D. Spasovski, E. Sandevska, Ljindita Djemaili Jakupi, Ana Vaslievska, Svetlana Krstevska Balkanov, A. Pivkova Veljanovska, Maja Jakimovska, Vladimir Mitreski, Nikola Chamurovski, Kujtim Iseini
{"title":"C-REACTIVE PROTEIN - THE MOST USEFUL REACTANT OF ACUTE PHASE IN RHEUMATOID ARTHRITIS","authors":"D. Spasovski, E. Sandevska, Ljindita Djemaili Jakupi, Ana Vaslievska, Svetlana Krstevska Balkanov, A. Pivkova Veljanovska, Maja Jakimovska, Vladimir Mitreski, Nikola Chamurovski, Kujtim Iseini","doi":"10.55302/jms2361068s","DOIUrl":"https://doi.org/10.55302/jms2361068s","url":null,"abstract":"","PeriodicalId":16444,"journal":{"name":"Journal of Morphological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71081371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In patients with increased PSA (prostate-specific antigen), the next diagnostics tool is transrectal ultrasound-guided biopsy-TRUS. Multiparametric magnetic resonance imaging (mp MRI) as non invasive diagnostic tool is used as a triage test to avoid biopsy, as well as to improve the diagnostics. In our study we want to prove the clinical meaning of T2W pulse sequence and diffusion as a part of mp MRI in prostate malignant lesions detection and their distinction from the benign lesions. This cohort prospective study included 100 patients with increased levels of PSA from 4 ng/ml to 76 ng/ml. The MRI equipment used was Siemens Essenza1,5T with body coil. The results from the T2W pulse sequence and diffusion are correlated with the values of diffusion and ADC map, in which the suspected zones are marked on a template. Patients undergo biopsy depending on the PIRADS (prostate-imaging and reporting data system) classification. The MRI results and the pathohistological findings are then compared. Clinically significant cancer is considered to be a cancer with a Gleason score 6, diameter > 6mm. The values of diffusion with its numerical ADC map are considerably lower for malignant nodules compared to benign ones. Hyposignal of T2W pulse sequence is characterized with score 2 and 3 in benign changes, and 4 and 5 in malignant changes using the PI RADS score system for differentiation. T2W pulse sequence combined with diffusion is a powerful tool for non-invasive differentiation of benign prostatic hyperplastic nodule and prostatitis from a malignant nodule. Keywords:prostate carcinoma, multiparametric MRI, T2Wpulse sequence,diffusion with ADC.
{"title":"THE ROLE OF T2W PULSE SEQUENCE AND DIFFUSION WITH ITS NUMERICAL ADC MAP IN PROSTATE CANCER DIAGNOSIS","authors":"Masha Kostova, Elizabeta Stojovska Jovanovska, Ace Dodevski, Dimitar Veljanovski, Sandra Dejanova Panev, Biljana Prgova Veljanova","doi":"10.55302/jms2362066k","DOIUrl":"https://doi.org/10.55302/jms2362066k","url":null,"abstract":"In patients with increased PSA (prostate-specific antigen), the next diagnostics tool is transrectal ultrasound-guided biopsy-TRUS. Multiparametric magnetic resonance imaging (mp MRI) as non invasive diagnostic tool is used as a triage test to avoid biopsy, as well as to improve the diagnostics. In our study we want to prove the clinical meaning of T2W pulse sequence and diffusion as a part of mp MRI in prostate malignant lesions detection and their distinction from the benign lesions. This cohort prospective study included 100 patients with increased levels of PSA from 4 ng/ml to 76 ng/ml. The MRI equipment used was Siemens Essenza1,5T with body coil. The results from the T2W pulse sequence and diffusion are correlated with the values of diffusion and ADC map, in which the suspected zones are marked on a template. Patients undergo biopsy depending on the PIRADS (prostate-imaging and reporting data system) classification. The MRI results and the pathohistological findings are then compared. Clinically significant cancer is considered to be a cancer with a Gleason score 6, diameter > 6mm. The values of diffusion with its numerical ADC map are considerably lower for malignant nodules compared to benign ones. Hyposignal of T2W pulse sequence is characterized with score 2 and 3 in benign changes, and 4 and 5 in malignant changes using the PI RADS score system for differentiation. T2W pulse sequence combined with diffusion is a powerful tool for non-invasive differentiation of benign prostatic hyperplastic nodule and prostatitis from a malignant nodule. Keywords:prostate carcinoma, multiparametric MRI, T2Wpulse sequence,diffusion with ADC.","PeriodicalId":16444,"journal":{"name":"Journal of Morphological Sciences","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olivera Jordanova, Velibor Tasic, Aspazija Sofijanova, Svetlana Cekovska, Sonja Bojadzieva, Nora Abazi, Danilo Nonkulovski, Aleksandra Janchevska, Bojan Teov, Marija Torkovska, Ardiana Bekjiri Jasari
