Background: The treatment staff should properly understand infection prevention and control (IPC) methods. Adherence to IPC has significant implications and outcomes for maintaining treatment staff safety, patient protection, and environmental care. Objectives: This study was conducted to examine infection control training in doctors. Methods: This study was conducted in Imam Khomeini Hospital in Tehran, Iran, and practitioners in internal and surgical departments participated. The research focused on infection prevention and control (IPC) through specialized workshops and questionnaires using a pre-and post-test design. The sessions included topics such as infection control, transmission, hospital-acquired infections, and components of the IPC program. Questionnaires based on the KAP method evaluated participants' knowledge, attitude, and performance. This study was approved by the university's research vice department and the research ethics committee. Data were analyzed using SPSS software, and the significance of P < 0.05 was emphasized. Results: Of the 251 medical residents, 189 completed the study, 122 of whom were in internal medicine and 67 in surgery. Among the 158 faculty members, 60 completed the study, 39 were in internal medicine, and 21 were in surgery. The mean pre-test scores for internal medicine residents were 15.63 (out of 30) and 13.11 for surgical residents, respectively, which increased to 22.41 and 18.09 in the post-test. Conclusions: The results showed that regular and standard periodic training can improve doctors' knowledge and performance in implementing infection prevention and control programs.
{"title":"How Effective Are In-Hospital Training Workshops on Infection Control for Physicians? First Report in Iran","authors":"Arash Seifi, E. Mohammadnejad, R. Miladi","doi":"10.5812/jkums-148562","DOIUrl":"https://doi.org/10.5812/jkums-148562","url":null,"abstract":"Background: The treatment staff should properly understand infection prevention and control (IPC) methods. Adherence to IPC has significant implications and outcomes for maintaining treatment staff safety, patient protection, and environmental care. Objectives: This study was conducted to examine infection control training in doctors. Methods: This study was conducted in Imam Khomeini Hospital in Tehran, Iran, and practitioners in internal and surgical departments participated. The research focused on infection prevention and control (IPC) through specialized workshops and questionnaires using a pre-and post-test design. The sessions included topics such as infection control, transmission, hospital-acquired infections, and components of the IPC program. Questionnaires based on the KAP method evaluated participants' knowledge, attitude, and performance. This study was approved by the university's research vice department and the research ethics committee. Data were analyzed using SPSS software, and the significance of P < 0.05 was emphasized. Results: Of the 251 medical residents, 189 completed the study, 122 of whom were in internal medicine and 67 in surgery. Among the 158 faculty members, 60 completed the study, 39 were in internal medicine, and 21 were in surgery. The mean pre-test scores for internal medicine residents were 15.63 (out of 30) and 13.11 for surgical residents, respectively, which increased to 22.41 and 18.09 in the post-test. Conclusions: The results showed that regular and standard periodic training can improve doctors' knowledge and performance in implementing infection prevention and control programs.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"5 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Capability of Artificial Intelligence in Enhancing Neonatal Care Quality in Iran","authors":"Mohammad Jalilian, Zohreh Hosseiniposhteh","doi":"10.5812/jkums-145909","DOIUrl":"https://doi.org/10.5812/jkums-145909","url":null,"abstract":"<jats:p/>","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"10 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medicinal Chemistry is Shaping the World of Therapy","authors":"Faisal Muhammad","doi":"10.5812/jkums-145262","DOIUrl":"https://doi.org/10.5812/jkums-145262","url":null,"abstract":"<jats:p />","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"41 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140082751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The use of micronutrients to maintain health, prevent disease, and reduce disease severity is increasing. Objectives: This study aimed to evaluate the impact of the COVID-19 pandemic on the trend of public opinion toward micronutrients in Iran. Methods: An ecological study was conducted in the Google Trend (GT) database. First, users' specified search terms related to “COVID-19,” “corona (Iranian COVID-19),” “vitamin-D,” “vitamin-C,” and “Neurobion” were searched among all searches performed using GTs from January 2017 to 2023. Then, Spearman's correlation coefficient was used to check the correlation between the keywords of Micronutrients with the words COVID-19 during different years. Results: The trend for all three micronutrients (vitamin D and C and Neurobion) increased significantly since 2020, consistent with the search trend for COVID-19, corona, and the waves of COVID-19 in Iran. Vitamin D peaks were observed in 2020 (first wave of COVID-19), vitamin C in 2021 (fifth wave), and Neurobion in 2022 (seventh and eighth waves). There was a high and objective correlation coefficient between COVID-19, vitamin C (R2 = 0.73, P = 0.001), and Neurobion (R2 = 0.63, P = 0.001). However, no correlation was observed with vitamin D (R2 = 0.18, P = 0.12). Conclusions: Based on the results, the search for micronutrients in Iran increased significantly during the COVID-19 pandemic. Public interest might reflect behavior and consumption. GT is a helpful tool for epidemiologists to understand the interests and trends of the general population.
