Toshiaki R Asakura, Sung-Mok Jung, Shihui Jin, Gang Hu, Akira Endo, Borame Lee Dickens
{"title":"Characterising global risk profiles of Mpox clade Ib importation.","authors":"Toshiaki R Asakura, Sung-Mok Jung, Shihui Jin, Gang Hu, Akira Endo, Borame Lee Dickens","doi":"10.1093/jtm/taae136","DOIUrl":"https://doi.org/10.1093/jtm/taae136","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ludovic Karkowski, Sylvie Gondoin, François Durupt, Tiphaine Gaillard, Meja Rabodonirina, François L E Moigne, Olivier Aoun
{"title":"Disseminated histoplasmosis in a Congolese migrant under long term steroid hormone replacement therapy.","authors":"Ludovic Karkowski, Sylvie Gondoin, François Durupt, Tiphaine Gaillard, Meja Rabodonirina, François L E Moigne, Olivier Aoun","doi":"10.1093/jtm/taae134","DOIUrl":"https://doi.org/10.1093/jtm/taae134","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriele Maurer, Vera Buerger, Julian Larcher-Senn, D I Florian Erlsbacher, Katrin Dubischar, Susanne Eder-Lingelbach, Juan-Carlos Jaramillo
Background: Chikungunya disease, caused by chikungunya virus (CHIKV), is associated with substantial morbidity, including debilitating CHIKV-related arthralgia.
Methods: Three clinical trials of a CHIKV vaccine (VLA1553, IXCHIQ®) were conducted in the US: a Phase 1 dose-finding trial, a pivotal Phase 3 trial, and a Phase 3 lot-to-lot consistency trial. Participants were healthy adults (≥18 years) and received a single intramuscular dose of VLA1553 (3520 participants) or placebo (1033 participants). Solicited injection site and systemic adverse events (AEs) (10 to 14 days post-vaccination), unsolicited AEs (28 and 180 days post-vaccination), AEs of special interest (AESIs) (28 days post-vaccination), medically attended AEs (MAAEs), serious AEs (SAEs) (180 days post-vaccination), and pregnancies were evaluated. Safety data were pooled, and analyses were descriptive.
Results: Overall, 63.7% of participants receiving VLA1553 experienced AEs, (44.7% for placebo), that were generally mild. Solicited injection site AEs, solicited systemic AEs, and unsolicited (Day 29) AEs were reported by 15.5%, 50.9%, 22.7% of participants who received VLA1553 and 11.1%, 26.9%, 13.4% who received placebo. Arthralgia was reported by 16.7% of participants who received VLA1553 and 4.8% of participants who received placebo; none required medical attention. MAAEs, AESIs, and SAEs were reported by 12.4%, 0.3%, 1.5% of participants who received VLA1553 and 11.3%, 0.1%, 0.8% of participants who received placebo. Protocol-defined AESIs were mild and short-lived, and two VLA1553-related SAEs resolved without sequelae. There were no clinically important differences in AE incidence based on age or medical history, and no VLA1553-related adverse pregnancy outcomes. There were 3 deaths (2 in the VLA1553 group and 1 in the placebo group), none was vaccine-related.
Conclusions: A single dose of VLA1553 presented with an excellent local tolerability profile and overall safety in line with that expected for a live-attenuated vaccine. The safety profile was comparable in participants aged 18-64 years and ≥65 years.
{"title":"Pooled safety evaluation for a new single-shot live-attenuated chikungunya vaccine.","authors":"Gabriele Maurer, Vera Buerger, Julian Larcher-Senn, D I Florian Erlsbacher, Katrin Dubischar, Susanne Eder-Lingelbach, Juan-Carlos Jaramillo","doi":"10.1093/jtm/taae133","DOIUrl":"https://doi.org/10.1093/jtm/taae133","url":null,"abstract":"<p><strong>Background: </strong>Chikungunya disease, caused by chikungunya virus (CHIKV), is associated with substantial morbidity, including debilitating CHIKV-related arthralgia.</p><p><strong>Methods: </strong>Three clinical trials of a CHIKV vaccine (VLA1553, IXCHIQ®) were conducted in the US: a Phase 1 dose-finding trial, a pivotal Phase 3 trial, and a Phase 3 lot-to-lot consistency trial. Participants were healthy adults (≥18 years) and received a single intramuscular dose of VLA1553 (3520 participants) or placebo (1033 participants). Solicited injection site and systemic adverse events (AEs) (10 to 14 days post-vaccination), unsolicited AEs (28 and 180 days post-vaccination), AEs of special interest (AESIs) (28 days post-vaccination), medically attended AEs (MAAEs), serious AEs (SAEs) (180 days post-vaccination), and pregnancies were evaluated. Safety data were pooled, and analyses were descriptive.</p><p><strong>Results: </strong>Overall, 63.7% of participants receiving VLA1553 experienced AEs, (44.7% for placebo), that were generally mild. Solicited injection site AEs, solicited systemic AEs, and unsolicited (Day 29) AEs were reported by 15.5%, 50.9%, 22.7% of participants who received VLA1553 and 11.1%, 26.9%, 13.4% who received placebo. Arthralgia was reported by 16.7% of participants who received VLA1553 and 4.8% of participants who received placebo; none required medical attention. MAAEs, AESIs, and SAEs were reported by 12.4%, 0.3%, 1.5% of participants who received VLA1553 and 11.3%, 0.1%, 0.8% of participants who received placebo. Protocol-defined AESIs were mild and short-lived, and two VLA1553-related SAEs resolved without sequelae. There were no clinically important differences in AE incidence based on age or medical history, and no VLA1553-related adverse pregnancy outcomes. There were 3 deaths (2 in the VLA1553 group and 1 in the placebo group), none was vaccine-related.