М. Studneva, A. Yuryev, Veronica Medvedeva, H. Abe, E. Antonova, V. Tsytsarev, T. Marshall, A. D. Miller, S. Suchkov
the of research. Despite a tremendous impact of human genome project on our understanding of the pathogenesis of cancer, autoimmune and other Abstract A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). To achieve the implementation of PM concept, it is necessary to create a fundamentally new strategy based upon the subclinical recognition of biopredictors of hidden abnormalities long before the disease clinically manifests itself. Each decision-maker values the impact of their decision to use PPM on their own budget and well-being, which may not necessarily be optimal for society as a whole. It would be extremely useful to integrate data harvesting from different databanks for applications such as prediction and personalization of further treatment to thus provide more tailored measures for the patients resulting in improved patient outcomes, reduced adverse events, and more cost effective use of health care resources. A lack of medical guidelines has been identified by the majority of responders as the predominant barrier for adoption, indicating a need for the development of best practices and guidelines to support the implementation of PPM! Implementation of PPM requires a lot before the current model «physician-patient» could be gradually displaced by a new model «medical advisor-healthy person-at-risk». This is the reason for developing global scientific, clinical, social, and educational projects in the area of PPM to elicit the content of the new branch.
{"title":"Personalized and Precision Medicine (PPM) as a Unique Healthcare Model of the Future to Come: Hype or Hope?","authors":"М. Studneva, A. Yuryev, Veronica Medvedeva, H. Abe, E. Antonova, V. Tsytsarev, T. Marshall, A. D. Miller, S. Suchkov","doi":"10.31038/imroj.2020542","DOIUrl":"https://doi.org/10.31038/imroj.2020542","url":null,"abstract":"the of research. Despite a tremendous impact of human genome project on our understanding of the pathogenesis of cancer, autoimmune and other Abstract A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, Personalized and Precision Medicine (PPM). To achieve the implementation of PM concept, it is necessary to create a fundamentally new strategy based upon the subclinical recognition of biopredictors of hidden abnormalities long before the disease clinically manifests itself. Each decision-maker values the impact of their decision to use PPM on their own budget and well-being, which may not necessarily be optimal for society as a whole. It would be extremely useful to integrate data harvesting from different databanks for applications such as prediction and personalization of further treatment to thus provide more tailored measures for the patients resulting in improved patient outcomes, reduced adverse events, and more cost effective use of health care resources. A lack of medical guidelines has been identified by the majority of responders as the predominant barrier for adoption, indicating a need for the development of best practices and guidelines to support the implementation of PPM! Implementation of PPM requires a lot before the current model «physician-patient» could be gradually displaced by a new model «medical advisor-healthy person-at-risk». This is the reason for developing global scientific, clinical, social, and educational projects in the area of PPM to elicit the content of the new branch.","PeriodicalId":158740,"journal":{"name":"Internal Medicine Research Open Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125636723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"https://researchopenworld.com/self-recovery-of-pancreatic-beta-cells-insulin-secretion-based-on-10-years-annualized-data-of-food-exercise-weight-and-glucose-using-ghmethod-math-physical-medicine-no-339/#","authors":"","doi":"10.31038/imroj.2020541","DOIUrl":"https://doi.org/10.31038/imroj.2020541","url":null,"abstract":"","PeriodicalId":158740,"journal":{"name":"Internal Medicine Research Open Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127970266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health Care Provider’s Knowledge on Snakes and Snakebites – A Study in the Three Tongu Districts of the Volta Region, Ghana","authors":"","doi":"10.31038/imroj.2020534","DOIUrl":"https://doi.org/10.31038/imroj.2020534","url":null,"abstract":"","PeriodicalId":158740,"journal":{"name":"Internal Medicine Research Open Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127068599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This paper describes the research results by comparing the glucose data from a Continuous Glucose Monitor (CGM) sensor device collecting glucose at 5-minute (5-min) and 15-minute (15-min) intervals during a period of 125 days, from 2/19/2020 to 6/23/2020, using the GH-Method: math-physical medicine approach. The purposes of this study are to compare the measurement differences and to uncover any possible useful information due to the different time intervals of the glucose collection.
