Pub Date : 2024-10-16DOI: 10.1016/j.jmpt.2024.08.018
Paulo Gomes de Oliveria Neto, Lucas Rego Ramos, Marcos F DosSantos
Objectives: The purpose of this study was to examine long-term brain and behavioral changes in patients with fibromyalgia (FM) compared to healthy individuals.
Methods: Data from 33 female volunteers with FM and 33 healthy controls women paired by age and school degree were used to analyze the cortical thickness from high-resolution T1-weighted magnetic resonance imaging (MRI) obtained through a 3T-MRI scanner. Additionally, the Toronto Alexithymia Scale, the Positive and Negative Affect Scale, the emotion regulation questionnaire (ERQ), and the Hamilton Depression and Anxiety rating scales were used to evaluate the behavioral changes.
Results: The findings indicate significant cortical structure differences in the right cerebral hemisphere between groups in the insular anterior cortex precentral and postcentral gyrus (P < .001). The FM group scored higher for alexithymia (P < .01), negative affect (P < .01), anxiety (P < .01), and depression (P < .01) symptoms, on the other hand, scored lower for positive affect (P < .01). No differences were found on the left cerebral hemisphere. Furthermore, there was a negative correlation between the right insular anterior cortex and Toronto Alexithymia Scale (P < .001).
Conclusion: This study showed long-term brain and behavioral changes in patients with FM, suggesting notable neurophysiological alterations associated with this chronic pain condition. It provides new insights into how FM may affect brain health and potential biomarkers for the condition.
{"title":"Behavioral Changes and Long-Term Cortical Thickness Alterations in Women with Fibromyalgia.","authors":"Paulo Gomes de Oliveria Neto, Lucas Rego Ramos, Marcos F DosSantos","doi":"10.1016/j.jmpt.2024.08.018","DOIUrl":"https://doi.org/10.1016/j.jmpt.2024.08.018","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to examine long-term brain and behavioral changes in patients with fibromyalgia (FM) compared to healthy individuals.</p><p><strong>Methods: </strong>Data from 33 female volunteers with FM and 33 healthy controls women paired by age and school degree were used to analyze the cortical thickness from high-resolution T1-weighted magnetic resonance imaging (MRI) obtained through a 3T-MRI scanner. Additionally, the Toronto Alexithymia Scale, the Positive and Negative Affect Scale, the emotion regulation questionnaire (ERQ), and the Hamilton Depression and Anxiety rating scales were used to evaluate the behavioral changes.</p><p><strong>Results: </strong>The findings indicate significant cortical structure differences in the right cerebral hemisphere between groups in the insular anterior cortex precentral and postcentral gyrus (P < .001). The FM group scored higher for alexithymia (P < .01), negative affect (P < .01), anxiety (P < .01), and depression (P < .01) symptoms, on the other hand, scored lower for positive affect (P < .01). No differences were found on the left cerebral hemisphere. Furthermore, there was a negative correlation between the right insular anterior cortex and Toronto Alexithymia Scale (P < .001).</p><p><strong>Conclusion: </strong>This study showed long-term brain and behavioral changes in patients with FM, suggesting notable neurophysiological alterations associated with this chronic pain condition. It provides new insights into how FM may affect brain health and potential biomarkers for the condition.</p>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-28DOI: 10.1016/j.jmpt.2024.08.004
Baojiang Chen, Henry S Brown, David Douphrate, Jud Janak, Kelley Pettee Gabriel, Trent Peng
Objective: This study aimed to evaluate the prospective associations of baseline personal characteristics with utilization frequency and expenditure of chiropractic care in US adults (≥18 years).
Methods: Data are from the 1358 respondents to the 2014 to 2016 Medical Expenditure Panel Survey who utilized chiropractic care. Individual, familial, health-related, and behavioral factors were included as covariates in the multivariate analytic model. Poisson and multinominal logistic regressions were modeled to examine the associations between the predictors and chiropractic utilization and expenditure.
