{"title":"DESCENTRALIZACIÓN FISCAL, ADMINISTRATIVA Y POLÍTICA","authors":"","doi":"10.2307/j.ctv23dxb62.6","DOIUrl":"https://doi.org/10.2307/j.ctv23dxb62.6","url":null,"abstract":"","PeriodicalId":158782,"journal":{"name":"Fundamentos de Finanzas Públicas","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123372430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PROPUESTA PARA EL NUEVO ENFOQUE DEL CONTROL FISCAL","authors":"","doi":"10.2307/j.ctv23dxb62.9","DOIUrl":"https://doi.org/10.2307/j.ctv23dxb62.9","url":null,"abstract":"","PeriodicalId":158782,"journal":{"name":"Fundamentos de Finanzas Públicas","volume":"404 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123875022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PASOS PARA LA EVALUACIÓN DEL SISTEMA DE CONTROL INTERNO","authors":"","doi":"10.2307/j.ctv23dxb62.13","DOIUrl":"https://doi.org/10.2307/j.ctv23dxb62.13","url":null,"abstract":"","PeriodicalId":158782,"journal":{"name":"Fundamentos de Finanzas Públicas","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115168316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ESTRUCTURA Y ORGANIZACIÓN DE LA ADMINISTRACIÒN PÙBLICA","authors":"","doi":"10.2307/j.ctv23dxb62.4","DOIUrl":"https://doi.org/10.2307/j.ctv23dxb62.4","url":null,"abstract":"","PeriodicalId":158782,"journal":{"name":"Fundamentos de Finanzas Públicas","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122583643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Facultad De Fisioterapia, D. Soria, Grado EN Fisioterapia, Trabajo Fin de Grado, Indicadores Fisiológicos, E. Calidad, De Vida, Desde EL Punto, D. Vista, DE LA Fisioterapia, Su aplicación, EN LA Valoración, C. Domínguez, Glosario DE Abreviaturas, Vida Diaria
Background and Objectives: Minimal residual disease (MRD) assessment by PCR in multiple myeloma (MM) has several shortcomings, including the lack of a suitable target. Kappa deleting element (KDE) rearrangements occur in virtually all Ig-lambda B-cell malignancies and in 1/3 of Ig-kappa are not affected by somatic hypermutation and, as in ALL, could be used as PCR targets. Methods: We have first investigated the incidence, gene segment usage, and CDR3 composition of IGK-KDE rearrangements in 96 untreated myeloma patients. Second, we tested 16 KDE gene rearrangements as molecular targets for MRD assessment by RQ-PCR using a germline reverse primer and a germline Taqman probe in combination with allele-specific oligonucleotides (ASO) as forward primers. Results: Monoclonal KDE rearrangements were amplified in 45% (43/96) of cases, monoallelic in 2/3 of them (29 cases), and biallellic in the remaining 14 cases. Overall, 88% of cases were successfully sequenced, KDE being equally frequently rearranged with VK and with intron-Recombination signal sequence (RSS). Median numbers of inserted and deleted nucleotides in the junctional region were one and five, respectively. Conclusions: Using KDE rearrangements as additional PCR target for MRD assessment in MM improves the applicability of these studies in 9% of cases overall and in 20% of lambda cases. Its use in the latter subset could represent a significant advance.
{"title":"GLOSARIO DE ABREVIATURAS","authors":"Facultad De Fisioterapia, D. Soria, Grado EN Fisioterapia, Trabajo Fin de Grado, Indicadores Fisiológicos, E. Calidad, De Vida, Desde EL Punto, D. Vista, DE LA Fisioterapia, Su aplicación, EN LA Valoración, C. Domínguez, Glosario DE Abreviaturas, Vida Diaria","doi":"10.2307/j.ctv23dxb62.12","DOIUrl":"https://doi.org/10.2307/j.ctv23dxb62.12","url":null,"abstract":"Background and Objectives: Minimal residual disease (MRD) assessment by PCR in multiple myeloma (MM) has several shortcomings, including the lack of a suitable target. Kappa deleting element (KDE) rearrangements occur in virtually all Ig-lambda B-cell malignancies and in 1/3 of Ig-kappa are not affected by somatic hypermutation and, as in ALL, could be used as PCR targets. Methods: We have first investigated the incidence, gene segment usage, and CDR3 composition of IGK-KDE rearrangements in 96 untreated myeloma patients. Second, we tested 16 KDE gene rearrangements as molecular targets for MRD assessment by RQ-PCR using a germline reverse primer and a germline Taqman probe in combination with allele-specific oligonucleotides (ASO) as forward primers. Results: Monoclonal KDE rearrangements were amplified in 45% (43/96) of cases, monoallelic in 2/3 of them (29 cases), and biallellic in the remaining 14 cases. Overall, 88% of cases were successfully sequenced, KDE being equally frequently rearranged with VK and with intron-Recombination signal sequence (RSS). Median numbers of inserted and deleted nucleotides in the junctional region were one and five, respectively. Conclusions: Using KDE rearrangements as additional PCR target for MRD assessment in MM improves the applicability of these studies in 9% of cases overall and in 20% of lambda cases. Its use in the latter subset could represent a significant advance.","PeriodicalId":158782,"journal":{"name":"Fundamentos de Finanzas Públicas","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132406666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SECTOR DESCENTRALIZADO POR SERVICIOS","authors":"","doi":"10.2307/j.ctv23dxb62.5","DOIUrl":"https://doi.org/10.2307/j.ctv23dxb62.5","url":null,"abstract":"","PeriodicalId":158782,"journal":{"name":"Fundamentos de Finanzas Públicas","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114067608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ALCANCE DE LAS PRUEBAS","authors":"","doi":"10.2307/j.ctv23dxb62.15","DOIUrl":"https://doi.org/10.2307/j.ctv23dxb62.15","url":null,"abstract":"","PeriodicalId":158782,"journal":{"name":"Fundamentos de Finanzas Públicas","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124913869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"APLICACIÓN DE CONTROL FISCAL —CASO PRÁCTICO—","authors":"","doi":"10.2307/j.ctv23dxb62.10","DOIUrl":"https://doi.org/10.2307/j.ctv23dxb62.10","url":null,"abstract":"","PeriodicalId":158782,"journal":{"name":"Fundamentos de Finanzas Públicas","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2005-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134463617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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