Chronic kidney disease(CKD) typically develops as a consequence of gradually advancing kidney ailments, and it rarely sees complete reversibility. The aim of the study is to evaluate the value of urinary biomarkers in children with progression of chronic kidney disease. The is a retrospective-prospective study in which includes 95 pediatric patients with clinical signs, symptoms, laboratory analyses, and imaging studies for CKD. The patients are aged 0 to 14 years who came to the University Clinic for Children's Diseases-Skopje at the nephrology department and the subspecialist nephrology outpatient clinic, in period from January 2019 to June 2022. The study group is divided into three groups, study group 1, which includes 41/95 pediatric patients(43.16%)with congenital anomalies of the kidneys and urinary tract, study group 2, which includes 34/95 pediatric patients(35.79%)with tubulopathies and metabolic disorders with renal affection and study group three which includes20/95(21.05%)pediatric patients with other nephrological-urological diseases. In our study, CKD is more prevalent in males 64 (67.37%) while 31 (32.63%) are females, according to age, patients aged 5-14 years (57.3 %). The average values of urine NGAL(ng/ml), β2-Microglobulin and albuminirua showed that there is a significant difference in relation to this parameter in three groups of pediatric patients at the first examination (p<0.05). As the landscape of CKD continues to reveal novel insights into its intricate mechanisms, urine biomarkers will continue to assume a pivotal role in furthering our comprehension of the disease and shaping the trajectory of personalized medicine for CKD children. Keywords: chronic kidney disease (CKD), urine biomarkers, NGAL (Neutrophil Gelatinase Associated Lipocalin.
{"title":"DIAGNOSTIC VALUE OF URINARY BIOMARKERS IN CHRONIC KIDNEY DISEASES AT CHILDREN","authors":"Olivera Jordanova, Velibor Tasic, Aspazija Sofijanova, Svetlana Cekovska, Sonja Bojadzieva, Nora Abazi, Danilo Nonkulovski, Aleksandra Janchevska, Bojan Teov, Marija Torkovska, Ardiana Bekjiri Jasari","doi":"10.55302/jms2362050j","DOIUrl":"https://doi.org/10.55302/jms2362050j","url":null,"abstract":"Chronic kidney disease(CKD) typically develops as a consequence of gradually advancing kidney ailments, and it rarely sees complete reversibility. The aim of the study is to evaluate the value of urinary biomarkers in children with progression of chronic kidney disease. The is a retrospective-prospective study in which includes 95 pediatric patients with clinical signs, symptoms, laboratory analyses, and imaging studies for CKD. The patients are aged 0 to 14 years who came to the University Clinic for Children's Diseases-Skopje at the nephrology department and the subspecialist nephrology outpatient clinic, in period from January 2019 to June 2022. The study group is divided into three groups, study group 1, which includes 41/95 pediatric patients(43.16%)with congenital anomalies of the kidneys and urinary tract, study group 2, which includes 34/95 pediatric patients(35.79%)with tubulopathies and metabolic disorders with renal affection and study group three which includes20/95(21.05%)pediatric patients with other nephrological-urological diseases. In our study, CKD is more prevalent in males 64 (67.37%) while 31 (32.63%) are females, according to age, patients aged 5-14 years (57.3 %). The average values of urine NGAL(ng/ml), β2-Microglobulin and albuminirua showed that there is a significant difference in relation to this parameter in three groups of pediatric patients at the first examination (p<0.05). As the landscape of CKD continues to reveal novel insights into its intricate mechanisms, urine biomarkers will continue to assume a pivotal role in furthering our comprehension of the disease and shaping the trajectory of personalized medicine for CKD children. Keywords: chronic kidney disease (CKD), urine biomarkers, NGAL (Neutrophil Gelatinase Associated Lipocalin.","PeriodicalId":16444,"journal":{"name":"Journal of Morphological Sciences","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristina Skeparovska, Ana Ilkoski, Aleksandra Biljan, Marta Drogrishki, Biljana Simonovska, Stefanija Mitrovska
Early pregnancy loss is associated with various psychological symptoms shortly after the miscarriage which, in some patients, can persist a longer period of time. The main goal of our study is to establish the occurrence-rate and risk factors for development of these symptoms. Patients with early pregnancy lose, who came in hospital were enrolled in the study. The HADS (Hospital Anxiety and Depression Scale) was used to measure symptoms of depression and/or anxiety of these patients. Chi-square test was used for statistical analysis. Out of total 70 patients, 60% reported symptoms of depression and/or anxiety at some point during the study. Half of them, i.e. 54.2% display the symptoms on the day of admission to the hospital, while 9.5% of the patients demonstrated onset of symptoms of depression and/or anxiety one month after the incident. The symptoms persisted at least one month following the miscarriage, in 64.3% of the patients. Regarding the studied variables (nationality, level of education, employment and marital status as well as number of previous pregnancy loss and the number of children), none of them shows statistically significant difference for developing symptoms of depression and/or anxiety. 