{"title":"Differences between 5-Minute and 15-Minute Measurement Time Intervals of the CGM Sensor Glucose Device Using GH-Method: Math-Physical Medicine (No. 281)","authors":"Gerald C. Hsu","doi":"10.31038/imroj.2020532","DOIUrl":"https://doi.org/10.31038/imroj.2020532","url":null,"abstract":"This paper describes the research results by comparing the glucose data from a Continuous Glucose Monitor (CGM) sensor device collecting glucose at 5-minute (5-min) and 15-minute (15-min) intervals during a period of 125 days, from 2/19/2020 to 6/23/2020, using the GH-Method: math-physical medicine approach. The purposes of this study are to compare the measurement differences and to uncover any possible useful information due to the different time intervals of the glucose collection.","PeriodicalId":158740,"journal":{"name":"Internal Medicine Research Open Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131068522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
development, cessation of disease in specific duration in specific place/s. So far we are devoid of the precise knowledge on the creation of covid-19 however many scientists have been trying to explore the mystery of the occurrences, nature and impact on the human population of the globe [3]. The duration or natural course of illness or diseases is important in the management of cases, carrier as well as prevention of complications and death [4]. Alert researchers identify the key factors of the disease when there is sudden rise of cases of similar features in a short period. Ignorance about the nature of pathogen and ignorance of the general population about the disease leads to higher number of deaths in a very short duration. Lack of alertness in changing behavior and environment of the disease in the population further complicates its management and increases the number of deaths. The challenge of the new disease, ignorance on the part of environment and human behavior help to expand disease dimensions in terms of time, place and person. Opportunities such as chance, experience, observation and experimentation lead to discovery and development of medicine and care system that can make our life easier, comfortable and lengthier. This is the beauty of medical discipline, research and practice in human population. A dynamic patience where a body and brain searches a remedy continuously in response to disease is probably the best stimulus to initiate new knowledge, skills, practice to cure patient and prevent death. Lack of precise knowledge of duration and the nature of the disease is biggest obstacles in managing covid-19 at present and many more diseases that are possible in the future. the of disease and management of the patient the continuous sharing among the fellow researchers and responsible are the most important of pandemic pandemic. Change in seasonality in different geographical regions may affect duration of the diseases and distribution of death in humans. This demands thinking globally and acting globally.
{"title":"Disease, Duration and Death","authors":"N. Basnet","doi":"10.31038/imroj.2020533","DOIUrl":"https://doi.org/10.31038/imroj.2020533","url":null,"abstract":"development, cessation of disease in specific duration in specific place/s. So far we are devoid of the precise knowledge on the creation of covid-19 however many scientists have been trying to explore the mystery of the occurrences, nature and impact on the human population of the globe [3]. The duration or natural course of illness or diseases is important in the management of cases, carrier as well as prevention of complications and death [4]. Alert researchers identify the key factors of the disease when there is sudden rise of cases of similar features in a short period. Ignorance about the nature of pathogen and ignorance of the general population about the disease leads to higher number of deaths in a very short duration. Lack of alertness in changing behavior and environment of the disease in the population further complicates its management and increases the number of deaths. The challenge of the new disease, ignorance on the part of environment and human behavior help to expand disease dimensions in terms of time, place and person. Opportunities such as chance, experience, observation and experimentation lead to discovery and development of medicine and care system that can make our life easier, comfortable and lengthier. This is the beauty of medical discipline, research and practice in human population. A dynamic patience where a body and brain searches a remedy continuously in response to disease is probably the best stimulus to initiate new knowledge, skills, practice to cure patient and prevent death. Lack of precise knowledge of duration and the nature of the disease is biggest obstacles in managing covid-19 at present and many more diseases that are possible in the future. the of disease and management of the patient the continuous sharing among the fellow researchers and responsible are the most important of pandemic pandemic. Change in seasonality in different geographical regions may affect duration of the diseases and distribution of death in humans. This demands thinking globally and acting globally.","PeriodicalId":158740,"journal":{"name":"Internal Medicine Research Open Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130215473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Internal Med Res Open J, Volume 5(2): 1–2, 2020 The world woke up in November 2019[1] to the arrival of a new “enemy” in its parade of infectious pathogens, firstly in China and in an ominous fashion, now across the globe – the coronavirus, named CoVid-19 by the WHO [2,3]. A dreaded new pandemic [4] has now announced its presence, swept through the globe with an unimaginable speed [5] and savagely wreaked havocto healthcare systems, financial sectors and lives [6] across the world.It has disrupted life as we knew it before the crisis, to an extent we have never imagined possible. The magnitude of this disaster and its multifaceted ramifications, together with its speed of spread [5] is a new and novel experience in history. Life cannot be the same again.
{"title":"CoVid-19 its Impact on Healthcare Workers and the Need for Occupational Healthcare Provision","authors":"Y. Fong, WY JonathanLam, C. Leng, T. B. Keng","doi":"10.31038/imroj.2020523","DOIUrl":"https://doi.org/10.31038/imroj.2020523","url":null,"abstract":"Internal Med Res Open J, Volume 5(2): 1–2, 2020 The world woke up in November 2019[1] to the arrival of a new “enemy” in its parade of infectious pathogens, firstly in China and in an ominous fashion, now across the globe – the coronavirus, named CoVid-19 by the WHO [2,3]. A dreaded new pandemic [4] has now announced its presence, swept through the globe with an unimaginable speed [5] and savagely wreaked havocto healthcare systems, financial sectors and lives [6] across the world.It has disrupted life as we knew it before the crisis, to an extent we have never imagined possible. The magnitude of this disaster and its multifaceted ramifications, together with its speed of spread [5] is a new and novel experience in history. Life cannot be the same again.","PeriodicalId":158740,"journal":{"name":"Internal Medicine Research Open Journal","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126006858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this paper, the author presents his numerical techniques of applying the first-order interpolation perturbation method to establish and predict a new Postprandial Plasma Glucose (PPG) waveform based on the “perturbation factor” of carbs/sugar intake amount. This is part of his GH-Method: math-physical medicine research methodology. He also uses two previously measured PPG datasets (waveforms) of high-protein breakfasts to validate this numerical methodology.
