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Journal of Hepato‐Biliary‐Pancreatic Sciences最新文献

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Rectus abdominis muscle wrap for effective control of hepatic artery bleeding.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-19 DOI: 10.1002/jhbp.12135
Teiichi Sugiura, Katsuhisa Ohgi, Ryo Ashida, Yoshiyasu Kato, Shimpei Otsuka, Hideyuki Dei, Katsuhiko Uesaka
{"title":"Rectus abdominis muscle wrap for effective control of hepatic artery bleeding.","authors":"Teiichi Sugiura, Katsuhisa Ohgi, Ryo Ashida, Yoshiyasu Kato, Shimpei Otsuka, Hideyuki Dei, Katsuhiko Uesaka","doi":"10.1002/jhbp.12135","DOIUrl":"https://doi.org/10.1002/jhbp.12135","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A useful technique using a traction device and a rotatable sphincterotome for difficult biliary cannulation of an intradiverticular papilla.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-19 DOI: 10.1002/jhbp.12134
Kyoko Asano, Shuntaro Mukai, Takao Itoi, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Kenjiro Yamamoto, Yukitoshi Matsunami, Hiroyuki Kojima, Atsushi Sofuni
{"title":"A useful technique using a traction device and a rotatable sphincterotome for difficult biliary cannulation of an intradiverticular papilla.","authors":"Kyoko Asano, Shuntaro Mukai, Takao Itoi, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Kenjiro Yamamoto, Yukitoshi Matsunami, Hiroyuki Kojima, Atsushi Sofuni","doi":"10.1002/jhbp.12134","DOIUrl":"https://doi.org/10.1002/jhbp.12134","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic factors and clinical significance of preoperative systemic therapy in patients with borderline resectable hepatocellular carcinoma: A JSHBPS project study 2023, Part 2.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-19 DOI: 10.1002/jhbp.12138
Junichi Shindoh, Masaru Matsumura, Shohei Komatsu, Takumi Fukumoto, Akihiko Ichida, Kiyoshi Hasegawa, Takamichi Ishii, Etsuro Hatano, Masafumi Nakamura, Masayuki Ohtsuka

Purpose: To explore factors influencing the prognosis in patients with borderline-resectable hepatocellular carcinoma (BR-HCC) undergoing surgery.

Methods: The clinical data of patients with BR-HCC according to the definition in the Expert Consensus Statement 2023 were collected from board-certified HPB training centers and analyzed in detail.

Results: Data of a total of 1509 patients with BR-HCC (BR1, n = 718 and BR2, n = 791) who underwent surgery were collected. The 5-year disease-specific survival rate (DSS) and 3-year recurrence-free survival rate (RFS) were determined as 40.8% and 19.7%, respectively. Multivariate analysis identified the oncological resectability category (i.e., BR2 vs. BR1) as a significant prognostic factor, and also the number of criteria fulfilled for classification into BR2 disease as being predictive of the DSS (hazard ratio (HR) [95% CI]: one factor: 1.32 [1.13-1.54]; two to three factors: 1.51 [1.15-1.96]). Preceding systemic therapy was significantly correlated with a longer DSS (HR, 0.41: 95% CI, 0.18-0.91) and RFS (HR, 0.80: 95% CI, 0.66-0.97) in the patients with BR1 disease, while its clinical significance was unclear in the patients with BR2 disease.

Conclusion: Multicenter data confirm the clinical relevance of the oncological resectability category and the potential advantage of preceding systemic therapy in a specific group of BR-HCC.