60% of women display symptoms of anxiety or/and depression following early pregnancy loss, majority of them immediate after the incident, so every hospital should be well-staffed by professionals and able to provide an adequate care and psychological support for these patients. The study failed to reveal any risk factor (among selected) significantly associated with development of symptoms of depression and anxiety. Hence, every woman with such diagnosis can potentially develop psychological stress, and should be monitored carefully. Keywords: anxiety, depression, early pregnancyloss, HADS.
{"title":"DEPRESSION AND ANXIETY FOLLOWING EARLY PREGNANCY LOSS – OCCURRENCE AND RISK FACTORS","authors":"Kristina Skeparovska, Ana Ilkoski, Aleksandra Biljan, Marta Drogrishki, Biljana Simonovska, Stefanija Mitrovska","doi":"10.55302/jms2362165s","DOIUrl":"https://doi.org/10.55302/jms2362165s","url":null,"abstract":"Early pregnancy loss is associated with various psychological symptoms shortly after the miscarriage which, in some patients, can persist a longer period of time. The main goal of our study is to establish the occurrence-rate and risk factors for development of these symptoms. Patients with early pregnancy lose, who came in hospital were enrolled in the study. The HADS (Hospital Anxiety and Depression Scale) was used to measure symptoms of depression and/or anxiety of these patients. Chi-square test was used for statistical analysis. Out of total 70 patients, 60% reported symptoms of depression and/or anxiety at some point during the study. Half of them, i.e. 54.2% display the symptoms on the day of admission to the hospital, while 9.5% of the patients demonstrated onset of symptoms of depression and/or anxiety one month after the incident. The symptoms persisted at least one month following the miscarriage, in 64.3% of the patients. Regarding the studied variables (nationality, level of education, employment and marital status as well as number of previous pregnancy loss and the number of children), none of them shows statistically significant difference for developing symptoms of depression and/or anxiety. 60% of women display symptoms of anxiety or/and depression following early pregnancy loss, majority of them immediate after the incident, so every hospital should be well-staffed by professionals and able to provide an adequate care and psychological support for these patients. The study failed to reveal any risk factor (among selected) significantly associated with development of symptoms of depression and anxiety. Hence, every woman with such diagnosis can potentially develop psychological stress, and should be monitored carefully. Keywords: anxiety, depression, early pregnancyloss, HADS.","PeriodicalId":16444,"journal":{"name":"Journal of Morphological Sciences","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135611809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilija Milev, Vesna Velikj Stefanovska, Ognen Kostovski, Aleksandar Mitevski, Panche Karagjozov, Stefan Petrovski
The purpose of this study is to evaluate the applicability of Alvarado, Appendicitis Inflammatory Response (AIR) and „Raja Isteri Pengiran Anak Saleha Appendicitis “(RIPASA) score in diagnosing acute appendicitis (AA) in our population, as well as the possibility for connection between certain values and the emergence of “adverse events” in relation to laparoscopic appendectomy (LA). We conducted a multicentric, prospective, cohort, clinical study on 75 patients with AA treated with LA. For all the patients, the values and corresponding group of the three scoring systems (Alvarado, AIR and RIPASA) were determined preoperatively. We registered the emergence of intraoperative complications and difficulties, reason for conversion and the presence of complications postoperatively. All the patients with some form of intraoperative complication or difficulties, patients on whom conversion to open approach was performed or patients with any kind of postoperative complication were placed in the group “with adverse events” and the rest in the group “without adverse events”. The RIPASA score had an insignificantly higher sensitivity (sens.=96% at a cut-off ˃7 and sens.=68% at a cut-off ˃12) than Alvarado score (sens.=90.7% at a cut-off ≥7 and sens.=62.7% at a cut-off ≥9) and both had significantly higher sensitivity than AIR score (sens.=40% at a cut-off ≥9). Further analysis showed that there was no association between the emergence of adverse events and the corresponding group of the scoring system. The RIPASA scoring system had the highest sensitivity in our population, The investigated scoring systems Alvarado, AIR and RIPASA could not be used for predicting possible unwanted course in patients with AA treated with LA. Keywords: scoring systems, sensitivity, laparoscopic appendectomy, adverse events.
