This study aimed to investigate the effects of aquatic exercises (AEs) and total resistance exercises (TRX) on the pain and function of women with knee osteoarthritis.
Methods
This randomized controlled trial was conducted on 53 patients diagnosed with knee osteoarthritis. The patients were randomly allocated into 3 groups of TRX (n = 19), AEs (n = 18), and control (n = 16). The experimental groups received 8 weeks of TRX and AEs, and the control group only received medication. Outcomes were measured before, after 8-weeks of intervention, and after a 6-month follow-up. Outcomes were the visual analog scale (VAS), the quadriceps strength was examined by a dynamometer, the function was assessed using the Western Ontario and McMaster universities osteoarthritis index (WOMAC), functional capacity was measured using the timed up and go test (TUG), 40-meter walking speed (WS) test, and going up and down 8-stair (GUDS), and the quality of life (QOL) was evaluated using the SF-36.
Results
Pain and QOL improved significantly after the 8-week intervention and 6-month follow-up in both experimental groups (P < .05). However, quadriceps strength, TUG, WS, and GUDS improved significantly after the 8-week intervention and 6-month follow-up only in the TRX group (P < .05). In addition, the WOMAC improved only in the AEs group (P < .05).
Conclusions
The TRX intervention enhanced the strength and functional capacity of the patients with knee osteoarthritis more effectively compared to the AEs, while improving pain and QOL were similar to the AEs.
{"title":"Effect of Total Resistance Exercises and Aquatic Exercises on Pain and Function of People With Knee Osteoarthritis: A Randomized Controlled Trial","authors":"Shirin Assar MD , Farzaneh Gandomi PhD , Homayoun Abbasi PhD","doi":"10.1016/j.jmpt.2025.10.063","DOIUrl":"10.1016/j.jmpt.2025.10.063","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effects of aquatic exercises (AEs) and total resistance exercises (TRX) on the pain and function of women with knee osteoarthritis.</div></div><div><h3>Methods</h3><div>This randomized controlled trial was conducted on 53 patients diagnosed with knee osteoarthritis. The patients were randomly allocated into 3 groups of TRX (n = 19), AEs (n = 18), and control (n = 16). The experimental groups received 8 weeks of TRX and AEs, and the control group only received medication. Outcomes were measured before, after 8-weeks of intervention, and after a 6-month follow-up. Outcomes were the visual analog scale (VAS), the quadriceps strength was examined by a dynamometer, the function was assessed using the Western Ontario and McMaster universities osteoarthritis index (WOMAC), functional capacity was measured using the timed up and go test (TUG), 40-meter walking speed (WS) test, and going up and down 8-stair (GUDS), and the quality of life (QOL) was evaluated using the SF-36.</div></div><div><h3>Results</h3><div>Pain and QOL improved significantly after the 8-week intervention and 6-month follow-up in both experimental groups (<em>P</em> < .05). However, quadriceps strength, TUG, WS, and GUDS improved significantly after the 8-week intervention and 6-month follow-up only in the TRX group (<em>P</em> < .05). In addition, the WOMAC improved only in the AEs group (<em>P</em> < .05).</div></div><div><h3>Conclusions</h3><div>The TRX intervention enhanced the strength and functional capacity of the patients with knee osteoarthritis more effectively compared to the AEs, while improving pain and QOL were similar to the AEs.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"48 6","pages":"Pages 904-913"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145549642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-11-13DOI: 10.1016/j.jmpt.2025.10.062
Bihter Akınoğlu , Tuğba Kocahan
Objective
The purpose of this study was to compare the static and dynamic balance ability of para taekwondo athletes, taekwondo athletes, and sedentary healthy individuals.
Methods
This comparative cross-sectional study was conducted with 9 para taekwondo athletes, 9 taekwondo athletes, and 11 healthy individuals with sedentary lifestyles. Static balance ability and dynamic balance ability were evaluated.
Results
The 2-leg static balance test area of the sedentary healthy group was lower than that of para taekwondo athletes. The duration of the single-leg static balance test was greater in para taekwondo athletes than in other groups, and the area was greater in taekwondo athletes than in other groups. The dynamic balance area was higher in the para taekwondo group than in the sedentary group.