{"title":"Prognostic factors and clinical significance of preoperative systemic therapy in patients with borderline resectable hepatocellular carcinoma: A JSHBPS project study 2023, Part 2.","authors":"Junichi Shindoh, Masaru Matsumura, Shohei Komatsu, Takumi Fukumoto, Akihiko Ichida, Kiyoshi Hasegawa, Takamichi Ishii, Etsuro Hatano, Masafumi Nakamura, Masayuki Ohtsuka","doi":"10.1002/jhbp.12138","DOIUrl":"https://doi.org/10.1002/jhbp.12138","url":null,"abstract":"<p><strong>Purpose: </strong>To explore factors influencing the prognosis in patients with borderline-resectable hepatocellular carcinoma (BR-HCC) undergoing surgery.</p><p><strong>Methods: </strong>The clinical data of patients with BR-HCC according to the definition in the Expert Consensus Statement 2023 were collected from board-certified HPB training centers and analyzed in detail.</p><p><strong>Results: </strong>Data of a total of 1509 patients with BR-HCC (BR1, n = 718 and BR2, n = 791) who underwent surgery were collected. The 5-year disease-specific survival rate (DSS) and 3-year recurrence-free survival rate (RFS) were determined as 40.8% and 19.7%, respectively. Multivariate analysis identified the oncological resectability category (i.e., BR2 vs. BR1) as a significant prognostic factor, and also the number of criteria fulfilled for classification into BR2 disease as being predictive of the DSS (hazard ratio (HR) [95% CI]: one factor: 1.32 [1.13-1.54]; two to three factors: 1.51 [1.15-1.96]). Preceding systemic therapy was significantly correlated with a longer DSS (HR, 0.41: 95% CI, 0.18-0.91) and RFS (HR, 0.80: 95% CI, 0.66-0.97) in the patients with BR1 disease, while its clinical significance was unclear in the patients with BR2 disease.</p><p><strong>Conclusion: </strong>Multicenter data confirm the clinical relevance of the oncological resectability category and the potential advantage of preceding systemic therapy in a specific group of BR-HCC.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to the Letter to the Editor.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-18 DOI: 10.1002/jhbp.12130
Shota Ebinuma, Yuichi Imanaka
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引用次数: 0
A questionnaire survey to explore the current treatment policies adopted for patients with advanced hepatocellular carcinoma at board-certified HPB training institutions in Japan: A JSHBPS project study 2023, Part 1.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-16 DOI: 10.1002/jhbp.12139
Junichi Shindoh, Masaru Matsumura, Satoshi Okubo, Takuma Okada, Masaji Hashimoto, Masafumi Nakamura, Masayuki Ohtsuka

Purpose: To clarify the views of expert hepatobiliary surgeons on the management of advanced hepatocellular carcinoma (HCC) in real-world clinical practice.

Methods: A questionnaire survey was conducted of Japanese board-certified HPB training centers.

Results: A total of 100 centers responded to the survey. For solitary large (>10 cm) lesions, 77% of the respondents selected upfront surgery, while an increasing number of respondents selected combined therapy with atezolizumab + bevacizumab as the treatment of first choice as the number of lesions increased. In regard to the treatment of patients with vascular invasion, the proportion of respondents who selected systemic therapy with the intent to "potential conversion" surgery increased according to the extent of tumor thrombosis, while only a limited number of respondents excluded these groups of patients from potential surgical indications. As for the initial treatment for extrahepatic spread, consideration of systemic conversion therapy was the most commonly selected option, while upfront surgery was frequently selected for right adrenal metastasis (50%) and solitary hilar node involvement (35%).

Conclusions: The present survey clarified the current clinical approaches for the treatment of advanced HCC at HPB training centers. Future analysis, including survival outcomes, would offer important insights into the optimal management of advanced HCC.

目的:明确肝胆外科专家在实际临床实践中对晚期肝细胞癌(HCC)治疗的看法:方法:对日本经委员会认证的肝胆外科培训中心进行问卷调查:共有 100 个中心对调查做出了回应。对于单发的大病灶(>10 厘米),77% 的受访者选择先期手术,而随着病灶数量的增加,越来越多的受访者选择阿特珠单抗+贝伐单抗联合治疗作为首选治疗方法。关于血管侵犯患者的治疗,根据肿瘤血栓形成的程度,选择系统治疗并打算 "潜在转换 "手术的受访者比例有所增加,而只有少数受访者将这类患者排除在潜在手术适应症之外。至于肝外转移的初始治疗,考虑全身转换疗法是最常见的选择,而右侧肾上腺转移(50%)和单发肝门结节受累(35%)则经常选择先期手术:本次调查明确了HPB培训中心目前治疗晚期HCC的临床方法。包括生存结果在内的未来分析将为晚期HCC的最佳治疗提供重要见解。
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引用次数: 0
Re-intervention for malignant hilar biliary obstruction after metallic stent placement using a novel flexible tapered endoscopic sheath cannula.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-16 DOI: 10.1002/jhbp.12132
Kazuya Koizumi, Karen Kimura, Jun Kubota
{"title":"Re-intervention for malignant hilar biliary obstruction after metallic stent placement using a novel flexible tapered endoscopic sheath cannula.","authors":"Kazuya Koizumi, Karen Kimura, Jun Kubota","doi":"10.1002/jhbp.12132","DOIUrl":"https://doi.org/10.1002/jhbp.12132","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Annual report of Japanese biliary tract cancer registry from 2021: Focus on the rate of R0 resection, postoperative complications, and site of lymph node metastasis.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-16 DOI: 10.1002/jhbp.12129
Hiroyuki Kato, Akihiko Horiguchi, Takao Ohtsuka, Atsushi Nanashima, Michiaki Unno, Toshifumi Wakai, Fumihiko Miura, Hiroyuki Isayama, Yoshiki Hirooka, Taku Aoki, Hiroyuki Yamamoto, Ichiro Yasuda, Itaru Endo

Purpose: This study aimed to clarify the current treatment status for biliary tract cancers based on data from the National Clinical Database (NCD) in Japan.