{"title":"THE UTILIZATION OF ALVARADO, AIR AND RIPASA SCORING SYSTEMS IN ADULTS WITH ACUTE APPENDICITIS TREATED WITH LAPAROSCOPIC APPENDECTOMY","authors":"Ilija Milev, Vesna Velikj Stefanovska, Ognen Kostovski, Aleksandar Mitevski, Panche Karagjozov, Stefan Petrovski","doi":"10.55302/jms2362120m","DOIUrl":"https://doi.org/10.55302/jms2362120m","url":null,"abstract":"The purpose of this study is to evaluate the applicability of Alvarado, Appendicitis Inflammatory Response (AIR) and „Raja Isteri Pengiran Anak Saleha Appendicitis “(RIPASA) score in diagnosing acute appendicitis (AA) in our population, as well as the possibility for connection between certain values and the emergence of “adverse events” in relation to laparoscopic appendectomy (LA). We conducted a multicentric, prospective, cohort, clinical study on 75 patients with AA treated with LA. For all the patients, the values and corresponding group of the three scoring systems (Alvarado, AIR and RIPASA) were determined preoperatively. We registered the emergence of intraoperative complications and difficulties, reason for conversion and the presence of complications postoperatively. All the patients with some form of intraoperative complication or difficulties, patients on whom conversion to open approach was performed or patients with any kind of postoperative complication were placed in the group “with adverse events” and the rest in the group “without adverse events”. The RIPASA score had an insignificantly higher sensitivity (sens.=96% at a cut-off ˃7 and sens.=68% at a cut-off ˃12) than Alvarado score (sens.=90.7% at a cut-off ≥7 and sens.=62.7% at a cut-off ≥9) and both had significantly higher sensitivity than AIR score (sens.=40% at a cut-off ≥9). Further analysis showed that there was no association between the emergence of adverse events and the corresponding group of the scoring system. The RIPASA scoring system had the highest sensitivity in our population, The investigated scoring systems Alvarado, AIR and RIPASA could not be used for predicting possible unwanted course in patients with AA treated with LA. Keywords: scoring systems, sensitivity, laparoscopic appendectomy, adverse events.","PeriodicalId":16444,"journal":{"name":"Journal of Morphological Sciences","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135660152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anita Morarcalieva Chochkova, M. Nakova, N. Velickova, B. Ismaili, Blazhe Chochkov
{"title":"DIAGNOSTIC CHALLENGE AND CONSERVATIVE MANAGEMENT OF CERVICAL PREGNANCY WITH UTEREUS PRESERVATION","authors":"Anita Morarcalieva Chochkova, M. Nakova, N. Velickova, B. Ismaili, Blazhe Chochkov","doi":"10.55302/jms2361093mch","DOIUrl":"https://doi.org/10.55302/jms2361093mch","url":null,"abstract":"","PeriodicalId":16444,"journal":{"name":"Journal of Morphological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71081195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhamet Bajrami, F. Koneski, Mirjana Markovska Arsovska, Irena Stojanova, P. Gjorgjievski
{"title":"THE EFFECT OF DEXAMETASONE IN REDUCING PAIN AND SWELLING AFTER ORAL SURGICAL INTERVENTIONS","authors":"Muhamet Bajrami, F. Koneski, Mirjana Markovska Arsovska, Irena Stojanova, P. Gjorgjievski","doi":"10.55302/jms2361156b","DOIUrl":"https://doi.org/10.55302/jms2361156b","url":null,"abstract":"","PeriodicalId":16444,"journal":{"name":"Journal of Morphological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71081813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katerina Boskovska, Julija Ivanovska, Hristijan Nestorov, Gorica Popova, Sandra Petlichkovska, Ivana Arnaudova - Danevska, Irena Chakalarovska
