Journal of toxicology. Clinical toxicology最新文献

The Internet may represent a new mechanism by which adolescents initiate the use of illicit substances. The existence of multiple partisan websites providing misinformation regarding the safety of these substances may lead to an increase in unsafe behavior among this age group. Adverse outcomes related to Internet-based drug information are rarely identified. We report a case of an adolescent whose use of the Internet to obtain drug information led to severe poisoning from the combination of a monoamine oxidase inhibitor, harmaline, and a hallucinogenic tryptamine, 5-methoxydimethyltryptamine (5-MeO-DMT).

Background: Necrotic arachnidism continues to be attributed to wolf spider bites. This study investigates the clinical effects of bites by wolf spiders in Australia (family Lycosidae).

Methods: Subjects were recruited prospectively from February 1999 to April 2001 from participating emergency departments or state poison information centers. Subjects were included if they had a definite bite by a wolf spider and had collected the spider, which was later identified by an arachnologist. Spiders were identified to the lowest taxonomic level possible and cephalothorax width was measured to correlate bite effects and spider size.

Results: There were 45 definite wolf spider bites (23 male and 22 female patients; age range 1 to 69 years, median age 28 years). Species level identifications (14 species) were possible for 31 of 43 spiders belonging to seven different generic groupings. Most bites were by spiders from four generic groupings, Tasmanicosa (including 'Lycosa') (15), Venatrix (8), Venator (10), and Hogna (7). Bites occurred more commonly in south-eastern Australia and occurred throughout the year, with 7 bites (16%) in late autumn or winter. In 7 cases (16%) the person was swimming in or cleaning a pool. Seventy-two percent of bites occurred on distal parts of limbs. Pain occurred in all bites and was severe in 11 cases (24%), with a median duration of 10 min (IQR: 2-60 min). Other effects included puncture marks/bleeding (33%), swelling (20%), redness (67%), and itchiness (13%). Minor systemic effects occurred in three patients (7%): nausea (two), headache (one) and malaise (one). There were no cases of necrotic ulcers [0%; 97.5% CI 0-8%]. Tasmanicosa spider bites caused significantly more itchiness and redness, and large spiders (>5 mm) more often caused severe pain and left fang marks.

Conclusion: Wolf spider bites cause minor effects, no more severe than most other spiders, and do not appear to cause necrotic ulcers. The effects are likely to be due to mechanical injury, although minor local envenomation occurs with Tasmanicosa bites.

Background: Olanzapine is an atypical antipsychotic drug that is increasingly used in intentional drug overdoses. Although acute olanzapine overdose is predominantly associated with anticholinergic symptoms and central nervous system depression, miosis and unpredictable fluctuations between somnolence/coma and agitation/ aggression have been suggested as typical signs of olanzapine intoxication in single case reports.

Aims: To confirm the suggestion that fluctuating central nervous system changes and miosis are characteristic signs of olanzapine intoxication. To estimate the dose-response relationship as a guide for the provision of optimal management of olanzapine intoxicated patients.

Methods: Retrospective analysis of all well-documented cases of olanzapine intoxication reported to the Swiss Toxicological Information Centre between January 1997 and October 2001. Inclusion criteria for detailed analysis were patient age > or = 16 yr, acute olanzapine monointoxication, ingested dose > 20 mg, and a causal relationship between olanzapine overdose and clinical effects. The Poisoning Severity Score of the European Association of Poison Centres and Clinical Toxicologists (EAPCCT) assessed the intoxication severity.

Results: Out of a total of 131 cases of olanzapine overdose, 26 cases fulfilled the inclusion criteria. The ingested olanzapine doses ranged from 30 to 840 mg. The most frequent findings were somnolence (77%), agitation (42%), and miosis (31%). The Poisoning Severity Score was "minor" in 14 (54%), "moderate" in 11 (42%), and "severe" in 1 (4%) patients. Nine patients (35% of all patients) with moderate olanzapine poisoning (120-840 mg) showed unpredictable fluctuations between somnolence and agitation. Five of these patients also demonstrated marked miosis. All patients recovered within 48h. One patient with severe poisoning (560 mg) had coma and convulsions. Moderate (and severe) symptoms occurred only at ingested doses above 120 mg. There was a statistically significant association between increasing ingested olanzapine doses and poisoning severity.