Methods: Total 3895 cases of biliary tract cancers registered in the NCD during 2021 were included. We identified the rates of resection, R0 resection, postoperative complications, and incidences of lymph node metastasis for gallbladder carcinoma, perihilar cholangiocarcinoma, distal bile duct carcinoma, and ampullary carcinoma.

Results: The number of biliary tract cancers registered in the NCD during 2021 was 3895 (1775 in extrahepatic bile duct carcinoma, 1422 in gallbladder carcinoma, and 698 in ampullary carcinoma). In gallbladder carcinoma, the resection (89.59%) and R0 resection rates (87.99%) were favorable, and the complication rate (6.05%) was lower than that of others. However, the postoperative complication rate could be higher in T3-T4 cases and when extrahepatic bile duct resection was performed concomitantly. Lymph node metastasis was frequently seen in 12.60% at the No. 13a lymph node. In perihilar cholangiocarcinoma, the R0 resection (69.82%) and complication rates (16.75%) were significantly lower and higher, respectively. In distal cholangiocarcinoma and ampullary carcinoma, metastasis was observed in approximately 2% and 10% of the dissected No. 16b1 para-aortic lymph nodes, respectively. In conclusion, although short-term surgical outcomes for biliary tract cancers in Japan might be acceptable, the significantly lower R0 resection and higher complication rates of perihilar cholangiocarcinomas indicate additional challenges for surgeons in the future and should continue to be monitored by the Japanese Society of Hepatobiliary and Pancreatic Surgery.

目的:本研究旨在根据日本国家临床数据库(NCD)的数据,明确胆道癌的治疗现状:方法:纳入 2021 年期间在 NCD 登记的 3895 例胆道癌病例。我们确定了胆囊癌、肝周胆管癌、远端胆管癌和ampullary癌的切除率、R0切除率、术后并发症和淋巴结转移发生率:2021 年期间,国家疾病登记中心登记的胆道癌症数量为 3895 例(肝外胆管癌 1775 例、胆囊癌 1422 例、膀胱癌 698 例)。胆囊癌的切除率(89.59%)和R0切除率(87.99%)良好,并发症发生率(6.05%)低于其他癌症。然而,T3-T4病例和同时进行肝外胆管切除术时,术后并发症发生率可能较高。淋巴结转移常见于 13a 号淋巴结,占 12.60%。在肝周胆管癌中,R0切除率(69.82%)和并发症发生率(16.75%)分别明显较低和较高。在远端胆管癌和膀胱癌中,分别有约2%和10%被切除的16b1主动脉旁淋巴结出现转移。总之,虽然日本胆道癌的短期手术效果可以接受,但肝周胆管癌的 R0 切除率明显较低且并发症发生率较高,这表明外科医生在未来将面临更多挑战,日本肝胆胰外科协会应继续对此进行监测。
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引用次数: 0
Robotic distal pancreatectomy using a novel surgical robot platform "hinotori™" (with video).
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-12 DOI: 10.1002/jhbp.12137
Takao Ide, Noriyuki Egawa, Kotaro Ito, Tomokazu Tanaka, Hirokazu Noshiro
{"title":"Robotic distal pancreatectomy using a novel surgical robot platform \"hinotori™\" (with video).","authors":"Takao Ide, Noriyuki Egawa, Kotaro Ito, Tomokazu Tanaka, Hirokazu Noshiro","doi":"10.1002/jhbp.12137","DOIUrl":"https://doi.org/10.1002/jhbp.12137","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor for "A retrospective comparative study of percutaneous transhepatic gallbladder drainage versus endoscopic gallbladder stenting on the clinical course of acute cholecystitis: A propensity score matching analysis using a Nationwide inpatient database in Japan".
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-10 DOI: 10.1002/jhbp.12131
Amogh Verma, Shubham Kumar, Ranjana Sah
{"title":"Letter to the editor for \"A retrospective comparative study of percutaneous transhepatic gallbladder drainage versus endoscopic gallbladder stenting on the clinical course of acute cholecystitis: A propensity score matching analysis using a Nationwide inpatient database in Japan\".","authors":"Amogh Verma, Shubham Kumar, Ranjana Sah","doi":"10.1002/jhbp.12131","DOIUrl":"https://doi.org/10.1002/jhbp.12131","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel method to prevent severe postoperative pancreatic fistula caused by lipolysis.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-03-05 DOI: 10.1002/jhbp.12128
Naoto Nakamura, Kazuyuki Nagai, Akihiro Kaneda, Akitada Yogo, Yosuke Kasai, Takayuki Anazawa, Yuichiro Uchida, Toshihiko Masui, Yasuhiko Tabata, Etsuro Hatano