{"title":"Search Trends for Micronutrients on Google Trends in Iran for Historical Effect of the COVID-19 Pandemic: A Ecological Study","authors":"Mohammadreza Rabiee, S. Pourrezaei, M. Mousavi","doi":"10.5812/jkums-139254","DOIUrl":"https://doi.org/10.5812/jkums-139254","url":null,"abstract":"Background: The use of micronutrients to maintain health, prevent disease, and reduce disease severity is increasing. Objectives: This study aimed to evaluate the impact of the COVID-19 pandemic on the trend of public opinion toward micronutrients in Iran. Methods: An ecological study was conducted in the Google Trend (GT) database. First, users' specified search terms related to “COVID-19,” “corona (Iranian COVID-19),” “vitamin-D,” “vitamin-C,” and “Neurobion” were searched among all searches performed using GTs from January 2017 to 2023. Then, Spearman's correlation coefficient was used to check the correlation between the keywords of Micronutrients with the words COVID-19 during different years. Results: The trend for all three micronutrients (vitamin D and C and Neurobion) increased significantly since 2020, consistent with the search trend for COVID-19, corona, and the waves of COVID-19 in Iran. Vitamin D peaks were observed in 2020 (first wave of COVID-19), vitamin C in 2021 (fifth wave), and Neurobion in 2022 (seventh and eighth waves). There was a high and objective correlation coefficient between COVID-19, vitamin C (R2 = 0.73, P = 0.001), and Neurobion (R2 = 0.63, P = 0.001). However, no correlation was observed with vitamin D (R2 = 0.18, P = 0.12). Conclusions: Based on the results, the search for micronutrients in Iran increased significantly during the COVID-19 pandemic. Public interest might reflect behavior and consumption. GT is a helpful tool for epidemiologists to understand the interests and trends of the general population.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"65 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139004261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Helicobacter pylori (H. pylori) induces gastric mucosal inflammation, which may lead to chronic gastritis and gastric ulcer, gastric adenocarcinoma, or mucosa-associated lymphoid tissue (MALT) lymphoma. Managing H. pylori-related complications requires H. pylori eradication. Probiotics are one of the potential supplements that can be effective against H. pylori infection by stabilizing or restoring endogenous physiological flora and preventing H. pylori growth. Objectives: The study aimed to evaluate the effectiveness of a quadruple regimen for H. pylori eradication plus probiotic supplementation. Methods: This randomized placebo-controlled trial was at a gastroenterology clinic in Kermanshah, Iran. A total of 142 H. pylori-positive subjects were randomized into either 10-day quadruple therapy (amoxicillin+ metronidazole+ pantoprazole + bismuth salt) plus placebo or quadruple therapy plus probiotic. H. pylori eradication was evaluated using a stool antigen test six weeks after treatment. The side effects of the treatment were recorded in both groups. Results: A total of three and five patients in the probiotics and placebo group did not complete the treatment or follow-up, respectively. The rate of H. pylori eradication was 44.1 and 34.8% for probiotic and placebo groups, respectively (P = 0.27). At the end of the trial, a lower rate of nausea (P = 0.004), taste disturbance (P = 0.002), headache/dizziness (P = 0.002), and flatulence/epigastric pain (P = 0.004) were recorded in the probiotic group compared to the placebo group. Conclusions: Based on the results, probiotics can be somewhat effective in eradicating H. pylori infection. Probiotic adjunctive therapy is suggested to relieve gastrointestinal symptoms when receiving antibiotic therapy.