Conclusions: Although olanzapine is tolerated relatively well in acute overdose, unpredictable and transient fluctuations between central nervous system depression and agitation, frequently associated with miosis, appear to be characteristic findings in moderate to high olanzapine overdoses. They are transient in nature and require careful clinical monitoring but rarely require specific therapeutic interventions.

Background: Pimozide overdose has rarely been reported in children. In adults, pimozide intoxication may cause seizures, extrapyramidal and anticholinergic effects, hypotension, QTc prolongation and torsades de pointes. We report dystonia, hypotension and drowsiness following pimozide ingestion in a child.

Case report: An alert 18-month-old presented to hospital 40 minutes after ingesting up to 6 mg (0.5 mg/kg) of pimozide. Vital signs: BP 91/62 mmHg, HR 130/min, RR 26/min, temperature 97.2 degrees F (36.2 degrees C). She received gastric lavage and activated charcoal. One hour later, her QTc interval was 420 msec, HR 150. She remained asymptomatic until 12 hours post-ingestion, when she developed drooling, tongue thrusting and drowsiness. BP was 75/40, HR 150, QTc 440 msec. BP increased to 95/50 after a bolus of normal saline. Her dystonia subsided over the next 12 hours without treatment. Drowsiness and tachycardia persisted until 40 hours post-ingestion. QTc interval at this time was 370 msec. Patient recovered without sequelae.

Conclusion: Pimozide overdose in children may be associated with delayed onset of symptoms, including dystonia.

Objective: The objective of this study was to determine current practices and opinions of poison center staff and directors regarding drug identification (ID) calls.

Methods: Surveys were developed and mailed to 911 poison center staff members and 69 managing directors at 69 poison control centers in the United States in December 2001.

Results: Responses were received from 317 staff members and 33 directors from 49 centers. Nearly half of the staff respondents stated that they had not received drug ID training beyond how to look up the identity of an oral medication. About one-half of staff and director respondents stated that their centers had only informal (unwritten) drug ID policies, while one-fourth each responded they had formal written policies or had no policy at all. A majority of respondents indicated that their centers either allow or require specialists to provide ID for non-ingestion-related cases. Nearly all staff and director respondents routinely provide ID services to law enforcement officers and health care professionals regardless of whether ingestion was involved. Slightly more than one-half of staff respondents inquire about possible ingestion with almost every request, while one-third only inquire when the caller gives some indication that ingestion may have occurred. Case-based questions reveal that different practices are utilized depending on the type of medication for which ID is being requested. Factors such as risk of liability, patient confidentiality, guardianship, and the person's best interest appear to contribute to decisions regarding the provision of medication ID.

Conclusion: Drug identification practices vary from center to center throughout the United States. Though the service is greatly utilized, few centers have written policies. In addition, training for the provision of this service appears to be inadequate in many centers. The development of drug identification guidelines to be utilized throughout poison centers would provide much needed consistency and guidance.

Background: Botulism caused by type F botulinum toxin accounts for less than 0.1% of all human botulism cases and is rarely reported in the literature.

