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Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献

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Antegrade stone removal using a novel non-slip balloon for dilation in a patient with hepaticojejunostomy anastomosis.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-02-02 DOI: 10.1002/jhbp.12116
Haruo Miwa, Ritsuko Oishi, Shin Maeda
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引用次数: 0
Early differential diagnosis of cystic biliary atresia and choledochal cyst in the fetus: A multicenter retrospective study.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-28 DOI: 10.1002/jhbp.12115
Xisi Guan, Wei Zhong, Yu Ouyang, Zhe Wang, Bin Yan, Longlong Hou, Junjie Wang, Yue Wu, Lin Huang, Xiaoxiong Liang, Qiuming He, Shangjie Xiao, Jiakang Yu

Background/purpose: Fetal hilar cyst is primarily diagnosed as two diseases after birth, cystic biliary atresia (CBA) and choledochal cyst (CC). The aim of our study was to explore more reliable indicators in early differential diagnosis of these cysts.

Methods: We recruited a total of 50 cases with a prenatal diagnosis of hepatic cyst at three centers, and patients were divided into a CBA group (n = 16) and CC group (n = 34) according to postnatal intraoperative diagnosis. Patient features, maximal cyst diameter as measured by prenatal and early postnatal ultrasonography were analyzed and compared between the two groups, as was the effect of cyst size in predicting CBA.

Results: The maximal cyst diameters in the last prenatal ultrasound (LPU) measurement and initial postnatal ultrasound (IPU) in the CBA group were significantly smaller than in the CC group, as was the difference between the IPU and the first prenatal ultrasound (FPU) (i.e., IPU-FPU) in the CBA group relative to the CC group. The IPU-FPU difference showed the best diagnostic performance as a single parameter (AUC, 0.9806), with a sensitivity and specificity of 100% and 90.3%, respectively, and a cutoff value of 7.5 mm.

Conclusion: Ultrasonographic measurement of the maximal cyst diameter can assist in early (within 1 week after birth) identification of CBA. An IPU-FPU <7.5 mm suggested a higher possibility of a postnatal diagnosis of CBA.

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引用次数: 0
Concerns about needle tract seeding after endoscopic ultrasound-guided tissue acquisition: A possibility not limited to pancreatic body and tail cancer.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-28 DOI: 10.1002/jhbp.12104
Tatsunori Satoh, Haruna Takahashi, Shinya Kawaguchi
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引用次数: 0
Duodenal transmural perforation caused by a dislodged pigtail plastic stent in a patient with benign biliary stricture.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-22 DOI: 10.1002/jhbp.12102
Noriyuki Hirakawa, Kenjiro Yamamoto, Takao Itoi
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引用次数: 0
Capnographic monitoring using a novel mainstream system during endoscopic ultrasound and endoscopic retrograde cholangiopancreatography: A prospective randomized controlled trial. 内窥镜超声和内窥镜逆行胰胆管造影中使用一种新型主流系统的血糖监测:一项前瞻性随机对照试验。
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-21 DOI: 10.1002/jhbp.12110
Yoichi Takimoto, Eisuke Iwasaki, Masayasu Horibe, Seiichiro Fukuhara, Kazuhiro Minami, Shintaro Kawasaki, Tatsuhiro Masaoka, Haruhiko Ogata, Fateh Bazerbachi, Takanori Kanai

Background/purpose: Insufficient studies exist on capnography efficacy during endoscopic ultrasound or endoscopic retrograde cholangiopancreatography, and no definitive conclusions have been drawn. To evaluate the feasibility and efficacy of a novel mainstream capnography using an over-the-biteblock end-tidal CO2 (EtCO2) detector in decreasing the risk of hypoxemia during endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP).

Methods: Patients undergoing EUS or ERCP with conscious sedation at a single Japanese center were randomized to a control or a novel capnography monitored (intervention) group in a 1:1 ratio. Hypoxemia correction maneuvers were pursued if the oxygen saturation decreased to <92% in the control or intervention group and if a 15-s suspension of EtCO2 wave occurred in the intervention group. The primary outcome was the incidence of hypoxemic events, defined as oxygen saturation <90%, during the procedures. Secondary outcomes included technical feasibility of EUS and ERCP with the use of this novel over-the-biteblock monitor.