Results: The mean annual number of visits was 8.2 visits (95% confidence interval [CI]: 7.9, 8.5), with annual expenditure of $677.43 U.S. dollars (95% CI: $595.47-$759.39) and $84.84 (95% CI: $77.89-$91.78) per visit. Female sex was associated with a 19% higher number of visits (rate ratio [RR] = 1.19, 95% CI: 1.01, 1.41) than males. Publicly insured and uninsured were associated with a 44% higher (RR = 1.44, 95% CI: 1.14, 1.82) and 36% lower (RR = 0.64, 95% CI: 0.48, 0.86) visit frequency, respectively, than those privately insured. Rheumatoid arthritis was associated with 7.38 times the risk of high expenditure (95% CI: 2.61, 24.67) than medium expenditure, compared to no arthritis. Relative to physically active individuals, physical inactivity was associated with a 27% higher visit frequency (RR = 1.27, 95% CI: 1.09, 1.49) and an 82% higher risk (relative risk ratio = 1.82, 95% CI: 1.05, 3.14) of high expenditure than low expenditure.
Conclusion: This analysis found distinct usage and expenditure patterns that vary according to specific baseline predictors. Female sex, being publicly insured, having rheumatoid arthritis, and physically inactive were associated with variance in expenditure. Results from this study may help identify chiropractic patients with tendencies for higher utilization or spending and may indirectly assist in predicting patients with slower response to care.
{"title":"Predictors of Utilization Frequency of and Expenditure Amount for Chiropractic Care in U.S. Adults: A Retrospective Cohort Study.","authors":"Baojiang Chen, Henry S Brown, David Douphrate, Jud Janak, Kelley Pettee Gabriel, Trent Peng","doi":"10.1016/j.jmpt.2024.08.004","DOIUrl":"https://doi.org/10.1016/j.jmpt.2024.08.004","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the prospective associations of baseline personal characteristics with utilization frequency and expenditure of chiropractic care in US adults (≥18 years).</p><p><strong>Methods: </strong>Data are from the 1358 respondents to the 2014 to 2016 Medical Expenditure Panel Survey who utilized chiropractic care. Individual, familial, health-related, and behavioral factors were included as covariates in the multivariate analytic model. Poisson and multinominal logistic regressions were modeled to examine the associations between the predictors and chiropractic utilization and expenditure.</p><p><strong>Results: </strong>The mean annual number of visits was 8.2 visits (95% confidence interval [CI]: 7.9, 8.5), with annual expenditure of $677.43 U.S. dollars (95% CI: $595.47-$759.39) and $84.84 (95% CI: $77.89-$91.78) per visit. Female sex was associated with a 19% higher number of visits (rate ratio [RR] = 1.19, 95% CI: 1.01, 1.41) than males. Publicly insured and uninsured were associated with a 44% higher (RR = 1.44, 95% CI: 1.14, 1.82) and 36% lower (RR = 0.64, 95% CI: 0.48, 0.86) visit frequency, respectively, than those privately insured. Rheumatoid arthritis was associated with 7.38 times the risk of high expenditure (95% CI: 2.61, 24.67) than medium expenditure, compared to no arthritis. Relative to physically active individuals, physical inactivity was associated with a 27% higher visit frequency (RR = 1.27, 95% CI: 1.09, 1.49) and an 82% higher risk (relative risk ratio = 1.82, 95% CI: 1.05, 3.14) of high expenditure than low expenditure.</p><p><strong>Conclusion: </strong>This analysis found distinct usage and expenditure patterns that vary according to specific baseline predictors. Female sex, being publicly insured, having rheumatoid arthritis, and physically inactive were associated with variance in expenditure. Results from this study may help identify chiropractic patients with tendencies for higher utilization or spending and may indirectly assist in predicting patients with slower response to care.</p>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-27DOI: 10.1016/j.jmpt.2024.08.005
Baojiang Chen, Henry S Brown, David Douphrate, Jud Janak, Kelley Pettee Gabriel, Trent Peng
Objective: This study aimed to examine the trends in the utilization and expenditure of chiropractic care in a representative sample of US adults, aged ≥18 years.
