Pub Date : 2022-10-30DOI: 10.17126/joralres.2022.062
K. Karthik, V. Ashwin, R. Balamurugan
Introduction: Mandibular fractures are the most common facial fractures affecting various anatomical sites of the mandible. Among the various mandibular fractures, management of condylar fractures remains a challenging task for surgeons. Case Report: We report the case of a 28 year old male patient who presented with pain in the chin and restricted mouth opening. Computed tomography revealed a sagittal fracture of the right condylar head with medial displacement of the fractured fragments. Management of diacapitular fractures includes open reduction and internal fixation of the right condyle using a single lag-screw. Results: The postoperative outcomes were favorable, where normal mandibular movements, desired dental occlusion and exact positioning of the condyle with rigid fixation were established thereby maintaining the shape of the condyle. Conclusion: Use of single lag screw fixation is highly recommended as it greatly supports the stabilized fracture fragments and also aid in prevention of fracture fragment rotation medially.
{"title":"Management of diacapitular mandibular condyle fracture using a single lag screw fixation: Case Repor","authors":"K. Karthik, V. Ashwin, R. Balamurugan","doi":"10.17126/joralres.2022.062","DOIUrl":"https://doi.org/10.17126/joralres.2022.062","url":null,"abstract":"Introduction: Mandibular fractures are the most common facial fractures affecting various anatomical sites of the mandible. Among the various mandibular fractures, management of condylar fractures remains a challenging task for surgeons. Case Report: We report the case of a 28 year old male patient who presented with pain in the chin and restricted mouth opening. Computed tomography revealed a sagittal fracture of the right condylar head with medial displacement of the fractured fragments. Management of diacapitular fractures includes open reduction and internal fixation of the right condyle using a single lag-screw. Results: The postoperative outcomes were favorable, where normal mandibular movements, desired dental occlusion and exact positioning of the condyle with rigid fixation were established thereby maintaining the shape of the condyle. Conclusion: Use of single lag screw fixation is highly recommended as it greatly supports the stabilized fracture fragments and also aid in prevention of fracture fragment rotation medially.","PeriodicalId":16625,"journal":{"name":"Journal of Oral Research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87149286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-30DOI: 10.17126/joralres.2022.059
Michael J. Kridanto Kamadjaja, Sherman Salim, Gigih Gemiudeas
Objetive: To determine the expression of Fibroblast Growth Factor (FGF)-2 and Bone Morphogenetic Protein (BMP)-2 after application of scaffold hydroxyapatite from Rajungan crab shell (Portunus pelagicus) in the tooth extraction socket of Cavia cobaya. Material and Methods: This study used a post-test only control group design with 28 Cavia cobaya separated into two groups, control and treatment group. The left mandibular incisor was extracted, and socket preservation was conducted. A hydroxyapatite graft derived from crab shells was mixed with gelatin and eventually turned into a scaffold, which was afterward put into the extraction socket. After 7 days and 14 days, each group was terminated and examined using immunohistochemical staining to observe the expression of FGF-2 and BMP-2. One-Way Anova and Tukey HSD were used to examine the research data. Results: FGF-2 and BMP-2 expressions were observed higher in the group that received hydroxyapatite scaffold at the post-extraction socket than those in the group that did not receive hydroxyapatite scaffold. Conclusion: The application of a hydroxyapatite scaffold from Rajungan crab shell (Portunus pelagicus) to the tooth extraction socket can increase FGF-2 and BMP-2 expression.
