首页 > 最新文献

Korean Circulation Journal最新文献

英文 中文
Low Aortic Pulsatility Index and Pulmonary Artery Pulsatility Index Are Associated With Increased Mortality in Patients With Dilated Cardiomyopathy Awaiting Heart Transplantation. 低主动脉搏动指数和肺动脉搏动指数与等待心脏移植的扩张型心肌病患者死亡率增加有关。
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-17 DOI: 10.4070/kcj.2024.0192
Yihang Wu, Yuhui Zhang, Jian Zhang

Background and objectives: Patients with dilated cardiomyopathy (DCM) tend to be accompanied by biventricular impairment. We hypothesized that the combination of the aortic pulsatility index (API) and pulmonary artery pulsatility index (PAPI) could refine risk stratification in DCM.

Methods: We studied 120 consecutive patients with advanced DCM who underwent right heart catheterization (RHC). The primary outcome was all-cause mortality within 1 year after RHC. We used the receiver operating characteristic curve to determine the optimal cut-off of API and PAPI to predict outcomes.

Results: The optimal cut-offs of API (1.02) and PAPI (2.16) were used to classify patients into four groups. There were significant differences in left ventricular ejection fraction (LVEF) and tricuspid annular plane systolic excursion (TAPSE) among the four groups (both p<0.05). When delineating API by LVEF above or below the median (28%), the cumulative rate of survival in patients with API <1.02 was lower than that of those with API ≥1.02 in both higher and lower LVEF groups (both p<0.05). Similar trends were observed when delineating PAPI using TAPSE higher or lower than the cut-off (17 mm) (both p<0.05). The cumulative rate of survival in the API <1.02 and PAPI <2.16 group was lower than that in the API ≥1.02 and/or PAPI ≥2.16 (all p<0.05).

Conclusions: API and PAPI could add additional prognostic value to LVEF and TAPSE, respectively. The combination of API and PAPI could provide a comprehensive assessment of biventricular function and refine risk stratification.

Trial registration: ClinicalTrials.gov Identifier: NCT02664818.

