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Jonathan Hutchinson – A multispecialist of medicine 乔纳森-哈钦森 - 医学多面手
Pub Date : 2024-04-23 DOI: 10.25259/jsstd_4_2024
Vishalakshi S. Pandit
Sir Jonathan Hutchinson was a renowned dermatologist, surgeon, syphilologist, neurologist, and medical educator. Although his fields of interest were medicine, surgery, and ophthalmology, he contributed tremendously in the field of dermatology. He had made many original observations and published articles; many of the signs and diseases are named after him. A few to name are Hutchinson teeth, triad, nail sign, facies. Along with being a prolific author, he was a collector and teacher of many subjects. He had a feather on cap of publishing more than 600 articles and case reports in dermatology. He wrote the 10 volumes of Archives of Surgery, a remarkable singlehanded labor. He had earned honorary degrees from Universities of Glasgow, Cambridge, Edinburgh, Oxford, Dublin, and Leeds. He was knighted in 1908.
乔纳森-哈钦森爵士是著名的皮肤病学家、外科医生、梅毒学家、神经学家和医学教育家。虽然他的兴趣领域是内科、外科和眼科,但他在皮肤科领域做出了巨大贡献。他进行了许多原创性的观察,并发表了许多文章;许多体征和疾病都以他的名字命名。其中包括哈钦森牙齿、三联征、指甲征和面部征。除了是一位多产作家,他还是许多学科的收藏家和教师。他发表了 600 多篇皮肤病学文章和病例报告。他撰写了 10 卷本的《外科档案》,这是一项了不起的单手工作。他曾获得格拉斯哥大学、剑桥大学、爱丁堡大学、牛津大学、都柏林大学和利兹大学的荣誉学位。1908 年,他被授予爵士称号。
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引用次数: 0
Asymptomatic skin lesions as a diagnostic clue in multiple myeloma – A case report 作为多发性骨髓瘤诊断线索的无症状皮损--病例报告
Pub Date : 2024-03-27 DOI: 10.25259/jsstd_3_2024
Anjana Jayaprakash, Thankappan Thonduparampil Pappen, Rhia Sebastian, Balachandran Parapattu Kunjukunju, Anju Joseph, Leny Mathew
Multiple myeloma (MM) is a rare cancer of plasma cells in the bone marrow. Cutaneous plasmacytoma is an uncommon but specific skin lesion in MM with an incidence of 2%. Cutaneous plasma cell infiltration in pre-existing MM is a very rare phenomenon, with approximately 100 cases described in the literature. Here, we report a case of a 61-year-old male who presented with asymptomatic skin nodules and plaques over the chest, abdomen, and back of the trunk for five months. Histopathological examination showed mononuclear cells with moderate cytoplasm and round to ovoid nuclei. Immunohistochemistry showed CD138 and kappa positivity and lambda and CD20 negativity, confirming the diagnosis of cutaneous plasmacytoma. Bone marrow biopsy and immunohistochemistry revealed bone marrow plasmacytosis with kappa light chain restriction. Serum free light chain ratio was 106.61 and fluorescence in situ hybridization showed del 13q. The clinical features and investigations fulfilled the diagnostic criteria for MM, and the patient was started on chemotherapy, following which the skin lesions improved. Development of skin lesions is seen in the advanced stages of MM and is considered a bad prognostic sign. However, they can also be seen as initial manifestations of the disease, as in this case. Hence, meticulous investigations and early diagnosis are of paramount importance.