Results: In total, 250 patients were enrolled without dropouts or missing data (control group: 125; capnography group: 125). There was no significant difference in the incidence of hypoxemia between the control and capnography groups (29.6% [37/125] vs. 26.4% [33/125]; p = .573). The estimated odds ratio was 0.925 (95% confidence interval: 0.708-1.208). The EtCO2 concentration was successfully captured without impeding endoscopic maneuvers from the beginning to the end of the procedure in all patients.

Conclusions: Although the novel mainstream capnography with an over-the-biteblock EtCO2 detector captures the EtCO2 concentration in EUS or ERCP under conscious sedation, it does not lead to the prevention of hypoxemia.

背景/目的:内镜超声或内镜逆行胰胆管造影中导管造影的疗效研究尚不充分,尚未得出明确结论。评估一种新型主流血管造影在内镜超声(EUS)和内镜逆行胆管胰胆管造影(ERCP)期间使用过咬块潮汐末CO2 (EtCO2)检测器降低低氧血症风险的可行性和有效性。方法:在单个日本中心接受EUS或ERCP并有意识镇静的患者按1:1的比例随机分为对照组或新型毛细血管造影监测(干预)组。干预组血氧饱和度降至2波时进行低氧血症矫正操作。主要终点是低氧血症事件的发生率,定义为氧饱和度。结果:总共有250例患者入组,无退出或丢失数据(对照组:125例;造影组:125人)。对照组与造影组低氧血症发生率无显著差异(29.6% [37/125]vs. 26.4% [33/125];p = .573)。估计比值比为0.925(95%可信区间:0.708-1.208)。在所有患者中,从手术开始到手术结束,EtCO2浓度都被成功捕获,没有妨碍内镜操作。结论:尽管采用过咬块EtCO2检测仪的新型主流血管造影技术可以捕获清醒镇静状态下EUS或ERCP的EtCO2浓度,但它并不能预防低氧血症。
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引用次数: 0
The efficacy of second-line chemotherapy for advanced biliary tract cancer: A systematic review and network meta-analysis. 二线化疗治疗晚期胆道癌的疗效:系统回顾和网络荟萃分析。
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-20 DOI: 10.1002/jhbp.12113
Inhwan Hwang, Sangah Han, Ji Hun Jeong, Chunhwa Ihm, Taeho Greg Rhee, Sung Ryul Shim

Background: This network meta-analysis (NMA) aims to provide evidence-based guidance for selecting the second-line chemotherapy for biliary tract cancer (BTC).

Methods: A comprehensive literature search was conducted on PubMed, Cochrane, and EMBASE through July 2024. Inclusion criteria involved: (1) patients underwent second-line chemotherapy following platinum-based first-line therapy, (2) intervention/comparator groups consisted of various chemotherapeutic agents, and (3) outcomes measured as hazard ratio (HR) of overall survival (OS) and progression-free survival (PFS) in randomized controlled trials (RCTs) and cohort studies.

Results: Outcomes were measured as HR of OS and PFS in RCTs and cohort studies. The eight studies consisting of 1621 patients were selected. In the NMA for OS, 5FU_plus_Plat (fluorouracil plus oxaliplatin or cisplatin; HR 0.52, 95% confidence interval [CI]: 0.30-0.91), nal-IRI_5FU_LV (nano-liposomal irinotecan plus fluorouracil and LV; HR 0.54 [95% CI: 0.32-0.92]), and FOLFOX (fluorouracil plus oxaliplatin; HR 0.69 [95% CI: 0.50-0.96]) demonstrated significant benefits in OS when compared to control. For PFS, nal-IRI_5FU_LV (HR 0.61 [95% CI: 0.44-0.85]) provided a significant advantage over 5FU.

Conclusions: Second-line chemotherapy for BTC after the failure of gemcitabine plus platinum as first-line therapy, nal-IRI_5FU_LV appears to be the most promising second-line therapy in terms of both OS and PFS.