背景和目的:扩张型心肌病(DCM)患者往往伴有双心室功能损害。我们假设,结合主动脉搏动指数(API)和肺动脉搏动指数(PAPI)可完善 DCM 的风险分层:我们对 120 名接受右心导管检查(RHC)的晚期 DCM 患者进行了连续研究。主要结果是 RHC 术后 1 年内的全因死亡率。我们使用接收者操作特征曲线确定了预测结果的 API 和 PAPI 最佳临界值:结果:API(1.02)和 PAPI(2.16)的最佳临界值将患者分为四组。四组患者的左心室射血分数(LVEF)和三尖瓣环平面收缩期偏移(TAPSE)存在明显差异(均为 pConclusions):API 和 PAPI 可分别为 LVEF 和 TAPSE 增加额外的预后价值。API 和 PAPI 的组合可提供双心室功能的综合评估,并完善风险分层:试验注册:ClinicalTrials.gov Identifier:试验注册:ClinicalTrials.gov Identifier:NCT02664818。
{"title":"Low Aortic Pulsatility Index and Pulmonary Artery Pulsatility Index Are Associated With Increased Mortality in Patients With Dilated Cardiomyopathy Awaiting Heart Transplantation.","authors":"Yihang Wu, Yuhui Zhang, Jian Zhang","doi":"10.4070/kcj.2024.0192","DOIUrl":"10.4070/kcj.2024.0192","url":null,"abstract":"<p><strong>Background and objectives: </strong>Patients with dilated cardiomyopathy (DCM) tend to be accompanied by biventricular impairment. We hypothesized that the combination of the aortic pulsatility index (API) and pulmonary artery pulsatility index (PAPI) could refine risk stratification in DCM.</p><p><strong>Methods: </strong>We studied 120 consecutive patients with advanced DCM who underwent right heart catheterization (RHC). The primary outcome was all-cause mortality within 1 year after RHC. We used the receiver operating characteristic curve to determine the optimal cut-off of API and PAPI to predict outcomes.</p><p><strong>Results: </strong>The optimal cut-offs of API (1.02) and PAPI (2.16) were used to classify patients into four groups. There were significant differences in left ventricular ejection fraction (LVEF) and tricuspid annular plane systolic excursion (TAPSE) among the four groups (both p<0.05). When delineating API by LVEF above or below the median (28%), the cumulative rate of survival in patients with API <1.02 was lower than that of those with API ≥1.02 in both higher and lower LVEF groups (both p<0.05). Similar trends were observed when delineating PAPI using TAPSE higher or lower than the cut-off (17 mm) (both p<0.05). The cumulative rate of survival in the API <1.02 and PAPI <2.16 group was lower than that in the API ≥1.02 and/or PAPI ≥2.16 (all p<0.05).</p><p><strong>Conclusions: </strong>API and PAPI could add additional prognostic value to LVEF and TAPSE, respectively. The combination of API and PAPI could provide a comprehensive assessment of biventricular function and refine risk stratification.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT02664818.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the Efficacy and Safety of Oral Anticoagulation Use for Stroke Prevention in Very Elderly Patients With Atrial Fibrillation. 老年心房颤动患者使用口服抗凝药预防脑卒中的有效性和安全性导航。
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-17 DOI: 10.4070/kcj.2024.0309
Seung Yong Shin, Woo Hyuk Song, Gregory Y H Lip
{"title":"Navigating the Efficacy and Safety of Oral Anticoagulation Use for Stroke Prevention in Very Elderly Patients With Atrial Fibrillation.","authors":"Seung Yong Shin, Woo Hyuk Song, Gregory Y H Lip","doi":"10.4070/kcj.2024.0309","DOIUrl":"10.4070/kcj.2024.0309","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shank3 Overexpression Leads to Cardiac Dysfunction in Mice by Disrupting Calcium Homeostasis in Cardiomyocytes. Shank3 过表达通过破坏心肌细胞中的钙平衡导致小鼠心功能失调
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-17 DOI: 10.4070/kcj.2024.0179
Tae Hee Ko, Yoonhee Kim, Chunmei Jin, Byeongil Yu, Minju Lee, Phuong Kim Luong, Tran Nguyet Trinh, Yeji Yang, Hyojin Kang, Yinhua Zhang, Ruiying Ma, Kwangmin Yoo, Jungmin Choi, Jin Young Kim, Sun-Hee Woo, Kihoon Han, Jong-Il Choi

Background and objectives: SH3 and multiple ankyrin repeat domains 3 (Shank3) proteins play crucial roles as neuronal postsynaptic scaffolds. Alongside neuropsychiatric symptoms, individuals with SHANK3 mutations often exhibit symptoms related to dysfunctions in other organs, including the heart. However, detailed insights into the cardiac functions of Shank3 remain limited. This study aimed to characterize the cardiac phenotypes of Shank3-overexpressing transgenic mice and explore the underlying mechanisms.

Methods: Cardiac histological analysis, electrocardiogram and echocardiogram recordings were conducted on Shank3-overexpressing transgenic mice. Electrophysiological properties, including action potentials and L-type Ca²⁺ channel (LTCC) currents, were measured in isolated cardiomyocytes. Ca²⁺ homeostasis was assessed by analyzing cytosolic Ca²⁺ transients and sarcoplasmic reticulum Ca²⁺ contents. Depolarization-induced cell shortening was examined in cardiomyocytes. Immunoprecipitation followed by mass spectrometry-based identification was employed to identify proteins in the cardiac Shank3 interactome. Western blot and immunocytochemical analyses were conducted to identify changes in protein expression in Shank3-overexpressing transgenic cardiomyocytes.