{"title":"The Effect of Quadruple Therapy Plus Probiotics on Helicobacter Pylori Eradication and Antibiotic-Associated Side Effects: A Randomized Placebo-Controlled Trial","authors":"Y. Hamzavi, H. Bashiri","doi":"10.5812/jkums-137908","DOIUrl":"https://doi.org/10.5812/jkums-137908","url":null,"abstract":"Background: Helicobacter pylori (H. pylori) induces gastric mucosal inflammation, which may lead to chronic gastritis and gastric ulcer, gastric adenocarcinoma, or mucosa-associated lymphoid tissue (MALT) lymphoma. Managing H. pylori-related complications requires H. pylori eradication. Probiotics are one of the potential supplements that can be effective against H. pylori infection by stabilizing or restoring endogenous physiological flora and preventing H. pylori growth. Objectives: The study aimed to evaluate the effectiveness of a quadruple regimen for H. pylori eradication plus probiotic supplementation. Methods: This randomized placebo-controlled trial was at a gastroenterology clinic in Kermanshah, Iran. A total of 142 H. pylori-positive subjects were randomized into either 10-day quadruple therapy (amoxicillin+ metronidazole+ pantoprazole + bismuth salt) plus placebo or quadruple therapy plus probiotic. H. pylori eradication was evaluated using a stool antigen test six weeks after treatment. The side effects of the treatment were recorded in both groups. Results: A total of three and five patients in the probiotics and placebo group did not complete the treatment or follow-up, respectively. The rate of H. pylori eradication was 44.1 and 34.8% for probiotic and placebo groups, respectively (P = 0.27). At the end of the trial, a lower rate of nausea (P = 0.004), taste disturbance (P = 0.002), headache/dizziness (P = 0.002), and flatulence/epigastric pain (P = 0.004) were recorded in the probiotic group compared to the placebo group. Conclusions: Based on the results, probiotics can be somewhat effective in eradicating H. pylori infection. Probiotic adjunctive therapy is suggested to relieve gastrointestinal symptoms when receiving antibiotic therapy.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"4 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farzan Soltani, Sahar Mafi, Ladan Jamshidy, Maryam Rad
Background: The Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Questionnaire is a validated instrument extensively used to diagnose TMD. Objectives: This study aimed to determine the reliability and validity of the Persian translation of the DC/TMD. Methods: A team of specialists assessed the questionnaire's final version for content and form validity after translation. A questionnaire was given to 150 students at the Kermanshah Faculty of Dentistry. The convergent validity was assessed by determining the connection between item scores and computing Cronbach's alpha coefficient. The test-retest reliability was evaluated by comparing the results obtained in two phases using the correlation and intraclass correlation coefficients of 30 students from the Faculty of Dentistry. Results: The ICC coefficient of the Persian DC/TMD questionnaire was 0.98. The questionnaire's overall Kaiser-Meyer-Olkin (KMO) measure was 0.62, suggesting that the questions were acceptable. The Bartlett's test was significant (P < 0.0001). The internal consistency of each question was strong, with a Cronbach's alpha rating of 0.90 or above. The content validity index (CVI) indicated an appropriate degree of content validity, which was 0.95. Conclusions: The Persian version of the questionnaire can be utilized in clinical settings to diagnose and assess TMD among Persian speaking populations.
