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Appropriate determination of the surgical transepicondylar axis can be achieved following distal femur resection in navigation-assisted total knee arthroplasty. 在导航辅助的全膝关节置换术中,股骨远端切除术后可适当确定手术经髁轴。
IF 3.1 Q1 ORTHOPEDICS Pub Date : 2021-11-10 DOI: 10.1186/s43019-021-00123-1
Sang Jun Song, Hyun Woo Lee, Kang Il Kim, Cheol Hee Park

Background: Many surgeons have determined the surgical transepicondylar axis (sTEA) after distal femur resection in total knee arthroplasty (TKA). However, in most navigation systems, the registration of the sTEA precedes the distal femur resection. This sequential difference can influence the accuracy of intraoperative determination for sTEA when considering the proximal location of the anatomical references for sTEA and the arthritic environment. We compared the accuracy and precision in determinations of the sTEA between before and after distal femur resection during navigation-assisted TKA.

Methods: Ninety TKAs with Attune posterior-stabilized prostheses were performed under imageless navigation. The sTEA was registered before distal femur resection, then reassessed and adjusted after distal resection. The femoral component was implanted finally according to the sTEA determined after distal femur resection. Computed tomography (CT) was performed postoperatively to analyze the true sTEA (the line connecting the tip of the lateral femoral epicondyle to the lowest point of the medial femoral epicondylar sulcus on axial CT images) and femoral component rotation (FCR) axis. The FCR angle after distal femur resection (FCRA-aR) was defined as the angle between the FCR axis and true sTEA on CT images. The FCR angle before distal resection (FCRA-bR) could be presumed to be the value of FCRA-aR minus the difference between the intraoperatively determined sTEAs before and after distal resection as indicated by the navigation system. It was considered that the FCRA-bR or FCRA-aR represented the differences between the sTEA determined before or after distal femur resection and the true sTEA, respectively.

Results: The FCRA-bR was -1.3 ± 2.4° and FCRA-aR was 0.3 ± 1.7° (p < 0.001). The range of FCRA-bR was from -6.6° to 4.1° and that of FCRA-aR was from -2.7° to 3.3°. The proportion of appropriate FCRA (≤ ±3°) was significantly higher after distal femur resection than that before resection (91.1% versus 70%; p < 0.001).

Conclusions: The FCR was more appropriate when the sTEA was determined after distal femur resection than before resection in navigation-assisted TKA. The reassessment and adjusted registration of sTEA after distal femur resection could improve the rotational alignment of the femoral component in navigation-assisted TKA.

Level of evidence: IV.

背景:许多外科医生已经确定了全膝关节置换术(TKA)中股骨远端切除术后的手术经髁轴(sTEA)。然而,在大多数导航系统中,sTEA的定位先于股骨远端切除术。当考虑到sTEA解剖参考点的近端位置和关节炎环境时,这种顺序差异会影响术中sTEA测定的准确性。我们比较了导航辅助TKA期间股骨远端切除前后测定sTEA的准确性和精密度。方法:在无图像导航的情况下,对90例tka进行后稳定修复。sTEA在股骨远端切除术前登记,在远端切除术后重新评估和调整。根据股骨远端切除术后确定的sTEA,最终植入股骨假体。术后行计算机断层扫描(CT)分析真sTEA(轴向CT图像上连接股外侧上髁尖端至股内侧上髁沟最低点的线)和股成分旋转轴(FCR)。股骨远端切除术后的FCR角(FCR - ar)定义为CT图像上FCR轴与真sTEA之间的夹角。远端切除前的FCR角(FCRA-bR)可推定为导航系统显示的FCRA-aR值减去术中测定的远端切除前后的stea之差。我们认为FCRA-bR或FCRA-aR分别代表了股骨远端切除术前后测定的sTEA与真实sTEA之间的差异。结果:FCRA-bR为-1.3±2.4°,FCRA-aR为0.3±1.7°(p)。结论:在导航辅助TKA中,股骨远端切除后测定sTEA比切除前测定FCR更合适。股骨远端切除术后sTEA的重新评估和调整配准可以改善导航辅助TKA中股骨假体的旋转对准。证据等级:四级。
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引用次数: 9
Normative FJS-12 scores for the knee in an Asian population: a cross-sectional study. 亚洲人群膝关节的标准FJS-12评分:一项横断面研究
IF 3.1 Q1 ORTHOPEDICS Pub Date : 2021-10-30 DOI: 10.1186/s43019-021-00122-2
Jia Ying Lee, Wai Weng Yeo, Zi Yang Chia, Paul Chang

