M. V. Yakusheva, A. P. Nebolsina, I. P. Charushina, V. V. Masalev, N. Vorobyova, O. N. Sumlyvaya, V. Nikolenko
Objective. To analyze the effectiveness of etiotropic antiviral therapy with direct antiviral drugs against chronic viral hepatitis C in the adult population of the Perm Krai. Materials and methods. In the regional register of Perm Krai, 20095 patients with chronic viral hepatitis C were registered. In 2019–2021, antiviral therapy with direct antiviral drugs, registered in the Russian Federation, and included in the list of vital and essential medicines for medical use was prescribed to 282 patients with chronic hepatitis C. There were 137 men (48.6 %), 145 (51.4 %) – women. The age of the patients ranged from 26 to 82 years, the duration of the disease – from 3 to 25 years. Results. All the therapy regimes we used showed 100 % effectiveness in the population of patients suffering from chronic hepatitis C associated with mild liver fibrosis regardless of genotype, whereas in the population of patients with grade 3 fibrosis or liver cirrhosis, 100 % effectiveness was achieved only after the use of sofosbuvir-containing schemes. The pangenotypic schemes resulted in 100 % achievement of a stable virological response among patients with genotype 1 regardless of the stage of liver fibrosis and previous therapy experience. In the treatment of patients infected with genotype 3 of hepatitis C virus with severe fibrosis, the effectiveness of 100 % was noted after the use of sofosbuvir-containing regimes. Conclusions. Among the adult population of Perm Krai, the overall effectiveness of therapy in patients with chronic hepatitis C, who used direct antiviral drugs, was 97.8 %.
{"title":"Treatment of chronic viral hepatitis c in perm Krai","authors":"M. V. Yakusheva, A. P. Nebolsina, I. P. Charushina, V. V. Masalev, N. Vorobyova, O. N. Sumlyvaya, V. Nikolenko","doi":"10.17816/pmj40631-39","DOIUrl":"https://doi.org/10.17816/pmj40631-39","url":null,"abstract":"Objective. To analyze the effectiveness of etiotropic antiviral therapy with direct antiviral drugs against chronic viral hepatitis C in the adult population of the Perm Krai. \u0000Materials and methods. In the regional register of Perm Krai, 20095 patients with chronic viral hepatitis C were registered. In 2019–2021, antiviral therapy with direct antiviral drugs, registered in the Russian Federation, and included in the list of vital and essential medicines for medical use was prescribed to 282 patients with chronic hepatitis C. There were 137 men (48.6 %), 145 (51.4 %) – women. The age of the patients ranged from 26 to 82 years, the duration of the disease – from 3 to 25 years. \u0000Results. All the therapy regimes we used showed 100 % effectiveness in the population of patients suffering from chronic hepatitis C associated with mild liver fibrosis regardless of genotype, whereas in the population of patients with grade 3 fibrosis or liver cirrhosis, 100 % effectiveness was achieved only after the use of sofosbuvir-containing schemes. The pangenotypic schemes resulted in 100 % achievement of a stable virological response among patients with genotype 1 regardless of the stage of liver fibrosis and previous therapy experience. In the treatment of patients infected with genotype 3 of hepatitis C virus with severe fibrosis, the effectiveness of 100 % was noted after the use of sofosbuvir-containing regimes. \u0000Conclusions. Among the adult population of Perm Krai, the overall effectiveness of therapy in patients with chronic hepatitis C, who used direct antiviral drugs, was 97.8 %.","PeriodicalId":155224,"journal":{"name":"Perm Medical Journal","volume":"85 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139606179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In 2023, we celebrate a historical date – the 100th anniversary of publishing the first issue of “Perm Medical Journal”. The first editor-in-chief was an outstanding doctor, the founder of the first surgical school, Professor V.N. Parin. The content of the first eight volumes of the journal issued from 1923 to 1930 is analyzed in the article. The first paper of the first issue of a journal was devoted to epidemic typhus and relapsing fever. The papers of great scientists, professors such as A.V. Pshenichnov, P.I. Pichugin, A.S. Lebedev, P.I. Chistyakov, V.P. Pervushin and others impress by profundity of thought. Great attention in the journal was paid to the questions of surgery and urology; these papers constituted 52% of the content of the first eight volumes. Analysis of the works belonging to V.N. Parin, D.P. Kuznetsky, V.P. Shipitsyn, B.Ya. Strelkov, A.A. Vechtomov and other authors, which were devoted to diagnostics, treatment and prevention of gastric ulcer, ventral hernias, tumors of different organs, inflammatory surgical diseases, vascular, urinary, urethral and genital injuries, rhinoplasty, show that these publications aroused interest among Russian and foreign scientists and physicians and significantly influenced a progress of medical science and practical health care.