Results: The hearts of Shank3-overexpressing transgenic mice displayed reduced weight and increased fibrosis. In vivo, sudden cardiac death, arrhythmia, and contractility impairments were identified. Shank3-overexpressing transgenic cardiomyocytes showed prolonged action potential duration and increased LTCC current density. Cytosolic Ca²⁺ transients were increased with prolonged decay time, while sarcoplasmic reticulum Ca²⁺ contents remained normal. Cell shortening was augmented in Shank3-overexpressing transgenic cardiomyocytes. The cardiac Shank3 interactome comprised 78 proteins with various functions. Troponin I levels were down-regulated in Shank3-overexpressing transgenic cardiomyocytes.

Conclusions: This study revealed cardiac dysfunction in Shank3-overexpressing transgenic mice, potentially attributed to changes in Ca²⁺ homeostasis and contraction, with a notable reduction in troponin I.

背景和目的:SH3和多重淀粉样蛋白重复结构域3(Shank3)蛋白作为神经元突触后支架发挥着至关重要的作用。除了神经精神症状外,SHANK3 基因突变患者还经常表现出与其他器官功能障碍有关的症状,包括心脏。然而,对Shank3心脏功能的详细了解仍然有限。本研究旨在描述Shank3过表达转基因小鼠的心脏表型,并探索其潜在机制:方法:对过表达 Shank3 的转基因小鼠进行心脏组织学分析、心电图和超声心动图记录。测量了离体心肌细胞的电生理特性,包括动作电位和 L 型 Ca²⁺ 通道(LTCC)电流。通过分析细胞质Ca²⁺瞬态和肌质网Ca²⁺含量评估了Ca²⁺的稳态。在心肌细胞中检测了去极化诱导的细胞缩短。通过免疫沉淀和质谱鉴定,确定了心脏 Shank3 相互作用组中的蛋白质。进行了 Western 印迹和免疫细胞化学分析,以确定 Shank3 过表达转基因心肌细胞中蛋白质表达的变化:结果:Shank3高表达转基因小鼠的心脏重量减轻,纤维化增加。在体内,发现了心脏性猝死、心律失常和收缩功能障碍。过表达 Shank3 的转基因心肌细胞表现出动作电位持续时间延长和 LTCC 电流密度增加。细胞质 Ca²⁺ 瞬时增加,衰减时间延长,而肌质网 Ca²⁺ 含量保持正常。在Shank3过表达的转基因心肌细胞中,细胞缩短增加。心脏 Shank3 相互作用组包括 78 个具有不同功能的蛋白质。在Shank3过表达的转基因心肌细胞中,肌钙蛋白I水平下调:这项研究揭示了 Shank3 高表达转基因小鼠的心脏功能障碍,这可能是由于 Ca²⁺ 平衡和收缩发生了变化,肌钙蛋白 I 显著减少。
{"title":"Shank3 Overexpression Leads to Cardiac Dysfunction in Mice by Disrupting Calcium Homeostasis in Cardiomyocytes.","authors":"Tae Hee Ko, Yoonhee Kim, Chunmei Jin, Byeongil Yu, Minju Lee, Phuong Kim Luong, Tran Nguyet Trinh, Yeji Yang, Hyojin Kang, Yinhua Zhang, Ruiying Ma, Kwangmin Yoo, Jungmin Choi, Jin Young Kim, Sun-Hee Woo, Kihoon Han, Jong-Il Choi","doi":"10.4070/kcj.2024.0179","DOIUrl":"10.4070/kcj.2024.0179","url":null,"abstract":"<p><strong>Background and objectives: </strong>SH3 and multiple ankyrin repeat domains 3 (Shank3) proteins play crucial roles as neuronal postsynaptic scaffolds. Alongside neuropsychiatric symptoms, individuals with <i>SHANK3</i> mutations often exhibit symptoms related to dysfunctions in other organs, including the heart. However, detailed insights into the cardiac functions of Shank3 remain limited. This study aimed to characterize the cardiac phenotypes of Shank3-overexpressing transgenic mice and explore the underlying mechanisms.