Pub Date : 2017-02-01DOI: 10.1007/s10162-016-0599-z
D. H. Keefe, M. Patrick Feeney, Lisa L. Hunter, Denis F. Fitzpatrick
{"title":"Aural Acoustic Stapedius-Muscle Reflex Threshold Procedures to Test Human Infants and Adults","authors":"D. H. Keefe, M. Patrick Feeney, Lisa L. Hunter, Denis F. Fitzpatrick","doi":"10.1007/s10162-016-0599-z","DOIUrl":"https://doi.org/10.1007/s10162-016-0599-z","url":null,"abstract":"","PeriodicalId":17236,"journal":{"name":"Journal of the Association for Research in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88670078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-01Epub Date: 2016-10-07DOI: 10.1007/s10162-016-0587-3
Hamid Motallebzadeh, Nima Maftoon, Jacob Pitaro, W Robert J Funnell, Sam J Daniel
Admittance measurement is a promising tool for evaluating the status of the middle ear in newborns. However, the newborn ear is anatomically very different from the adult one, and the acoustic input admittance is different than in adults. To aid in understanding the differences, a finite-element model of the newborn ear canal and middle ear was developed and its behaviour was studied for frequencies up to 2000 Hz. Material properties were taken from previous measurements and estimates. The simulation results were within the range of clinical admittance measurements made in newborns. Sensitivity analyses of the material properties show that in the canal model, the maximum admittance and the frequency at which that maximum admittance occurs are affected mainly by the stiffness parameter; in the middle-ear model, the damping is as important as the stiffness in influencing the maximum admittance magnitude but its effect on the corresponding frequency is negligible. Scaling up the geometries increases the admittance magnitude and shifts the resonances to lower frequencies. The results suggest that admittance measurements can provide more information about the condition of the middle ear when made at multiple frequencies around its resonance.
{"title":"Finite-Element Modelling of the Acoustic Input Admittance of the Newborn Ear Canal and Middle Ear.","authors":"Hamid Motallebzadeh, Nima Maftoon, Jacob Pitaro, W Robert J Funnell, Sam J Daniel","doi":"10.1007/s10162-016-0587-3","DOIUrl":"10.1007/s10162-016-0587-3","url":null,"abstract":"<p><p>Admittance measurement is a promising tool for evaluating the status of the middle ear in newborns. However, the newborn ear is anatomically very different from the adult one, and the acoustic input admittance is different than in adults. To aid in understanding the differences, a finite-element model of the newborn ear canal and middle ear was developed and its behaviour was studied for frequencies up to 2000 Hz. Material properties were taken from previous measurements and estimates. The simulation results were within the range of clinical admittance measurements made in newborns. Sensitivity analyses of the material properties show that in the canal model, the maximum admittance and the frequency at which that maximum admittance occurs are affected mainly by the stiffness parameter; in the middle-ear model, the damping is as important as the stiffness in influencing the maximum admittance magnitude but its effect on the corresponding frequency is negligible. Scaling up the geometries increases the admittance magnitude and shifts the resonances to lower frequencies. The results suggest that admittance measurements can provide more information about the condition of the middle ear when made at multiple frequencies around its resonance.</p>","PeriodicalId":17236,"journal":{"name":"Journal of the Association for Research in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73122303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-02-01DOI: 10.1007/s10162-016-0591-7
Pankhuri Vyas, Jingjing Sherry Wu, Amanda L. Zimmerman, P. Fuchs, E. Glowatzki
{"title":"Tyrosine Hydroxylase Expression in Type II Cochlear Afferents in Mice","authors":"Pankhuri Vyas, Jingjing Sherry Wu, Amanda L. Zimmerman, P. Fuchs, E. Glowatzki","doi":"10.1007/s10162-016-0591-7","DOIUrl":"https://doi.org/10.1007/s10162-016-0591-7","url":null,"abstract":"","PeriodicalId":17236,"journal":{"name":"Journal of the Association for Research in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80085892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-18DOI: 10.1007/s10162-016-0611-7
G. Andéol, C. Suied, S. Scannella, F. Dehais
{"title":"The Spatial Release of Cognitive Load in Cocktail Party Is Determined by the Relative Levels of the Talkers","authors":"G. Andéol, C. Suied, S. Scannella, F. Dehais","doi":"10.1007/s10162-016-0611-7","DOIUrl":"https://doi.org/10.1007/s10162-016-0611-7","url":null,"abstract":"","PeriodicalId":17236,"journal":{"name":"Journal of the Association for Research in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80332366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-17DOI: 10.1007/s10162-016-0612-6
Nima Salimi, M. S. Zilany, L. Carney