Methods: Serial cross-sectional data (2007-2016) from the Medical Expenditure Panel Survey (MEPS) were examined. Weighted descriptive statistics were analyzed to obtain national estimates of chiropractic utilization and expenditure, and time-series linear regression was used to assess trends over time. Socio-demographic characteristics and musculoskeletal diagnoses associated with chiropractic use were also reported.
Results: A statistically significantly increasing trend was observed for the number of adults receiving chiropractic care (p < .05), number of visits (p < .05) and utilization rate (P < .05) from 2007 to 2016. A similar trend was not found for chiropractic expenditure during this period (P > .05). The mean number of visits was 8.3 visits per year, with a mean expenditure of $86.94 USD per visit and $721.43 USD per person per year. Mean age of adult chiropractic users each year ranged between 48.6 and 51.2 years old, and users were primarily female (56.3%-60.4%), White persons (90.1%-93.5%), and privately insured (77.3%-82.8%). The most prevalent musculoskeletal diagnoses associated with chiropractic use were low back conditions (45.4%-58.1%), inflammatory/degenerative disc or joint conditions (21.2%-26.8%) and head and neck complaints (9.8%-13.7%).
Conclusion: The findings showed statistically significant increasing trends for the number of adult chiropractic users, the number of visits, and percent utilization of chiropractic care from 2007 to 2016. Conversely, we found a statistically null trend for the total annual expenditure on chiropractic care during the same time period. Findings from this analysis imply that, while chiropractic care appears to be growing, it may still be under-utilized, and more efforts should be devoted to ensuring sustained growth and a larger role in the management of musculoskeletal health.
{"title":"National Trends in the Utilization and Expenditure of Chiropractic Care in U.S. Adults: Analysis of the 2007-2016 Medical Expenditure Panel Survey.","authors":"Baojiang Chen, Henry S Brown, David Douphrate, Jud Janak, Kelley Pettee Gabriel, Trent Peng","doi":"10.1016/j.jmpt.2024.08.005","DOIUrl":"https://doi.org/10.1016/j.jmpt.2024.08.005","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the trends in the utilization and expenditure of chiropractic care in a representative sample of US adults, aged ≥18 years.</p><p><strong>Methods: </strong>Serial cross-sectional data (2007-2016) from the Medical Expenditure Panel Survey (MEPS) were examined. Weighted descriptive statistics were analyzed to obtain national estimates of chiropractic utilization and expenditure, and time-series linear regression was used to assess trends over time. Socio-demographic characteristics and musculoskeletal diagnoses associated with chiropractic use were also reported.</p><p><strong>Results: </strong>A statistically significantly increasing trend was observed for the number of adults receiving chiropractic care (p < .05), number of visits (p < .05) and utilization rate (P < .05) from 2007 to 2016. A similar trend was not found for chiropractic expenditure during this period (P > .05). The mean number of visits was 8.3 visits per year, with a mean expenditure of $86.94 USD per visit and $721.43 USD per person per year. Mean age of adult chiropractic users each year ranged between 48.6 and 51.2 years old, and users were primarily female (56.3%-60.4%), White persons (90.1%-93.5%), and privately insured (77.3%-82.8%). The most prevalent musculoskeletal diagnoses associated with chiropractic use were low back conditions (45.4%-58.1%), inflammatory/degenerative disc or joint conditions (21.2%-26.8%) and head and neck complaints (9.8%-13.7%).</p><p><strong>Conclusion: </strong>The findings showed statistically significant increasing trends for the number of adult chiropractic users, the number of visits, and percent utilization of chiropractic care from 2007 to 2016. Conversely, we found a statistically null trend for the total annual expenditure on chiropractic care during the same time period. Findings from this analysis imply that, while chiropractic care appears to be growing, it may still be under-utilized, and more efforts should be devoted to ensuring sustained growth and a larger role in the management of musculoskeletal health.</p>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate the locomotor behavior of older adults with and without a history of falls as they avoided obstacles with different physical characteristics.
