Journal of diabetes and its complications最新文献

{"title":"Effects of moderate-intensity aerobic training on cardiac structure and function in type 2 mellitus diabetic rats: Based on echocardiography and speckle tracking","authors":"Chunyan Huang ,&nbsp;Shengnan Lin ,&nbsp;Zhiwei Yan ,&nbsp;Weiliang Yu ,&nbsp;Dan Wang ,&nbsp;Yiping Liu","doi":"10.1016/j.jdiacomp.2024.108896","DOIUrl":"10.1016/j.jdiacomp.2024.108896","url":null,"abstract":"<div><h3>Purpose</h3><div>The present study aimed to evaluate the cardiac function changes using Layer-specific Speckle-tracking echocardiography (LS-STE) induced by Moderate-intensity aerobic training (MIAT) in Type 2 diabetes mellitus (T2DM) rats.</div></div><div><h3>Methods</h3><div>Twenty-six rats were divided into four groups: the Control group (Con), the Training control group (CT), the T2DM group (DM), and the T2DM training group (DT). The CT and DT groups underwent an 8 weeks MIAT. Cardiac structure and function were evaluated by echocardiography and LS-STE.</div></div><div><h3>Results</h3><div>Compared with the Con group, left atrial diameter (LAD), left ventricular end-diastolic diameter(LVEDD), relation wall thickness (RWT), and left ventricular mass (LVM) were significantly higher, and the <em>endo</em>-, mid-, and epi-longitudinal strain (LS), global radial strain (GRS), and <em>endo</em>- and mid-circumferential strain (CS) were significantly lower in DM rats (all <em>p</em> &lt; 0.05). The endo-, mid-, and epi-LS, GRS, endo- and mid-CS were increased in DT rats compared with DM rats (all <em>p</em> &lt; 0.05). Compared with Con rats, CT rats had a significant increase in LVEDD and LVM (all <em>p</em> &lt; 0.05), meanwhile myocardial strains had no significant differences (all <em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>LS-STE was a sensitive method to assess subclinical myocardial changes in T2DM rats. MIAT had the benefit of reversing cardiac systolic subclinical dysfunction in T2DM rats.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108896"},"PeriodicalIF":2.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant effects of a novel pioglitazone analogue (PA9) in a rat model of diabetes: Modulation of redox homeostasis and preservation of tissue architecture","authors":"Neda Shakour ,&nbsp;Mohammad Reza Mahdinezhad ,&nbsp;Fereshteh Asgharzadeh ,&nbsp;Majid Khazaei ,&nbsp;Luis E. Simental-Mendía ,&nbsp;Nema Mohamadian Roshan ,&nbsp;Amirhossein Sahebkar ,&nbsp;Farzin Hadizadeh","doi":"10.1016/j.jdiacomp.2024.108897","DOIUrl":"10.1016/j.jdiacomp.2024.108897","url":null,"abstract":"<div><div>Oxygen-free radicals have been implicated in the initiation of diabetic complications. Thiazolidinediones (TZDs), known for their antidiabetic properties, also demonstrate notable antioxidant and anti-inflammatory effects. Although a recently developed imidazolyl analogue of pioglitazone (<strong>PA9</strong>) has exhibited superior glucose-lowering efficacy compared to pioglitazone, its antioxidant effects remain unexplored. Thus, the objective of this study is to evaluate the antioxidant properties of <strong>PA9</strong> in animal models with diabetes.</div><div>Rats were randomly separated into the following four groups: control, diabetic, and two groups treated orally with pioglitazone as a standard drug and <strong>PA9</strong> for ten days. Upon completion of the experiment, tissues from the liver, heart, brain, pancreas, spleen, and kidneys were collected to assess oxidant/antioxidant markers and histological alterations. The administration of <strong>PA9</strong> resulted in a noteworthy reduction in malondialdehyde (MDA) levels compared to the diabetic group (<em>p</em> &lt; 0.05). The group receiving <strong>PA9</strong> displayed elevated levels of three antioxidant markers, catalase (CAT), superoxide dismutase (SOD), and total thiol, in pancreatic tissue compared to diabetic rats (<em>p</em> &lt; 0.05).