{"title":"Reviewing the pages of the first issues of «Perm medical journal»: 100th anniversary of this authoritative russian scientific edition","authors":"М. .. Davidov","doi":"10.17816/pmj406168-178","DOIUrl":"https://doi.org/10.17816/pmj406168-178","url":null,"abstract":"In 2023, we celebrate a historical date – the 100th anniversary of publishing the first issue of “Perm Medical Journal”. The first editor-in-chief was an outstanding doctor, the founder of the first surgical school, Professor V.N. Parin. The content of the first eight volumes of the journal issued from 1923 to 1930 is analyzed in the article. The first paper of the first issue of a journal was devoted to epidemic typhus and relapsing fever. The papers of great scientists, professors such as A.V. Pshenichnov, P.I. Pichugin, A.S. Lebedev, P.I. Chistyakov, V.P. Pervushin and others impress by profundity of thought. Great attention in the journal was paid to the questions of surgery and urology; these papers constituted 52% of the content of the first eight volumes. Analysis of the works belonging to V.N. Parin, D.P. Kuznetsky, V.P. Shipitsyn, B.Ya. Strelkov, A.A. Vechtomov and other authors, which were devoted to diagnostics, treatment and prevention of gastric ulcer, ventral hernias, tumors of different organs, inflammatory surgical diseases, vascular, urinary, urethral and genital injuries, rhinoplasty, show that these publications aroused interest among Russian and foreign scientists and physicians and significantly influenced a progress of medical science and practical health care.","PeriodicalId":155224,"journal":{"name":"Perm Medical Journal","volume":"19 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139608152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Е. А. Toropova, Е. V. Bukina, I. Е. Shtina, М. N. Repetskaya
Objective. To identify the presence of clinical and laboratory features in children and adolescents with an increase in the caudate lobe of the liver according to ultrasound data. Materials and methods. The observation group included 37 children and adolescents with enlarged liver caudate lobe (CL) at the age of 8.1 ± 0.67 years, the comparison group included 38 children and adolescents aged 9.2 ± 0.68 years. A comparative analysis of the data of anamnesis, complaints, objective examination, laboratory and ultrasound examinations was performed. Results. An increase in the size of liver CL was detected with equal frequency in children of both sexes (p = 0.51) without relation to age (p = 0.18). There were no specific complaints characteristic for increased size of the CL. In children with enlarged CL of the liver, obesity (p = 0.034), diffuse changes in the pancreas (p = 0.01), increased activity of AST and GGT (p = 0.025) and a higher average blood leukocyte content (p = 0.04) was registered significantly more often. Conclusions. An isolated increase in liver CL requires a more detailed assessment of the state of the liver and the general health of a child.