背景:本网络荟萃分析(NMA)旨在为胆道肿瘤(BTC)的二线化疗方案选择提供循证指导。方法:到2024年7月,在PubMed、Cochrane和EMBASE上进行全面的文献检索。纳入标准包括:(1)患者在以铂为基础的一线治疗后接受了二线化疗;(2)干预/比较组由各种化疗药物组成;(3)随机对照试验(rct)和队列研究中以总生存期(OS)和无进展生存期(PFS)的风险比(HR)衡量的结果。结果:在随机对照试验和队列研究中,以OS和PFS的HR来衡量结果。入选8项研究,共1621例患者。在OS的NMA中,5FU_plus_Plat(氟尿嘧啶加奥沙利铂或顺铂;HR 0.52, 95%可信区间[CI]: 0.30-0.91), nal-IRI_5FU_LV(纳米脂质体伊立替康联合氟尿嘧啶和LV;HR 0.54 [95% CI: 0.32-0.92])和FOLFOX(氟尿嘧啶加奥沙利铂;HR 0.69 [95% CI: 0.50-0.96])与对照组相比,在OS中表现出显著的益处。对于PFS, nal-IRI_5FU_LV (HR 0.61 [95% CI: 0.44-0.85])比5FU具有显著优势。结论:吉西他滨联合铂作为一线治疗失败后,nal-IRI_5FU_LV似乎是最有希望的二线治疗方案,无论是OS还是PFS。
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引用次数: 0
Genetic medicine of familial and hereditary pancreatic cancer: Recent update in the era of precision cancer medicine. 家族性和遗传性胰腺癌的遗传医学:精准癌症医学时代的最新进展。
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-15 DOI: 10.1002/jhbp.12112
Hiroyuki Matsubayashi, Yoshimi Kiyozumi, Hiroyuki Ono

In Japan, 5 years have passed since the initiation of precision cancer medicine, and recent data accumulation in familial pancreatic cancer (FPC) and hereditary pancreatic cancer is outstanding. Multigene germline panel tests (MGPTs) have revealed that 7%-18% of patients with pancreatic cancer (PC) harbor pathogenic germline variants (PGVs), almost equal to the levels of breast, ovarian, endometrial, and colorectal cancers, with a higher incidence in FPC (14%-26%). The majority of PGVs seen in PC patients are clinically actionable and associated with homologous recombination (HR) pathways (6%-10%, particularly BRCA1/2 in 5%-6%), and the clinical guidelines recommend or propose genetic testing for all PC patients. Consensus guidelines have been established for most of the hereditary syndromes associated with PC risks, and surveillances of the pancreas and other at-risk organs are recommended for PGV carriers. Hereditary breast and ovarian cancer (HBOC) is the commonest hereditary cancer syndrome that has moderately increasing life-time risks of PC (3%-7% in Western countries); however, recent Japanese research demonstrated a higher risk level (BRCA1: 16%, BRCA2: 14%). Moreover, recent evidence has suggested a risk linkage between PC and ovarian cancer in HBOC pedigrees. High scores of homologous recombination deficiency suggest biallelic dysfunction of BRCA or other HR-related genes, and the likely effectiveness of platinum agents and PARP inhibitors against PCs. Remote counseling and testing are possible option in the future genetic medicine. As PC ranks in the second commonest target of precision cancer medicine in Japan, we must treat the patients and manage their at-risk relatives efficiently.