Tuberculosis (TB)is a major public health problem worldwide. It is one of the main causes of infectious disease and mortality, especially in developing countries. Extra pulmonary tuberculosis accounts for 15-20 % of all types of tuberculosis. Lymph nodes are the second most common localization after pleural TB. In childhood, the most commonly envolved are the hilar lymph nodes. Material and methods: We analyzed the frequency of tuberculous lymphadenitis in children treated at the Institute for respiratory diseses in children-Kozle, in the last 14 years. From January 2006 to February 2020 , we’ve treated 397 children with TB. 55 of them (13,8%), were with tuberculous lymphadenitis. Female children were 34 (61%), the others were male.The most frequent was hilar lymphadenitis at 40 (72%), second localization were cervical lymph nodes in 10( 18%). There was 1 child with submandibular localization,1 supraclavicular, 2children with axillary lymphadenitis and one with mesenterial lymphadenitis. Most of the patients had contact with TB. The diagnosis was confirmed pathohistological in the patients with peripheral lymphadenitis. Tuberculosis treatment was started in all patients based on clinical criteria, exposure, positive TST, chest X-ray, or histological confirmation. All of the patients have finished the treatment successfully. Tuberculous lymphadenitis can be a diagnostic and therapeutic challenge in children. Early diagnosis and timely initiation of therapy lead to favorable therapeutic outcome and reduce complications. Key words: tuberculosis, children, lymphadentis.
{"title":"TUBERCULOUS LYMPHADENITIS IN CHILDREN –14 YEARS OF EXPERIENCE","authors":"Katerina Boskovska, Julija Ivanovska, Hristijan Nestorov, Gorica Popova, Sandra Petlichkovska, Ivana Arnaudova - Danevska, Irena Chakalarovska","doi":"10.55302/jms2362082b","DOIUrl":"https://doi.org/10.55302/jms2362082b","url":null,"abstract":"Tuberculosis (TB)is a major public health problem worldwide. It is one of the main causes of infectious disease and mortality, especially in developing countries. Extra pulmonary tuberculosis accounts for 15-20 % of all types of tuberculosis. Lymph nodes are the second most common localization after pleural TB. In childhood, the most commonly envolved are the hilar lymph nodes. Material and methods: We analyzed the frequency of tuberculous lymphadenitis in children treated at the Institute for respiratory diseses in children-Kozle, in the last 14 years. From January 2006 to February 2020 , we’ve treated 397 children with TB. 55 of them (13,8%), were with tuberculous lymphadenitis. Female children were 34 (61%), the others were male.The most frequent was hilar lymphadenitis at 40 (72%), second localization were cervical lymph nodes in 10( 18%). There was 1 child with submandibular localization,1 supraclavicular, 2children with axillary lymphadenitis and one with mesenterial lymphadenitis. Most of the patients had contact with TB. The diagnosis was confirmed pathohistological in the patients with peripheral lymphadenitis. Tuberculosis treatment was started in all patients based on clinical criteria, exposure, positive TST, chest X-ray, or histological confirmation. All of the patients have finished the treatment successfully. Tuberculous lymphadenitis can be a diagnostic and therapeutic challenge in children. Early diagnosis and timely initiation of therapy lead to favorable therapeutic outcome and reduce complications. Key words: tuberculosis, children, lymphadentis.  ","PeriodicalId":16444,"journal":{"name":"Journal of Morphological Sciences","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135659871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veronika Apostoloska, Elizabeta Stojovska Jovanovska, Maja Jakimovska Dimitrovska, Smiljana Bundovska Kocev, Sofija Crcevska, Nacko Stavreski
Tuberous sclerosis (TS) is a rare genetic disorder of autosomal - dominant inheritance. Tuberous sclerosis complex is characterized by the development of benign tumors affecting different body systems who results in hamartomas involving many organs, like the brain, heart, kidneys, skin, lungs and liver. The management of these patients is often multidisciplinary, involving specialists from various fields. TSC presents at any age as a wide range of clinical and phenotypic manifestations with varying severity. The most common manifestations are facial angiofibroma, seizures, cortical tubers, cardiac rhabdomyoma, renal cysts and tumor of the kidneys. We present four patients with characteristic clinical and radiological features of multilocular tuberous sclerosis. Keywords: Tuberous sclerosis complex (TSC), tuberous sclerosis (TS), cortical tubers, angiofibromas, renal angiomyolipomas (AML).