Conclusion
Para taekwondo athletes with upper limb deficiency at or below the elbow level had worse static 2-leg and single-leg static balance. However, the functional balance of these athletes was better compared to that of healthy individuals.
{"title":"Balance Ability in Para Taekwondo Athletes: A Cross-Sectional Study","authors":"Bihter Akınoğlu , Tuğba Kocahan","doi":"10.1016/j.jmpt.2025.10.062","DOIUrl":"10.1016/j.jmpt.2025.10.062","url":null,"abstract":"<div><h3>Objective</h3><div>The purpose of this study was to compare the static and dynamic balance ability of para taekwondo athletes, taekwondo athletes, and sedentary healthy individuals.</div></div><div><h3>Methods</h3><div>This comparative cross-sectional study was conducted with 9 para taekwondo athletes, 9 taekwondo athletes, and 11 healthy individuals with sedentary lifestyles. Static balance ability and dynamic balance ability were evaluated.</div></div><div><h3>Results</h3><div>The 2-leg static balance test area of the sedentary healthy group was lower than that of para taekwondo athletes. The duration of the single-leg static balance test was greater in para taekwondo athletes than in other groups, and the area was greater in taekwondo athletes than in other groups. The dynamic balance area was higher in the para taekwondo group than in the sedentary group.</div></div><div><h3>Conclusion</h3><div>Para taekwondo athletes with upper limb deficiency at or below the elbow level had worse static 2-leg and single-leg static balance. However, the functional balance of these athletes was better compared to that of healthy individuals.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"48 6","pages":"Pages 770-777"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145505116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-12-19DOI: 10.1016/S0161-4754(25)00131-9
{"title":"Information for Readers","authors":"","doi":"10.1016/S0161-4754(25)00131-9","DOIUrl":"10.1016/S0161-4754(25)00131-9","url":null,"abstract":"","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"48 6","pages":"Page A4"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145789642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-11-10DOI: 10.1016/j.jmpt.2025.10.047
Shanshan Xu PhD , Fai Fai Ho MPH , Talos Ming Hong Kwong BSc , Angus Siu-cheong Li PhD , Eun Hae Ha PhD , Heyu Hua PhD , Ching Liong PhD , Kwan Chi Leung PhD , Betty Huan Wang PhD , Ting Hung Leung PhD , Zhixiu Lin PhD , Samuel Yeung-Shan Wong PhD , Faming Pan PhD , Vincent Chi Ho Chung PhD
Objective
This study aimed to evaluate the satisfaction of patients with and without COVID-19 when using traditional Chinese medicine (TCM) telemedicine during the pandemic in Hong Kong.
Methods
This was a cross-sectional study of 122 COVID-19 patients and 90 non-COVID-19 patients who utilized a TCM telemedicine service provided by The Chinese University of Hong Kong Chinese Medicine Specialty Clinic cum Clinical Teaching and Research Centre during March to April 2022. A Telemedicine Satisfaction Questionnaire, consisting of factors of Information Exchange and Patient Comfort, was administered via an online survey after video consultations. Patients’ satisfaction on these aspects of satisfaction was assessed. Subgroup and linear regression analyses were conducted to explore patient characteristics associated with satisfaction with telemedicine.
Results
Overall patient satisfaction with Information Exchange was good (28.00 [4.00] out of 35), but rating on Patient Comfort was mediocre (21.00 [5.00] out of 35), with a clear preference for face-to-face consultation. Compared to non-COVID-19 patients, the total score for Information Exchange was slightly lower amongst those consulted for COVID-19, as a majority of them are new patients without a per-existing relationship with the clinician. Satisfaction tended to be higher among patients who were younger, female, better-educated, employed, and had complete COVID-19 vaccinations.
Conclusions
Despite being fairly satisfied with the TCM telemedicine service, both COVID-19 and non-COVID-19 patients expressed a preference for face-to-face consultation. While improving clinician-patient interaction during video consultation is expected to improve communication quality, it is expected that demand for face-to-face TCM services will rebound in the post-COVID era.
