Pub Date : 2016-03-18DOI: 10.1007/s11481-016-9664-y
Changqing Xu, Douglas J. Hermes, Ken Mackie, A. Lichtman, Bogna Marta Ignatowska-Jankowska, S. Fitting
{"title":"Cannabinoids Occlude the HIV-1 Tat-Induced Decrease in GABAergic Neurotransmission in Prefrontal Cortex Slices","authors":"Changqing Xu, Douglas J. Hermes, Ken Mackie, A. Lichtman, Bogna Marta Ignatowska-Jankowska, S. Fitting","doi":"10.1007/s11481-016-9664-y","DOIUrl":"https://doi.org/10.1007/s11481-016-9664-y","url":null,"abstract":"","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"11 1","pages":"316 - 331"},"PeriodicalIF":6.2,"publicationDate":"2016-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11481-016-9664-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53040460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-18DOI: 10.1007/s11481-016-9662-0
{"title":"Abstracts of the 22nd Scientific Conference of the Society on Neuroimmune Pharmacology","authors":"","doi":"10.1007/s11481-016-9662-0","DOIUrl":"https://doi.org/10.1007/s11481-016-9662-0","url":null,"abstract":"","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"11 1","pages":"3 - 61"},"PeriodicalIF":6.2,"publicationDate":"2016-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11481-016-9662-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53040303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-11DOI: 10.1007/s11481-016-9660-2
Yan Zhou, Hong-mei Tang, H. Xiong
{"title":"Chemokine CCL2 enhances NMDA receptor-mediated excitatory postsynaptic current in rat hippocampal slices-a potential mechanism for HIV-1-associated neuropathy?","authors":"Yan Zhou, Hong-mei Tang, H. Xiong","doi":"10.1007/s11481-016-9660-2","DOIUrl":"https://doi.org/10.1007/s11481-016-9660-2","url":null,"abstract":"","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"11 1","pages":"306 - 315"},"PeriodicalIF":6.2,"publicationDate":"2016-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11481-016-9660-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53040139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01Epub Date: 2015-11-18DOI: 10.1007/s11481-015-9644-7
Wenjuan Ru, Shao-Jun Tang
HIV-1 envelope glycoprotein gp120 (gp120) is a major virulence protein implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Although gp120 has been suggested to cause synaptic and neuronal injuries by disrupting NMDA receptor (NMDAR) function, the underlying mechanism is unclear. Here, we show that gp120Bal down-regulates the phosphorylation of the NMDAR subunit1 NR1 (at Ser896 and Ser897), which is essential for NMDAR function. This effect of gp120Bal is blocked by specific antagonists of both NMDA and AMPA receptors, indicating a critical role of synaptic activation. Furthermore, AMD3100 and maraviroc, antagonists of CCR5 and CXCR4 chemokine receptors, respectively, inhibit the effect of gp120Bal on NR1, suggesting that CXCR4 and CCR5 activation are involved. These findings may provide mechanistic insights into the synaptopathogenesis caused by HIV-1 infection.