在日本,精准癌症医学启动已有5年时间,家族性胰腺癌(FPC)和遗传性胰腺癌的最新数据积累尤为突出。多基因生殖系检测(MGPTs)显示,7%-18%的胰腺癌(PC)患者携带致病性生殖系变异(PGVs),几乎与乳腺癌、卵巢癌、子宫内膜癌和结直肠癌的水平相当,其中FPC的发病率更高(14%-26%)。在PC患者中发现的大多数PGVs在临床上是可操作的,并且与同源重组(HR)途径相关(6%-10%,特别是BRCA1/2在5%-6%),临床指南建议或建议对所有PC患者进行基因检测。对于大多数与PC风险相关的遗传综合征,已经建立了共识指南,并建议对PGV携带者进行胰腺和其他高危器官的监测。遗传性乳腺癌和卵巢癌(HBOC)是最常见的遗传性癌症综合征,其终生患PC的风险中等增加(在西方国家为3%-7%);然而,最近日本的研究表明,BRCA1: 16%, BRCA2: 14%的风险水平更高。此外,最近的证据表明,在HBOC家系中,PC和卵巢癌之间存在风险联系。同源重组缺乏症的高分提示BRCA或其他hr相关基因双等位基因功能障碍,铂类药物和PARP抑制剂对pc可能有效。远程咨询和检测是未来基因医学的可能选择。由于PC是日本精准癌症医学的第二大常见目标,我们必须有效地治疗患者和管理他们的高危亲属。
{"title":"Genetic medicine of familial and hereditary pancreatic cancer: Recent update in the era of precision cancer medicine.","authors":"Hiroyuki Matsubayashi, Yoshimi Kiyozumi, Hiroyuki Ono","doi":"10.1002/jhbp.12112","DOIUrl":"https://doi.org/10.1002/jhbp.12112","url":null,"abstract":"<p><p>In Japan, 5 years have passed since the initiation of precision cancer medicine, and recent data accumulation in familial pancreatic cancer (FPC) and hereditary pancreatic cancer is outstanding. Multigene germline panel tests (MGPTs) have revealed that 7%-18% of patients with pancreatic cancer (PC) harbor pathogenic germline variants (PGVs), almost equal to the levels of breast, ovarian, endometrial, and colorectal cancers, with a higher incidence in FPC (14%-26%). The majority of PGVs seen in PC patients are clinically actionable and associated with homologous recombination (HR) pathways (6%-10%, particularly BRCA1/2 in 5%-6%), and the clinical guidelines recommend or propose genetic testing for all PC patients. Consensus guidelines have been established for most of the hereditary syndromes associated with PC risks, and surveillances of the pancreas and other at-risk organs are recommended for PGV carriers. Hereditary breast and ovarian cancer (HBOC) is the commonest hereditary cancer syndrome that has moderately increasing life-time risks of PC (3%-7% in Western countries); however, recent Japanese research demonstrated a higher risk level (BRCA1: 16%, BRCA2: 14%). Moreover, recent evidence has suggested a risk linkage between PC and ovarian cancer in HBOC pedigrees. High scores of homologous recombination deficiency suggest biallelic dysfunction of BRCA or other HR-related genes, and the likely effectiveness of platinum agents and PARP inhibitors against PCs. Remote counseling and testing are possible option in the future genetic medicine. As PC ranks in the second commonest target of precision cancer medicine in Japan, we must treat the patients and manage their at-risk relatives efficiently.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A retrospective comparative study of percutaneous transhepatic gallbladder drainage versus endoscopic gallbladder stenting on the clinical course of acute cholecystitis: A propensity score matching analysis using a nationwide inpatient database in Japan. 经皮经肝胆囊引流与内镜下胆囊支架置入术对急性胆囊炎临床病程的回顾性比较研究:使用日本全国住院患者数据库进行倾向评分匹配分析。
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-15 DOI: 10.1002/jhbp.12114
Shota Ebinuma, Hiroyuki Nagano, Hisashi Itoshima, Susumu Kunisawa, Kiyohide Fushimi, Ryo Sugiura, Tatsuhiko Kakisaka, Akinobu Taketomi, Yuichi Imanaka

Background: We performed a retrospective comparative study to clarify the optimal gallbladder drainage method prior to elective cholecystectomy.

Methods: We collected data from the Diagnosis Procedure Combination database about cholecystitis patients who underwent gallbladder drainage prior to cholecystectomy in a subsequent hospitalization between April 2014 and March 2020. We divided the study population into two groups: an endoscopic gallbladder stenting (EGBS) group and a percutaneous transhepatic gallbladder drainage (PTGBD) group. We performed propensity score matching and compared surgical outcomes related to cholecystectomy.