{"title":"The Effect of Scaffold Hydroxyapatite derived from Portunus pelagicus Shell on the Expression of Fibroblast Growth Factor-2 (FGF-2) and Bone Morphogenetic Proteins-2 (BMP -2) in the Extraction Sockets of Cavia cobaya","authors":"Michael J. Kridanto Kamadjaja, Sherman Salim, Gigih Gemiudeas","doi":"10.17126/joralres.2022.059","DOIUrl":"https://doi.org/10.17126/joralres.2022.059","url":null,"abstract":"Objetive: To determine the expression of Fibroblast Growth Factor (FGF)-2 and Bone Morphogenetic Protein (BMP)-2 after application of scaffold hydroxyapatite from Rajungan crab shell (Portunus pelagicus) in the tooth extraction socket of Cavia cobaya. Material and Methods: This study used a post-test only control group design with 28 Cavia cobaya separated into two groups, control and treatment group. The left mandibular incisor was extracted, and socket preservation was conducted. A hydroxyapatite graft derived from crab shells was mixed with gelatin and eventually turned into a scaffold, which was afterward put into the extraction socket. After 7 days and 14 days, each group was terminated and examined using immunohistochemical staining to observe the expression of FGF-2 and BMP-2. One-Way Anova and Tukey HSD were used to examine the research data. Results: FGF-2 and BMP-2 expressions were observed higher in the group that received hydroxyapatite scaffold at the post-extraction socket than those in the group that did not receive hydroxyapatite scaffold. Conclusion: The application of a hydroxyapatite scaffold from Rajungan crab shell (Portunus pelagicus) to the tooth extraction socket can increase FGF-2 and BMP-2 expression.","PeriodicalId":16625,"journal":{"name":"Journal of Oral Research","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78740645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-30DOI: 10.17126/joralres.2022.052
Carlos Henrique Ferrari, Amjad Abu Hasna
Aim: To compare the accuracy of the panoramic radiography with cone-beam computed tomography (CBCT) scans in measuring the distances between root apexes and the adjacent anatomical structures including the maxillary sinus and the mandibular canal. Material and Methods: A total of 200 CBCT scans (100 maxillary and 100 mandibular) from patients who also had corresponding panoramic radiography were selected. Linear measurements (in mm) presenting centralized image were made between the apexes of the maxillary teeth and the inferior wall of the maxillary sinus, and between the apexes of the mandibular teeth and the superior border of the mandibular canal by using specific software for panoramic radiography and the measurements on the coronal sections in CBCT scans. Data were submitted to inferential statistical analysis and Student’s t-test for comparison between measurements. Results: CBCT scans were significantly more accurate than panoramic radiography to measure the distances between the apexes of the maxillary teeth and the inferior wall of the maxillary sinus (p<0.05) and between the apexes of the mandibular teeth and the superior border of the mandibular canal or mental foramen (p<0.05). Conclusion: CBCT scans present more accurate measurements than panoramic radiography.
{"title":"Panoramic radiography and cone-beam computed tomography to measure distances between root apexes and anatomical structures","authors":"Carlos Henrique Ferrari, Amjad Abu Hasna","doi":"10.17126/joralres.2022.052","DOIUrl":"https://doi.org/10.17126/joralres.2022.052","url":null,"abstract":"Aim: To compare the accuracy of the panoramic radiography with cone-beam computed tomography (CBCT) scans in measuring the distances between root apexes and the adjacent anatomical structures including the maxillary sinus and the mandibular canal. Material and Methods: A total of 200 CBCT scans (100 maxillary and 100 mandibular) from patients who also had corresponding panoramic radiography were selected. Linear measurements (in mm) presenting centralized image were made between the apexes of the maxillary teeth and the inferior wall of the maxillary sinus, and between the apexes of the mandibular teeth and the superior border of the mandibular canal by using specific software for panoramic radiography and the measurements on the coronal sections in CBCT scans. Data were submitted to inferential statistical analysis and Student’s t-test for comparison between measurements. Results: CBCT scans were significantly more accurate than panoramic radiography to measure the distances between the apexes of the maxillary teeth and the inferior wall of the maxillary sinus (p<0.05) and between the apexes of the mandibular teeth and the superior border of the mandibular canal or mental foramen (p<0.05). Conclusion: CBCT scans present more accurate measurements than panoramic radiography.","PeriodicalId":16625,"journal":{"name":"Journal of Oral Research","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84955379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-30DOI: 10.17126/joralres.2022.055
H. Rodríguez, José Rodríguez, M. A. de Camargo, Hazel Topel, M. Hirschhaut
Introduction: Ectodermal dysplasia is a rare genetic disorder that affects structures derived from ectoderm such as teeth, hair, nails, and sweat glands. Oligodontia is a common finding that affects the chewing, smiling and self- esteem of these pediatric patients. Case Report: We present a case report of a 7-years-old pediatric patient who consulted with his mother, showing the same condition. The intervention consisted of a removable prosthesis with satisfactory results. Conclusion: The X-linked hypohidrotic ectodermal dysplasia represents a challenge for a pediatric dentist who offers rehabilitation to the patient according to craniofacial development, age, socioeconomic status, and the number of missing teeth.