Methods
Twenty-one older adults participated in this study. The group was divided into higher risk of falling (n = 10) and lower risk of falling (n = 11). The following conditions were carried out: (1) walking and avoiding a solid obstacle and (2) walking and avoiding a fragile obstacle.
Results
Older adults at higher risk of falling had worse performance during the obstacle approach phase. Both groups performed worse when avoiding the fragile obstacle than when avoiding the solid obstacle. Older adults at higher risk of falling had their feet closer when avoiding the obstacle, and both groups raised their limbs higher to avoid a fragile obstacle. Older adults at higher risk of falling were closer to obstacles after avoiding them.
Conclusion
For the participants in this study, the physical characteristics of the obstacle did not interfere with the locomotor performance of older adults during obstacle avoidance. This study found that older adults at higher risk of falls modulated their locomotor pattern before avoiding the obstacles, presenting lower velocity, shorter step length, and greater step width compared with older adults at lower risk of falling.
{"title":"Influence of Physical Characteristics of Obstacles on the Locomotor Pattern of Older Adults at Higher Risk of Falling","authors":"Juliana Amaral Da Silva MS, Gabriela Vigorito Magalhães MS, Milena Razuk PhD, Natalia Madalena Rinaldi PhD","doi":"10.1016/j.jmpt.2024.09.002","DOIUrl":"10.1016/j.jmpt.2024.09.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the locomotor behavior of older adults with and without a history of falls as they avoided obstacles with different physical characteristics.</div></div><div><h3>Methods</h3><div>Twenty-one older adults participated in this study. The group was divided into higher risk of falling (n = 10) and lower risk of falling (n = 11). The following conditions were carried out: (1) walking and avoiding a solid obstacle and (2) walking and avoiding a fragile obstacle.</div></div><div><h3>Results</h3><div>Older adults at higher risk of falling had worse performance during the obstacle approach phase. Both groups performed worse when avoiding the fragile obstacle than when avoiding the solid obstacle. Older adults at higher risk of falling had their feet closer when avoiding the obstacle, and both groups raised their limbs higher to avoid a fragile obstacle. Older adults at higher risk of falling were closer to obstacles after avoiding them.</div></div><div><h3>Conclusion</h3><div>For the participants in this study, the physical characteristics of the obstacle did not interfere with the locomotor performance of older adults during obstacle avoidance. This study found that older adults at higher risk of falls modulated their locomotor pattern before avoiding the obstacles, presenting lower velocity, shorter step length, and greater step width compared with older adults at lower risk of falling.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"47 5","pages":"Pages 114-124"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.jmpt.2024.09.007
Jung-Hoon Choi MS , Heon-Seock Cynn PhD , Seung-Min Baik PhD , Seok-Hyun Kim MS
Objective
The purpose of this study was to compare the effects of foot positioning on muscle activities of the peroneus longus (PL), medial gastrocnemius (MG), and tibialis anterior (TA)/PL ratio in individuals with chronic ankle instabilities (CAI) during wobble board training.
Methods
Thirty individuals with CAI were included, and statistical significance of PL and MG muscle activities was determined using 1-way repeated measures analysis of variance alongside TA/PL activity ratio at the university research laboratory. The participants performed the wobble board training in 3 different foot positions: medial from the centerline of the wobble board (WBT-M), middle from the centerline of the wobble board, and lateral from the centerline of the wobble board (WBT-L). Peroneus longus, MG, and TA muscle activities were measured using surface electromyography.
Results
Peroneus longus activity was significantly higher in the WBT-L position than in the other 2 positions, and it was significantly higher in the middle from the centerline of the wobble board than in the WBT-M position. Medial gastrocnemius activity was significantly greater in the WBT-L position than in the other 2 positions. Tibialis anterior/PL ratio was higher in the WBT-M position than in the other 2 positions.