{"title":"Patient Satisfaction With Traditional Chinese Medicine Telemedicine Service During the COVID-19 Pandemic: A Cross-Sectional Study","authors":"Shanshan Xu PhD , Fai Fai Ho MPH , Talos Ming Hong Kwong BSc , Angus Siu-cheong Li PhD , Eun Hae Ha PhD , Heyu Hua PhD , Ching Liong PhD , Kwan Chi Leung PhD , Betty Huan Wang PhD , Ting Hung Leung PhD , Zhixiu Lin PhD , Samuel Yeung-Shan Wong PhD , Faming Pan PhD , Vincent Chi Ho Chung PhD","doi":"10.1016/j.jmpt.2025.10.047","DOIUrl":"10.1016/j.jmpt.2025.10.047","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to evaluate the satisfaction of patients with and without COVID-19 when using traditional Chinese medicine (TCM) telemedicine during the pandemic in Hong Kong.</div></div><div><h3>Methods</h3><div>This was a cross-sectional study of 122 COVID-19 patients and 90 non-COVID-19 patients who utilized a TCM telemedicine service provided by The Chinese University of Hong Kong Chinese Medicine Specialty Clinic cum Clinical Teaching and Research Centre during March to April 2022. A Telemedicine Satisfaction Questionnaire, consisting of factors of Information Exchange and Patient Comfort, was administered via an online survey after video consultations. Patients’ satisfaction on these aspects of satisfaction was assessed. Subgroup and linear regression analyses were conducted to explore patient characteristics associated with satisfaction with telemedicine.</div></div><div><h3>Results</h3><div>Overall patient satisfaction with Information Exchange was good (28.00 [4.00] out of 35), but rating on Patient Comfort was mediocre (21.00 [5.00] out of 35), with a clear preference for face-to-face consultation. Compared to non-COVID-19 patients, the total score for Information Exchange was slightly lower amongst those consulted for COVID-19, as a majority of them are new patients without a per-existing relationship with the clinician. Satisfaction tended to be higher among patients who were younger, female, better-educated, employed, and had complete COVID-19 vaccinations.</div></div><div><h3>Conclusions</h3><div>Despite being fairly satisfied with the TCM telemedicine service, both COVID-19 and non-COVID-19 patients expressed a preference for face-to-face consultation. While improving clinician-patient interaction during video consultation is expected to improve communication quality, it is expected that demand for face-to-face TCM services will rebound in the post-COVID era.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"48 6","pages":"Pages 671-682"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145482405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study was to assess the reliability of a visual-cognitive system for measuring simple, serial, and choice reaction times, and examined their associations with age, physical activity, and grip strength.
Methods
Ninety participants were divided into 3 age groups (18-34, 35-64, and 65+ years). Reaction times were assessed using a commercially available visual-cognitive training platform. Grip strength was measured with a hand dynamometer, and activity level was evaluated using the International Physical Activity Questionnaire–Short Form (IPAQ-SF).
Results
Choice reaction times differed significantly by age, with younger adults responding faster than older adults (P < .05). Simple and serial reaction times were also shortest in the youngest group. Significant associations were found between reaction times, age, and activity level (P < .05), with no significant differences by sex (P > .05). Intra-rater reliability was highest for simple reaction time (ICC = 0.70-0.80), followed by choice (ICC = 0.66-0.76) and serial (ICC = 0.62-0.73). Between-day reliability was good for simple (ICC = 0.81) and serial (ICC = 0.76) reaction times, and moderate for choice (ICC = 0.63). Inter-rater reliability was good across all measures (ICCs ≥ 0.70).
Conclusions
Choice reaction time appears to be particularly sensitive to age-related differences. Higher activity levels and greater grip strength are associated with faster responses. The tested visual-cognitive technology demonstrated acceptable reliability for assessing performance-related reaction times.