{"title":"X-linked hypohidrotic ectodermal dysplasia management with removable prosthesis in a pediatric patient. Case Report","authors":"H. Rodríguez, José Rodríguez, M. A. de Camargo, Hazel Topel, M. Hirschhaut","doi":"10.17126/joralres.2022.055","DOIUrl":"https://doi.org/10.17126/joralres.2022.055","url":null,"abstract":"Introduction: Ectodermal dysplasia is a rare genetic disorder that affects structures derived from ectoderm such as teeth, hair, nails, and sweat glands. Oligodontia is a common finding that affects the chewing, smiling and self- esteem of these pediatric patients. Case Report: We present a case report of a 7-years-old pediatric patient who consulted with his mother, showing the same condition. The intervention consisted of a removable prosthesis with satisfactory results. Conclusion: The X-linked hypohidrotic ectodermal dysplasia represents a challenge for a pediatric dentist who offers rehabilitation to the patient according to craniofacial development, age, socioeconomic status, and the number of missing teeth.","PeriodicalId":16625,"journal":{"name":"Journal of Oral Research","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76074743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-30DOI: 10.17126/joralres.2022.051
M. Navarrete, Héctor Oñate, Katarina x Katarina Loyola, Pamela Olivares
Aim: To evaluate the effect of the systemic administration of azi-thromycin (AZM) as an adjunct to non-surgical periodontal therapy (NSPT) on the clinical and microbiological variables of patients with periodontitis Material and Methods: Eighteen volunteers received NSPT combined with placebo or AZM (500 mg/day) for 3 days (n=9/group). They were monitored clinically for probing pocket depth (PPD), clinical attachment level (CAL), O'Leary index (OI), bleeding on probing (BoP) at baseline and during the first, third and sixth month and microbiologically, at baseline and at 3 and 6 months after therapy, by conventional polymerase chain reaction tests. Results: Fourteen patients completed the study (n=7/group). Differences statistically significant were observed among both groups. The experimental group presented: A PPD mean (p=0.04) significantly lower and PPD reduction (p=0.02), at 6-months post NSPT. Regarding changes (∆), at the third month post NSPT, there was a significant increase in the number of shallow sites (p<0.001) and a decrease in the intermediate sites (p<0.001). In addition, a significant decrease in the mean number of deep sites (p=0.04) was detected at 6 months post treatment. There was also a significant decrease in periodontal index BoP at 1 (p=0.01), 3 (p<0.001) and 6 (p=0.01) months and OI at 3- and 6-months (p<0.001), post treatment. Regarding the presence of periodontal pathogens, no significant differences were observed, intra and inter groups. Conclusion: AZM as an adjuvant to NSPT provides additional beneficial effects for PPD and BoP compared to NSPT alone.
{"title":"Effect of Periodontal Debridement plus Systemic Azithromycin in subjects with Stage III Periodontitis: A Randomized Controlled Clinical Trial","authors":"M. Navarrete, Héctor Oñate, Katarina x Katarina Loyola, Pamela Olivares","doi":"10.17126/joralres.2022.051","DOIUrl":"https://doi.org/10.17126/joralres.2022.051","url":null,"abstract":"Aim: To evaluate the effect of the systemic administration of azi-thromycin (AZM) as an adjunct to non-surgical periodontal therapy (NSPT) on the clinical and microbiological variables of patients with periodontitis Material and Methods: Eighteen volunteers received NSPT combined with placebo or AZM (500 mg/day) for 3 days (n=9/group). They were monitored clinically for probing pocket depth (PPD), clinical attachment level (CAL), O'Leary index (OI), bleeding on probing (BoP) at baseline and during the first, third and sixth month and microbiologically, at baseline and at 3 and 6 months after therapy, by conventional polymerase chain reaction tests. Results: Fourteen patients completed the study (n=7/group). Differences statistically significant were observed among both groups. The experimental group presented: A PPD mean (p=0.04) significantly lower and PPD reduction (p=0.02), at 6-months post NSPT. Regarding changes (∆), at the third month post NSPT, there was a significant increase in the number of shallow sites (p<0.001) and a decrease in the intermediate sites (p<0.001). In addition, a significant decrease in the mean number of deep sites (p=0.04) was detected at 6 months post treatment. There was also a significant decrease in periodontal index BoP at 1 (p=0.01), 3 (p<0.001) and 6 (p=0.01) months and OI at 3- and 6-months (p<0.001), post treatment. Regarding the presence of periodontal pathogens, no significant differences were observed, intra and inter groups. Conclusion: AZM as an adjuvant to NSPT provides additional beneficial effects for PPD and BoP compared to NSPT alone.","PeriodicalId":16625,"journal":{"name":"Journal of Oral Research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90984117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objetive: To compare the clinical behavior of two types of Bulk Fill composite resins and a nanohybrid resin at 18 months in occlusal restorations. Material and Methods: Three occlusal restorations were performed in each one of the 55 participants. They were