Background: The Forgotten Joint Score is a patient-reported outcome measure validated in assessing patients post knee arthroplasty, anterior cruciate ligament (ACL) reconstruction surgery and patellar dislocation. A previous study had established the normative scores of a population in the USA but included knees with pathology. The aim of our study is to obtain normative Forgotten Joint Scores in young Asian adults without any pre-existing knee pathologies to increase the interpretability of the Forgotten Joint Score-12 (FJS-12) score.

Methods: We conducted a cross-sectional study across young healthy Asian adults via electronic platforms. Participants who had sought either Western medical consultation, physiotherapy or traditional medical therapies were excluded. Demographic data, occupation, type of sport played, and FJS-12 scores were collected. Scores were stratified into subgroups and analysed.

Results: There were 172 participants who met our inclusion criteria for this study. The average age of participants in our study was 28.1 ± 10.5 years (range 14-70 years), with 83 (47.7%) participants falling into the ages 21-25 years. Average body mass index (BMI) was 21.9 ± 3.3 kg/m2 (range 14.7-36.3 kg/m2). The average FJS-12 score was 62.8 ± 25.6. The median FJS-12 was 63.5 with a range of 4.2-100. Nine participants (5.2%) scored the maximum score possible, and 56 (32.6%) participants scored below the midpoint score of 50. The percentiles for each subgroup of participants were tabulated and reported. Notably, males aged 46-70 years old scored the highest average FJS-12 score of 73.4 ± 5.5, and females aged 31-45 years old scored the lowest FJS-12 score of 57.1 ± 25.1. Females scored lower than males, although the difference was not statistically significant (p = 0.157). There were no significant correlations between BMI, age, or type of sport played with FJS-12; however, interestingly, we observed that women reported similar FJS-12 scores across all age groups, while men reported better scores with increasing age.Interestingly, we observed that women reported similar FJS-12 scores across all age groups, while men reported better scores with increasing age.  CONCLUSION: Having normative values provides opportunities for benchmarking and comparing individuals against age- and gender-matched peers in the general population. Knowledge of normative values for FJS-12 scores would aid evaluating and tracking progress in patients recovering from injuries or undergoing post-surgery rehabilitation. This would help clinicians  determine if they return to 'normal' post intervention.

背景:遗忘关节评分是一种患者报告的结果测量,用于评估膝关节置换术、前交叉韧带(ACL)重建手术和髌骨脱位后的患者。先前的一项研究建立了美国人群的标准分数,但包括了有病理的膝盖。本研究的目的是在没有任何既往膝关节疾病的年轻亚洲成年人中获得规范的遗忘关节评分,以增加遗忘关节评分-12 (FJS-12)评分的可解释性。方法:我们通过电子平台对年轻健康的亚洲成年人进行了横断面研究。接受过西医咨询、物理治疗或传统医学治疗的参与者被排除在外。收集人口统计数据、职业、运动类型和FJS-12分数。将评分分为亚组并进行分析。结果:172名受试者符合本研究的纳入标准。本研究参与者的平均年龄为28.1±10.5岁(14-70岁),其中83例(47.7%)参与者年龄在21-25岁之间。平均体重指数(BMI)为21.9±3.3 kg/m2(范围14.7 ~ 36.3 kg/m2)。FJS-12平均评分为62.8±25.6分。FJS-12的中位数为63.5,范围为4.2-100。9名参与者(5.2%)得分最高,56名参与者(32.6%)得分低于中点50分。每个亚组参与者的百分位数被制成表格并报告。其中,46 ~ 70岁男性FJS-12平均得分最高,为73.4±5.5,31 ~ 45岁女性FJS-12平均得分最低,为57.1±25.1。女性得分低于男性,但差异无统计学意义(p = 0.157)。BMI、年龄或运动类型与FJS-12之间没有显著相关性;然而,有趣的是,我们观察到,在所有年龄组中,女性报告的FJS-12分数相似,而男性报告的分数随着年龄的增长而提高。有趣的是,我们观察到,在所有年龄组中,女性报告的FJS-12分数相似,而男性报告的分数随着年龄的增长而提高。结论:拥有规范的价值观提供了基准和比较个体与一般人群中年龄和性别匹配的同龄人的机会。了解FJS-12评分的正常值将有助于评估和跟踪受伤患者康复或术后康复的进展。这将有助于临床医生确定他们在干预后是否恢复“正常”。
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引用次数: 0
Botulinum toxin injections as salvage therapy is beneficial for management of patellofemoral pain syndrome. 肉毒杆菌毒素注射作为挽救疗法对治疗髌骨股骨疼痛综合征很有益处。
IF 4.1 Q1 ORTHOPEDICS Pub Date : 2021-10-29 DOI: 10.1186/s43019-021-00121-3
Yuval Kesary, Vivek Singh, Tal Frenkel-Rutenberg, Arie Greenberg, Shmuel Dekel, Ran Schwarzkopf, Nimrod Snir