Results: We collected 6306 cases (PTGBD: 6112 cases; EGBS: 194 cases). In propensity score matching, we obtained 193 matched pairs from the study population. Long-term postoperative antibiotics therapy (2 vs. 9; risk ratio 4.7 [95% CI: 1.1-30.9]) was more frequent in the EGBS group than the PTGBD group. There were no significant differences between the two groups for laparotomic cholecystectomy and postoperative bile duct drainage. For reoperation, postoperative abdominal drainage and postoperative blood transfusion, there were few outcome occurrences and effect measures were not obtained.

Conclusion: Gallbladder drainage by EGBS may have more risk of surgical complications related to elective cholecystectomy than PTGBD. There are a few reports on this topic, so further research should be conducted.

背景:我们进行了一项回顾性比较研究,以阐明择期胆囊切除术前的最佳胆囊引流方法。方法:我们从2014年4月至2020年3月期间在胆囊切除术前接受胆囊引流并随后住院的胆囊炎患者的诊断程序组合数据库中收集数据。我们将研究人群分为两组:内镜胆囊支架置入术(EGBS)组和经皮经肝胆囊引流术(PTGBD)组。我们进行倾向评分匹配并比较胆囊切除术相关的手术结果。结果:共收集病例6306例(PTGBD: 6112例;EGBS: 194例)。在倾向评分匹配中,我们从研究人群中获得了193对匹配的配对。术后长期抗生素治疗(2 vs 9;风险比4.7 [95% CI: 1.1-30.9])在EGBS组中比PTGBD组更常见。两组在腹腔镜胆囊切除术及术后胆管引流方面无显著差异。再手术、术后腹腔引流及术后输血的结果发生较少,未得到有效措施。结论:EGBS胆囊引流术比PTGBD术更容易发生选择性胆囊切除术相关并发症。关于这个话题的报道很少,所以需要进一步的研究。
{"title":"A retrospective comparative study of percutaneous transhepatic gallbladder drainage versus endoscopic gallbladder stenting on the clinical course of acute cholecystitis: A propensity score matching analysis using a nationwide inpatient database in Japan.","authors":"Shota Ebinuma, Hiroyuki Nagano, Hisashi Itoshima, Susumu Kunisawa, Kiyohide Fushimi, Ryo Sugiura, Tatsuhiko Kakisaka, Akinobu Taketomi, Yuichi Imanaka","doi":"10.1002/jhbp.12114","DOIUrl":"https://doi.org/10.1002/jhbp.12114","url":null,"abstract":"<p><strong>Background: </strong>We performed a retrospective comparative study to clarify the optimal gallbladder drainage method prior to elective cholecystectomy.</p><p><strong>Methods: </strong>We collected data from the Diagnosis Procedure Combination database about cholecystitis patients who underwent gallbladder drainage prior to cholecystectomy in a subsequent hospitalization between April 2014 and March 2020. We divided the study population into two groups: an endoscopic gallbladder stenting (EGBS) group and a percutaneous transhepatic gallbladder drainage (PTGBD) group. We performed propensity score matching and compared surgical outcomes related to cholecystectomy.</p><p><strong>Results: </strong>We collected 6306 cases (PTGBD: 6112 cases; EGBS: 194 cases). In propensity score matching, we obtained 193 matched pairs from the study population. Long-term postoperative antibiotics therapy (2 vs. 9; risk ratio 4.7 [95% CI: 1.1-30.9]) was more frequent in the EGBS group than the PTGBD group. There were no significant differences between the two groups for laparotomic cholecystectomy and postoperative bile duct drainage. For reoperation, postoperative abdominal drainage and postoperative blood transfusion, there were few outcome occurrences and effect measures were not obtained.</p><p><strong>Conclusion: </strong>Gallbladder drainage by EGBS may have more risk of surgical complications related to elective cholecystectomy than PTGBD. There are a few reports on this topic, so further research should be conducted.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of endoscopic sphincterotomy on hepatolithiasis with Oddi sphincter-preserved cholangioplasty with hepatico-subcutaneous stoma: A three-decade, real word cohort study. 内镜下括约肌切开术对Oddi保留括约肌胆管成形术合并肝皮下瘘肝内结石的影响:一项30年的真实世界队列研究。
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-13 DOI: 10.1002/jhbp.12107
Xue Yu, Jie Zhang, Yunyi Zhang, Xiaoyu Zhao, Zhi Xu, Lixin Wang, Chunsheng Hou, Lingfu Zhang, Xiaofeng Ling

Background: Hepatolithiasis frequently presents with recurring cholangitis and complications. Oddi sphincter-preserved cholangioplasty with hepatico-subcutaneous stoma (OSPCHS), introduced in 1993, has shown favorable long-term results. Endoscopic sphincterotomy (EST) is commonly used, but its impact on OSPCHS outcomes remains unclear.