Case report: A 45-year-old woman presented to an emergency department complaining of blurred vision, difficulty focusing, and dysphagia. The treating physician initially considered the possibility of paralytic shellfish poisoning due to a report of shellfish ingestion, which was later determined to be frozen shrimp and a can of tuna, but no gastroenteritis or paresthesias were present. During the emergency department observation, the patient developed respiratory distress with hypercapnea and required intubation and mechanical ventilation. Within hours, ptosis, mydriasis, and weakness in the arms and legs developed. Bivalent (A, B) botulinum antitoxin was administered approximately 24 h from the onset of initial symptoms, but over the next two days complete paralysis progressed to the upper and lower extremities. Shortly thereafter a stool toxin assay demonstrated the presence of type F botulinum toxin. The patient subsequently received an experimental heptavalent botulinum antitoxin on hospital day 7 but paralysis was already complete. Her three-week hospital course was complicated by nosocomial pneumonia and a urinary tract infection, but she gradually improved and was discharged to a rehabilitation facility. Anaerobic cultures and toxin assays have yet to elucidate the source of exposure.

Conclusion: We report a rare case of type F botulism believed to be foodborne in etiology. Administration of bivalent botulinum antitoxin did not halt progression of paralysis.

Objective: The aim of this study is to determine the effects of fresh frozen plasma, as a source of cholinesterase, on butyrylcholinesterase (BuChE; plasma or pseudo cholinesterase) levels and outcomes in patients with organophosphate poisoning.

Materials and methods: This prospective study was performed at the Department of Intensive Care of Erciyes University Medical School. Over 2 yrs, patients admitted to the ICU for OP poisoning were entered into the study. OP poisoning was diagnosed on the basis of history and BuChE levels. All patients received atropine. Fresh frozen plasma was given to 12 patients. The study was approved by the Ethical Committee, and verbal informed consent was obtained.

Results: Thirty-three patients were included in the study. BuChE levels measured at admission and the pralidoxime and atropine doses administered were not different between groups (p>0.05). Although intermediate syndrome developed in 28.6% of patients receiving pralidoxime, there were no intermediate syndrome cases in patients receiving plasma prior to developing intermediate syndrome. The mortality rates were 14.3% in the pralidoxime group and 0% in the plasma+atropine+pralidoxime group. Two patients received plasma after developing the intermediate syndrome, and one patient who received only atropine died. BuChE levels of fresh frozen plasma were 4069.5 +/- 565.1 IU/L. Every two bags of plasma provided an increase in BuChE levels of approximately 461.7 +/- 142.1 IU/L.

Conclusion: Fresh frozen plasma therapy increases BuChE levels in patients with organophosphate poisonings. The administration of plasma may also prevent the development of intermediate syndrome and related mortality. Plasma (fresh frozen or freshly prepared) therapy may be used as an alternative or adjunctive treatment method in patients with organophosphate pesticide poisoning, especially in cases not given pralidoxime. Further randomized controlled and animal studies are required to infer a definitive result.

Introduction: Rattlesnakes are indigenous to the New World and hence their envenomations are a significant percentage of all poisonings in North and South America. Some years ago rattlesnake bites were virtually unknown in Europe. But the biodiversity of European household fauna has changed: cats and dogs are increasingly replaced by stingrays, tarantulas, fire fish, and rattlesnakes. This phenomenon is the background of a French-German cooperation to evaluate the relevance of rattlesnake bites for European doctors.

Material and methods: In a retrospective study all consultations of the GIZ-Nord poison centre in Göttingen and the Centre Antipoison in Marseille concerning bites of poisonous snakes in a 20-yr time period were analyzed.

Results: Altogether 671 cases of poisonous snake bites were registered. Rattlesnake bites came up to 21 (3.1% of all consultations due to poisonous snake bites). Over the years the number increased constantly. All patients were adult men with a mean age of 37.2 (20-64) years. There were no females and no pediatric patients involved. According to the Poisoning Severity Score there were 8 minor, 5 moderate, and 8 severe envenomations; no fatalities. The leading clinical symptoms consisted of rhabdomyolysis, neurological, and coagulational disorders. In 5 cases antivenom therapy was applied, and in 4 patients surgical therapy was performed.

Conclusion: Rattlesnake bites are rare in Europe, but the incidence is rising. The patients' profile is different from large American case series. European doctors should be aware of the increase in these infrequent envenomations.