</div><div>Furthermore, increased content of CAT was evident in the heart (<em>p</em> &lt; 0.05), spleen (<em>p</em> &lt; 0.001), brain, and kidney tissues in the <strong>PA9</strong>-treated group, along with augmented thiol content in the spleen compared to the diabetic group. Remarkably, no significant histological changes were observed in the liver, pancreas, heart, brain, spleen, and kidneys of the <strong>PA9</strong>-treated groups relative to diabetic rats. <strong>PA9</strong> effectively mitigates oxidative stress, modulates redox homeostasis, and shows promise in preventing diabetic complications. The proven safety profile of this analogue underscores its potential, warranting comprehensive clinical evaluation to thoroughly understand its therapeutic scope and efficacy in the management of diabetes.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108897"},"PeriodicalIF":2.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents/Barcode","authors":"","doi":"10.1016/S1056-8727(24)00214-9","DOIUrl":"10.1016/S1056-8727(24)00214-9","url":null,"abstract":"","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108888"},"PeriodicalIF":2.9,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and clinical implications of diabetes mellitus in autoimmune nodopathies: A systematic review","authors":"Anastasios Tentolouris ,&nbsp;Maria-Ioanna Stefanou ,&nbsp;Anastasia V. Vrettou ,&nbsp;Lina Palaiodimou ,&nbsp;Christos Moschovos ,&nbsp;Marianna Papadopoulou ,&nbsp;Panagiotis Kokotis ,&nbsp;Ioanna Eleftheriadou ,&nbsp;Nikolaos Tentolouris ,&nbsp;Georgios Tsivgoulis","doi":"10.1016/j.jdiacomp.2024.108883","DOIUrl":"10.1016/j.jdiacomp.2024.108883","url":null,"abstract":"<div><h3>Background and aims</h3><div>Autoimmune nodopathies comprise a newly-established subtype of immune-mediated peripheral neuropathies, characterized by circulating autoantibodies that target nodal-paranodal proteins, including contactin-1 (CNTN1), contactin-associated protein-1 (Caspr1), neurofascin-155 (NF155) and neurofascin-isoforms (NF140 and NF186). Emerging evidence suggests that diabetes mellitus (DM) may confer increased risk for autoimmune nodopathies.</div></div><div><h3>Methods</h3><div>A systematic search was performed including studies reporting on patients harboring nodal/paranodal antibodies (CNTN1, Caspr1, NF155, NF140 and NF186). We sought to evaluate: (1) the prevalence of DM among patients with autoimmune nodopathies; (2) the phenotype of DM-patients harboring different types of nodal/paranodal antibodies; (3) clinical features that allow distinction of autoimmune nodopathies from diabetic peripheral neuropathy (DPN).</div></div><div><h3>Results</h3><div>Five cohort studies, 3 case-reports and one case-series study were identified comprising 114 patients with autoimmune nodopathies. DM prevalence was documented to range between 10.5 % and 60 %. DM-patients harbored mostly paranodal antibodies; CNTN1: 58.3 %, followed by pan-neurofascin: 33.3 %, and Caspr1: 25 % antibodies. No significant differences in clinical phenotype were uncovered between DM-patients and their non-DM counterparts. Overall, DM patients were refractory to intravenous-immunoglobulins (IVIG), but responded well to escalation immunotherapies. Compared to DPN, distinctive features of autoimmune nodopathy comprised: (i) severe ataxia, tremor, and cranial nerve involvement; (ii) neurophysiological findings indicative of nodal-paranodal pathology, including (reversible) conduction failure and conduction velocity slowing, often accompanied by reduced compound muscle and sensory nerve action potentials; and (iii) marked protein-elevation or albuminocytological dissociation in cerebrospinal fluid analysis.</div></div><div><h3>Conclusions</h3><div>DM patients fall under the typical clinical phenotype of autoimmune nodopathy, displaying predominantly paranodal antibodies. Early suspicion is crucial, as unlike DPN, diagnosis of autoimmune nodopathy unfolds therapeutic perspectives.