{"title":"Increase in liver caudate lobe among children: clinical and laboratory features","authors":"Е. А. Toropova, Е. V. Bukina, I. Е. Shtina, М. N. Repetskaya","doi":"10.17816/pmj40616-23","DOIUrl":"https://doi.org/10.17816/pmj40616-23","url":null,"abstract":"Objective. To identify the presence of clinical and laboratory features in children and adolescents with an increase in the caudate lobe of the liver according to ultrasound data. \u0000Materials and methods. The observation group included 37 children and adolescents with enlarged liver caudate lobe (CL) at the age of 8.1 ± 0.67 years, the comparison group included 38 children and adolescents aged 9.2 ± 0.68 years. A comparative analysis of the data of anamnesis, complaints, objective examination, laboratory and ultrasound examinations was performed. \u0000Results. An increase in the size of liver CL was detected with equal frequency in children of both sexes (p = 0.51) without relation to age (p = 0.18). There were no specific complaints characteristic for increased size of the CL. In children with enlarged CL of the liver, obesity (p = 0.034), diffuse changes in the pancreas (p = 0.01), increased activity of AST and GGT (p = 0.025) and a higher average blood leukocyte content (p = 0.04) was registered significantly more often. \u0000Conclusions. An isolated increase in liver CL requires a more detailed assessment of the state of the liver and the general health of a child.","PeriodicalId":155224,"journal":{"name":"Perm Medical Journal","volume":"12 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
А. А. Baidarov, А. S. Vronsky, P. V. Lazarkov, N. Astashina, А. М. Shamarina
The research was carried out with financial support of Perm Scientific and Educational Center "Rational Subsoil Use" (2023), the project "New materials and technologies for medicine". The article provides a review of literature on the use of simulation learning in medical education. The review used articles on simulation in training at the specialty, residency and continuing postgraduate medical education levels. The research has demonstrated that simulation training leads to improved performance among future physicians. Simulation in the learning process allows improving teamwork and communication. With the introduction of medical accreditation and opening of simulation centers at medical universities throughout the country, simulation training is a basic principle of medical education in the Russian Federation. As medical simulation becomes more common, there is a need to develop new methods providing increase in effectiveness of training specialists including medical staff of the highest qualification.
{"title":"Simulation training in medicine: past, present and future","authors":"А. А. Baidarov, А. S. Vronsky, P. V. Lazarkov, N. Astashina, А. М. Shamarina","doi":"10.17816/pmj40653-60","DOIUrl":"https://doi.org/10.17816/pmj40653-60","url":null,"abstract":"The research was carried out with financial support of Perm Scientific and Educational Center \"Rational Subsoil Use\" (2023), the project \"New materials and technologies for medicine\". \u0000The article provides a review of literature on the use of simulation learning in medical education. The review used articles on simulation in training at the specialty, residency and continuing postgraduate medical education levels. The research has demonstrated that simulation training leads to improved performance among future physicians. Simulation in the learning process allows improving teamwork and communication. With the introduction of medical accreditation and opening of simulation centers at medical universities throughout the country, simulation training is a basic principle of medical education in the Russian Federation. As medical simulation becomes more common, there is a need to develop new methods providing increase in effectiveness of training specialists including medical staff of the highest qualification.","PeriodicalId":155224,"journal":{"name":"Perm Medical Journal","volume":"16 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A clinical case of highly aggressive multiple sclerosis in a patient with a family history of demyelinating disease is presented. The effectiveness of early pathogenetic therapy by blocking the adhesion molecules of lymphocytes is demonstrated.