Conclusion
The findings of this study showed that WBT-L increased PL muscle activity by >70% of the maximal voluntary isometric contraction without increasing TA/PL ratio in individuals with CAI.
研究目的本研究的目的是比较慢性踝关节不稳定(CAI)患者在进行摇摆板训练时,足部定位对腓肠肌(PL)、内侧腓肠肌(MG)肌肉活动以及胫骨前肌(TA)/PL比值的影响:方法:纳入 30 名 CAI 患者,在大学研究实验室使用单因素重复测量方差分析确定 PL 和 MG 肌肉活动与 TA/PL 活动比率的统计学意义。参与者以三种不同的脚部姿势进行摇摆板训练:从摇摆板中心线向内侧(WBT-M)、从摇摆板中心线向中间(WBT-M)和从摇摆板中心线向外侧(WBT-L)。用表面肌电图测量了腓肠肌、MG 和 TA 肌肉的活动:结果:WBT-L姿势下的腓肠肌活动明显高于其他两种姿势下的腓肠肌活动,而从摇摆板中心线开始的中间姿势下的腓肠肌活动明显高于WBT-M姿势下的腓肠肌活动。WBT-L姿势下的腓肠肌内侧活动明显高于其他两种姿势。WBT-M姿势下的胫骨前/PL比率高于其他两种姿势:本研究结果表明,WBT-L 体位可使 CAI 患者的 PL 肌肉活动增加最大自主等长收缩量的 70% 以上,但不会增加 TA/PL 比值。
{"title":"Effect of Foot Position on Ankle Muscle Activity During Wobble Board Training in Individuals With Chronic Ankle Instability","authors":"Jung-Hoon Choi MS , Heon-Seock Cynn PhD , Seung-Min Baik PhD , Seok-Hyun Kim MS","doi":"10.1016/j.jmpt.2024.09.007","DOIUrl":"10.1016/j.jmpt.2024.09.007","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to compare the effects of foot positioning on muscle activities of the peroneus longus (PL), medial gastrocnemius (MG), and tibialis anterior (TA)/PL ratio in individuals with chronic ankle instabilities (CAI) during wobble board training.</div></div><div><h3>Methods</h3><div>Thirty individuals with CAI were included, and statistical significance of PL and MG muscle activities was determined using 1-way repeated measures analysis of variance alongside TA/PL activity ratio at the university research laboratory. The participants performed the wobble board training in 3 different foot positions: medial from the centerline of the wobble board (WBT-M), middle from the centerline of the wobble board, and lateral from the centerline of the wobble board (WBT-L). Peroneus longus, MG, and TA muscle activities were measured using surface electromyography.</div></div><div><h3>Results</h3><div>Peroneus longus activity was significantly higher in the WBT-L position than in the other 2 positions, and it was significantly higher in the middle from the centerline of the wobble board than in the WBT-M position. Medial gastrocnemius activity was significantly greater in the WBT-L position than in the other 2 positions. Tibialis anterior/PL ratio was higher in the WBT-M position than in the other 2 positions.</div></div><div><h3>Conclusion</h3><div>The findings of this study showed that WBT-L increased PL muscle activity by >70% of the maximal voluntary isometric contraction without increasing TA/PL ratio in individuals with CAI.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"47 5","pages":"Pages 134-141"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study was to evaluate the effects of photobiomodulation therapy (PBMT) on the gastrocnemius muscle of X-linked muscular dystrophy (mdx) mice.
Methods
The study used an experimental model of Duchenne muscular dystrophy, at 3 stages of degeneration/regeneration of muscle fibers: an acute stage (14-28 days old), acute and stabilized stages (14-42 days old), and a stabilized stage (28-42 days old). Photobiomodulation therapy (also known as low-level light therapy) at 0.6 J was applied 3 times per week to the dystrophic gastrocnemius muscle of mdx mice at ages 14 to 28, 14 to 42, and 28 to 42 days. After the treatment period, the gastrocnemius muscle was collected, and cryosections were prepared for histopathologic analysis.