{"title":"Reliability of a Visual-Cognitive Technology in Measuring Reaction Times: Associations with Age, Activity Level, and Grip Strength","authors":"Tülay Çevik Saldıran PT, PhD , Abdurrahman Tanhan PhD , Rabia Çelikel PhD , Erhan Dinçer PhD","doi":"10.1016/j.jmpt.2025.10.054","DOIUrl":"10.1016/j.jmpt.2025.10.054","url":null,"abstract":"<div><h3>Objectives</h3><div>The purpose of this study was to assess the reliability of a visual-cognitive system for measuring simple, serial, and choice reaction times, and examined their associations with age, physical activity, and grip strength.</div></div><div><h3>Methods</h3><div>Ninety participants were divided into 3 age groups (18-34, 35-64, and 65+ years). Reaction times were assessed using a commercially available visual-cognitive training platform. Grip strength was measured with a hand dynamometer, and activity level was evaluated using the International Physical Activity Questionnaire–Short Form (IPAQ-SF).</div></div><div><h3>Results</h3><div>Choice reaction times differed significantly by age, with younger adults responding faster than older adults (<em>P</em> < .05). Simple and serial reaction times were also shortest in the youngest group. Significant associations were found between reaction times, age, and activity level (<em>P</em> < .05), with no significant differences by sex (<em>P</em> > .05). Intra-rater reliability was highest for simple reaction time (ICC = 0.70-0.80), followed by choice (ICC = 0.66-0.76) and serial (ICC = 0.62-0.73). Between-day reliability was good for simple (ICC = 0.81) and serial (ICC = 0.76) reaction times, and moderate for choice (ICC = 0.63). Inter-rater reliability was good across all measures (ICCs ≥ 0.70).</div></div><div><h3>Conclusions</h3><div>Choice reaction time appears to be particularly sensitive to age-related differences. Higher activity levels and greater grip strength are associated with faster responses. The tested visual-cognitive technology demonstrated acceptable reliability for assessing performance-related reaction times.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"48 6","pages":"Pages 789-799"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate tibial nerve dynamics during the straight leg raise (SLR) test in patients with lumbar disc herniation (LDH) and the relationship between neurological symptoms and dynamics at the radiating pain-occurring (RPO) angle.
Methods
Participants with LDH were 20 adults (10 males, 10 females, average age of 58.4 years, average body mass index [BMI] of 21.9 kg/m2) who visited the orthopedic clinic between November 2019 and December 2020. The SLR test was performed at 20°, 40°, and the RPO angle for patients with LDH. In healthy participants, the test was performed at 20°, 40°, and the maximum elevation angle. The excursion and strain of the proximal and distal ends of the tibial nerve were compared using ultrasound imaging at each angle. Furthermore, the nerve dynamics at the RPO angle were compared between the LDH groups with and without neurological symptoms.
Results
Movement at the proximal and distal ends of the tibial nerves at 20° and 40° leg elevation was smaller in the LDH group than in the healthy group. No significant difference was observed in the amounts of strain at these two angles. In LDH, nerve strain at the RPO angle was lower in the group with neurological symptoms than in the group without. During the SLR test, excursion of the tibial nerve was less in LDH than in healthy participants, suggesting that the sciatic nerve was more strained in LDH.
Conclusion
Our findings show an association between insufficient tibial nerve strain during SLR and neurological symptoms.
{"title":"Dynamics of the Tibial Nerve During Straight Leg Raise Test: A Study of Individuals With Lumbar Disc Herniation","authors":"Atsushi Toribe MS , Kyoji Okada PhD , Akira Saito PhD , Minoru Kimoto PhD , Yoshino Terui PhD","doi":"10.1016/j.jmpt.2025.11.001","DOIUrl":"10.1016/j.jmpt.2025.11.001","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to investigate tibial nerve dynamics during the straight leg raise (SLR) test in patients with lumbar disc herniation (LDH) and the relationship between neurological symptoms and dynamics at the radiating pain-occurring (RPO) angle.</div></div><div><h3>Methods</h3><div>Participants with LDH were 20 adults (10 males, 10 females, average age of 58.4 years, average body mass index [BMI] of 21.9 kg/m<sup>2</sup>) who visited the orthopedic clinic between November 2019 and December 2020. The SLR test was performed at 20°, 40°, and the RPO angle for patients with LDH. In healthy participants, the test was performed at 20°, 40°, and the maximum elevation angle. The excursion and strain of the proximal and distal ends of the tibial nerve were compared using ultrasound imaging at each angle. Furthermore, the nerve dynamics at the RPO angle were compared between the LDH groups with and without neurological symptoms.</div></div><div><h3>Results</h3><div>Movement at the proximal and distal ends of the tibial nerves at 20° and 40° leg elevation was smaller in the LDH group than in the healthy group. No significant difference was observed in the amounts of strain at these two angles. In LDH, nerve strain at the RPO angle was lower in the group with neurological symptoms than in the group without. During the SLR test, excursion of the tibial nerve was less in LDH than in healthy participants, suggesting that the sciatic nerve was more strained in LDH.</div></div><div><h3>Conclusion</h3><div>Our findings show an association between insufficient tibial nerve strain during SLR and neurological symptoms.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"48 6","pages":"Pages 967-976"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-11-13DOI: 10.1016/j.jmpt.2025.10.029
Song Wang B.S.Med , Yanping Hu MM , Meijia Ke B.S.Med , Xin Zhao MM , Heran Xiong MM , Chao Xiang MM , Zhen Ruan MM , Shenghua He MM
Objective
This study investigated the potential mechanism by which massage protects against intervertebral disc (IVD) trauma progression.