</p><p><strong>Methods: </strong>Cardiac histological analysis, electrocardiogram and echocardiogram recordings were conducted on Shank3-overexpressing transgenic mice. Electrophysiological properties, including action potentials and L-type Ca²⁺ channel (LTCC) currents, were measured in isolated cardiomyocytes. Ca²⁺ homeostasis was assessed by analyzing cytosolic Ca²⁺ transients and sarcoplasmic reticulum Ca²⁺ contents. Depolarization-induced cell shortening was examined in cardiomyocytes. Immunoprecipitation followed by mass spectrometry-based identification was employed to identify proteins in the cardiac Shank3 interactome. Western blot and immunocytochemical analyses were conducted to identify changes in protein expression in Shank3-overexpressing transgenic cardiomyocytes.</p><p><strong>Results: </strong>The hearts of Shank3-overexpressing transgenic mice displayed reduced weight and increased fibrosis. In vivo, sudden cardiac death, arrhythmia, and contractility impairments were identified. Shank3-overexpressing transgenic cardiomyocytes showed prolonged action potential duration and increased LTCC current density. Cytosolic Ca²⁺ transients were increased with prolonged decay time, while sarcoplasmic reticulum Ca²⁺ contents remained normal. Cell shortening was augmented in Shank3-overexpressing transgenic cardiomyocytes. The cardiac Shank3 interactome comprised 78 proteins with various functions. Troponin I levels were down-regulated in Shank3-overexpressing transgenic cardiomyocytes.</p><p><strong>Conclusions: </strong>This study revealed cardiac dysfunction in Shank3-overexpressing transgenic mice, potentially attributed to changes in Ca²⁺ homeostasis and contraction, with a notable reduction in troponin I.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pivot-Balloon: A First Step Toward a Novel Transcatheter Treatment for Severe Tricuspid Regurgitation. Pivot-Balloon:向治疗严重三尖瓣反流的新型经导管疗法迈出第一步。
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-08 DOI: 10.4070/kcj.2024.0304
Jaeoh Lee, Yong-Joon Lee
{"title":"Pivot-Balloon: A First Step Toward a Novel Transcatheter Treatment for Severe Tricuspid Regurgitation.","authors":"Jaeoh Lee, Yong-Joon Lee","doi":"10.4070/kcj.2024.0304","DOIUrl":"https://doi.org/10.4070/kcj.2024.0304","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Artery Dissection: Less Is Better When You Are Blue. 肺动脉交叉青出于蓝而胜于蓝
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-08 DOI: 10.4070/kcj.2024.0212
Merna Abdou, Justin Shipman, Francois Marcotte, Clinton Jokerst, David S Majdalany
{"title":"Pulmonary Artery Dissection: Less Is Better When You Are Blue.","authors":"Merna Abdou, Justin Shipman, Francois Marcotte, Clinton Jokerst, David S Majdalany","doi":"10.4070/kcj.2024.0212","DOIUrl":"10.4070/kcj.2024.0212","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2024 Korean Society of Myocardial Infarction/National Evidence-Based Healthcare Collaborating Agency Guideline for the Pharmacotherapy of Acute Coronary Syndromes. 2024 韩国心肌梗塞学会/全国循证医疗合作机构《急性冠状动脉综合征药物治疗指南》。
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-04 DOI: 10.4070/kcj.2024.0257
Hyun Kuk Kim, Seungeun Ryoo, Seung Hun Lee, Doyeon Hwang, Ki Hong Choi, Jungeun Park, Hyeon-Jeong Lee, Chang-Hwan Yoon, Jang Hoon Lee, Joo-Yong Hahn, Young Joon Hong, Jin Yong Hwang, Myung Ho Jeong, Dong Ah Park, Chang-Wook Nam, Weon Kim