Purpose: Patellofemoral pain syndrome (PFPS) is a common pathology usually presenting with anterior or retropatellar pain. It is associated with a relative imbalance between the vastus medialis oblique (VMO) and the vastus lateralis (VL) muscles. This can lead to considerable morbidity and reduced quality of life (QOL). This study aims to assess the long-term functional outcome of PFPS treated with VL muscle botulinum toxin A (BoNT-A) injection.

Materials and methods: A retrospective review was performed on 26 consecutive patients (31 knees) with a mean age of 50.1 years (± 19.7 years) who were treated with BoNT-A injections to the VL muscle followed by physiotherapy between 2008 and 2015. Pre- and post-treatment pain levels (numerical rating scale, NRS), QOL (SF-6D), and functional scores (Kujala and Lysholm questionnaires) were measured. Demographics, physical therapy compliance, previous surgeries, perioperative complications, and patient satisfaction levels were collected.

Results: The mean follow-up time was 58.8 ± 36.4 months. There were significant improvements in all the examined domains. The average pain score (NRS) decreased from 7.6 to 3.2 (P < 0.01), and the Kujala, Lysholm, and SF-6D scores improved from 58.9 to 82.7 (P < 0.001), 56.2 to 83.2 (P < 0.001), and 0.6 to 0.8 (P < 0.001), respectively. Similar delta improvement was achieved irrespective of gender, age, compliance to post-treatment physical therapy, or coexisting osteoarthritis. Patients who presented with a worse pre-treatment clinical status achieved greater improvement. Prior to BoNT-A intervention, 16 patients (18 knees) were scheduled for surgery, of whom 12 (75%, 13 knees) did not require further surgical intervention at the last follow-up.

Conclusions: A single intervention of BoNT-A injections to the VL muscle combined with physiotherapy is beneficial for the treatment of patients with persistent PFPS.

Level iii evidence: Retrospective cohort study.

目的:髌骨股骨疼痛综合征(PFPS)是一种常见病,通常表现为髌骨前或后疼痛。它与股内侧肌(VMO)和股外侧肌(VL)之间的相对不平衡有关。这可能导致相当高的发病率和生活质量下降(QOL)。本研究旨在评估使用 VL 肌肉肉毒杆菌毒素 A(BoNT-A)注射治疗 PFPS 的长期功能效果:该研究对 2008 年至 2015 年间连续接受 VL 肌肉 BoNT-A 注射治疗并随后接受物理治疗的 26 例患者(31 膝)进行了回顾性研究,这些患者的平均年龄为 50.1 岁(± 19.7 岁)。对治疗前后的疼痛程度(数字评分量表,NRS)、QOL(SF-6D)和功能评分(Kujala 和 Lysholm 问卷)进行了测量。此外,还收集了患者的人口统计学资料、物理治疗依从性、既往手术情况、围手术期并发症以及患者满意度:平均随访时间为 58.8 ± 36.4 个月。所有检查指标均有明显改善。平均疼痛评分(NRS)从 7.6 分降至 3.2 分(P 结论:BoNT-A 注射疗法是一种有效的治疗方法:对VL肌肉注射BoNT-A并结合物理疗法的单一干预措施有利于治疗顽固性PFPS患者:回顾性队列研究。
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引用次数: 0
Graft tunnel integration occurs early in the tibial tunnel compared with the femoral tunnel after anterior cruciate ligament reconstruction with preserved insertion hamstring tendon graft. 与股骨隧道相比,使用保留插入腘绳肌腱移植物进行前交叉韧带重建后,胫骨隧道内的移植物隧道整合发生得更早。
IF 4.1 Q1 ORTHOPEDICS Pub Date : 2021-10-09 DOI: 10.1186/s43019-021-00119-x
Ravi Gupta, Sandeep Singh, Anil Kapoor, Ashwani Soni, Ravinder Kaur, Narinder Kaur