Methods
A total of 24 male Sprague-Dawley rats were randomly divided into sham, model, and model plus massage groups (8 rats per group). A rat model of lumbar IVD trauma was established by needle puncture combined with intradiscal tumor necrosis factor-alpha (TNF-α) injection. Two days after modeling, rats received massage therapy on the BL23 acupoint once daily. Pain-related behavioral tests were conducted. Hematoxylin-eosin staining was employed for histopathological observation of lumbar IVDs. The levels of oxidative stress-related markers were determined using assay kits. Western blotting was utilized for estimating the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling-associated protein expression in rat lumbar IVDs.
Results
Rats in the massage group had less mechanical allodynia and thermal hyperalgesia. Following massage, the pathological damages in rat lumbar IVDs were improved, reactive oxygen species and malondialdehyde levels were reduced, and superoxide dismutase and glutathione contents were increased. The phosphorylation of JAK2 and STAT3 in lumbar IVDs was inhibited in rats with massage therapy.
Conclusions
Massage improves pain-related behaviors, inhibits oxidative stress, and suppresses the JAK2/STAT3 signaling pathway in puncture-induced rats.
目的：探讨按摩预防椎间盘外伤进展的可能机制。方法：将24只雄性Sprague-Dawley大鼠随机分为假手术组、模型组、模型加推拿组，每组8只。采用针刺联合椎间盘内注射肿瘤坏死因子-α (TNF-α)建立大鼠腰椎IVD损伤模型。造模2 d后，给予大鼠BL23穴按摩治疗，每日1次。进行了与疼痛相关的行为测试。采用苏木精-伊红染色对腰椎ivd进行组织病理学观察。使用测定试剂盒测定氧化应激相关标志物的水平。Western blotting检测大鼠腰椎ivd中Janus kinase 2/signal transducor and activator of transcription 3 （JAK2/STAT3）信号相关蛋白表达。结果：按摩组大鼠机械性异常痛和热痛觉过敏明显减少。按摩后，大鼠腰椎IVDs病理损伤得到改善，活性氧和丙二醛水平降低，超氧化物歧化酶和谷胱甘肽含量升高。按摩可抑制大鼠腰椎ivd中JAK2和STAT3的磷酸化。结论：按摩可改善针刺大鼠的疼痛相关行为，抑制氧化应激，抑制JAK2/STAT3信号通路。
{"title":"Effect of Massage on Regulating Oxidative Stress in Intervertebral Disc Degeneration in a Rat Model","authors":"Song Wang B.S.Med , Yanping Hu MM , Meijia Ke B.S.Med , Xin Zhao MM , Heran Xiong MM , Chao Xiang MM , Zhen Ruan MM , Shenghua He MM","doi":"10.1016/j.jmpt.2025.10.029","DOIUrl":"10.1016/j.jmpt.2025.10.029","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the potential mechanism by which massage protects against intervertebral disc (IVD) trauma progression.</div></div><div><h3>Methods</h3><div>A total of 24 male Sprague-Dawley rats were randomly divided into sham, model, and model plus massage groups (8 rats per group). A rat model of lumbar IVD trauma was established by needle puncture combined with intradiscal tumor necrosis factor-alpha (TNF-α) injection. Two days after modeling, rats received massage therapy on the BL23 acupoint once daily. Pain-related behavioral tests were conducted. Hematoxylin-eosin staining was employed for histopathological observation of lumbar IVDs. The levels of oxidative stress-related markers were determined using assay kits. Western blotting was utilized for estimating the Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling-associated protein expression in rat lumbar IVDs.</div></div><div><h3>Results</h3><div>Rats in the massage group had less mechanical allodynia and thermal hyperalgesia. Following massage, the pathological damages in rat lumbar IVDs were improved, reactive oxygen species and malondialdehyde levels were reduced, and superoxide dismutase and glutathione contents were increased. The phosphorylation of JAK2 and STAT3 in lumbar IVDs was inhibited in rats with massage therapy.</div></div><div><h3>Conclusions</h3><div>Massage improves pain-related behaviors, inhibits oxidative stress, and suppresses the JAK2/STAT3 signaling pathway in puncture-induced rats.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"48 6","pages":"Pages 813-819"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This randomized controlled trial aimed to evaluate the effects of transcutaneous electrical acupoint stimulation (TEAS) on sleep quality and menopausal symptoms in postmenopausal women.