{"title":"Validity and Reliability of the Persian Translation of the Diagnostic Criteria for Temporomandibular Disorders Questionnaire","authors":"Farzan Soltani, Sahar Mafi, Ladan Jamshidy, Maryam Rad","doi":"10.5812/jkums-140581","DOIUrl":"https://doi.org/10.5812/jkums-140581","url":null,"abstract":"Background: The Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) Questionnaire is a validated instrument extensively used to diagnose TMD. Objectives: This study aimed to determine the reliability and validity of the Persian translation of the DC/TMD. Methods: A team of specialists assessed the questionnaire's final version for content and form validity after translation. A questionnaire was given to 150 students at the Kermanshah Faculty of Dentistry. The convergent validity was assessed by determining the connection between item scores and computing Cronbach's alpha coefficient. The test-retest reliability was evaluated by comparing the results obtained in two phases using the correlation and intraclass correlation coefficients of 30 students from the Faculty of Dentistry. Results: The ICC coefficient of the Persian DC/TMD questionnaire was 0.98. The questionnaire's overall Kaiser-Meyer-Olkin (KMO) measure was 0.62, suggesting that the questions were acceptable. The Bartlett's test was significant (P < 0.0001). The internal consistency of each question was strong, with a Cronbach's alpha rating of 0.90 or above. The content validity index (CVI) indicated an appropriate degree of content validity, which was 0.95. Conclusions: The Persian version of the questionnaire can be utilized in clinical settings to diagnose and assess TMD among Persian speaking populations.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"3 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138584676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Identifying patient characteristics that may contribute to significant complications and mortality is essential. Objectives: This study was conducted to evaluate the mortality and survival of patients with COVID-19 by blood type. Methods: This study was performed on 644 patients with COVID-19 by a retrospective cohort method using recorded data of patients admitted to Farabi and Golestan-Kermanshah hospitals. The data were extracted from patients' records through a researcher-made checklist. Logistic regression and Cox regression models were utilized in STATA software version 14 to analyze the data. Results: About 74.53% of patients were male, and the average age was 52.55 ± 16.9 years. The prevalence of blood groups was 22.67% (n = 146) O, 11.49% (n = 74) AB, 24.38% (n = 157) B, and 41.46% (n = 267) A, respectively. Approximately 69.05% of patients were in the intensive care unit, 37.27% experienced intubations, and 18.94% died. The results showed that the chance of death in blood group AB, B, and A was 1.05 (P = 0.910) times, 2.09 (P = 0.022) times, and 2.29 (P = 0.005) times higher than in blood group O. In addition, the survival of patients with blood group A was lower than other blood groups (P = 0.001). Conclusions: Based on the results, blood groups O and B had a protective role against the death of COVID-19. Blood type O also required less intubation but was hospitalized longer.