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108883"},"PeriodicalIF":2.9,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of pulse wave velocity for cardiovascular disease risk stratification in diabetic patients: A systematic review and meta-analysis","authors":"Siao Suan Cheong ,&nbsp;Nazirah Samah ,&nbsp;Nur Aishah Che Roos ,&nbsp;Azizah Ugusman ,&nbsp;Mohd Shawal Faizal Mohamad ,&nbsp;Boon Cong Beh ,&nbsp;Isa Azzaki Zainal ,&nbsp;Amilia Aminuddin","doi":"10.1016/j.jdiacomp.2024.108894","DOIUrl":"10.1016/j.jdiacomp.2024.108894","url":null,"abstract":"<div><h3>Aim</h3><div>Arterial stiffness, a significant cardiovascular risk marker, is particularly important in patients with diabetes mellitus (DM). Pulse wave velocity (PWV), a non-invasive measure of arterial stiffness, has emerged as an independent predictor of cardiovascular morbidity and mortality. However, its precise prognostic value in DM patients for cardiovascular risk stratification remains unclear. To address this, a systematic review was conducted.</div></div><div><h3>Method</h3><div>A thorough search of Ovid and Scopus databases was performed for cohort studies on PWV measurements for cardiovascular risk stratification in DM patients. Nine studies were included, examining the relationship between PWV and cardiovascular events or composite endpoints in DM patients asymptomatic of cardiovascular diseases (CVD).</div></div><div><h3>Results</h3><div>The review revealed that optimal PWV cutoffs to predict composite cardiovascular events ranged from 10 to 12.16 m/s (aortic PWV) and 14 to 16.72 m/s (brachial-ankle PWV). In addition, meta-analysis yielded a HR of 1.15 (95 % CI 1.07–1.24, <em>p</em> &lt; 0.001, <em>I</em>² = 70 %) for aortic PWV in predicting cardiovascular events.</div></div><div><h3>Conclusion</h3><div>The assessment of arterial stiffness via PWV shows promise as an early diagnostic marker for CVD in DM patients, aiding in improved disease management. This underscores the potential of PWV in enhancing cardiovascular risk assessment and guiding clinical decisions in this high-risk population, without invasive procedures or radiation exposure.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108894"},"PeriodicalIF":2.9,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous rapid-acting insulin analogues in mild to moderate diabetic ketoacidosis: A meta-analysis of randomized controlled trials","authors":"Maria L.R. Defante ,&nbsp;Mariana de Moura de Souza ,&nbsp;Beatriz Ximenes Mendes ,&nbsp;Beatriz A. de A. De Hollanda Morais ,&nbsp;Vitória M. Prizão ,&nbsp;Salma Ali El Chab Parolin ,&nbsp;Hugo Valinho Francisco","doi":"10.1016/j.jdiacomp.2024.108882","DOIUrl":"10.1016/j.jdiacomp.2024.108882","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetic Ketoacidosis (DKA) is commonly treated with intravenous (IV) regular insulin. However, patients with less severe DKA may benefit from a subcutaneous (SC) scheme.</div></div><div><h3>Methods</h3><div>We systematically searched PubMed, Cochrane, and Embase for randomized controlled trials (RCTs) comparing SC rapid-acting insulin analogue (RAIAs) with IV regular insulin. Risk ratios (RR) were used to compare treatment effects for binary outcomes and mean differences (MD) for continuous data with the corresponding 95 % confidence intervals (CI). <em>P</em> values &lt;0.05 were considered statistically significant. We used the R version 4.3.2 for statistical analyses.</div></div><div><h3>Results</h3><div>Our meta-analysis included eight RCTs encompassing 415 patients. No statistically significant differences were found between RAIAs and IV regular insulin in the treatment of mild to moderate DKA in the pediatric and adult population in the primary outcome of time until DKA resolution (MD 0.00 h; 95 % CI -1.27 to 1.28; <em>P</em> = 1.00). Both treatments showed comparable results in the secondary outcomes total insulin usage (<em>P</em> = 0.65), time until hyperglycemia resolution (<em>P</em> = 0.22), length of hospital stay (<em>P</em> = 0.11), the incidence of hypoglycemia (<em>P</em> = 0.15) and DKA recurrence (P = Not estimable). There were no reports of death, cerebral edema, or venous thrombosis in the studies.