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Journal of The American Society of Nephrology最新文献

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Authors' Reply: The Role of Malnutrition and Psychiatric Illnesses in Olfactory Dysfunction Post-Kidney Transplantation. 作者回复：营养不良和精神疾病在肾移植后嗅觉功能障碍中的作用。
IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Journal of The American Society of Nephrology
Pub Date : 2024-08-27 DOI: 10.1681/ASN.0000000000000483
Aditi Gupta
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引用次数: 0
The Role of Malnutrition and Psychiatric Illnesses in Olfactory Dysfunction Post-Kidney Transplantation. 营养不良和精神疾病在肾移植后嗅觉功能障碍中的作用
IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Journal of The American Society of Nephrology
Pub Date : 2024-08-27 DOI: 10.1681/ASN.0000000000000482
Chia-Ter Chao
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引用次数: 0
Association of Genetically Predicted Skipping of COL4A4 Exon 27 with Hematuria and Albuminuria. 基因预测的 COL4A4 第 27 号外显子缺失与血尿和白蛋白尿的关系
IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Journal of The American Society of Nephrology
Pub Date : 2024-08-27 DOI: 10.1681/ASN.0000000000000480
Frida Lona-Durazo, Kohei Omachi, Damian Fermin, Felix Eichinger, Jonathan P Troost, Meei-Hua Lin, Ian R Dinsmore, Tooraj Mirshahi, Alexander R Chang, Jeffrey H Miner, Andrew D Paterson, Moumita Barua, Sarah A Gagliano Taliun
{"title":"Association of Genetically Predicted Skipping of COL4A4 Exon 27 with Hematuria and Albuminuria.","authors":"Frida Lona-Durazo, Kohei Omachi, Damian Fermin, Felix Eichinger, Jonathan P Troost, Meei-Hua Lin, Ian R Dinsmore, Tooraj Mirshahi, Alexander R Chang, Jeffrey H Miner, Andrew D Paterson, Moumita Barua, Sarah A Gagliano Taliun","doi":"10.1681/ASN.0000000000000480","DOIUrl":"10.1681/ASN.0000000000000480","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium-Glucose Cotransporter-2 Inhibitor and Glucagon-Like Peptide-1 Receptor Agonist Discontinuation in Patients with CKD. 慢性肾脏病患者停用钠-葡萄糖转运体-2 抑制剂和胰高血糖素样肽-1 受体激动剂。
IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Journal of The American Society of Nephrology
Pub Date : 2024-08-26 DOI: 10.1681/ASN.0000000000000477
L Parker Gregg, Peter A Richardson, Vijay Nambi, Laura A Petersen, Michael E Matheny, Salim S Virani, Sankar D Navaneethan
{"title":"Sodium-Glucose Cotransporter-2 Inhibitor and Glucagon-Like Peptide-1 Receptor Agonist Discontinuation in Patients with CKD.","authors":"L Parker Gregg, Peter A Richardson, Vijay Nambi, Laura A Petersen, Michael E Matheny, Salim S Virani, Sankar D Navaneethan","doi":"10.1681/ASN.0000000000000477","DOIUrl":"10.1681/ASN.0000000000000477","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ST2 + T-Regulatory Cells in Renal Inflammation and Fibrosis after Ischemic Kidney Injury. 缺血性肾损伤后肾脏炎症和纤维化中的 ST2+ T 调节细胞
IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Journal of The American Society of Nephrology
Pub Date : 2024-08-26 DOI: 10.1681/ASN.0000000000000471
Vikram Sabapathy, Airi Price, Nardos Tesfaye Cheru, Rajkumar Venkatadri, Murat Dogan, Gabrielle Costlow, Saleh Mohammad, Rahul Sharma
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引用次数: 0
Adaptive Designs for Clinical Trials in Nephrology. 肾脏病学临床试验的适应性设计。
IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Journal of The American Society of Nephrology
Pub Date : 2024-08-26 DOI: 10.1681/ASN.0000000000000497
Rathika Krishnasamy, Meg J Jardine
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引用次数: 0
Aquaporin-1 and Osmosis: From Physiology to Precision in Peritoneal Dialysis. Aquaporin-1与渗透：腹膜透析中从生理学到精确性。
IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Journal of The American Society of Nephrology
Pub Date : 2024-08-26 DOI: 10.1681/ASN.0000000000000496
Olivier Devuyst