{"title":"HIV-1 gp120Bal down-Regulates Phosphorylated NMDA Receptor Subunit 1 in Cortical Neurons via Activation of Glutamate and Chemokine Receptors.","authors":"Wenjuan Ru, Shao-Jun Tang","doi":"10.1007/s11481-015-9644-7","DOIUrl":"10.1007/s11481-015-9644-7","url":null,"abstract":"<p><p>HIV-1 envelope glycoprotein gp120 (gp120) is a major virulence protein implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Although gp120 has been suggested to cause synaptic and neuronal injuries by disrupting NMDA receptor (NMDAR) function, the underlying mechanism is unclear. Here, we show that gp120Bal down-regulates the phosphorylation of the NMDAR subunit1 NR1 (at Ser896 and Ser897), which is essential for NMDAR function. This effect of gp120Bal is blocked by specific antagonists of both NMDA and AMPA receptors, indicating a critical role of synaptic activation. Furthermore, AMD3100 and maraviroc, antagonists of CCR5 and CXCR4 chemokine receptors, respectively, inhibit the effect of gp120Bal on NR1, suggesting that CXCR4 and CCR5 activation are involved. These findings may provide mechanistic insights into the synaptopathogenesis caused by HIV-1 infection. </p>","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"11 1","pages":"182-91"},"PeriodicalIF":6.2,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53038823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-03-01Epub Date: 2015-11-20DOI: 10.1007/s11481-015-9643-8
Marpe Bam, Xiaoming Yang, Juhua Zhou, Jay P Ginsberg, Quinne Leyden, Prakash S Nagarkatti, Mitzi Nagarkatti
While Post Traumatic Stress Disorder (PTSD) is associated with immune dysfunction, the underlying mechanisms remain unclear. Studies suggest a role for involvement of epigenetic mechanisms and microRNAs (miRNAs). Here, we examined genome-wide histone and DNA methylation in the peripheral blood mononuclear cells (PBMCs) in PTSD. We noted significant differences in histone H3 trimethylation at K4, K9, K27 and K36 sites in PTSD when compared to control. While overall DNA methylation level did not differ significantly between control and PTSD, the promoters of several individual genes (e.g., Interferon gamma (IFNG) and Interleukin (IL)-12B) were differentially methylated. ChIP-seq data revealed that the promoter of IFNG and TBX-21 was associated with the activation marker H3K4me3 in PTSD. The transcript levels of both IFNG and TBX-21 were higher in PTSD correlating well with the altered methylation patterns. Furthermore, PTSD patients showed increased expression of IL-12 in their PBMCs. Analysis of both histone and DNA methylation markers suggested that the expression of IL-12 was also possibly activated through epigenetic modification. Knockdown of lysine (K)-specific demethylase 5B (KDM5B), or inhibition of DNA (Cytosine-5-)-methyltransferase 1 (DNMT1) caused up-regulation of IL-12. Furthermore, the expression of these cytokines was also regulated by miRNAs. Our miRNA microarray identified many downregulated miRNAs in PTSD that are predicted to target IFNG and IL-12. Consequently, we showed that up-regulation of hsa-miR-193a-5p could decrease the expression of IL-12. Overall, the current study demonstrated that the elevated expression of pro-inflammatory cytokines in PTSD patients might be regulated by multiple epigenetic mechanisms and miRNAs.
{"title":"Evidence for Epigenetic Regulation of Pro-Inflammatory Cytokines, Interleukin-12 and Interferon Gamma, in Peripheral Blood Mononuclear Cells from PTSD Patients.","authors":"Marpe Bam, Xiaoming Yang, Juhua Zhou, Jay P Ginsberg, Quinne Leyden, Prakash S Nagarkatti, Mitzi Nagarkatti","doi":"10.1007/s11481-015-9643-8","DOIUrl":"10.1007/s11481-015-9643-8","url":null,"abstract":"<p><p>While Post Traumatic Stress Disorder (PTSD) is associated with immune dysfunction, the underlying mechanisms remain unclear. Studies suggest a role for involvement of epigenetic mechanisms and microRNAs (miRNAs). Here, we examined genome-wide histone and DNA methylation in the peripheral blood mononuclear cells (PBMCs) in PTSD. We noted significant differences in histone H3 trimethylation at K4, K9, K27 and K36 sites in PTSD when compared to control. While overall DNA methylation level did not differ significantly between control and PTSD, the promoters of several individual genes (e.g., Interferon gamma (IFNG) and Interleukin (IL)-12B) were differentially methylated. ChIP-seq data revealed that the promoter of IFNG and TBX-21 was associated with the activation marker H3K4me3 in PTSD. The transcript levels of both IFNG and TBX-21 were higher in PTSD correlating well with the altered methylation patterns. Furthermore, PTSD patients showed increased expression of IL-12 in their PBMCs. Analysis of both histone and DNA methylation markers suggested that the expression of IL-12 was also possibly activated through epigenetic modification. Knockdown of lysine (K)-specific demethylase 5B (KDM5B), or inhibition of DNA (Cytosine-5-)-methyltransferase 1 (DNMT1) caused up-regulation of IL-12. Furthermore, the expression of these cytokines was also regulated by miRNAs. Our miRNA microarray identified many downregulated miRNAs in PTSD that are predicted to target IFNG and IL-12. Consequently, we showed that up-regulation of hsa-miR-193a-5p could decrease the expression of IL-12. Overall, the current study demonstrated that the elevated expression of pro-inflammatory cytokines in PTSD patients might be regulated by multiple epigenetic mechanisms and miRNAs. </p>","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"11 1","pages":"168-181"},"PeriodicalIF":6.2,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53038724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-27DOI: 10.1007/s11481-016-9659-8
G. Woody, E. Krupitsky, E. Zvartau
{"title":"Antagonist Models for Relapse Prevention and Reducing HIV Risk","authors":"G. Woody, E. Krupitsky, E. Zvartau","doi":"10.1007/s11481-016-9659-8","DOIUrl":"https://doi.org/10.1007/s11481-016-9659-8","url":null,"abstract":"","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"11 1","pages":"401 - 407"},"PeriodicalIF":6.2,"publicationDate":"2016-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11481-016-9659-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53039736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-22DOI: 10.1007/s11481-016-9657-x
Yu-Young Lee, Eun-Jung Lee, Jin‐Sun Park, Se-Eun Jang, Dong-Hyun Kim, Hee-Sun Kim
{"title":"Anti-Inflammatory and Antioxidant Mechanism of Tangeretin in Activated Microglia","authors":"Yu-Young Lee, Eun-Jung Lee, Jin‐Sun Park, Se-Eun Jang, Dong-Hyun Kim, Hee-Sun Kim","doi":"10.1007/s11481-016-9657-x","DOIUrl":"https://doi.org/10.1007/s11481-016-9657-x","url":null,"abstract":"","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"11 1","pages":"294 - 305"},"PeriodicalIF":6.2,"publicationDate":"2016-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11481-016-9657-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53039550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-02-02DOI: 10.1007/s11481-016-9654-0
Xilin Wu, Li Liu, Ka-wai Cheung, Hui Wang, Xiaofan Lu, A. K. L. Cheung, Wan Liu, Xiuyan Huang, Yanlei Li, Zhiwei Chen, Samantha M. Y. Chen, Tong Zhang, Hao Wu, Zhiwei Chen
{"title":"Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice","authors":"Xilin Wu, Li Liu, Ka-wai Cheung, Hui Wang, Xiaofan Lu, A. K. L. Cheung, Wan Liu, Xiuyan Huang, Yanlei Li, Zhiwei Chen, Samantha M. Y. Chen, Tong Zhang, Hao Wu, Zhiwei Chen","doi":"10.1007/s11481-016-9654-0","DOIUrl":"https://doi.org/10.1007/s11481-016-9654-0","url":null,"abstract":"","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"11 1","pages":"572 - 583"},"PeriodicalIF":6.2,"publicationDate":"2016-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11481-016-9654-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53039802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-01-23DOI: 10.1007/s11481-016-9651-3
Maiqiu Wang, Yunlong Ma, Wenji Yuan, Kunkai Su, Ming D. Li
{"title":"Meta-Analysis of the COMT Val158Met Polymorphism in Major Depressive Disorder: Effect of Ethnicity","authors":"Maiqiu Wang, Yunlong Ma, Wenji Yuan, Kunkai Su, Ming D. Li","doi":"10.1007/s11481-016-9651-3","DOIUrl":"https://doi.org/10.1007/s11481-016-9651-3","url":null,"abstract":"","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"11 1","pages":"434 - 445"},"PeriodicalIF":6.2,"publicationDate":"2016-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11481-016-9651-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53039356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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