Results
In all 3 stages evaluated, a significant reduction was observed in immunoglobulin G uptake by muscle fibers, the inflammatory area, macrophage infiltration, the reactive dihydroethidium area, and the number of autofluorescent lipofuscin granules in the gastrocnemius muscle of mdx mice after PBMT.
Conclusion
The results demonstrated that low-level light therapy, when applied during or after the acute phase of the degeneration/regeneration muscle process, improves the pathological histomorphologic features in dystrophic muscle. Based on these results, PBMT appears to be a promising therapy for dystrophinopathies, warranting further research in humans to verify its efficacy.
{"title":"Photobiomodulation Therapy Effects at Different Stages of the Dystrophic Phenotype: A Histomorphometric Study","authors":"Caroline Covatti PhD, Daniela Sayuri Mizobuti PhD, Guilherme Luiz da Rocha PhD, Heloina Nathalliê Mariano da Silva PhD, Elaine Minatel PhD","doi":"10.1016/j.jmpt.2024.09.008","DOIUrl":"10.1016/j.jmpt.2024.09.008","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to evaluate the effects of photobiomodulation therapy (PBMT) on the gastrocnemius muscle of X-linked muscular dystrophy (mdx) mice.</div></div><div><h3>Methods</h3><div>The study used an experimental model of Duchenne muscular dystrophy, at 3 stages of degeneration/regeneration of muscle fibers: an acute stage (14-28 days old), acute and stabilized stages (14-42 days old), and a stabilized stage (28-42 days old). Photobiomodulation therapy (also known as low-level light therapy) at 0.6 J was applied 3 times per week to the dystrophic gastrocnemius muscle of mdx mice at ages 14 to 28, 14 to 42, and 28 to 42 days. After the treatment period, the gastrocnemius muscle was collected, and cryosections were prepared for histopathologic analysis.</div></div><div><h3>Results</h3><div>In all 3 stages evaluated, a significant reduction was observed in immunoglobulin G uptake by muscle fibers, the inflammatory area, macrophage infiltration, the reactive dihydroethidium area, and the number of autofluorescent lipofuscin granules in the gastrocnemius muscle of mdx mice after PBMT.</div></div><div><h3>Conclusion</h3><div>The results demonstrated that low-level light therapy, when applied during or after the acute phase of the degeneration/regeneration muscle process, improves the pathological histomorphologic features in dystrophic muscle. Based on these results, PBMT appears to be a promising therapy for dystrophinopathies, warranting further research in humans to verify its efficacy.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"47 5","pages":"Pages 142-154"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/S0161-4754(24)00117-9
{"title":"TOC","authors":"","doi":"10.1016/S0161-4754(24)00117-9","DOIUrl":"10.1016/S0161-4754(24)00117-9","url":null,"abstract":"","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"47 5","pages":"Page A1"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/S0161-4754(24)00116-7
{"title":"Inside front cover Editorial board","authors":"","doi":"10.1016/S0161-4754(24)00116-7","DOIUrl":"10.1016/S0161-4754(24)00116-7","url":null,"abstract":"","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"47 5","pages":"Page IFC"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/S0161-4754(24)00118-0
{"title":"Information for Readers","authors":"","doi":"10.1016/S0161-4754(24)00118-0","DOIUrl":"10.1016/S0161-4754(24)00118-0","url":null,"abstract":"","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"47 5","pages":"Page A2"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/j.jmpt.2024.09.001
Anna Karolina M.L. Oliveira MSc , Victor R. Neves PhD , Patrícia F. Trevizan PhD , Rafael D.B. Oliveira PT , Danielle Aparecida Gomes Pereira PhD
Objective
The purpose of this study was to evaluate the accuracy of heel rise test (HRT) for assessing the functional capacity (FC) of individuals with peripheral arterial disease (PAD) and determine the best sensitivity cutoff point to stratify individuals with worse FC.
