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The impact of extra-pancreatic infections on outcomes of acute pancreatitis: A systematic review and meta-analysis.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-02-14 DOI: 10.1002/jhbp.12099
XueMin Zhang, Ping Zhu, YanFei Zhang, ShanShan Dai

Background: The impact of extrapancreatic infections (EPI) on outcomes of acute pancreatitis has received limited attention in the literature. We compiled data from published studies to present high-quality evidence on the prognostic role of EPI on acute pancreatitis.

Methods: This PRISMA-compliant and PROSPERO registered review (CRD42024516872) searched Embase, Scopus, Web of Science, and PubMed for comparative studies between EPI and no-EPI. Outcomes assessed were mortality, intensive care unit (ICU) admission, necrosis, organ failure, persistent organ failure, and length of hospital stay (LOS).

Results: Seven studies were included in the review. The meta-analysis found that patients with EPI had a significantly higher risk of mortality as compared to the no-EPI group (OR: 3.85 95% CI: 2.79, 5.31). The risk of ICU admission (OR: 12.24 95% CI: 3.56, 42.10), necrosis (OR: 3.50 95% CI: 1.37, 8.89) organ failure (OR: 6.03 95% CI: 3.75, 9.70) and persistent organ failure (OR: 6.72 95% CI: 3.58, 12.62) was significantly increased in the EPI group compared to the non-EPI group. The meta-analysis also found significantly longer LOS in the EPI group (MD: 11.92 95% CI: 4.75, 19.08).

Conclusion: EPI is associated with a worse prognosis in acute pancreatitis. EPI was associated with an increased risk of mortality, ICU admission, organ failure, and prolonged LOS. Limited number of studies and baseline confounding are drawbacks of current evidence which need to be rectified by future studies.

{"title":"The impact of extra-pancreatic infections on outcomes of acute pancreatitis: A systematic review and meta-analysis.","authors":"XueMin Zhang, Ping Zhu, YanFei Zhang, ShanShan Dai","doi":"10.1002/jhbp.12099","DOIUrl":"https://doi.org/10.1002/jhbp.12099","url":null,"abstract":"<p><strong>Background: </strong>The impact of extrapancreatic infections (EPI) on outcomes of acute pancreatitis has received limited attention in the literature. We compiled data from published studies to present high-quality evidence on the prognostic role of EPI on acute pancreatitis.</p><p><strong>Methods: </strong>This PRISMA-compliant and PROSPERO registered review (CRD42024516872) searched Embase, Scopus, Web of Science, and PubMed for comparative studies between EPI and no-EPI. Outcomes assessed were mortality, intensive care unit (ICU) admission, necrosis, organ failure, persistent organ failure, and length of hospital stay (LOS).</p><p><strong>Results: </strong>Seven studies were included in the review. The meta-analysis found that patients with EPI had a significantly higher risk of mortality as compared to the no-EPI group (OR: 3.85 95% CI: 2.79, 5.31). The risk of ICU admission (OR: 12.24 95% CI: 3.56, 42.10), necrosis (OR: 3.50 95% CI: 1.37, 8.89) organ failure (OR: 6.03 95% CI: 3.75, 9.70) and persistent organ failure (OR: 6.72 95% CI: 3.58, 12.62) was significantly increased in the EPI group compared to the non-EPI group. The meta-analysis also found significantly longer LOS in the EPI group (MD: 11.92 95% CI: 4.75, 19.08).</p><p><strong>Conclusion: </strong>EPI is associated with a worse prognosis in acute pancreatitis. EPI was associated with an increased risk of mortality, ICU admission, organ failure, and prolonged LOS. Limited number of studies and baseline confounding are drawbacks of current evidence which need to be rectified by future studies.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High preoperative Glasgow prognostic score increases a risk of hospital mortality in elderly patients with perihilar cholangiocarcinoma.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-02-13 DOI: 10.1002/jhbp.12111
Takashi Kokumai, Shuichi Aoki, Kei Nakagawa, Masahiro Iseki, Hideaki Sato, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Michiaki Unno

Background: Hemihepatectomy with extrahepatic bile duct resection is considered the only curative treatment for perihilar cholangiocarcinoma. The aim of the study was to clarify the survival benefits in this invasive surgical procedure for elderly patients.