{"title":"Modeling Responses in the Superior Paraolivary Nucleus: Implications for Forward Masking in the Inferior Colliculus","authors":"Nima Salimi, M. S. Zilany, L. Carney","doi":"10.1007/s10162-016-0612-6","DOIUrl":"https://doi.org/10.1007/s10162-016-0612-6","url":null,"abstract":"","PeriodicalId":17236,"journal":{"name":"Journal of the Association for Research in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77121314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-03DOI: 10.1007/s10162-016-0609-1
E. King, R. Shepherd, D. J. Brown, J. Fallon
{"title":"Gentamicin Applied to the Oval Window Suppresses Vestibular Function in Guinea Pigs","authors":"E. King, R. Shepherd, D. J. Brown, J. Fallon","doi":"10.1007/s10162-016-0609-1","DOIUrl":"https://doi.org/10.1007/s10162-016-0609-1","url":null,"abstract":"","PeriodicalId":17236,"journal":{"name":"Journal of the Association for Research in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80861597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-03DOI: 10.1007/s10162-016-0610-8
J. Ison, P. Allen, D. Oertel
{"title":"Deleting the HCN1 Subunit of Hyperpolarization-Activated Ion Channels in Mice Impairs Acoustic Startle Reflexes, Gap Detection, and Spatial Localization","authors":"J. Ison, P. Allen, D. Oertel","doi":"10.1007/s10162-016-0610-8","DOIUrl":"https://doi.org/10.1007/s10162-016-0610-8","url":null,"abstract":"","PeriodicalId":17236,"journal":{"name":"Journal of the Association for Research in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82257926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-12-01Epub Date: 2016-10-17DOI: 10.1007/s10162-016-0589-1
Kevin K Ohlemiller, Sherri M Jones, Kenneth R Johnson
Laboratory mice (Mus musculus) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization, and confirmation. Every application of mice is founded on assumptions about what mice represent and how the information gained may be generalized. A host of successes support the continued use of mice to understand hearing and balance. Depending on the research question, however, some mouse models and research designs will be more appropriate than others. Here, we recount some of the history and successes of the use of mice in hearing and vestibular studies and offer guidelines to those considering how to apply mouse models.
{"title":"Application of Mouse Models to Research in Hearing and Balance.","authors":"Kevin K Ohlemiller, Sherri M Jones, Kenneth R Johnson","doi":"10.1007/s10162-016-0589-1","DOIUrl":"10.1007/s10162-016-0589-1","url":null,"abstract":"<p><p>Laboratory mice (Mus musculus) have become the major model species for inner ear research. The major uses of mice include gene discovery, characterization, and confirmation. Every application of mice is founded on assumptions about what mice represent and how the information gained may be generalized. A host of successes support the continued use of mice to understand hearing and balance. Depending on the research question, however, some mouse models and research designs will be more appropriate than others. Here, we recount some of the history and successes of the use of mice in hearing and vestibular studies and offer guidelines to those considering how to apply mouse models.</p>","PeriodicalId":17236,"journal":{"name":"Journal of the Association for Research in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82609864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study examined whether the mechanical characteristics of the cochlea could influence individual variation in the ability to use temporal fine structure (TFS) information. Cochlear mechanical functioning was evaluated by swept-tone evoked otoacoustic emissions (OAEs), which are thought to comprise linear reflection by micromechanical impedance perturbations, such as spatial variations in the number or geometry of outer hair cells, on the basilar membrane (BM). Low-rate (2 Hz) frequency modulation detection limens (FMDLs) were measured for carrier frequency of 1000 Hz and interaural phase difference (IPD) thresholds as indices of TFS sensitivity and high-rate (16 Hz) FMDLs and amplitude modulation detection limens (AMDLs) as indices of sensitivity to non-TFS cues. Significant correlations were found among low-rate FMDLs, low-rate AMDLs, and IPD thresholds (R = 0.47-0.59). A principal component analysis was used to show a common factor that could account for 81.1, 74.1, and 62.9 % of the variance in low-rate FMDLs, low-rate AMDLs, and IPD thresholds, respectively. An OAE feature, specifically a characteristic dip around 2-2.5 kHz in OAE spectra, showed a significant correlation with the common factor (R = 0.54). High-rate FMDLs and AMDLs were correlated with each other (R = 0.56) but not with the other measures. The results can be interpreted as indicating that (1) the low-rate AMDLs, as well as the IPD thresholds and low-rate FMDLs, depend on the use of TFS information coded in neural phase locking and (2) the use of TFS information is influenced by a particular aspect of cochlear mechanics, such as mechanical irregularity along the BM.