Background: Preservation of hamstring tendon insertion at the time of anterior cruciate ligament (ACL) reconstruction is a well-known technique; however, its effect on graft integration is not well studied. The present study was conducted to study the graft integration inside the tibial and femoral tunnels, respectively, after ACL reconstruction using hamstring tendon graft with preserved insertion.

Methods: Twenty-five professional athletes who underwent ACL reconstruction using hamstring tendon graft with preserved tibia insertion were enrolled in the study. Functional outcomes were checked at final follow-up using Lysholm score and Tegner activity scale. Magnetic resonance imaging (MRI) was done at 8 months and 14 months follow-up to study the graft tunnel integration of the ACL graft at both tibial and femoral tunnels.

Results: The mean Fibrous interzone (FI) score (tibial tunnel) decreased from 2.61 (1-5) at 8 months to 2.04 (1-4) at 14 months follow-up (p = 0.02). The mean FI score (femoral side) decreased from 3.04 (2-5) at 8 months to 2.57 (2-4) at 14 months (p = 0.02).

Conclusions: Graft integration occurs early in the tibial tunnel as compared with the femur tunnel with preserved insertion hamstring tendon autograft. Trial registration CTRI/2019/07/020320 [registered on 22/07/2019]; http://www.ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=33884&EncHid=&modid=&compid=%27,%2733884det%27.

背景:在前交叉韧带(ACL)重建时保留腘绳肌腱插入部是一项众所周知的技术,但其对移植物整合的影响尚未得到很好的研究。本研究旨在研究使用保留插入部位的腘绳肌腱移植物进行前交叉韧带重建后,移植物分别在胫骨和股骨隧道内的整合情况:方法:25 名专业运动员接受了前交叉韧带重建术,使用保留胫骨插入的腘绳肌腱移植物。最后随访时使用 Lysholm 评分和 Tegner 活动量表检查功能结果。分别在随访 8 个月和 14 个月时进行核磁共振成像(MRI),以研究前交叉韧带移植物在胫骨和股骨隧道内的融合情况:纤维区(FI)平均得分(胫骨隧道)从 8 个月时的 2.61(1-5)降至 14 个月随访时的 2.04(1-4)(P = 0.02)。平均FI评分(股骨侧)从8个月时的3.04(2-5)降至14个月时的2.57(2-4)(P = 0.02):结论:与保留插入腘绳肌腱自体移植物的股骨隧道相比,胫骨隧道的移植物整合发生得更早。试验注册号:CTRI/2019/07/020320 [注册日期:2019年7月22日];http://www.ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=33884&EncHid=&modid=&compid=%27,%2733884det%27。
{"title":"Graft tunnel integration occurs early in the tibial tunnel compared with the femoral tunnel after anterior cruciate ligament reconstruction with preserved insertion hamstring tendon graft.","authors":"Ravi Gupta, Sandeep Singh, Anil Kapoor, Ashwani Soni, Ravinder Kaur, Narinder Kaur","doi":"10.1186/s43019-021-00119-x","DOIUrl":"10.1186/s43019-021-00119-x","url":null,"abstract":"<p><strong>Background: </strong>Preservation of hamstring tendon insertion at the time of anterior cruciate ligament (ACL) reconstruction is a well-known technique; however, its effect on graft integration is not well studied. The present study was conducted to study the graft integration inside the tibial and femoral tunnels, respectively, after ACL reconstruction using hamstring tendon graft with preserved insertion.</p><p><strong>Methods: </strong>Twenty-five professional athletes who underwent ACL reconstruction using hamstring tendon graft with preserved tibia insertion were enrolled in the study. Functional outcomes were checked at final follow-up using Lysholm score and Tegner activity scale. Magnetic resonance imaging (MRI) was done at 8 months and 14 months follow-up to study the graft tunnel integration of the ACL graft at both tibial and femoral tunnels.</p><p><strong>Results: </strong>The mean Fibrous interzone (FI) score (tibial tunnel) decreased from 2.61 (1-5) at 8 months to 2.04 (1-4) at 14 months follow-up (p = 0.02). The mean FI score (femoral side) decreased from 3.04 (2-5) at 8 months to 2.57 (2-4) at 14 months (p = 0.02).</p><p><strong>Conclusions: </strong>Graft integration occurs early in the tibial tunnel as compared with the femur tunnel with preserved insertion hamstring tendon autograft. Trial registration CTRI/2019/07/020320 [registered on 22/07/2019]; http://www.ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=33884&EncHid=&modid=&compid=%27,%2733884det%27.</p>","PeriodicalId":17886,"journal":{"name":"Knee Surgery & Related Research","volume":"33 1","pages":"37"},"PeriodicalIF":4.1,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39500146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A characteristic MRI finding to diagnose a partial tear of the medial meniscus posterior root: an ocarina sign. 诊断内侧半月板后根部分撕裂的特征性MRI表现:笛卡征。
IF 3.1 Q1 ORTHOPEDICS Pub Date : 2021-10-09 DOI: 10.1186/s43019-021-00120-4
Takayuki Furumatsu, Takaaki Hiranaka, Keisuke Kintaka, Yuki Okazaki, Naohiro Higashihara, Masanori Tamura, Toshifumi Ozaki