Methods: From January 1993 to June 2021, 254 patients with hepatolithiasis underwent OSPCHS. A total of 31 patients had prior EST (group with EST, n = 31), while 223 did not (group without EST, n = 223). Perioperative and long-term outcomes were compared, and risk factors for stone and cholangitis recurrence were analyzed using a Cox regression model.

Results: The immediate and final stone clearance rates were 67.3% and 81.9%, respectively. Patients with prior EST had higher rates of stone recurrence (57.7% vs. 35.7%, p = .031), shorter stone-free duration (median: 51.5 vs. 112.0 months, p = .001), higher cholangitis recurrence (45.2% vs. 25.6%, p = .023), and shorter cholangitis-free duration (median: 71.0 vs. 134.0 months, p = .006). Multivariable analysis identified bilateral intrahepatic stones (HR: 1.815, p = .010) and prior EST (HR: 3.157, p = .000) as independent risk factors for stone recurrence, whereas combined hepatectomy was a protective factor (HR: 0.448, p = .001). For cholangitis recurrence, male gender (HR: 2.308, p = .001) and EST (HR: 2.241, p = .009) were independent risk factors, while complete stone clearance reduced recurrence risk (HR: 0.423, p = .002).

Conclusion: Prior EST adversely affects the long-term outcomes of OSPCHS. Therefore, in the management of hepatolithiasis, emphasis should be placed on preserving the Oddi sphincter.

背景:肝内胆管炎常伴有复发性胆管炎及并发症。Oddi保留括约肌胆管成形术合并肝皮下造口(OSPCHS)于1993年引入,显示出良好的长期效果。内镜下括约肌切开术(EST)是常用的治疗方法,但其对OSPCHS预后的影响尚不清楚。方法:1993年1月至2021年6月,254例肝内胆管结石患者行OSPCHS。共有31例患者有EST病史(有EST组,n = 31), 223例患者没有EST病史(未EST组,n = 223)。比较围手术期和远期预后,并采用Cox回归模型分析结石和胆管炎复发的危险因素。结果:结石即刻清除率为67.3%,最终清除率为81.9%。既往EST患者结石复发率较高(57.7% vs. 35.7%, p = 0.031),无结石持续时间较短(中位数:51.5 vs. 112.0个月,p = 0.001),胆管炎复发率较高(45.2% vs. 25.6%, p = 0.023),无胆管炎持续时间较短(中位数:71.0 vs. 134.0个月,p = 0.006)。多变量分析发现双侧肝内结石(HR: 1.815, p = 0.010)和既往EST (HR: 3.157, p = 0.000)是结石复发的独立危险因素,而联合肝切除术是结石复发的保护因素(HR: 0.448, p = 0.001)。对于胆管炎复发,男性(HR: 2.308, p = 0.001)和EST (HR: 2.241, p = 0.009)是独立危险因素,而结石完全清除降低了复发风险(HR: 0.423, p = 0.002)。结论:既往EST对OSPCHS的远期预后有不利影响。因此,在肝内胆管结石的治疗中,应重视保留Oddi括约肌。
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引用次数: 0
Questionnaire on the surgical indications for intrahepatic cholangiocarcinoma administered to Japanese board-certified expert hepatobiliary and pancreatic surgeons and instructors. 对日本委员会认证的专家肝胆胰外科医生和指导员进行了关于肝内胆管癌手术指征的问卷调查。
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-08 DOI: 10.1002/jhbp.12108
Shintaro Kuroda, Tsuyoshi Kobayashi, Etsuro Hatano, Shoji Kubo, Itaru Endo, Hideki Ohdan

Background: Treatment of intrahepatic cholangiocarcinoma (ICC) remains challenging owing to the lack of clear guidelines on surgical resection. The 2021 ICC guidelines have not fully resolved the ongoing debate between surgical and nonsurgical treatment options. This study aimed to identify trends and issues in ICC treatment strategies in the clinical field by surveying the attitudes of hepatobiliary and pancreatic (HBP) surgeons.