多发性骨髓瘤(MM)是一种罕见的骨髓浆细胞癌症。皮肤浆细胞瘤是多发性骨髓瘤中一种不常见但特殊的皮肤病变,发病率为 2%。已存在 MM 的皮肤浆细胞浸润是一种非常罕见的现象,文献中描述的病例约有 100 例。在此,我们报告了一例 61 岁男性患者的病例,患者胸部、腹部和躯干后部出现无症状皮肤结节和斑块长达 5 个月。组织病理学检查显示,患者为单核细胞,胞浆中等,核圆形至卵圆形。免疫组化显示 CD138 和 kappa 阳性,λ 和 CD20 阴性,确诊为皮肤浆细胞瘤。骨髓活检和免疫组化显示骨髓浆细胞增多症,kappa轻链受限。血清游离轻链比值为106.61,荧光原位杂交显示del 13q。临床特征和检查结果均符合 MM 的诊断标准,患者开始接受化疗,随后皮损有所改善。皮损出现在 MM 晚期,被认为是预后不良的征兆。然而,皮损也可作为疾病的初期表现出现,本病例就是如此。因此,细致的检查和早期诊断至关重要。
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引用次数: 0
Rituximab-induced vasculitis: A rare occurrence 利妥昔单抗诱发的血管炎:罕见病例
Pub Date : 2024-03-13 DOI: 10.25259/jsstd_72_2023
Anusha P, Amitta Rachel Santhosh, Amoolya Manalil Trikkovil, Jayalakshmi S, Celine M. I, M. Vineetha, Amitha Mary Jacob
Rituximab is a chimeric murine/human monoclonal antibody that targets the CD20 antigen expressed on B lymphocytes. It is Food and Drug Administration-approved for use in pemphigus vulgaris (PV). Usual adverse effects are mild, and vasculitis has been reported very rarely. There are only three biopsy-proven case reports of rituximab-induced vasculitis in medical published literature and none in pemphigus. Here, we report a case of rituximab-induced vasculitis in a 46-year-old female with PV.
利妥昔单抗是一种针对 B 淋巴细胞上表达的 CD20 抗原的嵌合鼠/人单克隆抗体。它已获得美国食品和药物管理局批准,用于治疗寻常天疱疮(PV)。通常的不良反应较轻,血管炎的报道极少。在已发表的医学文献中,仅有三例经活检证实的利妥昔单抗诱发血管炎的病例报告,其中没有一例发生在丘疹性荨麻疹中。在此,我们报告了一例利妥昔单抗诱导的血管炎病例,患者是一名 46 岁的女性丘疹性荨麻疹患者。
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引用次数: 0
Eccrine angiomatous hamartoma – A rare painful skin tumor 泌尿生殖器血管瘤--一种罕见的疼痛性皮肤肿瘤
Pub Date : 2024-03-07 DOI: 10.25259/jsstd_66_2023
Niveditha M, P. Prathap, N. Asokan
We report a 68-year-old male with a progressively enlarging, reddish raised painful lesion on the right arm for the previous 3 years. The starch iodine test was positive, dermoscopic findings were yellowish-brown globules on an erythematous background. Biopsy from the lesion showed the presence of eccrine glands, hair follicles, and lobules of capillary sized vessels surrounding hair follicles in the dermis. On immunohistochemistry, epithelial membrane antigen (a marker for eccrine gland) and CD31 (endothelial marker) were positive. A final diagnosis of eccrine angiomatous hamartoma (EAH) was made. There should be a high index of suspicion about EAH if the skin lesions are reddish and tender with associated localized sweating.
我们报告了一名 68 岁男性的病例,他的右臂上有一个逐渐增大、红色隆起的疼痛性病变,已经持续了 3 年。淀粉碘试验呈阳性,皮肤镜检查结果为红斑背景上的黄褐色球状物。病变部位的活检结果显示,真皮层中存在肾上腺、毛囊和毛囊周围的毛细血管小叶。免疫组化结果显示,上皮膜抗原(肾上腺标记物)和 CD31(内皮标记物)呈阳性。最终诊断为肾上腺血管瘤性脂肪瘤(EAH)。如果皮损发红、触痛并伴有局部出汗,则应高度怀疑 EAH。
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引用次数: 0
The clinical, dermoscopic, and histopathologic differentiation of cutaneous leishmaniasis from cutaneous sarcoidosis and tuberculosis: A review article 皮肤利什曼病与皮肤肉样瘤病和结核病的临床、皮肤镜和组织病理学鉴别:综述文章
Pub Date : 2024-02-03 DOI: 10.25259/jsstd_55_2023
Jacob Al-Dabbagh, Nemat Ismail
Leishmaniasis is a neglected tropical disease caused by infected female sandflies (Phlebotomus and Lutzomyia), which are vector-borne protozoan parasites belonging to the genus Leishmania. The diagnosis of cutaneous leishmaniasis (CL) can be challenging and delayed, particularly in areas where leishmaniasis is not endemic. CL is known as “the great imitator” because it can mimic many skin disorders due to its various clinical manifestations. Cutaneous sarcoidosis (CS) and cutaneous tuberculosis (CTB), which are also known as “the great imitators,” should be differentiated from CL due to the common clinical, dermoscopic, and histopathologic features. In this article, we aim to help clinicians differentiate CL by listing its clinical manifestations those are similar to CS and CTB and highlighting common and uncommon dermoscopic and histopathologic findings. We have also created a brief approach to diagnose CL, CS, and CTB, which is presented as a diagram. A search was performed on PubMed and Google Scholar using the keywords CL, CTB, CS, and granulomatous disease for all articles, with no restrictions. Updated articles on leishmaniasis, tuberculosis, and sarcoidosis, including some new concepts in clinical presentations, dermoscopy, and histopathology, were reviewed.