randomly distributed into three groups, TN: Tetric-N-Ceram Bulk-Fill, FK: Filtek Bulk-Fill, and Z350: Filtek Z350XT. Adhesive techniques and restorative procedures were performed according to the manufacturer's instructions for each restorative material used. In TN and FK an increment of 4mm was applied, and in Z350 increments of ≤2mm depth were applied. Two calibrated operators evaluated the restorations at baseline and at 18 months using the FDI World Dental Federations system (1: excellent, 2: good, 3: satisfactory, 4: unsatisfactory, 5: poor) for clinical marginal staining (MS) properties, fracture-retention (FR), superficial texture (ST), marginal integrity (MI), postoperative sensitivity (PS) and caries (C). Kruskal-Wallis and Wilcoxon were used to compare the 3 groups at 18 months (5% significance). Results: 38 patients with a total of 114 restorations were assessed, being evaluated with excellent clinical behavior; MI, 78.9% in Z350, 89.51% in TN and 81.6% in FK; ST 73.5% in Z350, 86.8% in TN, and 84.2% in FK; MS 84.2% in Z350, 84.2% in TN, and 91.2% in FK; PS 100% in Z350 and 97.3% in TN and FK; in C and FR, 100% in the 3 groups. There were no significant differences between the three groups (p>0.05). Conclusion: The three resins studied presented a good clinical performance at 18 months without showing significant differences in the clinical properties evaluated.
{"title":"Clinical follow-up at 18 months of two Bulk Fill occlusal composite resins. A double-blind randomized clinical study","authors":"Patricio Vildósola Grez, Sara Rodriguez Dueri, Jenifer Carrión, Constanza Saez, Jorge Nakouzi Momares","doi":"10.17126/joralres.2022.061","DOIUrl":"https://doi.org/10.17126/joralres.2022.061","url":null,"abstract":"Objetive: To compare the clinical behavior of two types of Bulk Fill composite resins and a nanohybrid resin at 18 months in occlusal restorations. Material and Methods: Three occlusal restorations were performed in each one of the 55 participants. They were randomly distributed into three groups, TN: Tetric-N-Ceram Bulk-Fill, FK: Filtek Bulk-Fill, and Z350: Filtek Z350XT. Adhesive techniques and restorative procedures were performed according to the manufacturer's instructions for each restorative material used. In TN and FK an increment of 4mm was applied, and in Z350 increments of ≤2mm depth were applied. Two calibrated operators evaluated the restorations at baseline and at 18 months using the FDI World Dental Federations system (1: excellent, 2: good, 3: satisfactory, 4: unsatisfactory, 5: poor) for clinical marginal staining (MS) properties, fracture-retention (FR), superficial texture (ST), marginal integrity (MI), postoperative sensitivity (PS) and caries (C). Kruskal-Wallis and Wilcoxon were used to compare the 3 groups at 18 months (5% significance). Results: 38 patients with a total of 114 restorations were assessed, being evaluated with excellent clinical behavior; MI, 78.9% in Z350, 89.51% in TN and 81.6% in FK; ST 73.5% in Z350, 86.8% in TN, and 84.2% in FK; MS 84.2% in Z350, 84.2% in TN, and 91.2% in FK; PS 100% in Z350 and 97.3% in TN and FK; in C and FR, 100% in the 3 groups. There were no significant differences between the three groups (p>0.05). Conclusion: The three resins studied presented a good clinical performance at 18 months without showing significant differences in the clinical properties evaluated.","PeriodicalId":16625,"journal":{"name":"Journal of Oral Research","volume":"470 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87142089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-30DOI: 10.17126/joralres.2022.053
B. Ashwath, M. Shanmugam, Elumalai Agila, V. Anitha, D. Aishwarya, Aanisha Zafrin
Background: Probing of the periodontal pocket is an essential part of the diagnosis of periodontal disease and 15-77% of untreated periodontal patients experience pain during probing. Therefore, the objective of this study is to evaluate the pain perceived by patients with dental plaque-induced gingivitis and chronic periodontitis during periodontal probing and the main objective includes the evaluation of the relationship between pain perceived during periodontal probing and gingival inflammatory parameters. Material and Methods: A total of 475 participants were recruited into the study. The patients were divided into two groups: Group-A (Gingivitis Group - 275 patients) and Group-B (Chronic Periodontitis Group - 200 patients). Clinical parameters included analysis of bleeding on probing, simplified gingival index, pocket depth on probing, and clinical attachment level. Pain score was recorded using the HP VAS scale and all patients participated in the study after a detailed explanation of the study protocol. Results: A significant difference in pain perception was noted between groups, highlighting the role of the degree of inflammation in the examination of periodontal parameters. Conclusion: Within the limitations of the present study, we can conclude that pain perception is directly correlated with the degree of inflammation in periodontitis rather than plaque-induced gingivitis during periodontal probing. Therefore, some form of adjuvant topical anesthesia may be considered in order to reduce pain levels in severely inflamed patients, to encourage continued acceptance of supportive periodontal therapy.