Methods
A total of 69 eligible postmenopausal women were recruited and randomly assigned to 1 of 3 groups: experimental TEAS, sham, or control (n = 23 each), using a block randomization method. The TEAS group received cutaneous electrical stimulation at 5 specific acupuncture points, while the sham group received stimulation at nonrelated points, and the control group received no intervention, all groups received routine primary care. Outcome measures included the Pittsburgh Sleep Quality Index (PSQI) and the Menopause Rating Scale (MRS), administered at baseline, immediately after the intervention, and one month postintervention. Data were analyzed using SPSS24, Kruskal–Wallis, Mann–Whitney, Toki and Chi-square tests. A significance level of P < .05 was considered significant.
Results
Data from 65 participants were analyzed after accounting for exclusions. At baseline, there were no significant differences in PSQI scores across the 3 groups. However, the TEAS group showed significantly greater improvement in PSQI scores immediately after the intervention (7.36 ± 3.21 vs 9.36 ± 2.38 and 9.76 ± 2.46, P = .012) and 1 month later (6.90 ± 2.97 vs 9.04 ± 2.62 and 9.61 ± 2.33, P = .003) compared to the sham and control groups. Although no significant differences in MRS scores were observed immediately postintervention, a significant reduction in menopausal symptoms was noted in the TEAS group 1 month later (26.18 ± 4.83 vs 29.95 ± 5.65 and 27.42 ± 4.15, P = .042).
Conclusion
TEAS appeared to be effective in improving sleep quality and reducing menopausal symptoms in postmenopausal women.
目的：本随机对照试验旨在评估经皮穴位电刺激（TEAS）对绝经后妇女睡眠质量和更年期症状的影响。方法：采用分组随机法，共招募69名符合条件的绝经后妇女，随机分为实验组、假手术组或对照组（n = 23）。tea组在5个特定穴位进行皮电刺激，假手术组在不相关穴位进行皮电刺激，对照组不进行干预，所有组均进行常规初级保健。结果测量包括匹兹堡睡眠质量指数（PSQI）和更年期评定量表（MRS），分别在基线、干预后立即和干预后一个月进行。采用SPSS24、Kruskal-Wallis、Mann-Whitney、Toki和卡方检验对数据进行分析。结果：在排除因素后，对65名参与者的数据进行了分析。在基线时，三组间PSQI评分无显著差异。然而，与假手术组和对照组相比，干预后立即（7.36±3.21 vs 9.36±2.38和9.76±2.46,P = 0.012）和1个月后（6.90±2.97 vs 9.04±2.62和9.61±2.33,P = 0.003）的PSQI评分明显改善。虽然干预后立即观察到MRS评分无显著差异，但1个月后tea组的更年期症状明显减轻（26.18±4.83 vs 29.95±5.65和27.42±4.15,P = 0.042）。结论：tea对改善绝经后妇女的睡眠质量和减轻更年期症状有效。试验注册：伊朗临床试验注册中心IRCT20130812014333N167（注册，18/04/2021）。
{"title":"Effect of Transcutaneous Electrical Acupoint Stimulation on Sleep Quality and Menopausal Symptoms in Postmenopausal Women: A Randomized Controlled Trial","authors":"Somaye Parvandi MSc , Sousan Heydarpour PhD , Behnam Khaledi MSc , Fatemeh Heydarpour PhD","doi":"10.1016/j.jmpt.2025.10.052","DOIUrl":"10.1016/j.jmpt.2025.10.052","url":null,"abstract":"<div><h3>Objectives</h3><div>This randomized controlled trial aimed to evaluate the effects of transcutaneous electrical acupoint stimulation (TEAS) on sleep quality and menopausal symptoms in postmenopausal women.</div></div><div><h3>Methods</h3><div>A total of 69 eligible postmenopausal women were recruited and randomly assigned to 1 of 3 groups: experimental TEAS, sham, or control (n = 23 each), using a block randomization method. The TEAS group received cutaneous electrical stimulation at 5 specific acupuncture points, while the sham group received stimulation at nonrelated points, and the control group received no intervention, all groups received routine primary care. Outcome measures included the Pittsburgh Sleep Quality Index (PSQI) and the Menopause Rating Scale (MRS), administered at baseline, immediately after the intervention, and one month postintervention. Data were analyzed using SPSS24, Kruskal–Wallis, Mann–Whitney, Toki and Chi-square tests. A significance level of <em>P</em> < .05 was considered significant.