T he d-isomer of synthetic diphenyl propionate derivative propoxyphene, with narcotic analgesic effect. T his agent mimics the effects of the endogenous opiate dextropropoxyphene, by binding to mu receptors located throughout the central nervous system. T he binding results in GT P to GDP exchanges on the mu-G-protein complex, by which effector adenylate cyclase is inactivated thereby decreasing intracellular cAMP. T his, in turn, inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, dextropropoxyphene closes N-type voltagegated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. T his results in hyperpolarization, thereby reducing neuronal excitability, which further decreases the perception of pain. Qeios · Definition, February 7, 2020
{"title":"Propoxyphene.","authors":"R. Poust, J. Jaffe","doi":"10.32388/uorgka","DOIUrl":"https://doi.org/10.32388/uorgka","url":null,"abstract":"T he d-isomer of synthetic diphenyl propionate derivative propoxyphene, with narcotic analgesic effect. T his agent mimics the effects of the endogenous opiate dextropropoxyphene, by binding to mu receptors located throughout the central nervous system. T he binding results in GT P to GDP exchanges on the mu-G-protein complex, by which effector adenylate cyclase is inactivated thereby decreasing intracellular cAMP. T his, in turn, inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, dextropropoxyphene closes N-type voltagegated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. T his results in hyperpolarization, thereby reducing neuronal excitability, which further decreases the perception of pain. Qeios · Definition, February 7, 2020","PeriodicalId":17212,"journal":{"name":"Journal of the American Pharmaceutical Association","volume":"20 1","pages":"97-100"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81296054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A broad-spectrum, short-acting sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfisoxazole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.
{"title":"Sulfisoxazole.","authors":"","doi":"10.32388/o9oqqi","DOIUrl":"https://doi.org/10.32388/o9oqqi","url":null,"abstract":"A broad-spectrum, short-acting sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfisoxazole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.","PeriodicalId":17212,"journal":{"name":"Journal of the American Pharmaceutical Association","volume":"58 1","pages":"617-20"},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89493265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The “shaking‐out” method for the quantitative estimation of alkaloids. II. Effect of clarification and “salting‐out”","authors":"G. Beal, T. S. Hamilton","doi":"10.1002/JPS.3080090104","DOIUrl":"https://doi.org/10.1002/JPS.3080090104","url":null,"abstract":"","PeriodicalId":17212,"journal":{"name":"Journal of the American Pharmaceutical Association","volume":"8 1","pages":"9-15"},"PeriodicalIF":0.0,"publicationDate":"2018-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86828455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-05-01DOI: 10.1542/9781581109276-drug
L. Block, P. Lamy
{"title":"Drug interactions.","authors":"L. Block, P. Lamy","doi":"10.1542/9781581109276-drug","DOIUrl":"https://doi.org/10.1542/9781581109276-drug","url":null,"abstract":"","PeriodicalId":17212,"journal":{"name":"Journal of the American Pharmaceutical Association","volume":"18 1","pages":"202-7"},"PeriodicalIF":0.0,"publicationDate":"2015-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79183164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A common freshman year for all students entering professional colleges","authors":"F. J. Wulling","doi":"10.1002/JPS.3080110815","DOIUrl":"https://doi.org/10.1002/JPS.3080110815","url":null,"abstract":"","PeriodicalId":17212,"journal":{"name":"Journal of the American Pharmaceutical Association","volume":"147 1","pages":"626-627"},"PeriodicalIF":0.0,"publicationDate":"2009-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80615940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Detection of diethylphthalate in whisky","authors":"A. Lyons","doi":"10.1002/JPS.3080110407","DOIUrl":"https://doi.org/10.1002/JPS.3080110407","url":null,"abstract":"","PeriodicalId":17212,"journal":{"name":"Journal of the American Pharmaceutical Association","volume":"60 1","pages":"262-265"},"PeriodicalIF":0.0,"publicationDate":"2008-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84903409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pharmazeutischer Kalender 1922. Herausgegeben von Ernst Urban. 62. Edition. In 2 parts. Berlin, Verlag von Julius Springer","authors":"Otto Raubenheimer","doi":"10.1002/JPS.3080110424","DOIUrl":"https://doi.org/10.1002/JPS.3080110424","url":null,"abstract":"","PeriodicalId":17212,"journal":{"name":"Journal of the American Pharmaceutical Association","volume":"28 1 1","pages":"319-319"},"PeriodicalIF":0.0,"publicationDate":"2008-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85185735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Soluble compound spirit of orange and a simplified process for aromatic elixir","authors":"Ernest Jones","doi":"10.1002/JPS.3080110411","DOIUrl":"https://doi.org/10.1002/JPS.3080110411","url":null,"abstract":"","PeriodicalId":17212,"journal":{"name":"Journal of the American Pharmaceutical Association","volume":"36 1","pages":"277-278"},"PeriodicalIF":0.0,"publicationDate":"2008-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79156798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dehydrated products in commerce and in the sciences","authors":"L. Gershenfeld","doi":"10.1002/JPS.3080110205","DOIUrl":"https://doi.org/10.1002/JPS.3080110205","url":null,"abstract":"","PeriodicalId":17212,"journal":{"name":"Journal of the American Pharmaceutical Association","volume":"32 1","pages":"86-90"},"PeriodicalIF":0.0,"publicationDate":"2008-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77241459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Manufacture of Synthetic Medicinal Chemicals in America","authors":"Alfred S. Burdick","doi":"10.1002/JPS.3080110209","DOIUrl":"https://doi.org/10.1002/JPS.3080110209","url":null,"abstract":"","PeriodicalId":17212,"journal":{"name":"Journal of the American Pharmaceutical Association","volume":"44 1","pages":"98-108"},"PeriodicalIF":0.0,"publicationDate":"2008-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85564695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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