{"title":"Applying the First-Order Interpolation Perturbation Method to Establish Predicted PPG Waveforms Based on Carbs/Sugar Intake Amounts (GH-Method: Math- Physical Medicine)","authors":"Gerald C. Hsu","doi":"10.31038/imroj.2020521","DOIUrl":"https://doi.org/10.31038/imroj.2020521","url":null,"abstract":"In this paper, the author presents his numerical techniques of applying the first-order interpolation perturbation method to establish and predict a new Postprandial Plasma Glucose (PPG) waveform based on the “perturbation factor” of carbs/sugar intake amount. This is part of his GH-Method: math-physical medicine research methodology. He also uses two previously measured PPG datasets (waveforms) of high-protein breakfasts to validate this numerical methodology.","PeriodicalId":158740,"journal":{"name":"Internal Medicine Research Open Journal","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131500398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Initially, he applied segmentation pattern analysis to analyze his 1,825 meals with 23,725 PPG Sensor data collected during a period of 5/5/201812/13/2019. Initially, his two segments were based on both “first factor” of meal’s carbs/sugar intake amounts and “second factor” of post-meal walking steps. His low-carb meals occupy about 2/3 of the total meals (1,209 meals with 8.5 grams per meal) and high-carb meals occupy about 1/3 of the total meals (615 meals with 27.1 grams per meal). A standard waveform (curve) contains 13 data points for each PPG curve and one input data for each 15-minute time segment. His postmeal walking steps are comparable (4,238 vs. 4,282 steps). Therefore, he decided to focus on the first factor of carbs/sugar intake amount only.
{"title":"Applying First-Order Perturbation Theory of Quantum Mechanics to Predict and Build a Postprandial Plasma Glucose Waveform (GH-Method: Math- Physical Medicine)","authors":"Gerald C. Hsu","doi":"10.31038/imroj.2020522","DOIUrl":"https://doi.org/10.31038/imroj.2020522","url":null,"abstract":"Initially, he applied segmentation pattern analysis to analyze his 1,825 meals with 23,725 PPG Sensor data collected during a period of 5/5/201812/13/2019. Initially, his two segments were based on both “first factor” of meal’s carbs/sugar intake amounts and “second factor” of post-meal walking steps. His low-carb meals occupy about 2/3 of the total meals (1,209 meals with 8.5 grams per meal) and high-carb meals occupy about 1/3 of the total meals (615 meals with 27.1 grams per meal). A standard waveform (curve) contains 13 data points for each PPG curve and one input data for each 15-minute time segment. His postmeal walking steps are comparable (4,238 vs. 4,282 steps). Therefore, he decided to focus on the first factor of carbs/sugar intake amount only.","PeriodicalId":158740,"journal":{"name":"Internal Medicine Research Open Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127602041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alameeri Amel, Lane Stephen, Mohammed Nur Mutaz, Loftus Barbara, Hogan Brenden
Pulmonary Langerhans Cell Histiocytosis (LCH) in adults is a rare disease and no precise epidemiological data are available concerning its prevalence. Bilateral diffuse nodular infiltration without cystic changes could be one of the Langerhans Cell Histiocytosis (LCH) presentation depend on the stage of evolution of the process. We are reporting in this case an early possible manifestation of LCH that can mimic other wide deferential diagnosis especially among smokers.
{"title":"An Uncommon Cause of Bilateral Pulmonary Nodules in a Long-Term Smoker","authors":"Alameeri Amel, Lane Stephen, Mohammed Nur Mutaz, Loftus Barbara, Hogan Brenden","doi":"10.31038/imroj.2020512","DOIUrl":"https://doi.org/10.31038/imroj.2020512","url":null,"abstract":"Pulmonary Langerhans Cell Histiocytosis (LCH) in adults is a rare disease and no precise epidemiological data are available concerning its prevalence. Bilateral diffuse nodular infiltration without cystic changes could be one of the Langerhans Cell Histiocytosis (LCH) presentation depend on the stage of evolution of the process. We are reporting in this case an early possible manifestation of LCH that can mimic other wide deferential diagnosis especially among smokers.","PeriodicalId":158740,"journal":{"name":"Internal Medicine Research Open Journal","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133342346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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