{"title":"Therapeutic options in a patient with highly aggressive multiple sclerosis and genetic predisposition to autoimmune process: a clinical case","authors":"T. Baidina, T. N. Trushnikova, I. Y. Danchenko","doi":"10.17816/pmj406120-127","DOIUrl":"https://doi.org/10.17816/pmj406120-127","url":null,"abstract":"A clinical case of highly aggressive multiple sclerosis in a patient with a family history of demyelinating disease is presented. The effectiveness of early pathogenetic therapy by blocking the adhesion molecules of lymphocytes is demonstrated.","PeriodicalId":155224,"journal":{"name":"Perm Medical Journal","volume":"7 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139607615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A clinical description of Urbach – Wiethe disease (lipoid proteinosis), an extremely rare pathology, is presented, currently only 300 cases are known. This hereditary disease, transmitted by an autosomal recessive type, is associated with a mutation of the extracellular matrix 1 (ECM1) gene located on chromosome 1, locus 1q21. It is based on a violation of collagen synthesis and deposition of hyaline in the dermis along the collagen fibers, in the mucous membranes, sometimes in the internal organs. The chemical composition of hyaline is not completely determined; it is noted that it includes collagen, glycoproteins, lipids, proteoglycans. The disease begins in early childhood and is characterized by changes in the ENT organs and skin, confirmed by histological examination, which reveals thickening of the dermis, degeneration of collagen fibers, hyalinosis with deposition around the vessels, in their walls, around the sweat glands of ribbon-like, weakly eosinophilic, homogeneous substances, which include phospholipids, sometimes there may be cracks with deposition of lipids. Patient V., born in 1990, the disease began almost from birth with the appearance of polymorphic rashes on the skin and hoarseness of the voice. In 1999, a histological examination of the affected skin was performed, confirming the diagnosis of lipoid proteinosis of Urbach – Wiethe. The skin pathological process is widespread, symmetrical, on the face it is represented by reticulated telangiectatic erythema, along the edge of the lower eyelids there are miliary nodules similar to a string of pearls. Hypoplasia and stagnant erythema of the auricles are determined. There are yellowish lenticular papules on the trunk and limbs, waxy translucent plaques of a dense consistency in the area of the extensor surface of the elbow joints. Besides, secondary hyperpigmentation and foci of atrophy were detected on the face, trunk and limbs. Skin changes are accompanied by lesion of the ENT organs in the form of bilateral maxillary sinusitis, frontitis, chronic pharyngitis, chronic laryngitis. Concomitant pathology is important: polyvalent sensitization, chronic hepatitis B, biliary dyskinesia against the background of gallbladder deformation, chronic gastroduodenitis. The patient has been on disability since 2000, needs dispensary supervision and correction of all identified violations.
{"title":"A clinical case of Urbach-Wiethe disease","authors":"М. Y. Kobernik, V. Elkin, Т. G. Sedova","doi":"10.17816/pmj406107-113","DOIUrl":"https://doi.org/10.17816/pmj406107-113","url":null,"abstract":"A clinical description of Urbach – Wiethe disease (lipoid proteinosis), an extremely rare pathology, is presented, currently only 300 cases are known. This hereditary disease, transmitted by an autosomal recessive type, is associated with a mutation of the extracellular matrix 1 (ECM1) gene located on chromosome 1, locus 1q21. It is based on a violation of collagen synthesis and deposition of hyaline in the dermis along the collagen fibers, in the mucous membranes, sometimes in the internal organs. The chemical composition of hyaline is not completely determined; it is noted that it includes collagen, glycoproteins, lipids, proteoglycans. The disease begins in early childhood and is characterized by changes in the ENT organs and skin, confirmed by histological examination, which reveals thickening of the dermis, degeneration of collagen fibers, hyalinosis with deposition around the vessels, in their walls, around the sweat glands of ribbon-like, weakly eosinophilic, homogeneous substances, which include phospholipids, sometimes there may be cracks with deposition of lipids. \u0000Patient V., born in 1990, the