利什曼病是一种被忽视的热带疾病,由受感染的雌性沙蝇(Phlebotomus 和 Lutzomyia)引起。皮肤利什曼病(CL)的诊断可能具有挑战性和延迟性,尤其是在利什曼病没有流行的地区。皮肤利什曼病被称为 "伟大的模仿者",因为它的各种临床表现可以模仿许多皮肤疾病。皮肤肉芽肿病(CS)和皮肤结核病(CTB)也被称为 "伟大的模仿者",但由于它们具有共同的临床、皮肤镜和组织病理学特征,因此应将它们与 CL 区分开来。在本文中,我们列举了 CL 与 CS 和 CTB 相似的临床表现,并强调了常见和不常见的皮肤镜和组织病理学结果,旨在帮助临床医生区分 CL。我们还创建了一个诊断 CL、CS 和 CTB 的简要方法,并以图表的形式呈现。我们在 PubMed 和 Google Scholar 上以 CL、CTB、CS 和肉芽肿病为关键词对所有文章进行了搜索,没有任何限制。还查阅了有关利什曼病、结核病和肉芽肿病的最新文章,包括临床表现、皮肤镜检查和组织病理学方面的一些新概念。
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引用次数: 0
The clinical, dermoscopic, and histopathologic differentiation of cutaneous leishmaniasis from cutaneous sarcoidosis and tuberculosis: A review article 皮肤利什曼病与皮肤肉样瘤病和结核病的临床、皮肤镜和组织病理学鉴别:综述文章
Pub Date : 2024-02-03 DOI: 10.25259/jsstd_55_2023
Jacob Al-Dabbagh, Nemat Ismail
Leishmaniasis is a neglected tropical disease caused by infected female sandflies (Phlebotomus and Lutzomyia), which are vector-borne protozoan parasites belonging to the genus Leishmania. The diagnosis of cutaneous leishmaniasis (CL) can be challenging and delayed, particularly in areas where leishmaniasis is not endemic. CL is known as “the great imitator” because it can mimic many skin disorders due to its various clinical manifestations. Cutaneous sarcoidosis (CS) and cutaneous tuberculosis (CTB), which are also known as “the great imitators,” should be differentiated from CL due to the common clinical, dermoscopic, and histopathologic features. In this article, we aim to help clinicians differentiate CL by listing its clinical manifestations those are similar to CS and CTB and highlighting common and uncommon dermoscopic and histopathologic findings. We have also created a brief approach to diagnose CL, CS, and CTB, which is presented as a diagram. A search was performed on PubMed and Google Scholar using the keywords CL, CTB, CS, and granulomatous disease for all articles, with no restrictions. Updated articles on leishmaniasis, tuberculosis, and sarcoidosis, including some new concepts in clinical presentations, dermoscopy, and histopathology, were reviewed.