</div></div><div><h3>Results</h3><div>Data from 65 participants were analyzed after accounting for exclusions. At baseline, there were no significant differences in PSQI scores across the 3 groups. However, the TEAS group showed significantly greater improvement in PSQI scores immediately after the intervention (7.36 ± 3.21 vs 9.36 ± 2.38 and 9.76 ± 2.46, <em>P</em> = .012) and 1 month later (6.90 ± 2.97 vs 9.04 ± 2.62 and 9.61 ± 2.33, <em>P</em> = .003) compared to the sham and control groups. Although no significant differences in MRS scores were observed immediately postintervention, a significant reduction in menopausal symptoms was noted in the TEAS group 1 month later (26.18 ± 4.83 vs 29.95 ± 5.65 and 27.42 ± 4.15, <em>P</em> = .042).</div></div><div><h3>Conclusion</h3><div>TEAS appeared to be effective in improving sleep quality and reducing menopausal symptoms in postmenopausal women.</div></div><div><h3>Trial registration</h3><div>Iranian Clinical Trials Registry IRCT20130812014333N167 (registered, 18/04/2021).</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"48 6","pages":"Pages 871-881"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145513098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-11-10DOI: 10.1016/j.jmpt.2025.10.056
Ruixue Zhao MA , Jiayi Li BA , Jiameng Wang PhD
Objectives
The purpose of this study was to investigate the impact of various dance rhythms on heart rate variability (HRV), to determine the relationship between dance rhythms and HRV during the recovery period, and to provide reliable recommendations for dance interventions in the field of cardiovascular disease.
Method
A total of 160 college students enrolled at Yan’an University as of September 1, 2023 were randomly selected and assigned to 3 groups. Each group underwent dance interventions at rhythms of 60 beats per minute (bpm), 100 bpm, and 140 bpm, respectively, conducted in 3 sessions, each lasting 5 minutes. Heart rate recovery and HRV data were collected before and after the tests for statistical analysis.
Results
Analysis of HRV indicators before the dance rhythm intervention showed no statistically significant difference between men and women (P > .05). However, HRV and the standard deviation of normal-to-normal intervals (SDNN) during the recovery period were statistically significantly different between men and women under different dance rhythm interventions (P < .05). Moreover, HRV and SDNN values after the intervention at 140 bpm were significantly lower than those after the interventions at 60 bpm and 100 bpm (P < .05).
Conclusion
These study results demonstrate that dance rhythm significantly affected HRV. This information may be potentially helpful in informing further research studies for dance interventions in the field of cardiovascular diseases.