</div></div><div><h3>Conclusion</h3><div>In this meta-analysis of eight RCTs we found that SC RAIAs and regular IV insulin are comparable in resolving mild to moderate DKA in children and adults. PROSPERO registration: CRD42023485032.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108882"},"PeriodicalIF":2.9,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual and joint effects of diabetes and depression on incident cardiovascular diseases and all-cause mortality: Results from a population-based cohort study","authors":"Qiang Tu ,&nbsp;Karice Hyun ,&nbsp;Shuanglan Lin ,&nbsp;Nashid Hafiz ,&nbsp;Deborah Manandi ,&nbsp;Qian Zhang ,&nbsp;Xinzheng Wang ,&nbsp;Na Zhang ,&nbsp;Haisheng Wu ,&nbsp;Julie Redfern","doi":"10.1016/j.jdiacomp.2024.108878","DOIUrl":"10.1016/j.jdiacomp.2024.108878","url":null,"abstract":"<div><h3>Aims</h3><div>To assess the individual and joint effects of diabetes and depression on all-cause mortality and cardiovascular disease (CVD) in the middle-aged and elderly Chinese populations.</div></div><div><h3>Methods</h3><div>9105 individuals without CVD from the China Health and Retirement Longitudinal Study (CHARLS) were included and followed up for 9 years. Participants were divided into four comparative groups: diabetes alone, depression alone, both conditions, and neither condition. Multivariate binary logistic regression models were performed to compare the risks of all-cause mortality and CVD among the four groups.</div></div><div><h3>Results</h3><div>When compared to those without diabetes and depression, the multivariate adjusted odds ratios (aORs) for CVD in individuals who had diabetes only, depression only, and both diabetes and depression were 1.245 (95 % CI 1.023 to 1.515), 1.318 (95 % CI 1.171 to 1.485) and 1.722 (95 % CI 1.361 to 2.178), respectively. The aORs for all-cause mortality were 1.366 (95 % CI 1.035–1.804) for diabetes alone, 1.082 (95 % CI 0.916–1.279) for depression alone, and 1.590 (95 % CI 1.152–2.195) for both conditions when compared with those with neither condition.</div></div><div><h3>Conclusions</h3><div>Individuals with both diabetes and depression had greater risk of CVD and all-cause mortality when compared to those with diabetes or depression alone, or those without either condition.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108878"},"PeriodicalIF":2.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-cause mortality and factors associated with it in Finnish patients with type 1 diabetes","authors":"Elena Putula ,&nbsp;Tuuli Kauppala ,&nbsp;Sini Vanhamäki ,&nbsp;Jaason Haapakoski ,&nbsp;Tiina Laatikainen ,&nbsp;Saara Metso","doi":"10.1016/j.jdiacomp.2024.108881","DOIUrl":"10.1016/j.jdiacomp.2024.108881","url":null,"abstract":"<div><h3>Aims</h3><div>To assess the effect of comorbidities, risk classification for chronic kidney disease (CKD) according to albuminuria and eGFR, HbA1c and LDL-cholesterol levels on all-cause mortality in patients with type 1 diabetes (DM1).</div></div><div><h3>Methods</h3><div>The study included all 45,801 DM1 patients from the Finnish Diabetes Registry during 2018–2022. Mortality of patients with DM1 was compared with mortality in non-diabetic population in Finland by estimating standardized mortality rates (SMRs). Poisson regression model was used to estimate the effect of risk factors on the SMR.</div></div><div><h3>Results</h3><div>A total of 2469 patients died during follow-up. SMR for the total cohort was 1.84 (95 % CI 1.77–1.92) peaking at the age of 30–49 years. The coverage of HbA1c values was 98 %, that of LDL-cholesterol 94 %, and U-ACR and eGFR 80 %. In a multivariate analysis, assessing the effect on mortality, the rate ratio for end-stage renal disease was 2.66, cardiovascular diseases 1.92, mental and behavioural disorders 1.64, foot complications 1.51, high or very high risk for CKD 3.64, LDL-cholesterol ≥2.6 mmol/l 1.33, and HbA1c ≥8 % (64 mmol/mol) 1.27.