Methods: A survey was conducted among 235 board-certified HBP surgeons affiliated with the Japanese Society of Hepato-Biliary-Pancreatic Surgery. This survey explored the perspectives on tumor conditions that define resectable, borderline resectable, and unresectable diseases, focusing on tumor size, number, and vascular invasion.

Results: Notable variability was observed in the criteria for oncological resectability. While 42.1% of the respondents considered a maximum tumor diameter of 5 cm as resectable, 37.5% indicated no size limit for resectability. Opinions regarding the resectability of tumors with lymph node involvement and vascular invasion vary widely, highlighting the need for standardized criteria.

Conclusion: This survey revealed diverse approaches for defining resectability in ICC, emphasizing the necessity for more precise guidelines. Further research and expert consensus are required to establish standardized criteria that can guide clinical decision-making and improve patient outcomes.

背景:由于缺乏明确的手术切除指南,肝内胆管癌(ICC)的治疗仍然具有挑战性。2021年的ICC指南并没有完全解决手术和非手术治疗方案之间的持续争论。本研究旨在通过调查肝胆胰(HBP)外科医生的态度,确定临床领域ICC治疗策略的趋势和问题。方法:对日本肝胆胰外科学会附属的235名委员会认证的HBP外科医生进行调查。这项调查探讨了肿瘤条件的观点,定义可切除,边缘可切除和不可切除的疾病,重点是肿瘤的大小,数量和血管侵犯。结果:肿瘤可切除性的标准存在显著差异。42.1%的受访者认为最大肿瘤直径为5厘米是可切除的,37.5%的受访者认为可切除的大小没有限制。关于淋巴结受累和血管侵犯的肿瘤的可切除性,意见分歧很大,强调了标准化标准的必要性。结论:该调查揭示了定义ICC可切除性的多种方法,强调了制定更精确指南的必要性。需要进一步的研究和专家共识来建立标准化的标准,以指导临床决策和改善患者的预后。
{"title":"Questionnaire on the surgical indications for intrahepatic cholangiocarcinoma administered to Japanese board-certified expert hepatobiliary and pancreatic surgeons and instructors.","authors":"Shintaro Kuroda, Tsuyoshi Kobayashi, Etsuro Hatano, Shoji Kubo, Itaru Endo, Hideki Ohdan","doi":"10.1002/jhbp.12108","DOIUrl":"https://doi.org/10.1002/jhbp.12108","url":null,"abstract":"<p><strong>Background: </strong>Treatment of intrahepatic cholangiocarcinoma (ICC) remains challenging owing to the lack of clear guidelines on surgical resection. The 2021 ICC guidelines have not fully resolved the ongoing debate between surgical and nonsurgical treatment options. This study aimed to identify trends and issues in ICC treatment strategies in the clinical field by surveying the attitudes of hepatobiliary and pancreatic (HBP) surgeons.</p><p><strong>Methods: </strong>A survey was conducted among 235 board-certified HBP surgeons affiliated with the Japanese Society of Hepato-Biliary-Pancreatic Surgery. This survey explored the perspectives on tumor conditions that define resectable, borderline resectable, and unresectable diseases, focusing on tumor size, number, and vascular invasion.</p><p><strong>Results: </strong>Notable variability was observed in the criteria for oncological resectability. While 42.1% of the respondents considered a maximum tumor diameter of 5 cm as resectable, 37.5% indicated no size limit for resectability. Opinions regarding the resectability of tumors with lymph node involvement and vascular invasion vary widely, highlighting the need for standardized criteria.</p><p><strong>Conclusion: </strong>This survey revealed diverse approaches for defining resectability in ICC, emphasizing the necessity for more precise guidelines. Further research and expert consensus are required to establish standardized criteria that can guide clinical decision-making and improve patient outcomes.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of Hepato‐Biliary‐Pancreatic Sciences
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