Objective: To observe the curative effect of Zizhu Xiaoliu Powder in the treatment of patients with cervical low-grade squamous intraepithelial neoplasia (LSIL) of damp-heat stasis type, and to pro-vide a reference for clinical application of traditional Chinese medicine in the treatment of LSIL. Methods: Selected from August 2020 to January 2022 in our hospital's gynecological outpatient clinic, confirmed by histopathology that LSIL complicated with HR-HPV infection, P16/Ki67 double staining was positive, and a total of 120 patients with TCM syndrome matching with damp-heat stasis syndrome were selected. The traditional Chinese medicine treatment group applied Zizhu Xiaoliu Powder to the cervix and cervical canal for 3 courses of treatment, while the western medicine treatment group applied recombinant human interferon α -2b vaginal effervescent capsules (Xinfuning®) to the fornix of the vagina for 3 courses of treatment. In the blank control group, no treatment was taken, and the negative conversion of high-risk HPV virus and the expression of P16/Ki67 were compared before and after treatment. Results: The HR-HPV negative conversion rate in the traditional Chinese medicine treatment group was higher than that in the western medicine treatment group and the blank group, and the difference was statistically significant ( P < 0.05). The HR-HPV negative conversion rate in the western medicine group was higher than that in the blank group, but the difference was not statistically significant ( P < 0.0167). After treatment, the negative rate of P16/Ki67 double staining in the traditional Chinese medicine treatment group was higher than that in the western medicine treatment group and the blank group, and the difference was statistically significant ( P < 0.05). The negative rate of P16/Ki67 double staining in the western medicine treatment group was higher than that in the blank group, but the difference was not statistically significant ( P < 0.0167). Conclusion: Zizhu Xiaoliu San and interferon can re-verse HR-HPV infection to a certain extent, but Zizhu Xiaoliu San has more advantages in resisting HPV infection and reversing the progress of LSIL, and it is worthy of clinical promotion.
{"title":"Effects of Zizhu Xiaoliu San on the Expression of P16/Ki67 in Cervical Low-Grade Squamous Intraepithelial Neoplasia","authors":"秋燕 陈","doi":"10.12677/md.2022.122028","DOIUrl":"https://doi.org/10.12677/md.2022.122028","url":null,"abstract":"Objective: To observe the curative effect of Zizhu Xiaoliu Powder in the treatment of patients with cervical low-grade squamous intraepithelial neoplasia (LSIL) of damp-heat stasis type, and to pro-vide a reference for clinical application of traditional Chinese medicine in the treatment of LSIL. Methods: Selected from August 2020 to January 2022 in our hospital's gynecological outpatient clinic, confirmed by histopathology that LSIL complicated with HR-HPV infection, P16/Ki67 double staining was positive, and a total of 120 patients with TCM syndrome matching with damp-heat stasis syndrome were selected. The traditional Chinese medicine treatment group applied Zizhu Xiaoliu Powder to the cervix and cervical canal for 3 courses of treatment, while the western medicine treatment group applied recombinant human interferon α -2b vaginal effervescent capsules (Xinfuning®) to the fornix of the vagina for 3 courses of treatment. In the blank control group, no treatment was taken, and the negative conversion of high-risk HPV virus and the expression of P16/Ki67 were compared before and after treatment. Results: The HR-HPV negative conversion rate in the traditional Chinese medicine treatment group was higher than that in the western medicine treatment group and the blank group, and the difference was statistically significant ( P < 0.05). The HR-HPV negative conversion rate in the western medicine group was higher than that in the blank group, but the difference was not statistically significant ( P < 0.0167). After treatment, the negative rate of P16/Ki67 double staining in the traditional Chinese medicine treatment group was higher than that in the western medicine treatment group and the blank group, and the difference was statistically significant ( P < 0.05). The negative rate of P16/Ki67 double staining in the western medicine treatment group was higher than that in the blank group, but the difference was not statistically significant ( P < 0.0167). Conclusion: Zizhu Xiaoliu San and interferon can re-verse HR-HPV infection to a certain extent, but Zizhu Xiaoliu San has more advantages in resisting HPV infection and reversing the progress of LSIL, and it is worthy of clinical promotion.","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90119957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current Situation and New Progress of the Prevention and Treatment of Diabetic Macular Oedema","authors":"丽连 刘","doi":"10.12677/md.2022.121012","DOIUrl":"https://doi.org/10.12677/md.2022.121012","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77737817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on Electroacupuncture Assisted Nerve Block in Pain after Total Knee Arthroplasty","authors":"波 徐","doi":"10.12677/md.2022.122029","DOIUrl":"https://doi.org/10.12677/md.2022.122029","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79660845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advances in Magnetic Resonance Research on Vestibular Migraine","authors":"虹 倪","doi":"10.12677/md.2022.124048","DOIUrl":"https://doi.org/10.12677/md.2022.124048","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75865412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of Gene Detection Result of 1165 Cases of Thalassemia","authors":"燕 陈","doi":"10.12677/md.2022.121005","DOIUrl":"https://doi.org/10.12677/md.2022.121005","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82598223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research Progress of Different Treatment Methods for Endometrial Polyps","authors":"瑜 李","doi":"10.12677/md.2022.123036","DOIUrl":"https://doi.org/10.12677/md.2022.123036","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84402816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Mifepristone on Recurrence after Laparoscopic Myomectomy","authors":"霞飞 吕","doi":"10.12677/md.2022.122026","DOIUrl":"https://doi.org/10.12677/md.2022.122026","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82318629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case Report of Türthle Cell Neoplasms and Related Literature Analysis","authors":"孝丽 满","doi":"10.12677/md.2022.121004","DOIUrl":"https://doi.org/10.12677/md.2022.121004","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77011107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Lymphoma with Multiple Serous Effusion as the First Symptom","authors":"萍 魏","doi":"10.12677/md.2022.124047","DOIUrl":"https://doi.org/10.12677/md.2022.124047","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75800646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New Progress in Drug Treatment of Recurrent and Metastatic Cervical Cancer","authors":"宇 孟","doi":"10.12677/md.2022.121001","DOIUrl":"https://doi.org/10.12677/md.2022.121001","url":null,"abstract":"","PeriodicalId":17544,"journal":{"name":"Journal of Veterinary Science & Medical Diagnosis","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83689086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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