Methods: A total of 290 patients who underwent surgical resection for perihilar cholangiocarcinoma in our department from 2000 to 2020 were categorized into the E group (62 patients aged ≥75 years) and NE group (228 patients aged <74 years).

Results: The E group exhibited decreased pathological lymph node metastasis (p = .001) and had a shorter operative time (p = .021) and fewer cases of combined vascular resection (p = .002). We found no significant differences in postoperative mortality; however, disease-specific survival was significantly better in the E group (3-year survival: 75.6 vs. 60.3%, p = .031). After propensity score matching, overall survival and disease-specific survival did not differ between the two groups; nevertheless, the hospital mortality rate was significantly higher in the E group (11.5 vs. 1.6%, p = .020). In the E group, a high preoperative Glasgow prognostic score was the only factor associated with hospital mortality (odds ratio, 7.35; p = .026) and indicated worse prognosis.

Conclusions: A high preoperative Glasgow prognostic score was associated with hospital mortality and poor prognosis in elderly patients with perihilar cholangiocarcinoma.

{"title":"High preoperative Glasgow prognostic score increases a risk of hospital mortality in elderly patients with perihilar cholangiocarcinoma.","authors":"Takashi Kokumai, Shuichi Aoki, Kei Nakagawa, Masahiro Iseki, Hideaki Sato, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Masamichi Mizuma, Michiaki Unno","doi":"10.1002/jhbp.12111","DOIUrl":"https://doi.org/10.1002/jhbp.12111","url":null,"abstract":"<p><strong>Background: </strong>Hemihepatectomy with extrahepatic bile duct resection is considered the only curative treatment for perihilar cholangiocarcinoma. The aim of the study was to clarify the survival benefits in this invasive surgical procedure for elderly patients.</p><p><strong>Methods: </strong>A total of 290 patients who underwent surgical resection for perihilar cholangiocarcinoma in our department from 2000 to 2020 were categorized into the E group (62 patients aged ≥75 years) and NE group (228 patients aged <74 years).</p><p><strong>Results: </strong>The E group exhibited decreased pathological lymph node metastasis (p = .001) and had a shorter operative time (p = .021) and fewer cases of combined vascular resection (p = .002). We found no significant differences in postoperative mortality; however, disease-specific survival was significantly better in the E group (3-year survival: 75.6 vs. 60.3%, p = .031). After propensity score matching, overall survival and disease-specific survival did not differ between the two groups; nevertheless, the hospital mortality rate was significantly higher in the E group (11.5 vs. 1.6%, p = .020). In the E group, a high preoperative Glasgow prognostic score was the only factor associated with hospital mortality (odds ratio, 7.35; p = .026) and indicated worse prognosis.</p><p><strong>Conclusions: </strong>A high preoperative Glasgow prognostic score was associated with hospital mortality and poor prognosis in elderly patients with perihilar cholangiocarcinoma.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholangiogram of durvalumab-related sclerosing cholangitis as immune-mediated adverse event.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-02-12 DOI: 10.1002/jhbp.12119
Naosuke Kuraoka, Tetsuro Ujihara, Shun Sakai
{"title":"Cholangiogram of durvalumab-related sclerosing cholangitis as immune-mediated adverse event.","authors":"Naosuke Kuraoka, Tetsuro Ujihara, Shun Sakai","doi":"10.1002/jhbp.12119","DOIUrl":"https://doi.org/10.1002/jhbp.12119","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraprocedural mixed-reality hologram support in endoscopic retrograde cholangiography (ERC) for bile leaks.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-02-12 DOI: 10.1002/jhbp.12098
Hirohito Minami, Kazumasa Nagai, Maki Sugimoto, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Shuntaro Mukai, Kenjiro Yamamoto, Hiroyuki Kojima, Takao Itoi
{"title":"Intraprocedural mixed-reality hologram support in endoscopic retrograde cholangiography (ERC) for bile leaks.","authors":"Hirohito Minami, Kazumasa Nagai, Maki Sugimoto, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Shuntaro Mukai, Kenjiro Yamamoto, Hiroyuki Kojima, Takao Itoi","doi":"10.1002/jhbp.12098","DOIUrl":"https://doi.org/10.1002/jhbp.12098","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antegrade stone removal using a novel non-slip balloon for dilation in a patient with hepaticojejunostomy anastomosis.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-02-02 DOI: 10.1002/jhbp.12116
Haruo Miwa, Ritsuko Oishi, Shin Maeda
{"title":"Antegrade stone removal using a novel non-slip balloon for dilation in a patient with hepaticojejunostomy anastomosis.","authors":"Haruo Miwa, Ritsuko Oishi, Shin Maeda","doi":"10.1002/jhbp.12116","DOIUrl":"https://doi.org/10.1002/jhbp.12116","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early differential diagnosis of cystic biliary atresia and choledochal cyst in the fetus: A multicenter retrospective study.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-28 DOI: 10.1002/jhbp.12115
Xisi Guan, Wei Zhong, Yu Ouyang, Zhe Wang, Bin Yan, Longlong Hou, Junjie Wang, Yue Wu, Lin Huang, Xiaoxiong Liang, Qiuming He, Shangjie Xiao, Jiakang Yu