disease began almost from birth with the appearance of polymorphic rashes on the skin and hoarseness of the voice. In 1999, a histological examination of the affected skin was performed, confirming the diagnosis of lipoid proteinosis of Urbach – Wiethe. The skin pathological process is widespread, symmetrical, on the face it is represented by reticulated telangiectatic erythema, along the edge of the lower eyelids there are miliary nodules similar to a string of pearls. Hypoplasia and stagnant erythema of the auricles are determined. There are yellowish lenticular papules on the trunk and limbs, waxy translucent plaques of a dense consistency in the area of the extensor surface of the elbow joints. Besides, secondary hyperpigmentation and foci of atrophy were detected on the face, trunk and limbs. Skin changes are accompanied by lesion of the ENT organs in the form of bilateral maxillary sinusitis, frontitis, chronic pharyngitis, chronic laryngitis. Concomitant pathology is important: polyvalent sensitization, chronic hepatitis B, biliary dyskinesia against the background of gallbladder deformation, chronic gastroduodenitis. The patient has been on disability since 2000, needs dispensary supervision and correction of all identified violations.","PeriodicalId":155224,"journal":{"name":"Perm Medical Journal","volume":"30 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139606851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. V. Lazarkov, Е. N. Orekhova, Ya .B. Khovaeva, V. А. Belov, О. V. Soloviev
Objective. To study the echocardiographic (Echo-CG) indicators in infants of the first year of life with ventricular septal defect (VSD) in the early postoperative period after surgical correction of the defect. Materials and methods. Examination of 205 infants with VSD was carried out. Complex examination before the surgery, 6, 24 hours and the day 10th after the surgery was fulfilled. Results. In the early postoperative period, myocardial dysfunction (MD) was detected in 30.2 % of cases (n = 62). The patients were longer subjected to artificial lung ventilation (p = 0.04), had a longer period of staying in the intensive care unit (p = 0.002) and hospital (p = 0.004). The data, predicting the postoperative MD were revealed including VSD area index (OR 2.7; р = 0.00001), longitudinal deformation of the left ventricle (SLV; OR 2.69; р = 0.00001), longitudinal deformation of the free wall of the right ventricle (SRV; OR 1.04; р = 0.0001) and the average estimated pressure in the lung artery (OR 1.6; р = 0.0001). Conclusions. 1. After the surgery, MD was detected in 30.2 % of cases. 2. SLV and SRV in infants with MD demonstrate the aggravation of ventricular contractility earlier than traditional indicators of the systolic function. 3. Preoperative SLV «–» 12 %, SRV «–» 6 %, VSD area index 100,5 mm2/m2, average estimated pressure in the lung artery 38 mm Hg are independent predictors of complications accompanied by MD during the first day after the VSD closure. 4. Complications, connected with longer ALV, are associated with duration of staying in the intensive care unit and hospital.
{"title":"Possibilities of predicting early postoperative complications after surgical correction in infants of the first year of life with ventricular septal defect","authors":"P. V. Lazarkov, Е. N. Orekhova, Ya .B. Khovaeva, V. А. Belov, О. V. Soloviev","doi":"10.17816/pmj40674-89","DOIUrl":"https://doi.org/10.17816/pmj40674-89","url":null,"abstract":"Objective. To study the echocardiographic (Echo-CG) indicators in infants of the first year of life with ventricular septal defect (VSD) in the early postoperative period after surgical correction of the defect. \u0000Materials and methods. Examination of 205 infants with VSD was carried out. Complex examination before the surgery, 6, 24 hours and the day 10th after the surgery was fulfilled. \u0000Results. In the early postoperative period, myocardial dysfunction (MD) was detected in 30.2 % of cases (n = 62). The patients were longer subjected to artificial lung ventilation (p = 0.04), had a longer period of staying in the intensive care unit (p = 0.002) and hospital (p = 0.004). The data, predicting the postoperative MD were revealed including VSD area index (OR 2.7; р = 0.00001), longitudinal deformation of the left ventricle (SLV; OR 2.69; р = 0.00001), longitudinal deformation of the free wall of the right ventricle (SRV; OR 1.04; р = 0.0001) and the average estimated pressure in the lung artery (OR 1.6; р = 0.0001). \u0000Conclusions. 