syndrome, and familial non-syndromic TAADs. Syndromic TAADs are typically caused by pathogenic variants in the transforming growth factor- β signal and extracellular matrix-related genes, such as FBN1, TGFBR1, TGFBR2, SMAD3, TGFB2, COL3A1, while approximately 20% of the non-syndromic hereditary TAADs result from altered components of the contractile apparatus of vascular smooth muscle cells, encoded by ACTA2, MYH11, MYLK, and PRKG1 genes. The genotype–phenotype relationship of hereditary TAADs has been extensively investigated to improve the methods for risk stratification and personalized treatment strategies. In this review, we present the current understanding of genotype–phenotype relationship and molecular mechanisms responsible for aortopathies of hereditary TAADs.
{"title":"Pathophysiology of Hereditary Thoracic Aneurysms","authors":"Hiroki Yagi, N. Takeda, H. Akazawa","doi":"10.7133/jca.19-00030","DOIUrl":"https://doi.org/10.7133/jca.19-00030","url":null,"abstract":"syndrome, and familial non-syndromic TAADs. Syndromic TAADs are typically caused by pathogenic variants in the transforming growth factor- β signal and extracellular matrix-related genes, such as FBN1, TGFBR1, TGFBR2, SMAD3, TGFB2, COL3A1, while approximately 20% of the non-syndromic hereditary TAADs result from altered components of the contractile apparatus of vascular smooth muscle cells, encoded by ACTA2, MYH11, MYLK, and PRKG1 genes. The genotype–phenotype relationship of hereditary TAADs has been extensively investigated to improve the methods for risk stratification and personalized treatment strategies. In this review, we present the current understanding of genotype–phenotype relationship and molecular mechanisms responsible for aortopathies of hereditary TAADs.","PeriodicalId":171701,"journal":{"name":"The Journal of Japanese College of Angiology","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129933773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"第24回 日本血管病理研究会","authors":"","doi":"10.7133/jca.600201","DOIUrl":"https://doi.org/10.7133/jca.600201","url":null,"abstract":"","PeriodicalId":171701,"journal":{"name":"The Journal of Japanese College of Angiology","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115361726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Yachi, Tetsuya Saito, E. Yoshida, M. Takeyama, S. Ayabe
Objectives: We investigated the relation between success placement of central venous (CV) port and anatomical factors associated with left brachiocephalic vein (LBV) stenosis. Methods: One hundred forty-nine patients who underwent CV port placement were included from Jan. 2014 to Dec. 2017 in our institu-tion. All patients performed CT scan prior to CV port placement. We investigated the diameter of LBV, the distance between sternum and aorta, and the curving angle of LBV around aorta. We compared them with success rate of CV catheter insertion. Results: CV catheter insertion was failed in 9.5% of patients who received CV catheter insertion from left side. In the failure group of CV catheter insertion, the diameter of LBV, the distance between sternum and aorta, and the curving angle of LBV around aorta were signifi-cantly smaller than in the success group. Conclusions: Success rate of CV catheter insertion was associated with LBV stenosis, the distance between sternum and aorta, and the curving angle of LBV around aorta.
