Pub Date : 2021-01-01DOI: 10.35248/2329-6887.21.9.308
Mirmazloomi
COVID-19 pandemic started in December 2019, and is a worldwide health disaster today, pulmonary fibrosis and cytokine storm are two major complications in COVID-19 patients which can decrease life quality after recovery, and cause death. Histamine effects on the immune system through 4 histamine receptors. The function pattern of histamine 4 receptor has many similarities to COVID-19 pathogenesis pattern.H4R antagonists prevent lung fibrosis in bleomycine-induced lung fibrosis murine models, it can reduce TNF-α and IL-6 secretion in several immunemediated diseases such as asthma, colitis and dermatitis.H4R stimulation also decreases IL-12 which is not detected to be high in COVID-19 patients.TH- 17 acts as an important inflammatory effector in COVID-19 pathogenesis, through IL-17 secretion which results in TNF-α and IL-6 secretion, and also IL-17 promotes tissue remodeling and fibrosis via matrix metalloproteinase induction.TH-17 expresses H4R which can be stimulated by H4R antagonist and results in IL-17 production, this process can explain the relation between H4R and COVID-19 pathogenesis. The other content supporting this theory is the compatibility of gastrointestinal, neurologic, and dermatologic signs and symptoms of COVID-19 with the H4R function pattern.in addition to the previous evidences, clusters of Kawasaki-like disease are reported recently, these patients were highly infected with SARS- COV2, and this can be explained by the important role of IL-17 in Kawasaki disease and the stimulatory effect of H4R on TH-17. According to the above content the author hypothesis that H4R stimulation by SARS-COV2 results in IL-17 expression which is associated with cytokine release, and H4R is a potential target point for COVID-19 treatment. This hypothesis can be evaluated by a clinical trial study of the therapeutic and preventive effect of H4R antagonists in COVID-19 patient’s complication, severity progression, and mortality
{"title":"Histamine 4 receptor is a Potential Target for COVID-19 Treatment","authors":"Mirmazloomi","doi":"10.35248/2329-6887.21.9.308","DOIUrl":"https://doi.org/10.35248/2329-6887.21.9.308","url":null,"abstract":"COVID-19 pandemic started in December 2019, and is a worldwide health disaster today, pulmonary fibrosis and cytokine storm are two major complications in COVID-19 patients which can decrease life quality after recovery, and cause death. Histamine effects on the immune system through 4 histamine receptors. The function pattern of histamine 4 receptor has many similarities to COVID-19 pathogenesis pattern.H4R antagonists prevent lung fibrosis in bleomycine-induced lung fibrosis murine models, it can reduce TNF-α and IL-6 secretion in several immunemediated diseases such as asthma, colitis and dermatitis.H4R stimulation also decreases IL-12 which is not detected to be high in COVID-19 patients.TH- 17 acts as an important inflammatory effector in COVID-19 pathogenesis, through IL-17 secretion which results in TNF-α and IL-6 secretion, and also IL-17 promotes tissue remodeling and fibrosis via matrix metalloproteinase induction.TH-17 expresses H4R which can be stimulated by H4R antagonist and results in IL-17 production, this process can explain the relation between H4R and COVID-19 pathogenesis. The other content supporting this theory is the compatibility of gastrointestinal, neurologic, and dermatologic signs and symptoms of COVID-19 with the H4R function pattern.in addition to the previous evidences, clusters of Kawasaki-like disease are reported recently, these patients were highly infected with SARS- COV2, and this can be explained by the important role of IL-17 in Kawasaki disease and the stimulatory effect of H4R on TH-17. According to the above content the author hypothesis that H4R stimulation by SARS-COV2 results in IL-17 expression which is associated with cytokine release, and H4R is a potential target point for COVID-19 treatment. This hypothesis can be evaluated by a clinical trial study of the therapeutic and preventive effect of H4R antagonists in COVID-19 patient’s complication, severity progression, and mortality","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"55 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80196166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6887.21.9.302
S. Nimmagadda