{"title":"The Effects of Blood Group Types on the Mortality and Survival of Patients with COVID-19 Infection","authors":"Zahra Naghibifar, Alireza Janbakhsh, Marya Shirvani, Armin Naghipour","doi":"10.5812/jkums-138949","DOIUrl":"https://doi.org/10.5812/jkums-138949","url":null,"abstract":"Background: Identifying patient characteristics that may contribute to significant complications and mortality is essential. Objectives: This study was conducted to evaluate the mortality and survival of patients with COVID-19 by blood type. Methods: This study was performed on 644 patients with COVID-19 by a retrospective cohort method using recorded data of patients admitted to Farabi and Golestan-Kermanshah hospitals. The data were extracted from patients' records through a researcher-made checklist. Logistic regression and Cox regression models were utilized in STATA software version 14 to analyze the data. Results: About 74.53% of patients were male, and the average age was 52.55 ± 16.9 years. The prevalence of blood groups was 22.67% (n = 146) O, 11.49% (n = 74) AB, 24.38% (n = 157) B, and 41.46% (n = 267) A, respectively. Approximately 69.05% of patients were in the intensive care unit, 37.27% experienced intubations, and 18.94% died. The results showed that the chance of death in blood group AB, B, and A was 1.05 (P = 0.910) times, 2.09 (P = 0.022) times, and 2.29 (P = 0.005) times higher than in blood group O. In addition, the survival of patients with blood group A was lower than other blood groups (P = 0.001). Conclusions: Based on the results, blood groups O and B had a protective role against the death of COVID-19. Blood type O also required less intubation but was hospitalized longer.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nzar Hussein Hassan, Afsaneh Shamsi, P. Soufivand, Fariborz Bahremand, M. Taghadosi, Seyed Askar Roghani
Background: Cardiovascular disease (CVD) is the most considerable long-term outcome of rheumatoid arthritis (RA) and the leading cause of premature death in RA patients. The pathogenesis of CVD in RA is largely determined by persistent systemic inflammation and its underlying factors, including chemokines. In this regard, C-X-C motif chemokine ligand 12 (CXCL12) has a crucial role in the CVD and RA pathogenesis. For the first time, plasma CXCL12 was related to conventional CV risk and well-established cardiac biomarkers in RA patients. Methods: This study was conducted on 30 RA patients who have been newly diagnosed, 30 under-treatment RA patients, and 30 healthy subjects. The plasma levels of CXCL12 and N-terminal pro-B-type natriuretic peptide (NT-ProBNP) were measured using the enzyme-linked immunosorbent assay (ELISA) technique. The high sensitivity C-reactive protein (HS-CRP) concentration was evaluated in plasma samples using the ADVIA 1800 Clinical Chemistry System based on the latex-enhanced immunoturbidimetric assay. The CVD risk was measured by calculating the Framingham risk score (FRS) and systematic coronary risk evaluation (SCORE). Results: The mean FRS and plasma concentration of high-density lipid (HDL), NT-proBNP, and HS-CRP were significantly different between the three groups (P = 0.029, P < 0.001, P = 0.016, P < 0.001, respectively). A significant positive correlation was found between CXCL12 with disease activity score-28 (DAS-28) (P = 0.024, r = 0.293) and NT-proBNP (P < 0.0001, r = 0.570) in the patients’ group. Conclusions: Based on the results, there was a significant relationship between the inflammatory mediator CXCL12 and a well-known cardiac biomarker, NT-proBNP.
背景:心血管疾病(CVD)是类风湿性关节炎(RA)最重要的长期结局，也是RA患者过早死亡的主要原因。RA中CVD的发病机制在很大程度上取决于持续的全身炎症及其潜在因素，包括趋化因子。因此，C-X-C基序趋化因子配体12 (CXCL12)在CVD和RA发病中起着至关重要的作用。这是第一次，血浆CXCL12与RA患者的常规心血管风险和已建立的心脏生物标志物相关。方法:本研究选取30例新诊断的RA患者、30例治疗不足的RA患者和30例健康受试者。采用酶联免疫吸附试验(ELISA)技术检测血浆CXCL12和n端前b型利钠肽(NT-ProBNP)水平。采用基于乳胶增强免疫比浊法的ADVIA 1800临床化学系统评估血浆样品中高灵敏度c -反应蛋白(HS-CRP)浓度。通过计算Framingham风险评分(FRS)和系统冠状动脉风险评估(score)来衡量CVD风险。结果:三组患者FRS均值及血浆高密度脂(HDL)、NT-proBNP、HS-CRP浓度差异均有统计学意义(P = 0.029, P < 0.001, P = 0.016, P < 0.001)。CXCL12与患者组疾病活动性评分-28 (DAS-28) (P = 0.024, r = 0.293)、NT-proBNP (P < 0.0001, r = 0.570)呈显著正相关。结论:基于这些结果，炎症介质CXCL12与著名的心脏生物标志物NT-proBNP之间存在显著关系。