The discovery of the aquaporin family of water channels has provided a molecular counterpart to the movement of water across biological membranes. The distribution of aquaporins in specific cell types, their selectivity and very high capacity for water permeation, and the control of their expression and/or trafficking are key to sustain osmosis in multiple tissues. Here, we review the convergent evidence demonstrating that aquaporin-1 (AQP1) facilitates water transport across endothelial cells in the peritoneal membrane, a key process for peritoneal dialysis-the leading modality of home-based dialysis therapy for patients with kidney failure. Genetic and pharmacologic studies in mouse and cell models indicated that AQP1 plays a critical role in crystalloid osmosis, with clinically relevant effects on water transport and risk of death and technique failure for patients on dialysis. By contrast, AQP1 plays no role in colloid osmosis. These studies substantiate potential strategies to improve free water transport and ultrafiltration in patients treated by peritoneal dialysis.

摘要：水通道的水蒸发素家族的发现为水在生物膜上的移动提供了分子对应物。水通道蛋白在特定细胞类型中的分布、其选择性和极高的水渗透能力以及对其表达和/或贩运的控制是维持多种组织渗透的关键。在此，我们回顾了证明水蒸发素-1（AQP1）促进腹膜内皮细胞水转运的汇聚证据，这是腹膜透析的关键过程--腹膜透析是肾衰竭患者家庭透析治疗的主要方式。在小鼠和细胞模型中进行的遗传学和药理学研究表明，AQP1 在晶体渗透中起着关键作用，对透析患者的水转运、死亡风险和技术衰竭具有临床意义。相比之下，AQP1 在胶体渗透中不起作用。这些研究证实了改善腹膜透析患者自由水转运和超滤的潜在策略。
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引用次数: 0
Lactobacillus casei Cell Wall Extract and Production of Galactose-Deficient IgA1 in a Humanized IGHA1 Mouse Model. 干酪乳杆菌细胞壁提取物与人源化 IGHA1 小鼠模型中半乳糖缺陷 IgA1 的产生
IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Journal of The American Society of Nephrology
Pub Date : 2024-08-22 DOI: 10.1681/ASN.0000000000000465
Run Li, Manliu Wang, Jingyi Li, Li Zhu, Xinfang Xie, Hui Wang, Xu Zhang, Wenmin Tian, Yong Zhang, Yaping Dong, Jincan Zan, Hongyu Li, Yuemiao Zhang, Xujie Zhou, Sufang Shi, Chutian Shu, Lijun Liu, Jing Jin, Jicheng Lv, Hong Zhang
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引用次数: 0
Correction: HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes. 更正：HNF1B 改变了目标基因的进化保守肾原性程序。
IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Journal of The American Society of Nephrology
Pub Date : 2024-08-21 DOI: 10.1681/ASN.0000000000000472
{"title":"Correction: HNF1B Alters an Evolutionarily Conserved Nephrogenic Program of Target Genes.","authors":"","doi":"10.1681/ASN.0000000000000472","DOIUrl":"10.1681/ASN.0000000000000472","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Kidney Outcomes in Children with Posterior Urethral Valves: A Population-Based Cohort Study. 尿道后瓣膜患儿的长期肾脏预后：基于人群的队列研究。
IF 10.3 1区 医学 Q1 UROLOGY & NEPHROLOGY
Journal of The American Society of Nephrology
Pub Date : 2024-08-21 DOI: 10.1681/ASN.0000000000000468
Cal H Robinson, Mandy Rickard, Nivethika Jeyakumar, Graham Smith, Juliane Richter, Tim Van Mieghem, Joana Dos Santos, Rahul Chanchlani, Armando J Lorenzo
{"title":"Long-Term Kidney Outcomes in Children with Posterior Urethral Valves: A Population-Based Cohort Study.","authors":"Cal H Robinson, Mandy Rickard, Nivethika Jeyakumar, Graham Smith, Juliane Richter, Tim Van Mieghem, Joana Dos Santos, Rahul Chanchlani, Armando J Lorenzo","doi":"10.1681/ASN.0000000000000468","DOIUrl":"10.1681/ASN.0000000000000468","url":null,"abstract":"","PeriodicalId":17217,"journal":{"name":"Journal of The American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":10.3,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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