Background: Although several prophylactic strategies have been developed for postoperative pancreatic fistula (POPF), research on its severe form is few. Recently, it has been reported that severe POPF can be caused by intraabdominal lipolysis. This study aimed to establish a rat model of severe POPF by combining pancreatic juice leakage and lipolysis and to develop a prophylactic strategy for POPF.

Methods: Sprague-Dawley rats were subjected to pancreatic transection to induce pancreatic juice leakage (PT group). Autologous fat tissue was thermally treated to prepare a fat solution, which was intraperitoneally administered to the rats in the PT group (PT + F group). A water-solubilized lipase inhibitor (cetilistat) was administered intraperitoneally to the rats in the PT + F group. A polyethylene glycol-based hydrogel (PEG-HG) formulation of water-solubilized cetilistat was equally administered. Ascitic and serum biochemical tests, including free fatty acids (FFA) levels, macroscopic or microscopic examinations, and survival analyses, were performed.

Results: In the PT + F group, significantly elevated ascitic and serum FFA levels and serum inflammatory cytokine levels were observed 24 h postoperatively (p < .001), and the survival rate was significantly exacerbated (p < .0001). Intraperitoneal administration of water-solubilized cetilistat resulted in reduced inflammation and improved outcomes. Although PEG hydrogel itself did not improve blood parameters or survival outcomes, the incorporation of water-solubilized cetilistat into the PEG-HG enabled similar improvement.

Conclusion: Intraperitoneal administration of water-solubilized cetilistat prevented severe inflammation and multiple failures associated with severe POPF. The incorporation of water-solubilized cetilistat into the PEG-HG is a promising delivery system for clinical application.

{"title":"Novel method to prevent severe postoperative pancreatic fistula caused by lipolysis.","authors":"Naoto Nakamura, Kazuyuki Nagai, Akihiro Kaneda, Akitada Yogo, Yosuke Kasai, Takayuki Anazawa, Yuichiro Uchida, Toshihiko Masui, Yasuhiko Tabata, Etsuro Hatano","doi":"10.1002/jhbp.12128","DOIUrl":"https://doi.org/10.1002/jhbp.12128","url":null,"abstract":"<p><strong>Background: </strong>Although several prophylactic strategies have been developed for postoperative pancreatic fistula (POPF), research on its severe form is few. Recently, it has been reported that severe POPF can be caused by intraabdominal lipolysis. This study aimed to establish a rat model of severe POPF by combining pancreatic juice leakage and lipolysis and to develop a prophylactic strategy for POPF.</p><p><strong>Methods: </strong>Sprague-Dawley rats were subjected to pancreatic transection to induce pancreatic juice leakage (PT group). Autologous fat tissue was thermally treated to prepare a fat solution, which was intraperitoneally administered to the rats in the PT group (PT + F group). A water-solubilized lipase inhibitor (cetilistat) was administered intraperitoneally to the rats in the PT + F group. A polyethylene glycol-based hydrogel (PEG-HG) formulation of water-solubilized cetilistat was equally administered. Ascitic and serum biochemical tests, including free fatty acids (FFA) levels, macroscopic or microscopic examinations, and survival analyses, were performed.</p><p><strong>Results: </strong>In the PT + F group, significantly elevated ascitic and serum FFA levels and serum inflammatory cytokine levels were observed 24 h postoperatively (p < .001), and the survival rate was significantly exacerbated (p < .0001). Intraperitoneal administration of water-solubilized cetilistat resulted in reduced inflammation and improved outcomes. Although PEG hydrogel itself did not improve blood parameters or survival outcomes, the incorporation of water-solubilized cetilistat into the PEG-HG enabled similar improvement.</p><p><strong>Conclusion: </strong>Intraperitoneal administration of water-solubilized cetilistat prevented severe inflammation and multiple failures associated with severe POPF. The incorporation of water-solubilized cetilistat into the PEG-HG is a promising delivery system for clinical application.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Journal of Hepato‐Biliary‐Pancreatic Sciences
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