Background/purpose: Fetal hilar cyst is primarily diagnosed as two diseases after birth, cystic biliary atresia (CBA) and choledochal cyst (CC). The aim of our study was to explore more reliable indicators in early differential diagnosis of these cysts.

Methods: We recruited a total of 50 cases with a prenatal diagnosis of hepatic cyst at three centers, and patients were divided into a CBA group (n = 16) and CC group (n = 34) according to postnatal intraoperative diagnosis. Patient features, maximal cyst diameter as measured by prenatal and early postnatal ultrasonography were analyzed and compared between the two groups, as was the effect of cyst size in predicting CBA.

Results: The maximal cyst diameters in the last prenatal ultrasound (LPU) measurement and initial postnatal ultrasound (IPU) in the CBA group were significantly smaller than in the CC group, as was the difference between the IPU and the first prenatal ultrasound (FPU) (i.e., IPU-FPU) in the CBA group relative to the CC group. The IPU-FPU difference showed the best diagnostic performance as a single parameter (AUC, 0.9806), with a sensitivity and specificity of 100% and 90.3%, respectively, and a cutoff value of 7.5 mm.

Conclusion: Ultrasonographic measurement of the maximal cyst diameter can assist in early (within 1 week after birth) identification of CBA. An IPU-FPU <7.5 mm suggested a higher possibility of a postnatal diagnosis of CBA.