{"title":"Relation between Success Placement of Central Venous Port and Left Brachiocephalic Vein Stenosis","authors":"S. Yachi, Tetsuya Saito, E. Yoshida, M. Takeyama, S. Ayabe","doi":"10.7133/jca.19-00023","DOIUrl":"https://doi.org/10.7133/jca.19-00023","url":null,"abstract":"Objectives: We investigated the relation between success placement of central venous (CV) port and anatomical factors associated with left brachiocephalic vein (LBV) stenosis. Methods: One hundred forty-nine patients who underwent CV port placement were included from Jan. 2014 to Dec. 2017 in our institu-tion. All patients performed CT scan prior to CV port placement. We investigated the diameter of LBV, the distance between sternum and aorta, and the curving angle of LBV around aorta. We compared them with success rate of CV catheter insertion. Results: CV catheter insertion was failed in 9.5% of patients who received CV catheter insertion from left side. In the failure group of CV catheter insertion, the diameter of LBV, the distance between sternum and aorta, and the curving angle of LBV around aorta were signifi-cantly smaller than in the success group. Conclusions: Success rate of CV catheter insertion was associated with LBV stenosis, the distance between sternum and aorta, and the curving angle of LBV around aorta.","PeriodicalId":171701,"journal":{"name":"The Journal of Japanese College of Angiology","volume":"363 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115974226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stent-graft Treatment for Subclavian Artery Aneurysm: Report of a Case","authors":"M. Hirano, H. Kitou","doi":"10.7133/jca.19-00016","DOIUrl":"https://doi.org/10.7133/jca.19-00016","url":null,"abstract":"","PeriodicalId":171701,"journal":{"name":"The Journal of Japanese College of Angiology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125242887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of NLRP3 Inflammasome in Atherosclerosis and Aortic Aneurysm","authors":"Ryouta Kamata, Masafumi Takahashi","doi":"10.7133/jca.19-00022","DOIUrl":"https://doi.org/10.7133/jca.19-00022","url":null,"abstract":"","PeriodicalId":171701,"journal":{"name":"The Journal of Japanese College of Angiology","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114973958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case Report of Simultaneous Carotid and Aortic Valve Surgery under Cardiopulmonary Bypass","authors":"M. Yoda, T. Miyazaki, Minoru Yoshida","doi":"10.7133/jca.19-00008","DOIUrl":"https://doi.org/10.7133/jca.19-00008","url":null,"abstract":"","PeriodicalId":171701,"journal":{"name":"The Journal of Japanese College of Angiology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130671234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Imai, R. Kyuragi, M. Yoshikawa, N. Sakamoto, T. Onohara
The tailoring technique, which involves partial resection of an aneurysm followed by direct suture of the remaining arterial wall, is one of the surgical options for renal artery aneurysm (RAA). We evaluated the short- and long-term outcomes of eight patients who underwent surgery for saccular RAAs using the tailoring technique. Acute kidney injury was postoperatively reported in only one patient, and no patient required hemodialysis. During the long-term follow-up period (mean, 5.3 ± 3.6 years), renal artery stenosis, renal artery occlusion, and RAA recurrence did not occur among the patients. Aneurysmorrhaphy using the tailoring technique is an effective surgical option because of its favorable long-term outcomes. (J
{"title":"Surgical Treatment Using Tailoring Technique for Renal Artery Aneurysm","authors":"S. Imai, R. Kyuragi, M. Yoshikawa, N. Sakamoto, T. Onohara","doi":"10.7133/jca.19-00018","DOIUrl":"https://doi.org/10.7133/jca.19-00018","url":null,"abstract":"The tailoring technique, which involves partial resection of an aneurysm followed by direct suture of the remaining arterial wall, is one of the surgical options for renal artery aneurysm (RAA). We evaluated the short- and long-term outcomes of eight patients who underwent surgery for saccular RAAs using the tailoring technique. Acute kidney injury was postoperatively reported in only one patient, and no patient required hemodialysis. During the long-term follow-up period (mean, 5.3 ± 3.6 years), renal artery stenosis, renal artery occlusion, and RAA recurrence did not occur among the patients. Aneurysmorrhaphy using the tailoring technique is an effective surgical option because of its favorable long-term outcomes. (J","PeriodicalId":171701,"journal":{"name":"The Journal of Japanese College of Angiology","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134516779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shingo Nakai, Tetsuo Watanabe, Y. Nakano, M. Tsuda, H. Sakakibara, S. Toyama, Keiichiro Kawamura, M. Sadahiro
{"title":"Endovascular Therapy for Nutcracker Syndrome: A Case Report","authors":"Shingo Nakai, Tetsuo Watanabe, Y. Nakano, M. Tsuda, H. Sakakibara, S. Toyama, Keiichiro Kawamura, M. Sadahiro","doi":"10.7133/jca.18-00041","DOIUrl":"https://doi.org/10.7133/jca.18-00041","url":null,"abstract":"","PeriodicalId":171701,"journal":{"name":"The Journal of Japanese College of Angiology","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115195756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of Early Diagnosis and Therapeutic Agent for CTEPH Focused on a Novel Pathogenic Protein TAFI","authors":"K. Satoh, T. Satoh, N. Yaoita, H. Shimokawa","doi":"10.7133/JCA.19-00011","DOIUrl":"https://doi.org/10.7133/JCA.19-00011","url":null,"abstract":"","PeriodicalId":171701,"journal":{"name":"The Journal of Japanese College of Angiology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122275462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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