Methods
This retrospective methodological study included adults of both sexes diagnosed with PAD and intermittent claudication. Individuals performed the HRT (number of plantar flexions, execution time, and execution rate were recorded) and the incremental shuttle walking test (distance walked was recorded). The accuracy analysis and the determination of the sensitivity of the HRT in assessing FC were performed by the receiver operating characteristic curve based on the following incremental shuttle walking test cutoff point: 380 meters. Alpha was set at 5%.
Results
In this study, 120 individuals were included (64 ± 9.65 years). The number of plantar flexions showed better accuracy for FC assessment (area under the curve, 0.78; 95% CI, 0.65-0.90). The best sensitivity cutoff to stratify the individuals with the worst FC was 63 plantar flexions (sensitivity, 0.952; specificity, 0.562).
Conclusion
The HRT showed good accuracy, adequate sensitivity, and acceptable specificity in assessing the FC of individuals with PAD. The best sensitivity cutoff point to stratify individuals with worse FC was 63 plantar flexions.
研究目的本研究旨在评估足跟站立试验(HRT)在评估外周动脉疾病(PAD)患者功能能力(FC)方面的准确性,并确定最佳灵敏度临界点,以对功能能力较差的患者进行分层:这项回顾性方法学研究包括被诊断患有 PAD 和间歇性跛行的成年男女。受试者进行了HRT(记录跖屈次数、执行时间和执行率)和增量穿梭步行测试(记录步行距离)。根据以下增量穿梭步行测试临界点:380 米,通过接收器操作特征曲线对 HRT 评估 FC 的准确性和灵敏度进行了分析。α设定为5%:本研究共纳入 120 人(64 ± 9.65 岁)。跖屈次数对 FC 评估的准确性更高(曲线下面积,0.78;95% CI,0.65-0.90)。对 FC 最差者进行分层的最佳灵敏度临界值为 63 个跖屈(灵敏度为 0.952;特异度为 0.562):结论:HRT 在评估 PAD 患者的 FC 方面具有良好的准确性、足够的灵敏度和可接受的特异性。对 FC 较差的患者进行分层的最佳灵敏度临界点是跖屈63次。
{"title":"Heel Rise Test Accuracy in the Assessment of the Functional Capacity of Individuals With Peripheral Arterial Disease","authors":"Anna Karolina M.L. Oliveira MSc , Victor R. Neves PhD , Patrícia F. Trevizan PhD , Rafael D.B. Oliveira PT , Danielle Aparecida Gomes Pereira PhD","doi":"10.1016/j.jmpt.2024.09.001","DOIUrl":"10.1016/j.jmpt.2024.09.001","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to evaluate the accuracy of heel rise test (HRT) for assessing the functional capacity (FC) of individuals with peripheral arterial disease (PAD) and determine the best sensitivity cutoff point to stratify individuals with worse FC.</div></div><div><h3>Methods</h3><div>This retrospective methodological study included adults of both sexes diagnosed with PAD and intermittent claudication. Individuals performed the HRT (number of plantar flexions, execution time, and execution rate were recorded) and the incremental shuttle walking test (distance walked was recorded). The accuracy analysis and the determination of the sensitivity of the HRT in assessing FC were performed by the receiver operating characteristic curve based on the following incremental shuttle walking test cutoff point: 380 meters. Alpha was set at 5%.</div></div><div><h3>Results</h3><div>In this study, 120 individuals were included (64 ± 9.65 years). The number of plantar flexions showed better accuracy for FC assessment (area under the curve, 0.78; 95% CI, 0.65-0.90). The best sensitivity cutoff to stratify the individuals with the worst FC was 63 plantar flexions (sensitivity, 0.952; specificity, 0.562).</div></div><div><h3>Conclusion</h3><div>The HRT showed good accuracy, adequate sensitivity, and acceptable specificity in assessing the FC of individuals with PAD. The best sensitivity cutoff point to stratify individuals with worse FC was 63 plantar flexions.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"47 5","pages":"Pages 107-113"},"PeriodicalIF":1.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}