At Erasmus MC, scan techniques for precise audits are frequently planned by means of an administrator intervened search administration. The data experts of Erasmus MC built up an effective technique that encourages them perform look in numerous data sets in a lot more limited time than different strategies. This strategy for writing looking and a down to earth assessment thereof are distributed in independent diary articles. To put it plainly, the technique comprises of an effective method to consolidate thesaurus terms and title/unique terms into a solitary line search system [1]. This pursuit is then enhanced. Articles that are filed with a bunch of distinguished thesaurus terms, yet don't contain the flow search terms in title or unique, are screened to find likely new terms. New competitor terms are added to the essential inquiry and assessed. When ideal review is accomplished, macros are utilized to interpret the hunt sentence structures between data sets, however manual transformation of the thesaurus terms is as yet vital [2]. Survey projects at Erasmus MC cover a wide scope of clinical points, from remedial viability and symptomatic precision to morals and general wellbeing. When all is said in done, look are created in MEDLINE in (Ovid MEDLINE® In-Process and Other Non-Indexed Citations, Ovid MEDLINE® Daily and Ovid MEDLINE®, from 1946); Embase.com (looking through both Embase and MEDLINE records, with full inclusion including Embase Classic); the Cochrane Central Register of Controlled Trials (CENTRAL) by means of the Wiley Interface; Web of Science Core Collection (henceforth called Web of Science); PubMed confining to records in the subset "as provided by distributer" to discover references that not yet listed in MEDLINE (utilizing the language structure distributer [sb]); and Google Scholar. All in all, we utilize the initial 200 references as arranged in the importance positioning of Google Scholar [3]. At the point when the quantity of references from different information bases was low, we anticipated the absolute number of likely important references to be low. For this situation, the quantity of hits from Google Scholar was restricted to 100. At the point when the general number of hits was low, we furthermore looked through Scopus, and when suitable for the theme, we included CINAHL (EBSCOhost), PsycINFO (Ovid), and SportDiscus (EBSCOhost) in our hunt. Starting in May 2013, the quantity of records recovered from each quest for every information base was recorded right now of looking [4]. The total outcomes from all information bases utilized for every one of the deliberate surveys were brought into an exceptional EndNote library upon scan fulfillment and saved without deduplication for this examination. The analysts that mentioned the pursuit got a deduplicated EndNote document from which they chose the references significant for consideration in their methodical audit. All ventures in this investigation were created and execut
在Erasmus MC，精确审计的扫描技术经常通过管理员干预的搜索管理来计划。Erasmus MC的数据专家建立了一种有效的技术，鼓励他们在更有限的时间内查看大量数据集，而不是使用不同的策略。这种写作策略和对其的实地评估在独立的日记文章中分发。说白了，该技术包括将同义词典术语和标题/唯一术语合并到一个孤立行搜索系统的有效方法[1]。这种追求随后得到加强。如果文章的标题中没有包含流搜索词，但在同义词典中有一堆不同的词，那么文章就会被筛选，以找到可能的新词。新的竞争对手条款被添加到基本的查询和评估中。当完成理想的审查时，可以使用宏来解释数据集之间的搜索句子结构，但是手工转换同义词库术语仍然至关重要[2]。伊拉斯谟医学中心的调查项目涵盖了广泛的临床要点，从治疗可行性和症状准确性到道德和一般健康。当所有这些都说完了，在MEDLINE中创建(Ovid MEDLINE®在处理和其他非索引引文，Ovid MEDLINE®Daily和Ovid MEDLINE®，从1946年开始);Embase.com(查看Embase和MEDLINE记录，包括Embase Classic);通过Wiley接口检索Cochrane中央对照试验注册表(Central);Web of Science核心合集(以下称为Web of Science);PubMed限制在“由distributer提供的”子集中的记录，以发现尚未在MEDLINE中列出的引用(利用语言结构distributer [sb]);和谷歌学术搜索。总而言之，我们利用了Google Scholar重要性定位中安排的前200篇参考文献[3]。当来自不同信息库的参考文献数量较低时，我们预计可能重要的参考文献的绝对数量会较低。在这种情况下，来自Google Scholar的点击率被限制为100。当点击率较低时，我们进一步查看Scopus，当适合主题时，我们将CINAHL (EBSCOhost)， PsycINFO (Ovid)和SportDiscus (EBSCOhost)纳入我们的搜索范围。从2013年5月开始，对每个信息库的每次查询所恢复的记录量进行记录[4]。每次刻意调查所使用的所有信息库的总结果在扫描完成后被带入一个特殊的EndNote库，并在不重复数据删除的情况下保存以供本次检查。提到追踪的分析师获得了一份重复数据删除的EndNote文档，他们从中选择了在系统审计中重要的参考文献。本次调查的所有项目均由W.M.B创建并执行[5]。
{"title":"Methods of Prospective Exploratory Study","authors":"S. Nimmagadda","doi":"10.35248/2329-6887.21.9.302","DOIUrl":"https://doi.org/10.35248/2329-6887.21.9.302","url":null,"abstract":"At Erasmus MC, scan techniques for precise audits are frequently planned by means of an administrator intervened search administration. The data experts of Erasmus MC built up an effective technique that encourages them perform look in numerous data sets in a lot more limited time than different strategies. This strategy for writing looking and a down to earth assessment thereof are distributed in independent diary articles. To put it plainly, the technique comprises of an effective method to consolidate thesaurus terms and title/unique terms into a solitary line search system [1]. This pursuit is then enhanced. Articles that are filed with a bunch of distinguished thesaurus terms, yet don't contain the flow search terms in title or unique, are screened to find likely new terms. New competitor terms are added to the essential inquiry and assessed. When ideal review is accomplished, macros are utilized to interpret the hunt sentence structures between data sets, however manual transformation of the thesaurus terms is as yet vital [2]. Survey projects at Erasmus MC cover a wide scope of clinical points, from remedial viability and symptomatic precision to morals and general wellbeing. When all is said in done, look are created in MEDLINE in (Ovid MEDLINE® In-Process and Other