利什曼病是一种被忽视的热带疾病,由受感染的雌性沙蝇(Phlebotomus 和 Lutzomyia)引起。皮肤利什曼病(CL)的诊断可能具有挑战性和延迟性,尤其是在利什曼病没有流行的地区。皮肤利什曼病被称为 "伟大的模仿者",因为它的各种临床表现可以模仿许多皮肤疾病。皮肤肉芽肿病(CS)和皮肤结核病(CTB)也被称为 "伟大的模仿者",但由于它们具有共同的临床、皮肤镜和组织病理学特征,因此应将它们与 CL 区分开来。在本文中,我们列举了 CL 与 CS 和 CTB 相似的临床表现,并强调了常见和不常见的皮肤镜和组织病理学结果,旨在帮助临床医生区分 CL。我们还创建了一个诊断 CL、CS 和 CTB 的简要方法,并以图表的形式呈现。我们在 PubMed 和 Google Scholar 上以 CL、CTB、CS 和肉芽肿病为关键词对所有文章进行了搜索,没有任何限制。还查阅了有关利什曼病、结核病和肉芽肿病的最新文章,包括临床表现、皮肤镜检查和组织病理学方面的一些新概念。
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引用次数: 0
Dermoscopy of lipoid proteinosis – Topographic diverse features 类脂蛋白沉积症的皮肤镜检查--不同的地形特征
Pub Date : 2024-01-31 DOI: 10.25259/jsstd_69_2023
Arun Somasundaram
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引用次数: 0
The use of topical Rapamycin in successfully treating non-Langerhans cell histiocytosis in a pediatric patient 使用外用雷帕霉素成功治疗一名儿童患者的非朗格汉斯细胞组织细胞增生症
Pub Date : 2024-01-20 DOI: 10.25259/jsstd_61_2023
David Pudukadan, Jeevana Mary Jose
Non-Langerhans cell histiocytosis (non-LCH) refers to a collection of medical conditions distinguished by the excessive growth of histiocytes in bodily tissues. It is important to note that these conditions do not meet the established diagnostic criteria for Langerhans cell histiocytosis (LCH). Juvenile xanthogranuloma (JXG) and benign cephalic histiocytosis (BCH) represent the prevailing forms of cutaneous non-LCH. We present a case of JXG which responded to topical treatment with a 0.1% topical ointment of Rapamycin. Rapamycin, an immunosuppressive and antineoplastic agent, can thus be a viable alternative non-invasive topical modality for managing JXG. However, it is imperative to conduct prolonged observations to evaluate the efficacy and potential adverse reactions.
非朗格汉斯细胞组织细胞增生症(Non-Langerhans cell histiocytosis,Non-LCH)是指身体组织中组织细胞过度生长的一系列病症。需要注意的是,这些病症并不符合朗格汉斯细胞组织细胞增生症(LCH)的既定诊断标准。幼年黄疽瘤(JXG)和良性头颅组织细胞增生症(BCH)是皮肤非 LCH 的主要表现形式。我们介绍了一例 JXG 病例,该病例对 0.1% 雷帕霉素外用软膏的局部治疗产生了反应。雷帕霉素是一种免疫抑制剂和抗肿瘤药,因此可以作为治疗 JXG 的另一种可行的非侵入性局部治疗方法。不过,必须进行长期观察,以评估疗效和潜在的不良反应。
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引用次数: 0
Neutrophilic dermatosis of dorsal hands: A unilateral presentation 手背嗜中性皮肤病:单侧表现
Pub Date : 2024-01-18 DOI: 10.25259/jsstd_57_2023
Anju Joseph, Thankappan Thonduparampil Pappen, Balachandran Parapattu Kunjukunju, Leny Mathew, Anjana Jayaprakash
A rare localized version of Sweet syndrome known as neutrophilic dermatosis of dorsal hands is characterized by bluish or hemorrhagic papules, bullae, and nodules on the dorsal hands. Cases have been associated with myeloproliferative disorders, malignancy, inflammatory bowel disease, and rheumatoid arthritis. We are reporting a case of a 39-year-old male presented with sudden onset hyperpigmented raised lesions studded with fluid-filled vesicles on the left dorsal hands. Histology confirmed the clinical diagnosis of neutrophilic dermatosis of dorsal hands. Unilateral presentation of neutrophilic dermatosis of dorsal hands is rarely encountered in day-to-day practice. Hence, we are reporting this case.
手背嗜中性粒细胞皮炎是斯威特综合征的一种罕见局部病症,其特征是手背出现淡蓝色或出血性丘疹、鼓包和结节。病例与骨髓增生性疾病、恶性肿瘤、炎症性肠病和类风湿性关节炎有关。我们报告了一例 39 岁男性病例,患者左手背突然出现色素沉着的隆起性病变,并伴有充满液体的囊泡。组织学确诊为手背嗜中性粒细胞性皮肤病。单侧表现的手背嗜中性皮肤病在日常诊疗中很少见。因此,我们报告了这一病例。
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引用次数: 0
Multifocal infantile hemangiomas in a 4-month-old female infant 一名 4 个月大女婴的多灶性婴儿血管瘤
Pub Date : 2024-01-18 DOI: 10.25259/jsstd_62_2023
Linza P. Zachariah, P. Prathap, N. Asokan, T. Zacharia
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引用次数: 0
期刊
Journal of Skin and Sexually Transmitted Diseases
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