Many countries have published clinical practice guidelines for appropriate clinical decisions, optimal treatment, and improved clinical outcomes in patients with acute coronary syndrome. Developing guidelines that are specifically tailored to the Korean environment is crucial, considering the treatment system, available medications and medical devices, racial differences, and level of language communication. In 2017, the Korean Society of Myocardial Infarction established a guideline development committee. However, at that time, it was not feasible to develop guidelines, owing to the lack of knowledge and experience in guideline development and the absence of methodology experts. In 2022, the National Evidence-Based Healthcare Collaborating Agency collaborated with a relevant academic association to develop internationally reliable guidelines, with strict adherence to the methodology for evidence-based guideline development. The first Korean acute coronary syndrome guideline starts from the 9 key questions for pharmacotherapy.

许多国家都发布了临床实践指南,以帮助急性冠状动脉综合征患者做出适当的临床决策、进行最佳治疗并改善临床疗效。考虑到治疗系统、可用药物和医疗设备、种族差异以及语言交流水平,制定专门针对韩国环境的指南至关重要。2017 年,韩国心肌梗死学会成立了指南制定委员会。但当时由于缺乏制定指南的知识和经验,也没有方法论专家,因此制定指南并不可行。2022 年,国家循证医疗协作机构与相关学术协会合作,严格遵守循证指南制定方法,制定了国际上可靠的指南。韩国首部急性冠脉综合征指南从药物治疗的 9 个关键问题入手。
{"title":"2024 Korean Society of Myocardial Infarction/National Evidence-Based Healthcare Collaborating Agency Guideline for the Pharmacotherapy of Acute Coronary Syndromes.","authors":"Hyun Kuk Kim, Seungeun Ryoo, Seung Hun Lee, Doyeon Hwang, Ki Hong Choi, Jungeun Park, Hyeon-Jeong Lee, Chang-Hwan Yoon, Jang Hoon Lee, Joo-Yong Hahn, Young Joon Hong, Jin Yong Hwang, Myung Ho Jeong, Dong Ah Park, Chang-Wook Nam, Weon Kim","doi":"10.4070/kcj.2024.0257","DOIUrl":"https://doi.org/10.4070/kcj.2024.0257","url":null,"abstract":"<p><p>Many countries have published clinical practice guidelines for appropriate clinical decisions, optimal treatment, and improved clinical outcomes in patients with acute coronary syndrome. Developing guidelines that are specifically tailored to the Korean environment is crucial, considering the treatment system, available medications and medical devices, racial differences, and level of language communication. In 2017, the Korean Society of Myocardial Infarction established a guideline development committee. However, at that time, it was not feasible to develop guidelines, owing to the lack of knowledge and experience in guideline development and the absence of methodology experts. In 2022, the National Evidence-Based Healthcare Collaborating Agency collaborated with a relevant academic association to develop internationally reliable guidelines, with strict adherence to the methodology for evidence-based guideline development. The first Korean acute coronary syndrome guideline starts from the 9 key questions for pharmacotherapy.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Korean Organ Transplant Registry (KOTRY): Third Official Adult Heart Transplant Report. 韩国器官移植登记处(KOTRY):第三份官方成人心脏移植报告。
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-04 DOI: 10.4070/kcj.2024.0176
Hyo-In Choi, Sang Eun Lee, Junho Hyun, Darae Kim, Dong-Ju Choi, Eun-Seok Jeon, Hae-Young Lee, Hyun-Jai Cho, Hyungseop Kim, In-Cheol Kim, Jaewon Oh, Minjae Yoon, Jin Joo Park, Jin-Oh Choi, Min Ho Ju, Seok-Min Kang, Soo Yong Lee, Sung-Ho Jung, Jae-Joong Kim

Background and objectives: The Korean Organ Transplant Registry (KOTRY) provided data for this third official report on adult heart transplantation (HT), including information from 709 recipients.

Methods: Data from HTs performed at seven major centers in Korea between March 2014 and December 2020 were analyzed, focusing on immunosuppression, acute rejection, cardiac allograft vasculopathy (CAV), post-transplant survival, and mechanical circulatory support (MCS) usage.