{"title":"Comparison of Gingival Inflammatory Parameters and Pain Perception on Periodontal Probing - A cross sectional study, Part II","authors":"B. Ashwath, M. Shanmugam, Elumalai Agila, V. Anitha, D. Aishwarya, Aanisha Zafrin","doi":"10.17126/joralres.2022.053","DOIUrl":"https://doi.org/10.17126/joralres.2022.053","url":null,"abstract":"Background: Probing of the periodontal pocket is an essential part of the diagnosis of periodontal disease and 15-77% of untreated periodontal patients experience pain during probing. Therefore, the objective of this study is to evaluate the pain perceived by patients with dental plaque-induced gingivitis and chronic periodontitis during periodontal probing and the main objective includes the evaluation of the relationship between pain perceived during periodontal probing and gingival inflammatory parameters. Material and Methods: A total of 475 participants were recruited into the study. The patients were divided into two groups: Group-A (Gingivitis Group - 275 patients) and Group-B (Chronic Periodontitis Group - 200 patients). Clinical parameters included analysis of bleeding on probing, simplified gingival index, pocket depth on probing, and clinical attachment level. Pain score was recorded using the HP VAS scale and all patients participated in the study after a detailed explanation of the study protocol. Results: A significant difference in pain perception was noted between groups, highlighting the role of the degree of inflammation in the examination of periodontal parameters. Conclusion: Within the limitations of the present study, we can conclude that pain perception is directly correlated with the degree of inflammation in periodontitis rather than plaque-induced gingivitis during periodontal probing. Therefore, some form of adjuvant topical anesthesia may be considered in order to reduce pain levels in severely inflamed patients, to encourage continued acceptance of supportive periodontal therapy.","PeriodicalId":16625,"journal":{"name":"Journal of Oral Research","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85750177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-31DOI: 10.17126/joralres.2022.047
María Morales-Herrero, I. Ortega-Medina
Introduction: DMBA is a chemical carcinogen that induces carcinomas within a few weeks of its application. We developed an experimental model of carcinogenesis induced by DMBA dissolved in 0,5% paraffin oil (DMBA-PO), verifying the inhibitory effect of the carcinogenicity of phenyl isothiocyanate (PhITC), phenethyl (PhnITC) and benzyl isothiocyanate (BITC). Material and Methods: For this, 88 hamsters were distributed into three groups: one exposed to DMBA-PO (Group 1, n=12), three subgroups (n=12) exposed to PhITC, PhnITC, BITC and DMBA-PO (Group 2, n=36) and four control subgroups (n=10) that were not exposed to the carcinogen in which PO (paraffin oil) and isothiocyanates were applied (Group 3, n=40). Results: The experiment had a duration of 20 weeks, at the end of which the inhibitory effect was established by comparing the lesions developed in the groups that received isothiocyanates with the group that was only treated with DMBA-PO. The carcinogenic effect of DMBA-PO is 100% (35 carcinomas) and the inhibitory effect was 0, whereas in the presence of isothiocyanates the carcinogenic effect decreases, with an inhibitory effect of 86% for BITC (5 carcinomas) and 74% for PhITC (9 carcinomas). Conclusion: The inhibitory effect for PhnITC is 80% in relation to invasive OSCC (1 carcinoma).