</div></div><div><h3>Conclusions</h3><div>There's substantial excess mortality due to DM1 in Finland. Interventions should focus on addressing both renal and cardiovascular risk factors but also pay more attention to mental health.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108881"},"PeriodicalIF":2.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the relationship between social determinants of health and risk of albuminuria among children with type 1 diabetes","authors":"Jia Xin Huang ,&nbsp;T. Charles Casper ,&nbsp;Casey Pitts ,&nbsp;Sage R. Myers ,&nbsp;Rebecca Lynch ,&nbsp;Lindsey Loomba ,&nbsp;Janani Ramesh ,&nbsp;Nathan Kuppermann ,&nbsp;Elaine Ku ,&nbsp;Nicole Glaser","doi":"10.1016/j.jdiacomp.2024.108880","DOIUrl":"10.1016/j.jdiacomp.2024.108880","url":null,"abstract":"<div><div>In a cohort of 2303 children with type 1 diabetes (T1D), we found that non-English speaking status (HR 2.82, 95% CI 1.54–5.18) and public insurance (HR 1.48, 95% CI 1.07–2.05) were associated with an increased risk of incident albuminuria, after adjusting for T1D-related variables (age, hemoglobin A1c, diabetic ketoacidosis episodes with acute kidney injury).</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 12","pages":"Article 108880"},"PeriodicalIF":2.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endothelial dysfunction markers syndecan-1 and thrombomodulin are associated with higher albuminuria levels in type 2 diabetes with no history of clinical cardiovascular disease","authors":"Luis F. Ferreira-Divino ,&nbsp;Christina G. Poulsen ,&nbsp;Viktor Rotbain Curovic ,&nbsp;Oliver B. Pedersen ,&nbsp;Nete Tofte ,&nbsp;Marie Frimodt-Møller ,&nbsp;Tine W. Hansen ,&nbsp;Anne-Mette Hvas ,&nbsp;Peter Rossing","doi":"10.1016/j.jdiacomp.2024.108879","DOIUrl":"10.1016/j.jdiacomp.2024.108879","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals with type 2 diabetes and increased albuminuria, a well-established marker of microvascular complications, are at a higher risk for cardiovascular disease (CVD) and premature mortality. Therefore, a better understanding of the underlying pathophysiology is needed to improve risk stratification and tailor prevention and intervention.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study including 463 individuals with type 2 diabetes, various degrees of albuminuria and without CVD. We analysed the association between albuminuria and markers of endothelial function (thrombomodulin and syndecan-1), thrombin generation (thrombin-antithrombin complex, prothrombin fragment 1 + 2), fibrinogen, platelet function (activation using soluble plasma selectin and aggregation using Multiplate® Analyzer) using regression models.</div></div><div><h3>Results</h3><div>In the study cohort 33 % were women, the mean ± SD age was 65 ± 9 years, and median [IQR] diabetes duration was 15 [9–20] years. In total, 344 (74 %) individuals had normal albuminuria, 87 (19 %) moderately- and 32 (7 %) severely increased albuminuria levels. Higher markers of endothelial function and fibrinogen were independently associated with higher albuminuria levels (<em>p</em> &lt; 0.01). No association between albuminuria and markers of thrombin generation and platelet was demonstrated.</div></div><div><h3>Conclusion</h3><div>We demonstrated an independent association between albuminuria and markers of endothelial function and fibrinogen in individuals with type 2 diabetes and no history of CVD.</div></div>","PeriodicalId":15659,"journal":{"name":"Journal of diabetes and its complications","volume":"38 11","pages":"Article 108879"},"PeriodicalIF":2.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}