Results: The median ages of the recipients and donors were 56.0 and 43.0 years, respectively. Cardiomyopathy and ischemic heart disease were the most common preceding conditions for HT. A significant portion of patients underwent HT at waiting list status 1 and 0. In the multivariate analysis, a predicted heart mass mismatch was associated with a higher risk of 1-year mortality. Patients over 70 years old had a significantly increased risk of 6-year mortality. The risk of CAV was higher for male donors and donors older than 45 years. Acute rejection was more likely in patients with panel reactive antibody levels above 80%, while statin use was associated with a reduced risk. The employment of left ventricular assist device as a bridge to transplantation increased from 2.17% to 22.4%. Pre-transplant extra-corporeal membrane oxygenation was associated with worse post-transplant survival.

Conclusions: In this third KOTRY report, we analyzed changes in the characteristics of adult HT recipients and donors and their impact on post-transplant outcomes. The most notable discovery was the increased use of MCS before HT and their impact on post-transplant outcomes.

背景和目的:韩国器官移植登记处(KOTRY)为这份关于成人心脏移植(HT)的第三次官方报告提供了数据,其中包括 709 名受者的信息:方法:分析2014年3月至2020年12月期间在韩国7个主要中心进行的心脏移植数据,重点关注免疫抑制、急性排斥反应、心脏异体移植血管病变(CAV)、移植后存活率和机械循环支持(MCS)的使用情况:受体和供体的中位年龄分别为 56.0 岁和 43.0 岁。心肌病和缺血性心脏病是最常见的先心病。在多变量分析中,预测的心脏质量不匹配与较高的1年死亡风险有关。70岁以上患者的6年死亡风险明显增加。男性捐献者和年龄超过45岁的捐献者发生CAV的风险更高。面板反应性抗体水平超过 80% 的患者更容易发生急性排斥反应,而使用他汀类药物则可降低风险。使用左心室辅助装置作为移植桥梁的比例从2.17%上升到22.4%。移植前体外膜肺氧合与移植后存活率降低有关:在第三份 KOTRY 报告中,我们分析了成人 HT 受体和供体特征的变化及其对移植后结果的影响。最值得注意的发现是体外膜肺氧合术前使用MCS的增加及其对移植后预后的影响。
{"title":"The Korean Organ Transplant Registry (KOTRY): Third Official Adult Heart Transplant Report.","authors":"Hyo-In Choi, Sang Eun Lee, Junho Hyun, Darae Kim, Dong-Ju Choi, Eun-Seok Jeon, Hae-Young Lee, Hyun-Jai Cho, Hyungseop Kim, In-Cheol Kim, Jaewon Oh, Minjae Yoon, Jin Joo Park, Jin-Oh Choi, Min Ho Ju, Seok-Min Kang, Soo Yong Lee, Sung-Ho Jung, Jae-Joong Kim","doi":"10.4070/kcj.2024.0176","DOIUrl":"https://doi.org/10.4070/kcj.2024.0176","url":null,"abstract":"<p><strong>Background and objectives: </strong>The Korean Organ Transplant Registry (KOTRY) provided data for this third official report on adult heart transplantation (HT), including information from 709 recipients.</p><p><strong>Methods: </strong>Data from HTs performed at seven major centers in Korea between March 2014 and December 2020 were analyzed, focusing on immunosuppression, acute rejection, cardiac allograft vasculopathy (CAV), post-transplant survival, and mechanical circulatory support (MCS) usage.</p><p><strong>Results: </strong>The median ages of the recipients and donors were 56.0 and 43.0 years, respectively. Cardiomyopathy and ischemic heart disease were the most common preceding conditions for HT. A significant portion of patients underwent HT at waiting list status 1 and 0. In the multivariate analysis, a predicted heart mass mismatch was associated with a higher risk of 1-year mortality. Patients over 70 years old had a significantly increased risk of 6-year mortality. The risk of CAV was higher for male donors and donors older than 45 years. Acute rejection was more likely in patients with panel reactive antibody levels above 80%, while statin use was associated with a reduced risk. The employment of left ventricular assist device as a bridge to transplantation increased from 2.17% to 22.4%. Pre-transplant extra-corporeal membrane oxygenation was associated with worse post-transplant survival.</p><p><strong>Conclusions: </strong>In this third KOTRY report, we analyzed changes in the characteristics of adult HT recipients and donors and their impact on post-transplant outcomes. The most notable discovery was the increased use of MCS before HT and their impact on post-transplant outcomes.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 25-Year Journey in the Fight Against Pulmonary Arterial Hypertension at a Korean Center: What Has Changed and What Is Missing? 韩国一家中心对抗肺动脉高压的 25 年历程:改变了什么,缺失了什么?
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-01 DOI: 10.4070/kcj.2024.0314
Jung Hyun Choi, Jae Hyeong Park
{"title":"A 25-Year Journey in the Fight Against Pulmonary Arterial Hypertension at a Korean Center: What Has Changed and What Is Missing?","authors":"Jung Hyun Choi, Jae Hyeong Park","doi":"10.4070/kcj.2024.0314","DOIUrl":"10.4070/kcj.2024.0314","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Long-term Outcomes and Risk Factors of Complications After Fontan Surgery: From the Korean Fontan Registry (KFR). 丰坦手术后的长期疗效和并发症风险因素:来自韩国方坦注册中心(KFR)。
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-01 Epub Date: 2024-07-08 DOI: 10.4070/kcj.2023.0211
Sang-Yun Lee, Soo-Jin Kim, Chang-Ha Lee, Chun Soo Park, Eun Seok Choi, Hoon Ko, Hyo Soon An, I Seok Kang, Ja Kyoung Yoon, Jae Suk Baek, Jae Young Lee, Jinyoung Song, Joowon Lee, June Huh, Kyung-Jin Ahn, Se Yong Jung, Seul Gi Cha, Yeo Hyang Kim, Youngseok Lee, Sanghoon Cho