{"title":"Early differential diagnosis of cystic biliary atresia and choledochal cyst in the fetus: A multicenter retrospective study.","authors":"Xisi Guan, Wei Zhong, Yu Ouyang, Zhe Wang, Bin Yan, Longlong Hou, Junjie Wang, Yue Wu, Lin Huang, Xiaoxiong Liang, Qiuming He, Shangjie Xiao, Jiakang Yu","doi":"10.1002/jhbp.12115","DOIUrl":"https://doi.org/10.1002/jhbp.12115","url":null,"abstract":"<p><strong>Background/purpose: </strong>Fetal hilar cyst is primarily diagnosed as two diseases after birth, cystic biliary atresia (CBA) and choledochal cyst (CC). The aim of our study was to explore more reliable indicators in early differential diagnosis of these cysts.</p><p><strong>Methods: </strong>We recruited a total of 50 cases with a prenatal diagnosis of hepatic cyst at three centers, and patients were divided into a CBA group (n = 16) and CC group (n = 34) according to postnatal intraoperative diagnosis. Patient features, maximal cyst diameter as measured by prenatal and early postnatal ultrasonography were analyzed and compared between the two groups, as was the effect of cyst size in predicting CBA.</p><p><strong>Results: </strong>The maximal cyst diameters in the last prenatal ultrasound (LPU) measurement and initial postnatal ultrasound (IPU) in the CBA group were significantly smaller than in the CC group, as was the difference between the IPU and the first prenatal ultrasound (FPU) (i.e., IPU-FPU) in the CBA group relative to the CC group. The IPU-FPU difference showed the best diagnostic performance as a single parameter (AUC, 0.9806), with a sensitivity and specificity of 100% and 90.3%, respectively, and a cutoff value of 7.5 mm.</p><p><strong>Conclusion: </strong>Ultrasonographic measurement of the maximal cyst diameter can assist in early (within 1 week after birth) identification of CBA. An IPU-FPU <7.5 mm suggested a higher possibility of a postnatal diagnosis of CBA.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concerns about needle tract seeding after endoscopic ultrasound-guided tissue acquisition: A possibility not limited to pancreatic body and tail cancer.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-28 DOI: 10.1002/jhbp.12104
Tatsunori Satoh, Haruna Takahashi, Shinya Kawaguchi
{"title":"Concerns about needle tract seeding after endoscopic ultrasound-guided tissue acquisition: A possibility not limited to pancreatic body and tail cancer.","authors":"Tatsunori Satoh, Haruna Takahashi, Shinya Kawaguchi","doi":"10.1002/jhbp.12104","DOIUrl":"https://doi.org/10.1002/jhbp.12104","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Duodenal transmural perforation caused by a dislodged pigtail plastic stent in a patient with benign biliary stricture.
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-22 DOI: 10.1002/jhbp.12102
Noriyuki Hirakawa, Kenjiro Yamamoto, Takao Itoi
{"title":"Duodenal transmural perforation caused by a dislodged pigtail plastic stent in a patient with benign biliary stricture.","authors":"Noriyuki Hirakawa, Kenjiro Yamamoto, Takao Itoi","doi":"10.1002/jhbp.12102","DOIUrl":"https://doi.org/10.1002/jhbp.12102","url":null,"abstract":"","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Capnographic monitoring using a novel mainstream system during endoscopic ultrasound and endoscopic retrograde cholangiopancreatography: A prospective randomized controlled trial. 内窥镜超声和内窥镜逆行胰胆管造影中使用一种新型主流系统的血糖监测:一项前瞻性随机对照试验。
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-21 DOI: 10.1002/jhbp.12110
Yoichi Takimoto, Eisuke Iwasaki, Masayasu Horibe, Seiichiro Fukuhara, Kazuhiro Minami, Shintaro Kawasaki, Tatsuhiro Masaoka, Haruhiko Ogata, Fateh Bazerbachi, Takanori Kanai

Background/purpose: Insufficient studies exist on capnography efficacy during endoscopic ultrasound or endoscopic retrograde cholangiopancreatography, and no definitive conclusions have been drawn. To evaluate the feasibility and efficacy of a novel mainstream capnography using an over-the-biteblock end-tidal CO2 (EtCO2) detector in decreasing the risk of hypoxemia during endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP).

Methods: Patients undergoing EUS or ERCP with conscious sedation at a single Japanese center were randomized to a control or a novel capnography monitored (intervention) group in a 1:1 ratio. Hypoxemia correction maneuvers were pursued if the oxygen saturation decreased to <92% in the control or intervention group and if a 15-s suspension of EtCO2 wave occurred in the intervention group. The primary outcome was the incidence of hypoxemic events, defined as oxygen saturation <90%, during the procedures. Secondary outcomes included technical feasibility of EUS and ERCP with the use of this novel over-the-biteblock monitor.