Non-Indexed Citations, Ovid MEDLINE® Daily and Ovid MEDLINE®, from 1946); Embase.com (looking through both Embase and MEDLINE records, with full inclusion including Embase Classic); the Cochrane Central Register of Controlled Trials (CENTRAL) by means of the Wiley Interface; Web of Science Core Collection (henceforth called Web of Science); PubMed confining to records in the subset \"as provided by distributer\" to discover references that not yet listed in MEDLINE (utilizing the language structure distributer [sb]); and Google Scholar. All in all, we utilize the initial 200 references as arranged in the importance positioning of Google Scholar [3]. At the point when the quantity of references from different information bases was low, we anticipated the absolute number of likely important references to be low. For this situation, the quantity of hits from Google Scholar was restricted to 100. At the point when the general number of hits was low, we furthermore looked through Scopus, and when suitable for the theme, we included CINAHL (EBSCOhost), PsycINFO (Ovid), and SportDiscus (EBSCOhost) in our hunt. Starting in May 2013, the quantity of records recovered from each quest for every information base was recorded right now of looking [4]. The total outcomes from all information bases utilized for every one of the deliberate surveys were brought into an exceptional EndNote library upon scan fulfillment and saved without deduplication for this examination. The analysts that mentioned the pursuit got a deduplicated EndNote document from which they chose the references significant for consideration in their methodical audit. All ventures in this investigation were created and execut","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"6 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79389402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6887.21.9.313
Kriti Singh
Medication-related adverse events or negative drug reactions (ADRs) are harmful activities resulting from medication. ADRs could have profound consequences at the patients’ quality of lifestyles, as well as creating an expanded burden on the healthcare system [1]. ADRs are one of the growing reasons of morbidity and mortality internationally, and could stay a enormous public health trouble with the multiplied complexity in medicine, to treat diverse sicknesses in an getting older society.
{"title":"Morbidity and Mortality of Adverse Drug Reactions","authors":"Kriti Singh","doi":"10.35248/2329-6887.21.9.313","DOIUrl":"https://doi.org/10.35248/2329-6887.21.9.313","url":null,"abstract":"Medication-related adverse events or negative drug reactions (ADRs) are harmful activities resulting from medication. ADRs could have profound consequences at the patients’ quality of lifestyles, as well as creating an expanded burden on the healthcare system [1]. ADRs are one of the growing reasons of morbidity and mortality internationally, and could stay a enormous public health trouble with the multiplied complexity in medicine, to treat diverse sicknesses in an getting older society.","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"32 10 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77410613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6887.21.9.333
Priya Singh
{"title":"Therapeutic Drug Monitoring: Its Types, Characteristics on Candidates and Practice done on Monitoring","authors":"Priya Singh","doi":"10.35248/2329-6887.21.9.333","DOIUrl":"https://doi.org/10.35248/2329-6887.21.9.333","url":null,"abstract":"","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"69 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76303739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6887.21.9.314
Larry L Mweetwa, K. Tshiamo, P. C. Adiukwu, Thatoyaone JKenaope, E. Oluwabusola
Background: The primary concern of Pharmacovigilance (PV) is to strengthen patient care and improve public safety in terms of effective use of medication. The aim of this research was to analyse the impact of the existing Pharmacovigilance systems in the African region and its significant impact on adverse drug reactions (ADRs) reported by the Doctors, Pharmacists, and Nurses working in Federal-State Hospitals in Nigeria. Methods: The research design opted for this study is constructed on a questionnaire-based quantitative design that has helped in determining the correlation between Healthcare Professionals (HCP) training and awareness of ADR reporting incidences in different federal government hospital settings of Nigeria. Results: The Pearson chi-square test of independence with df = 2 yields chi-square = 101.4 (n = 318, p < 0.05, phi = 0.565), affirming that there is a statistically significant relationship between the awareness of ADR-reporting system and professions. Conclusion: The findings revealed that a majority of pharmacist and doctors possessed a good knowledge regarding PV, whereas the majority of nurses had poor knowledge about PV.