Background and objectives: This study aimed to analyze the outcomes of Fontan surgery in the Republic of Korea, as there were only a few studies from Asian countries.

Methods: The medical records of 1,732 patients who underwent Fontan surgery in 10 cardiac centers were reviewed.

Results: Among them, 1,040 (58.8%) were men. The mean age at Fontan surgery was 4.3±4.2 years, and 395 (22.8%) patients presented with heterotaxy syndrome. According to the types of Fontan surgery, 157 patients underwent atriopulmonary (AP) type; 303, lateral tunnel (LT) type; and 1,266, extracardiac conduit (ECC) type. The overall survival rates were 91.7%, 87.1%, and 74.4% at 10, 20, and 30 years, respectively. The risk factors of early mortality were male, heterotaxy syndrome, AP-type Fontan surgery, high mean pulmonary artery pressure (mPAP) in pre-Fontan cardiac catheterization, and early Fontan surgery year. The risk factors of late mortality were heterotaxy syndrome, genetic disorder, significant atrioventricular valve regurgitation (AVVR) before Fontan surgery, high mPAP in pre-Fontan cardiac catheterization, and no fenestration.

Conclusions: In Asian population with a high incidence of heterotaxy syndrome, the heterotaxy syndrome was identified as the poor prognostic factors for Fontan surgery. The preoperative low mPAP and less AVVR are associated with better early and long-term outcomes of Fontan surgery.