{"title":"The Relationship of Inflammatory Chemokine, CXCL12, with NT-proBNP: A Marker of Congestive Heart Failure in Rheumatoid Arthritis Patients","authors":"Nzar Hussein Hassan, Afsaneh Shamsi, P. Soufivand, Fariborz Bahremand, M. Taghadosi, Seyed Askar Roghani","doi":"10.5812/jkums-141254","DOIUrl":"https://doi.org/10.5812/jkums-141254","url":null,"abstract":"Background: Cardiovascular disease (CVD) is the most considerable long-term outcome of rheumatoid arthritis (RA) and the leading cause of premature death in RA patients. The pathogenesis of CVD in RA is largely determined by persistent systemic inflammation and its underlying factors, including chemokines. In this regard, C-X-C motif chemokine ligand 12 (CXCL12) has a crucial role in the CVD and RA pathogenesis. For the first time, plasma CXCL12 was related to conventional CV risk and well-established cardiac biomarkers in RA patients. Methods: This study was conducted on 30 RA patients who have been newly diagnosed, 30 under-treatment RA patients, and 30 healthy subjects. The plasma levels of CXCL12 and N-terminal pro-B-type natriuretic peptide (NT-ProBNP) were measured using the enzyme-linked immunosorbent assay (ELISA) technique. The high sensitivity C-reactive protein (HS-CRP) concentration was evaluated in plasma samples using the ADVIA 1800 Clinical Chemistry System based on the latex-enhanced immunoturbidimetric assay. The CVD risk was measured by calculating the Framingham risk score (FRS) and systematic coronary risk evaluation (SCORE). Results: The mean FRS and plasma concentration of high-density lipid (HDL), NT-proBNP, and HS-CRP were significantly different between the three groups (P = 0.029, P < 0.001, P = 0.016, P < 0.001, respectively). A significant positive correlation was found between CXCL12 with disease activity score-28 (DAS-28) (P = 0.024, r = 0.293) and NT-proBNP (P < 0.0001, r = 0.570) in the patients’ group. Conclusions: Based on the results, there was a significant relationship between the inflammatory mediator CXCL12 and a well-known cardiac biomarker, NT-proBNP.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"49 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138596536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Oral squamous cell carcinoma (OSCC) represents the most widespread type of squamous cell carcinoma (SCC) in the head and neck region, comprising 90% of all cases of oral cancer. Treatments based on immunological methods, cell therapy, gene therapy, and nanotechnology-based methods have been performed in addition to conventional treatment methods. Objectives: This study aimed to investigate the anticancer effects of polyvinyl alcohol/MgO nanocomposite on human oral cancer cells. Methods: In this study, the structure and size of nanoparticles and nanocomposite were identified using scanning electron microscope (SEM) analysis after synthesizing PVA/MgO nanocomposite. The anticancer activity of the synthesized nanocomposite was investigated against oral cancer cells of KB type. Results: SEM analysis confirmed the proper synthesis of PVA/MgO nanocomposite. MTT test showed that the nanocomposite synthesized in the concentration range of 25-200μl has maximum anticancer properties against KB cancer cells. In addition, PVA/MgO nanocomposite influenced the apoptosis pathway of KB cancer cells by increasing ROS, decreasing mitochondrial membrane potential, and increasing the activities of caspases 3 and 7. Conclusions: Based on the results, the PVA/MgO nanocomposite showed considerable potential as a viable contender for novel anticancer interventions.