{"title":"Experimental carcinogenesis with 7,12-dimethylbenz(a)anthrazene (DMBA) and its inhibition with isothi-ocyanates","authors":"María Morales-Herrero, I. Ortega-Medina","doi":"10.17126/joralres.2022.047","DOIUrl":"https://doi.org/10.17126/joralres.2022.047","url":null,"abstract":"Introduction: DMBA is a chemical carcinogen that induces carcinomas within a few weeks of its application. We developed an experimental model of carcinogenesis induced by DMBA dissolved in 0,5% paraffin oil (DMBA-PO), verifying the inhibitory effect of the carcinogenicity of phenyl isothiocyanate (PhITC), phenethyl (PhnITC) and benzyl isothiocyanate (BITC). Material and Methods: For this, 88 hamsters were distributed into three groups: one exposed to DMBA-PO (Group 1, n=12), three subgroups (n=12) exposed to PhITC, PhnITC, BITC and DMBA-PO (Group 2, n=36) and four control subgroups (n=10) that were not exposed to the carcinogen in which PO (paraffin oil) and isothiocyanates were applied (Group 3, n=40). Results: The experiment had a duration of 20 weeks, at the end of which the inhibitory effect was established by comparing the lesions developed in the groups that received isothiocyanates with the group that was only treated with DMBA-PO. The carcinogenic effect of DMBA-PO is 100% (35 carcinomas) and the inhibitory effect was 0, whereas in the presence of isothiocyanates the carcinogenic effect decreases, with an inhibitory effect of 86% for BITC (5 carcinomas) and 74% for PhITC (9 carcinomas). Conclusion: The inhibitory effect for PhnITC is 80% in relation to invasive OSCC (1 carcinoma).","PeriodicalId":16625,"journal":{"name":"Journal of Oral Research","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74410182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-31DOI: 10.17126/joralres.2022.035
L. Orellana
{"title":"Evolution of the concept of disability in Chile","authors":"L. Orellana","doi":"10.17126/joralres.2022.035","DOIUrl":"https://doi.org/10.17126/joralres.2022.035","url":null,"abstract":"","PeriodicalId":16625,"journal":{"name":"Journal of Oral Research","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73317325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-31DOI: 10.17126/joralres.2022.050
Giselle Davis-Toledo
Background: The society and the State must provide dental care and help prevent oral health problems by implementing public policies with cultural relevance that allow society to address and improve the inequity in health care that systematically affects people's well-being. The present study seeks to understand the representations of dental health in people who attend primary care services in vulnerable urban and rural areas of the central zone of Chile. Specifically, the representations of the causes, morbidities, and symptoms attributed to the healthy and diseased mouth. Material and Methods: A qualitative study based on the Grounded Theory was conducted, analyzing the social representations of oral health in a sample of 161 adult people receiving treatment at public primary care services and dental emergency units in rural and urban communes. Empirical saturation and triangulation by time, place, and subjects give reliability to the study. Results: The data obtained show that dental health is mainly valued for its implications for self-esteem and social integration. A naturalization of dental health problems is evidenced as an adaptive strategy to traditional access barriers, which is counterproductive with preventive strategies. Conclusion: The results of the study suggest the need to reinforce education in dental health implemented in a transversal manner, having aesthetic values and the population's expectations of sociability as the key to action.
{"title":"Healthy or diseased mouth? Repre-sentations of oral health in vulnerable populations","authors":"Giselle Davis-Toledo","doi":"10.17126/joralres.2022.050","DOIUrl":"https://doi.org/10.17126/joralres.2022.050","url":null,"abstract":"Background: The society and the State must provide dental care and help prevent oral health problems by implementing public policies with cultural relevance that allow society to address and improve the inequity in health care that systematically affects people's well-being. The present study seeks to understand the representations of dental health in people who attend primary care services in vulnerable urban and rural areas of the central zone of Chile. Specifically, the representations of the causes, morbidities, and symptoms attributed to the healthy and diseased mouth. Material and Methods: A qualitative study based on the Grounded Theory was conducted, analyzing the social representations of oral health in a sample of 161 adult people receiving treatment at public primary care services and dental emergency units in rural and urban communes. Empirical saturation and triangulation by time, place, and subjects give reliability to the study. Results: The data obtained show that dental health is mainly valued for its implications for self-esteem and social integration. A naturalization of dental health problems is evidenced as an adaptive strategy to traditional access barriers, which is counterproductive with preventive strategies. Conclusion: The results of the study suggest the need to reinforce education in dental health implemented in a transversal manner, having aesthetic values and the population's expectations of sociability as the key to action.","PeriodicalId":16625,"journal":{"name":"Journal of Oral Research","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73646116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：