1. After the surgery, MD was detected in 30.2 % of cases. 2. SLV and SRV in infants with MD demonstrate the aggravation of ventricular contractility earlier than traditional indicators of the systolic function. 3. Preoperative SLV «–» 12 %, SRV «–» 6 %, VSD area index 100,5 mm2/m2, average estimated pressure in the lung artery 38 mm Hg are independent predictors of complications accompanied by MD during the first day after the VSD closure. 4. Complications, connected with longer ALV, are associated with duration of staying in the intensive care unit and hospital.","PeriodicalId":155224,"journal":{"name":"Perm Medical Journal","volume":"26 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. V. Feldblyum, E. V. Gorelikova, V. I. Sergevnin, N. V. Isaeva, M. Y. Devyatkov, M. G. Menshikova, S. D. Novgorodova, I. A. Okuneva
The article is devoted to the 110th anniversary of the birth of Anna Timofeevna Faidysh – Doctor of Medical Sciences, Professor, Head of the Department of Epidemiology of Perm Medical Institute (1960–1973), honorary member of the Memorial Complex dedicated to the Battle of Stalingrad. Anna Timofeevna graduated with honors from the First Kharkov Medical Institute and took postgraduate studies at the Department of Microbiology. In June 1941, the Great Patriotic War began. For her participation in the military actions, she was awarded two orders and six medals. From 1960 to 1973, Anna Timofeevna worked as the Head of the Department of Epidemiology at Perm Medical institute. In 1965, she defended her doctoral dissertation and became a professor. A.T. Faidysh introduced a course of military epidemiology into the educational process. She is the author of more than 100 scientific papers. Under her leadership, four PhD theses were defended.
{"title":"Professor Anna Timofeevna Faidysh: 110th anniversary of her birth","authors":"I. V. Feldblyum, E. V. Gorelikova, V. I. Sergevnin, N. V. Isaeva, M. Y. Devyatkov, M. G. Menshikova, S. D. Novgorodova, I. A. Okuneva","doi":"10.17816/pmj406158-161","DOIUrl":"https://doi.org/10.17816/pmj406158-161","url":null,"abstract":"The article is devoted to the 110th anniversary of the birth of Anna Timofeevna Faidysh – Doctor of Medical Sciences, Professor, Head of the Department of Epidemiology of Perm Medical Institute (1960–1973), honorary member of the Memorial Complex dedicated to the Battle of Stalingrad. Anna Timofeevna graduated with honors from the First Kharkov Medical Institute and took postgraduate studies at the Department of Microbiology. In June 1941, the Great Patriotic War began. For her participation in the military actions, she was awarded two orders and six medals. From 1960 to 1973, Anna Timofeevna worked as the Head of the Department of Epidemiology at Perm Medical institute. In 1965, she defended her doctoral dissertation and became a professor. A.T. Faidysh introduced a course of military epidemiology into the educational process. She is the author of more than 100 scientific papers. Under her leadership, four PhD theses were defended.","PeriodicalId":155224,"journal":{"name":"Perm Medical Journal","volume":"64 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139606580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
А. S. Vronsky, Е. А. Golovacheva, A. Oborin, S. V. Mozgovaya, P. V. Lazarkov, К. V. Prokhorov
Wound complications after carotid endarterectomy are rare ones. One of them is the formation of a salivary fistula due to the damage of the submandibular salivary gland. A factor that increases the likelihood of the damage of the salivary gland is a high bifurcation of the carotid arteries. This article presents a case of conservative treatment of the salivary fistula after carotid endarterectomy. Modern diagnostic methods, consisting in biochemical analysis of the secreted fluid for alpha-amylase, contribute to rapid diagnostics. Treatment with the anticholinergic drug 0.1 % atropine sulfate, 6 drops under the tongue half an hour before each meal, has proved its efficiency. In conjunction with medical treatment, it is necessary to ensure an adequate outflow of saliva from the wound to prevent the formation of salivoma and compression of the airways. Long-term conservative therapy makes it possible to achieve a complete cessation of sialorrhea through a salivary fistula and to eliminate the need for surgical treatment.