Results: In total, 250 patients were enrolled without dropouts or missing data (control group: 125; capnography group: 125). There was no significant difference in the incidence of hypoxemia between the control and capnography groups (29.6% [37/125] vs. 26.4% [33/125]; p = .573). The estimated odds ratio was 0.925 (95% confidence interval: 0.708-1.208). The EtCO2 concentration was successfully captured without impeding endoscopic maneuvers from the beginning to the end of the procedure in all patients.

Conclusions: Although the novel mainstream capnography with an over-the-biteblock EtCO2 detector captures the EtCO2 concentration in EUS or ERCP under conscious sedation, it does not lead to the prevention of hypoxemia.

背景/目的:内镜超声或内镜逆行胰胆管造影中导管造影的疗效研究尚不充分,尚未得出明确结论。评估一种新型主流血管造影在内镜超声(EUS)和内镜逆行胆管胰胆管造影(ERCP)期间使用过咬块潮汐末CO2 (EtCO2)检测器降低低氧血症风险的可行性和有效性。方法:在单个日本中心接受EUS或ERCP并有意识镇静的患者按1:1的比例随机分为对照组或新型毛细血管造影监测(干预)组。干预组血氧饱和度降至2波时进行低氧血症矫正操作。主要终点是低氧血症事件的发生率,定义为氧饱和度。结果:总共有250例患者入组,无退出或丢失数据(对照组:125例;造影组:125人)。对照组与造影组低氧血症发生率无显著差异(29.6% [37/125]vs. 26.4% [33/125];p = .573)。估计比值比为0.925(95%可信区间:0.708-1.208)。在所有患者中,从手术开始到手术结束,EtCO2浓度都被成功捕获,没有妨碍内镜操作。结论:尽管采用过咬块EtCO2检测仪的新型主流血管造影技术可以捕获清醒镇静状态下EUS或ERCP的EtCO2浓度,但它并不能预防低氧血症。
{"title":"Capnographic monitoring using a novel mainstream system during endoscopic ultrasound and endoscopic retrograde cholangiopancreatography: A prospective randomized controlled trial.","authors":"Yoichi Takimoto, Eisuke Iwasaki, Masayasu Horibe, Seiichiro Fukuhara, Kazuhiro Minami, Shintaro Kawasaki, Tatsuhiro Masaoka, Haruhiko Ogata, Fateh Bazerbachi, Takanori Kanai","doi":"10.1002/jhbp.12110","DOIUrl":"https://doi.org/10.1002/jhbp.12110","url":null,"abstract":"<p><strong>Background/purpose: </strong>Insufficient studies exist on capnography efficacy during endoscopic ultrasound or endoscopic retrograde cholangiopancreatography, and no definitive conclusions have been drawn. To evaluate the feasibility and efficacy of a novel mainstream capnography using an over-the-biteblock end-tidal CO<sub>2</sub> (EtCO<sub>2</sub>) detector in decreasing the risk of hypoxemia during endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP).</p><p><strong>Methods: </strong>Patients undergoing EUS or ERCP with conscious sedation at a single Japanese center were randomized to a control or a novel capnography monitored (intervention) group in a 1:1 ratio. Hypoxemia correction maneuvers were pursued if the oxygen saturation decreased to <92% in the control or intervention group and if a 15-s suspension of EtCO<sub>2</sub> wave occurred in the intervention group. The primary outcome was the incidence of hypoxemic events, defined as oxygen saturation <90%, during the procedures. Secondary outcomes included technical feasibility of EUS and ERCP with the use of this novel over-the-biteblock monitor.</p><p><strong>Results: </strong>In total, 250 patients were enrolled without dropouts or missing data (control group: 125; capnography group: 125). There was no significant difference in the incidence of hypoxemia between the control and capnography groups (29.6% [37/125] vs. 26.4% [33/125]; p = .573). The estimated odds ratio was 0.925 (95% confidence interval: 0.708-1.208). The EtCO<sub>2</sub> concentration was successfully captured without impeding endoscopic maneuvers from the beginning to the end of the procedure in all patients.</p><p><strong>Conclusions: </strong>Although the novel mainstream capnography with an over-the-biteblock EtCO<sub>2</sub> detector captures the EtCO<sub>2</sub> concentration in EUS or ERCP under conscious sedation, it does not lead to the prevention of hypoxemia.</p>","PeriodicalId":16056,"journal":{"name":"Journal of Hepato‐Biliary‐Pancreatic Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The efficacy of second-line chemotherapy for advanced biliary tract cancer: A systematic review and network meta-analysis. 二线化疗治疗晚期胆道癌的疗效:系统回顾和网络荟萃分析。
IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Pub Date : 2025-01-20 DOI: 10.1002/jhbp.12113
Inhwan Hwang, Sangah Han, Ji Hun Jeong, Chunhwa Ihm, Taeho Greg Rhee, Sung Ryul Shim