{"title":"Investigating the Impact of Existing Pharmacovigilance Systems in Africa and How They Influence Adverse Drug Reaction Reporting by Nurses, Doctors and Pharmacists Working in Federal Government Hospitals - A Case Study of Nigeria","authors":"Larry L Mweetwa, K. Tshiamo, P. C. Adiukwu, Thatoyaone JKenaope, E. Oluwabusola","doi":"10.35248/2329-6887.21.9.314","DOIUrl":"https://doi.org/10.35248/2329-6887.21.9.314","url":null,"abstract":"Background: The primary concern of Pharmacovigilance (PV) is to strengthen patient care and improve public safety in terms of effective use of medication. The aim of this research was to analyse the impact of the existing Pharmacovigilance systems in the African region and its significant impact on adverse drug reactions (ADRs) reported by the Doctors, Pharmacists, and Nurses working in Federal-State Hospitals in Nigeria. Methods: The research design opted for this study is constructed on a questionnaire-based quantitative design that has helped in determining the correlation between Healthcare Professionals (HCP) training and awareness of ADR reporting incidences in different federal government hospital settings of Nigeria. Results: The Pearson chi-square test of independence with df = 2 yields chi-square = 101.4 (n = 318, p < 0.05, phi = 0.565), affirming that there is a statistically significant relationship between the awareness of ADR-reporting system and professions. Conclusion: The findings revealed that a majority of pharmacist and doctors possessed a good knowledge regarding PV, whereas the majority of nurses had poor knowledge about PV.","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"8 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78769285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6887.21.9.301
Yamini Sai Nikita Dakamarry
Opioid analgesic overdose is a preventable and potentially lethal condition that outcomes from endorsing rehearses, insufficient comprehension on the patient's important for the dangers of prescription abuse, blunders in medication organization, and drug misuse. Three highlights are critical to a comprehension of narcotic pain relieving harmfulness. To begin with, narcotic pain relieving excess can have hazardous harmful impacts in numerous organ frameworks. Second, typical pharmacokinetic properties are regularly upset during an ingest too much and can draw out inebriation significantly. Third, the span of activity changes among narcotic plans, and inability to perceive such varieties can prompt unseemly treatment choices, once in a while with deadly outcomes.
{"title":"A Note on Opioid Analgesics Overdose","authors":"Yamini Sai Nikita Dakamarry","doi":"10.35248/2329-6887.21.9.301","DOIUrl":"https://doi.org/10.35248/2329-6887.21.9.301","url":null,"abstract":"Opioid analgesic overdose is a preventable and potentially lethal condition that outcomes from endorsing rehearses, insufficient comprehension on the patient's important for the dangers of prescription abuse, blunders in medication organization, and drug misuse. Three highlights are critical to a comprehension of narcotic pain relieving harmfulness. To begin with, narcotic pain relieving excess can have hazardous harmful impacts in numerous organ frameworks. Second, typical pharmacokinetic properties are regularly upset during an ingest too much and can draw out inebriation significantly. Third, the span of activity changes among narcotic plans, and inability to perceive such varieties can prompt unseemly treatment choices, once in a while with deadly outcomes.","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"34 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77745711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6887.21.9.327
N. Singh
{"title":"A Note on Protocol Writing In Clinical Research","authors":"N. Singh","doi":"10.35248/2329-6887.21.9.327","DOIUrl":"https://doi.org/10.35248/2329-6887.21.9.327","url":null,"abstract":"","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"36 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74407852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.35248/2329-6887.21.9.312
Nirupama Mythri
{"title":"Anxiety and Depression in COVID-19 Survivors: Clinical Predictors.","authors":"Nirupama Mythri","doi":"10.35248/2329-6887.21.9.312","DOIUrl":"https://doi.org/10.35248/2329-6887.21.9.312","url":null,"abstract":"","PeriodicalId":16958,"journal":{"name":"Journal of Pharmacovigilance","volume":"48 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80289444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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