{"title":"TUBEROUS SCLEROSIS COMPLEX- RADIOLOGICAL FEATURES IN DIFFERENT BODY SYSTEMS","authors":"Veronika Apostoloska, Elizabeta Stojovska Jovanovska, Maja Jakimovska Dimitrovska, Smiljana Bundovska Kocev, Sofija Crcevska, Nacko Stavreski","doi":"10.55302/jms2362041a","DOIUrl":"https://doi.org/10.55302/jms2362041a","url":null,"abstract":"Tuberous sclerosis (TS) is a rare genetic disorder of autosomal - dominant inheritance. Tuberous sclerosis complex is characterized by the development of benign tumors affecting different body systems who results in hamartomas involving many organs, like the brain, heart, kidneys, skin, lungs and liver. The management of these patients is often multidisciplinary, involving specialists from various fields. TSC presents at any age as a wide range of clinical and phenotypic manifestations with varying severity. The most common manifestations are facial angiofibroma, seizures, cortical tubers, cardiac rhabdomyoma, renal cysts and tumor of the kidneys. We present four patients with characteristic clinical and radiological features of multilocular tuberous sclerosis. Keywords: Tuberous sclerosis complex (TSC), tuberous sclerosis (TS), cortical tubers, angiofibromas, renal angiomyolipomas (AML).  ","PeriodicalId":16444,"journal":{"name":"Journal of Morphological Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135659897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stefana Chakar Kocevski, I. Gavrilovikj, Bruno Nikolovski
Dental crowding is the most common form of malocclusion. It is more pronounced in the mandible than in the maxilla and tends to increase with age. Depending on the degree of space deficiency and the age of the children the prevalence of dental crowding can be as high as 50%. Schwartz appliance and lip bumper have been widely used as an early treatment for increasing lower dental arch dimensions. The aim of this review is to evaluate the scientific research about the efficacy of Schwartz appliance and lip bumper and compare the changes caused by the two appliances in addressing mandibular crowding in the mixed dentition. A comprehensive literature search on the electronic databases: PubMed, Cochrane Library and Google Scholar was performed. Also, a search of the reference lists of included studies was conducted, to ensure comprehensive coverage of the literature. Search terms included "Schwartz appliance" OR "removable appliance" AND "lip bumper" OR "fixed appliance" AND "mandibular crowding" AND "mixed dentition" OR "early dentition". The search resulted in identifying several studies that met the inclusion criteria. Results show that both Schwartz appliance and lip bumper can effectively improve mandibular crowding in mixed dentition, although the extent and type of changes produced by these appliances may vary. Schwartz appliance is more effective in increasing inter canine width, while the lip bumper has more effect on increasing the arch length. Patient compliance as well as treatment duration are important factors that can have an effect on the success of orthodontic treatment.
{"title":"SCHWARTZ APPLIANCE AND LIP BUMPER AS TREATMENT MODALITIES FOR MANDIBULAR CROWDING IN MIXED DENTITIONS","authors":"Stefana Chakar Kocevski, I. Gavrilovikj, Bruno Nikolovski","doi":"10.55302/jms2361169chk","DOIUrl":"https://doi.org/10.55302/jms2361169chk","url":null,"abstract":"Dental crowding is the most common form of malocclusion. It is more pronounced in the mandible than in the maxilla and tends to increase with age. Depending on the degree of space deficiency and the age of the children the prevalence of dental crowding can be as high as 50%. Schwartz appliance and lip bumper have been widely used as an early treatment for increasing lower dental arch dimensions. The aim of this review is to evaluate the scientific research about the efficacy of Schwartz appliance and lip bumper and compare the changes caused by the two appliances in addressing mandibular crowding in the mixed dentition. A comprehensive literature search on the electronic databases: PubMed, Cochrane Library and Google Scholar was performed. Also, a search of the reference lists of included studies was conducted, to ensure comprehensive coverage of the literature. Search terms included \"Schwartz appliance\" OR \"removable appliance\" AND \"lip bumper\" OR \"fixed appliance\" AND \"mandibular crowding\" AND \"mixed dentition\" OR \"early dentition\". The search resulted in identifying several studies that met the inclusion criteria. Results show that both Schwartz appliance and lip bumper can effectively improve mandibular crowding in mixed dentition, although the extent and type of changes produced by these appliances may vary. Schwartz appliance is more effective in increasing inter canine width, while the lip bumper has more effect on increasing the arch length. Patient compliance as well as treatment duration are important factors that can have an effect on the success of orthodontic treatment.","PeriodicalId":16444,"journal":{"name":"Journal of Morphological Sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71081855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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