Background: This network meta-analysis (NMA) aims to provide evidence-based guidance for selecting the second-line chemotherapy for biliary tract cancer (BTC).

Methods: A comprehensive literature search was conducted on PubMed, Cochrane, and EMBASE through July 2024. Inclusion criteria involved: (1) patients underwent second-line chemotherapy following platinum-based first-line therapy, (2) intervention/comparator groups consisted of various chemotherapeutic agents, and (3) outcomes measured as hazard ratio (HR) of overall survival (OS) and progression-free survival (PFS) in randomized controlled trials (RCTs) and cohort studies.

Results: Outcomes were measured as HR of OS and PFS in RCTs and cohort studies. The eight studies consisting of 1621 patients were selected. In the NMA for OS, 5FU_plus_Plat (fluorouracil plus oxaliplatin or cisplatin; HR 0.52, 95% confidence interval [CI]: 0.30-0.91), nal-IRI_5FU_LV (nano-liposomal irinotecan plus fluorouracil and LV; HR 0.54 [95% CI: 0.32-0.92]), and FOLFOX (fluorouracil plus oxaliplatin; HR 0.69 [95% CI: 0.50-0.96]) demonstrated significant benefits in OS when compared to control. For PFS, nal-IRI_5FU_LV (HR 0.61 [95% CI: 0.44-0.85]) provided a significant advantage over 5FU.

Conclusions: Second-line chemotherapy for BTC after the failure of gemcitabine plus platinum as first-line therapy, nal-IRI_5FU_LV appears to be the most promising second-line therapy in terms of both OS and PFS.

背景:本网络荟萃分析(NMA)旨在为胆道肿瘤(BTC)的二线化疗方案选择提供循证指导。方法:到2024年7月,在PubMed、Cochrane和EMBASE上进行全面的文献检索。纳入标准包括:(1)患者在以铂为基础的一线治疗后接受了二线化疗;(2)干预/比较组由各种化疗药物组成;(3)随机对照试验(rct)和队列研究中以总生存期(OS)和无进展生存期(PFS)的风险比(HR)衡量的结果。结果:在随机对照试验和队列研究中,以OS和PFS的HR来衡量结果。入选8项研究,共1621例患者。在OS的NMA中,5FU_plus_Plat(氟尿嘧啶加奥沙利铂或顺铂;HR 0.52, 95%可信区间[CI]: 0.30-0.91), nal-IRI_5FU_LV(纳米脂质体伊立替康联合氟尿嘧啶和LV;HR 0.54 [95% CI: 0.32-0.92])和FOLFOX(氟尿嘧啶加奥沙利铂;HR 0.69 [95% CI: 0.50-0.96])与对照组相比,在OS中表现出显著的益处。对于PFS, nal-IRI_5FU_LV (HR 0.61 [95% CI: 0.44-0.85])比5FU具有显著优势。结论:吉西他滨联合铂作为一线治疗失败后,nal-IRI_5FU_LV似乎是最有希望的二线治疗方案,无论是OS还是PFS。
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Journal of Hepato‐Biliary‐Pancreatic Sciences
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