背景和目的:本研究旨在分析大韩民国丰坦手术的结果,因为亚洲国家的研究很少:方法:研究人员查阅了在 10 家心脏中心接受丰坦手术的 1,732 名患者的病历:结果:其中 1,040 人(58.8%)为男性。接受丰坦手术的平均年龄为(4.3±4.2)岁,395 例(22.8%)患者出现异位综合征。根据丰坦手术的类型,157名患者接受了肺动脉型(AP)手术;303名患者接受了侧隧道型(LT)手术;1,266名患者接受了心外导管型(ECC)手术。10年、20年和30年的总存活率分别为91.7%、87.1%和74.4%。早期死亡的风险因素为男性、异位综合征、AP型丰坦手术、丰坦前心导管检查时平均肺动脉压(mPAP)高以及丰坦手术年份早。晚期死亡率的风险因素为异位综合征、遗传性疾病、丰坦手术前房室瓣明显返流、丰坦手术前心导管检查时平均肺动脉压(mPAP)高以及未进行瓣膜置换术:在异位综合征发病率较高的亚洲人群中,异位综合征被认为是丰坦手术的不良预后因素。术前低 mPAP 和较少的 AVVR 与丰坦手术较好的早期和长期预后相关。
{"title":"The Long-term Outcomes and Risk Factors of Complications After Fontan Surgery: From the Korean Fontan Registry (KFR).","authors":"Sang-Yun Lee, Soo-Jin Kim, Chang-Ha Lee, Chun Soo Park, Eun Seok Choi, Hoon Ko, Hyo Soon An, I Seok Kang, Ja Kyoung Yoon, Jae Suk Baek, Jae Young Lee, Jinyoung Song, Joowon Lee, June Huh, Kyung-Jin Ahn, Se Yong Jung, Seul Gi Cha, Yeo Hyang Kim, Youngseok Lee, Sanghoon Cho","doi":"10.4070/kcj.2023.0211","DOIUrl":"10.4070/kcj.2023.0211","url":null,"abstract":"<p><strong>Background and objectives: </strong>This study aimed to analyze the outcomes of Fontan surgery in the Republic of Korea, as there were only a few studies from Asian countries.</p><p><strong>Methods: </strong>The medical records of 1,732 patients who underwent Fontan surgery in 10 cardiac centers were reviewed.</p><p><strong>Results: </strong>Among them, 1,040 (58.8%) were men. The mean age at Fontan surgery was 4.3±4.2 years, and 395 (22.8%) patients presented with heterotaxy syndrome. According to the types of Fontan surgery, 157 patients underwent atriopulmonary (AP) type; 303, lateral tunnel (LT) type; and 1,266, extracardiac conduit (ECC) type. The overall survival rates were 91.7%, 87.1%, and 74.4% at 10, 20, and 30 years, respectively. The risk factors of early mortality were male, heterotaxy syndrome, AP-type Fontan surgery, high mean pulmonary artery pressure (mPAP) in pre-Fontan cardiac catheterization, and early Fontan surgery year. The risk factors of late mortality were heterotaxy syndrome, genetic disorder, significant atrioventricular valve regurgitation (AVVR) before Fontan surgery, high mPAP in pre-Fontan cardiac catheterization, and no fenestration.</p><p><strong>Conclusions: </strong>In Asian population with a high incidence of heterotaxy syndrome, the heterotaxy syndrome was identified as the poor prognostic factors for Fontan surgery. The preoperative low mPAP and less AVVR are associated with better early and long-term outcomes of Fontan surgery.</p>","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Percutaneous Retrieval of an Embolized MitraClip in the Left Atrium. 经皮取回左心房栓塞的 MitraClip。
IF 3 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI: 10.4070/kcj.2024.0088
Jinho Lee, Ga Yun Kim, Jae Suk Yoo, Dae-Hee Kim, Do-Yoon Kang
{"title":"Percutaneous Retrieval of an Embolized MitraClip in the Left Atrium.","authors":"Jinho Lee, Ga Yun Kim, Jae Suk Yoo, Dae-Hee Kim, Do-Yoon Kang","doi":"10.4070/kcj.2024.0088","DOIUrl":"10.4070/kcj.2024.0088","url":null,"abstract":"","PeriodicalId":17850,"journal":{"name":"Korean Circulation Journal","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Korean Circulation Journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1