</p><p><strong>Conclusions: </strong>A single dose of VLA1553 presented with an excellent local tolerability profile and overall safety in line with that expected for a live-attenuated vaccine. The safety profile was comparable in participants aged 18-64 years and ≥65 years.</p>","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernando Salvador, Xavier Serres, Lidia Goterris, Joan Martínez-Campreciós, Juan Espinosa-Pereiro, Esperanza Esteban, Israel Molina
{"title":"Acute fascioliasis in a returning traveller from Ethiopia.","authors":"Fernando Salvador, Xavier Serres, Lidia Goterris, Joan Martínez-Campreciós, Juan Espinosa-Pereiro, Esperanza Esteban, Israel Molina","doi":"10.1093/jtm/taae132","DOIUrl":"https://doi.org/10.1093/jtm/taae132","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiyang Chan, Niels Best, Maris Arcilla, Jarne Hattem, Damian C Melles, Menno D Jong, Constance Schultsz, Perry J J Genderen, Martin C J Bootsma, Abraham Goorhuis, Martin P Grobusch, Astrid M Oude Lashof, Henri A Verbrugh, John Penders
{"title":"Antimicrobial resistance genes acquisition among Dutch intercontinental travellers: a prospective multicentre study.","authors":"Jiyang Chan, Niels Best, Maris Arcilla, Jarne Hattem, Damian C Melles, Menno D Jong, Constance Schultsz, Perry J J Genderen, Martin C J Bootsma, Abraham Goorhuis, Martin P Grobusch, Astrid M Oude Lashof, Henri A Verbrugh, John Penders","doi":"10.1093/jtm/taae131","DOIUrl":"https://doi.org/10.1093/jtm/taae131","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edilene Pereira Pimentel, Jessiane Rodrigues Ribeiro, Hillquias Monteiro Moreira, Karolaine Santos Teixeira, Tárcio Peixoto Roca, Ana Maisa Passos-Silva, Jackson Alves da Silva Queiroz, Juan Miguel Villalobos-Salcedo, Mauro Shugiro Tada, Stenio Perdigão Fragoso, Marco Aurelio Krieger, Rita de Cássia Pontello Rampazzo, Deusilene Vieira
{"title":"Prevalence of Mayaro infections in Amazonian peri-urban areas.","authors":"Edilene Pereira Pimentel, Jessiane Rodrigues Ribeiro, Hillquias Monteiro Moreira, Karolaine Santos Teixeira, Tárcio Peixoto Roca, Ana Maisa Passos-Silva, Jackson Alves da Silva Queiroz, Juan Miguel Villalobos-Salcedo, Mauro Shugiro Tada, Stenio Perdigão Fragoso, Marco Aurelio Krieger, Rita de Cássia Pontello Rampazzo, Deusilene Vieira","doi":"10.1093/jtm/taae126","DOIUrl":"https://doi.org/10.1093/jtm/taae126","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karl M Hess, Sheila M Seed, Eva H Clark, Tara Lombardo, Francesca F Norman, Gerard Flaherty
{"title":"Multidisciplinary Travel Health Education: Current Status and Rationale for Standardized Competencies.","authors":"Karl M Hess, Sheila M Seed, Eva H Clark, Tara Lombardo, Francesca F Norman, Gerard Flaherty","doi":"10.1093/jtm/taae130","DOIUrl":"10.1093/jtm/taae130","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariana Torres Portillo, Anindita Marwah, Moritz U G Kraemer, Andrea Thomas-Bachli, Kamran Khan, Isaac I Bogoch
{"title":"Potential for international spread of Oropouche virus via commercial air travel.","authors":"Mariana Torres Portillo, Anindita Marwah, Moritz U G Kraemer, Andrea Thomas-Bachli, Kamran Khan, Isaac I Bogoch","doi":"10.1093/jtm/taae128","DOIUrl":"https://doi.org/10.1093/jtm/taae128","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olivia Veit, Ula Maniewski, Camilla Rothe, Gilles Eperon, Margarita Boering, Sami Alcedo, Gerhard Boecken, Michael Ramharter, Noud Schel, Patrick Soentjens, Cornelia Staehelin, Michele van Vugt, Thomas Weitzel, Leo G Visser, Patricia Schlagenhauf, Christoph Hatz, Andreas Neumayr
{"title":"Methodology of the joint malaria prevention recommendations of Switzerland, Germany, Belgium, and the Netherlands.","authors":"Olivia Veit, Ula Maniewski, Camilla Rothe, Gilles Eperon, Margarita Boering, Sami Alcedo, Gerhard Boecken, Michael Ramharter, Noud Schel, Patrick Soentjens, Cornelia Staehelin, Michele van Vugt, Thomas Weitzel, Leo G Visser, Patricia Schlagenhauf, Christoph Hatz, Andreas Neumayr","doi":"10.1093/jtm/taae129","DOIUrl":"https://doi.org/10.1093/jtm/taae129","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Descriptive analysis of professional societies in travel and tropical medicine.","authors":"Loukas Kakoullis, Gerard T Flaherty, Lin H Chen","doi":"10.1093/jtm/taae127","DOIUrl":"https://doi.org/10.1093/jtm/taae127","url":null,"abstract":"","PeriodicalId":17407,"journal":{"name":"Journal of travel medicine","volume":" ","pages":""},"PeriodicalIF":9.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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