{"title":"Evaluating the Anticancer Effects of Polyvinyl Alcohol/Magnesium Oxide Bionanocomposite on Human Oral Cancer Cells","authors":"Hasti Sarabikia, Razieh Souri, Mohsen Safaei","doi":"10.5812/jkums-140157","DOIUrl":"https://doi.org/10.5812/jkums-140157","url":null,"abstract":"Background: Oral squamous cell carcinoma (OSCC) represents the most widespread type of squamous cell carcinoma (SCC) in the head and neck region, comprising 90% of all cases of oral cancer. Treatments based on immunological methods, cell therapy, gene therapy, and nanotechnology-based methods have been performed in addition to conventional treatment methods. Objectives: This study aimed to investigate the anticancer effects of polyvinyl alcohol/MgO nanocomposite on human oral cancer cells. Methods: In this study, the structure and size of nanoparticles and nanocomposite were identified using scanning electron microscope (SEM) analysis after synthesizing PVA/MgO nanocomposite. The anticancer activity of the synthesized nanocomposite was investigated against oral cancer cells of KB type. Results: SEM analysis confirmed the proper synthesis of PVA/MgO nanocomposite. MTT test showed that the nanocomposite synthesized in the concentration range of 25-200μl has maximum anticancer properties against KB cancer cells. In addition, PVA/MgO nanocomposite influenced the apoptosis pathway of KB cancer cells by increasing ROS, decreasing mitochondrial membrane potential, and increasing the activities of caspases 3 and 7. Conclusions: Based on the results, the PVA/MgO nanocomposite showed considerable potential as a viable contender for novel anticancer interventions.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139263020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khosro Farhadi, Mehdi Rahimi, Afshar Shahmohammadi
Background: Urinary tract infection (UTI) is the highest incidence of hospital-acquired infection (HAI), and hospital-acquired urinary tract infections (HAUTI) are a common problem of critical illness. Objectives: This study aimed to determine the epidemiology of HAUTIs in medical intensive care units (ICUs) and hospitals in Kermanshah, Iran. Methods: This cross-sectional and descriptive/analytical study was conducted in the ICUs of hospitals in Kermanshah from March 2018 to 2019. All the recognized HAUTIs were recorded in the Iranian National Nosocomial Infection Surveillance System. Descriptive and inferential statistics such as t-tests and chi-square were used for data interpretation. Results: A total of 1136 patients were admitted to the two ICUs (61 missed out of 1197 patients). The number of patients with UTI was 51, and the overall HAI rate was 4.5%. The results showed a significant relationship between sex and HAUTI (P = 0.038), so women tended to have more HAUTIs than men (6.3 and 3.6%, respectively). A significant relationship was observed between age, date (different seasons of the year), and HAUTI (P = 0.588, 0.115, respectively). Conclusions: There are few studies on HAUTIs, especially on intensive care unit-acquired infections, and more studies are required to describe the epidemiology and management of these problems. Improving conditions for expanding any strategy to reduce infections associated with HAUTIs in ICUs is recommended.
{"title":"The Epidemiology of Hospital-Acquired Urinary Tract Infections in Intensive Care Units in Kermanshah Hospitals (Iran)","authors":"Khosro Farhadi, Mehdi Rahimi, Afshar Shahmohammadi","doi":"10.5812/jkums-137000","DOIUrl":"https://doi.org/10.5812/jkums-137000","url":null,"abstract":"Background: Urinary tract infection (UTI) is the highest incidence of hospital-acquired infection (HAI), and hospital-acquired urinary tract infections (HAUTI) are a common problem of critical illness. Objectives: This study aimed to determine the epidemiology of HAUTIs in medical intensive care units (ICUs) and hospitals in Kermanshah, Iran. Methods: This cross-sectional and descriptive/analytical study was conducted in the ICUs of hospitals in Kermanshah from March 2018 to 2019. All the recognized HAUTIs were recorded in the Iranian National Nosocomial Infection Surveillance System. Descriptive and inferential statistics such as t-tests and chi-square were used for data interpretation. Results: A total of 1136 patients were admitted to the two ICUs (61 missed out of 1197 patients). The number of patients with UTI was 51, and the overall HAI rate was 4.5%. The results showed a significant relationship between sex and HAUTI (P = 0.038), so women tended to have more HAUTIs than men (6.3 and 3.6%, respectively). A significant relationship was observed between age, date (different seasons of the year), and HAUTI (P = 0.588, 0.115, respectively). Conclusions: There are few studies on HAUTIs, especially on intensive care unit-acquired infections, and more studies are required to describe the epidemiology and management of these problems. Improving conditions for expanding any strategy to reduce infections associated with HAUTIs in ICUs is recommended.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134935410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：