{"title":"Sialorrhoea due to development of salivary fistula after carotid endarterectomy. Diagnostics and treatment. A clinical case","authors":"А. S. Vronsky, Е. А. Golovacheva, A. Oborin, S. V. Mozgovaya, P. V. Lazarkov, К. V. Prokhorov","doi":"10.17816/pmj406114-119","DOIUrl":"https://doi.org/10.17816/pmj406114-119","url":null,"abstract":"Wound complications after carotid endarterectomy are rare ones. One of them is the formation of a salivary fistula due to the damage of the submandibular salivary gland. A factor that increases the likelihood of the damage of the salivary gland is a high bifurcation of the carotid arteries. This article presents a case of conservative treatment of the salivary fistula after carotid endarterectomy. Modern diagnostic methods, consisting in biochemical analysis of the secreted fluid for alpha-amylase, contribute to rapid diagnostics. Treatment with the anticholinergic drug 0.1 % atropine sulfate, 6 drops under the tongue half an hour before each meal, has proved its efficiency. In conjunction with medical treatment, it is necessary to ensure an adequate outflow of saliva from the wound to prevent the formation of salivoma and compression of the airways. Long-term conservative therapy makes it possible to achieve a complete cessation of sialorrhea through a salivary fistula and to eliminate the need for surgical treatment.","PeriodicalId":155224,"journal":{"name":"Perm Medical Journal","volume":"30 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139606972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Y. Mishlanov, V. А. Chereshnev, G. P. Vdovina, А. Burlutskaya, А. L. Zuev, E. P. Koshurnikova, V. V. Emelkina, V. Samartsev, V. Gavrilov
Objective. To study the regenerative activity of a mineral complex containing ions of cerium, manganese, zinc and silver in model experiments of the planar skin wounds and acute bronchitis in laboratory animals for the development of new techniques of surgical and pulmonological diseases treatment. Materials and methods. An experimental study of the regenerative activity of a mineral complex containing ions of cerium, manganese, zinc and silver was carried out on models of the planar skin wounds and acute bronchitis in rats. Results. The results of histological examination of tissues showed the advantage of the mineral complex over the control groups of animals. The anti-inflammatory and regenerative activity of the mineral complex was established in a model of acute bronchitis and regenerative activity in a model of a planar skin wound. Conclusions. The effectiveness of the mineral complex depended on the concentration of cerium ions and was manifested at a dose of 0.003 μg/kg of animal weight.
{"title":"Experimental studies of effectiveness of a new mineral complex for regeneration of epithelial tissues and skin","authors":"V. Y. Mishlanov, V. А. Chereshnev, G. P. Vdovina, А. Burlutskaya, А. L. Zuev, E. P. Koshurnikova, V. V. Emelkina, V. Samartsev, V. Gavrilov","doi":"10.17816/pmj406148-157","DOIUrl":"https://doi.org/10.17816/pmj406148-157","url":null,"abstract":"Objective. To study the regenerative activity of a mineral complex containing ions of cerium, manganese, zinc and silver in model experiments of the planar skin wounds and acute bronchitis in laboratory animals for the development of new techniques of surgical and pulmonological diseases treatment. \u0000Materials and methods. An experimental study of the regenerative activity of a mineral complex containing ions of cerium, manganese, zinc and silver was carried out on models of the planar skin wounds and acute bronchitis in rats. \u0000Results. The results of histological examination of tissues showed the advantage of the mineral complex over the control groups of animals. The anti-inflammatory and regenerative activity of the mineral complex was established in a model of acute bronchitis and regenerative activity in a model of a planar skin wound. \u0000Conclusions. The effectiveness of the mineral complex depended on the concentration of cerium ions and was manifested at a dose of 0.003 μg/kg of animal weight.","PeriodicalId":155224,"journal":{"name":"Perm Medical Journal","volume":"13 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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