area of the trade-off between sensitivity and specificity, and cutoff points were used with different studied markers for discriminating different three pairs of countries (which have different BCG practices). Results: BCG vaccination and high TB prevalence were found significantly associated with decreased MIS-C no. and COVID-19 deaths. Conclusion: Findings might explain variances of MIS-C incidence and COVID-19 mortality among countries worldwide. Further studies to confirm this relationship and to confirm possible similar relations in Kawasaki Disease (KD) in previous epidemics are recommended. Ovarian Cancer (EOC) in early stage is difficult to diagnose. Serum indicators for stage I-II of epithelial ovarian cancer which confined to pelvic cavity were found through retrospective analysis, possible early detection methods might be found. Methods: 165 patients were diagnosed as epithelial ovarian cancer at stage I-II from January 1st, 2015 to December 31st, 2019. Data was collected including age, pathological type, serum D-dimer (D-D), Neutrophil to Lymphocyte ratio (N/L), the platelet to Lymphocyte ratio (P/L), Cancer Antigen 125 (CA125), Human Epididymis Protein 4 (HE4) and diameter of the ovarian mass by ultrasound. Results: D-D, CA125, HE4, ROMA, diameter, pathological type and age were significantly different in the different stage, age showed independent effect after logistical regression (P<0.05). D-D, CA125, HE4, ROMA, diameter, age and stage were significantly different in the different pathological type, and diameter showed significant independent influence on different pathological type after binary logistic regression (P<0.05). Conclusion: CA125, HE4, ROMA, diameter of tumor, D-dimer and age were found significantly different between stage I and stage II, with age shows good effect on the diagnosis for stage II and diameter of tumor shows diagnostic value for non-serous ovarian cancer. Combined diagnosis may improve the diagnosis rate of early ovarian cancer.","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"96 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83366144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal Cell Carcinoma on a Nevus Sebaceous of Jadassohn","authors":"A. Abdelmouttalib, A. Khayri, M. Meziane, N. Ismaili, L. Benzekri, K. Senouci","doi":"10.35248/2167-0870.21.11.445","DOIUrl":"https://doi.org/10.35248/2167-0870.21.11.445","url":null,"abstract":"We report the case of a 68-year-old women with a yellowish plaque located in the left temporal region since birth, without any medical follow-up. She reported a change of the lesion with appearance of an ulceration developed 6 months ago. A physical examination revealed a warty plaque measuring 56* 45 mm with an ulceration at the lower part of the lesion shown in Figure 1. Local alopecia was present. Dermoscopy found a pinkish-yellowish plaque with a fiat mamillonated surface, shiny white to red areas, short fine telangiectasia, arborizing vessels and large blue-gray ovoid nests shown in Figure 2. The rest of the clinical examination was normal. The whole evoked the secondary appearance of a BCC developed in a sebaceous nevus.","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"39 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89560088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitive Detection of Epidermal Growth Factor Receptor T790M using BNAClamp Real-Time PCR","authors":"A. Dinkel, Rachel A. Hoffmeister, Andrew Huckelby, A. Castro, Miguel M. Castro, Sung-Kun Kim","doi":"10.35248/2167-0870.21.11.460","DOIUrl":"https://doi.org/10.35248/2167-0870.21.11.460","url":null,"abstract":"Mutations on Epidermal Growth Factor Receptor (EGFR) cause a variety of cancers including breast and lung cancers. The single mutation T790M on the tyrosine kinase domain of EGFR signifies the response to the cancer drugs gefitinib, which leads to the development of resistance to such a drug. Detecting the mutation thus provides effective therapeutic options for patients who are in need of cancer drug treatments. We sought to develop a facile, rapid detection method for the T790M mutation using Bridged Nucleic Acids (BNA), which has been known to enhance the hybridization affinity of oligonucleotides. Oligonucleotides containing BNA bases, called BNA-clamp and designed to block PCR reaction against wild-type genes were used to discriminate the presence of mutant genes mixed with a large number of wild-type genes. Real-time PCR in conjugation with BNA-clamping allows us to observe different degrees of PCR amplification depending on the ratio of wild-type and mutant genes. In an effort to explore the possibility, several 13-mer oligonucleotide clamps were prepared with various numbers of BNA bases. Tm value analysis suggests that the clamps containing 9 BNA bases (BNA-clamp-9) would be most effective in distinguishing the mutant from wild-type genes, and sensitivity tests using BNA-clamp-9 revealed that the clamp had the ability to detect 0.1% or lower levels of the T790M mutation among wild-type genes. Furthermore, binding structures were analyzed via Molecular Dynamics (MD) simulations, revealing that BNA-clamp-9 distorts the originally constructed BDNA structure. Additionally through umbrella sampling, binding free energies with -60 kJ/mol for the wild-type and -40 kJ/mol for the mutant gene were obtained. This BNA-clamping and real time PCR technology may offer a promising avenue to detect clinically important mutations in the future","PeriodicalId":15375,"journal":{"name":"Journal of clinical trials","volume":"10 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89601371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}