{"title":"Effect of Different Dance Rhythms on the Recovery Period of the Autonomic Nervous System","authors":"Ruixue Zhao MA , Jiayi Li BA , Jiameng Wang PhD","doi":"10.1016/j.jmpt.2025.10.056","DOIUrl":"10.1016/j.jmpt.2025.10.056","url":null,"abstract":"<div><h3>Objectives</h3><div>The purpose of this study was to investigate the impact of various dance rhythms on heart rate variability (HRV), to determine the relationship between dance rhythms and HRV during the recovery period, and to provide reliable recommendations for dance interventions in the field of cardiovascular disease.</div></div><div><h3>Method</h3><div>A total of 160 college students enrolled at Yan’an University as of September 1, 2023 were randomly selected and assigned to 3 groups. Each group underwent dance interventions at rhythms of 60 beats per minute (bpm), 100 bpm, and 140 bpm, respectively, conducted in 3 sessions, each lasting 5 minutes. Heart rate recovery and HRV data were collected before and after the tests for statistical analysis.</div></div><div><h3>Results</h3><div>Analysis of HRV indicators before the dance rhythm intervention showed no statistically significant difference between men and women (<em>P</em> > .05). However, HRV and the standard deviation of normal-to-normal intervals (SDNN) during the recovery period were statistically significantly different between men and women under different dance rhythm interventions (<em>P</em> < .05). Moreover, HRV and SDNN values after the intervention at 140 bpm were significantly lower than those after the interventions at 60 bpm and 100 bpm (<em>P</em> < .05).</div></div><div><h3>Conclusion</h3><div>These study results demonstrate that dance rhythm significantly affected HRV. This information may be potentially helpful in informing further research studies for dance interventions in the field of cardiovascular diseases.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"48 6","pages":"Pages 662-670"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145482317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01Epub Date: 2025-11-12DOI: 10.1016/j.jmpt.2025.10.014
Márcia R. de Andrade MSc , Alessandro de Oliveira PhD , Luan A. Pereira MSc , Ismael A.L. Santos BSc , Maria Eduarda P. Campos BSc , Luna S.C. Vaz BSc , Laila C.M. Damázio PhD
Objective
The aim of this study was to investigate the morphology of growth plates (GP) in young rats submitted to high and medium-intensity physical exercise.
Methods
The sample consisted of 24 Wistar rats divided into 3 groups: untrained controls (RC), high-intensity physical exercise (R1), and medium-intensity physical exercise (R2). A weight-adjusted ladder training protocol was adopted (five times a week for 4 weeks). Histomorphometric analysis of the GP of the right tibia was performed in a longitudinal section after staining with hematoxylin-eosin and Gomori’s trichrome, in addition to cell counts and GP thickness measurements. One-way ANOVA and Tukey’s post-test (α < 0.05) were used to analyze the means.
Results
The GP presented inferior thickness and chondrocyte counts in the group that underwent high-intensity physical training (355.5 μm and 1157.3) compared to the control (407.6 μm and 1329.7) and medium-intensity groups (312.4 μm and 1328.5).
Conclusion
High and medium-intensity training promoted a reduction in the GP of young rats compared to the control group. Therefore, ladder training protocols may anticipate GP closure in young rats, thus impairing tibial length in these animals.
{"title":"Effect of Different Intensities of Progressive Physical Exercise on Growth Plate Closure in Young Rats","authors":"Márcia R. de Andrade MSc , Alessandro de Oliveira PhD , Luan A. Pereira MSc , Ismael A.L. Santos BSc , Maria Eduarda P. Campos BSc , Luna S.C. Vaz BSc , Laila C.M. Damázio PhD","doi":"10.1016/j.jmpt.2025.10.014","DOIUrl":"10.1016/j.jmpt.2025.10.014","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to investigate the morphology of growth plates (GP) in young rats submitted to high and medium-intensity physical exercise.</div></div><div><h3>Methods</h3><div>The sample consisted of 24 Wistar rats divided into 3 groups: untrained controls (RC), high-intensity physical exercise (R1), and medium-intensity physical exercise (R2). A weight-adjusted ladder training protocol was adopted (five times a week for 4 weeks). Histomorphometric analysis of the GP of the right tibia was performed in a longitudinal section after staining with hematoxylin-eosin and Gomori’s trichrome, in addition to cell counts and GP thickness measurements. One-way ANOVA and Tukey’s post-test (<em>α</em> < 0.05) were used to analyze the means.</div></div><div><h3>Results</h3><div>The GP presented inferior thickness and chondrocyte counts in the group that underwent high-intensity physical training (355.5 μm and 1157.3) compared to the control (407.6 μm and 1329.7) and medium-intensity groups (312.4 μm and 1328.5).</div></div><div><h3>Conclusion</h3><div>High and medium-intensity training promoted a reduction in the GP of young rats compared to the control group. Therefore, ladder training protocols may anticipate GP closure in young rats, thus impairing tibial length in these animals.</div></div>","PeriodicalId":16132,"journal":{"name":"Journal of Manipulative and Physiological Therapeutics","volume":"48 6","pages":"Pages 698-705"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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