{"title":"Relation Between Cochlear Mechanics and Performance of Temporal Fine Structure-Based Tasks.","authors":"Sho Otsuka, Shigeto Furukawa, Shimpei Yamagishi, Koich Hirota, Makio Kashino","doi":"10.1007/s10162-016-0581-9","DOIUrl":"10.1007/s10162-016-0581-9","url":null,"abstract":"<p><p>This study examined whether the mechanical characteristics of the cochlea could influence individual variation in the ability to use temporal fine structure (TFS) information. Cochlear mechanical functioning was evaluated by swept-tone evoked otoacoustic emissions (OAEs), which are thought to comprise linear reflection by micromechanical impedance perturbations, such as spatial variations in the number or geometry of outer hair cells, on the basilar membrane (BM). Low-rate (2 Hz) frequency modulation detection limens (FMDLs) were measured for carrier frequency of 1000 Hz and interaural phase difference (IPD) thresholds as indices of TFS sensitivity and high-rate (16 Hz) FMDLs and amplitude modulation detection limens (AMDLs) as indices of sensitivity to non-TFS cues. Significant correlations were found among low-rate FMDLs, low-rate AMDLs, and IPD thresholds (R = 0.47-0.59). A principal component analysis was used to show a common factor that could account for 81.1, 74.1, and 62.9 % of the variance in low-rate FMDLs, low-rate AMDLs, and IPD thresholds, respectively. An OAE feature, specifically a characteristic dip around 2-2.5 kHz in OAE spectra, showed a significant correlation with the common factor (R = 0.54). High-rate FMDLs and AMDLs were correlated with each other (R = 0.56) but not with the other measures. The results can be interpreted as indicating that (1) the low-rate AMDLs, as well as the IPD thresholds and low-rate FMDLs, depend on the use of TFS information coded in neural phase locking and (2) the use of TFS information is influenced by a particular aspect of cochlear mechanics, such as mechanical irregularity along the BM.</p>","PeriodicalId":17236,"journal":{"name":"Journal of the Association for Research in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76851714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2016-09-12DOI: 10.1007/s10162-016-0585-5
H. Holman, V. Tran, Mausam Kalita, Lynn Nguyen, Sailaja Arungundram, B. Kuberan, R. Rabbitt
{"title":"BODIPY-Conjugated Xyloside Primes Fluorescent Glycosaminoglycans in the Inner Ear of Opsanus tau","authors":"H. Holman, V. Tran, Mausam Kalita, Lynn Nguyen, Sailaja Arungundram, B. Kuberan, R. Rabbitt","doi":"10.1007/s10162-016-0585-5","DOIUrl":"https://doi.org/10.1007/s10162-016-0585-5","url":null,"abstract":"","PeriodicalId":17236,"journal":{"name":"Journal of the Association for Research in Otolaryngology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76946578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}