Background: Diagnosing partial tears of the medial meniscus (MM) posterior root is difficult. The aim of this study was to evaluate diagnostic values involved in conventional magnetic resonance imaging (MRI) features of MM posterior root tears (MMPRTs) and find other MRI-based findings in patients with partial MMPRTs.

Methods: Eighteen patients who had arthroscopically confirmed partial MMPRTs were included. As a control, 18 patients who underwent partial meniscectomy for other types of MM tears were evaluated. Isolated partial MMPRTs were classified into the following three types: type A, accurate partial stable tear (cleavage < 1/2 of root width); type B, bridged unstable root tear (cleavage ≥ 1/2 of root width); type C, complex horn tear expanded to the root. Conventional MRI-based findings of MMPRTs were evaluated between two groups (n = 23). Posterior root irregularity, bone marrow spot, and ocarina-like appearance showing several condensed circles in triangular meniscal horn (ocarina sign) were also evaluated.

Results: Posterior root irregularity and bone marrow spot were frequently observed in the partial MMPRTs (47.8%), compared with the other MM tears (P = 0.007 and 0.023, respectively). The ocarina sign was detected in 69.6% of patients with partial MMPRTs. A significant difference between two groups was observed in a positive ratio of ocarina sign (P < 0.001). Types A, B, and C of the partial tear/damage were observed in three, eight, and seven patients, respectively. The ocarina sign was the most common MRI finding in each type of partial MMPRT.

Conclusions: This study demonstrated that a characteristic MRI finding, "ocarina sign," was frequently observed in patients with partial tear/damage of the MM posterior root. The ocarina sign was the most common MRI finding in several types of partial MMPRTs. Our results suggest that the ocarina sign may be useful to diagnose unnoticed partial MMPRTs.

Level of evidence: IV, retrospective comparative study.

背景:诊断内侧半月板(MM)后根部分撕裂是困难的。本研究的目的是评估MM后根撕裂(MMPRTs)的常规磁共振成像(MRI)特征的诊断价值,并寻找部分MMPRTs患者的其他MRI发现。方法:纳入18例关节镜确认的部分MMPRTs患者。作为对照,我们评估了18例因其他类型MM撕裂而接受半月板部分切除术的患者。分离的部分MMPRTs分为以下3种类型:A型,准确部分稳定撕裂(裂解结果:与其他MM撕裂相比,部分MMPRTs多见后根不规则和骨髓斑点(47.8%)(P分别= 0.007和0.023)。69.6%的部分mmprt患者检测到ocarina征。结论:本研究表明,在MM后根部分撕裂/损伤的患者中,经常观察到一种特征性的MRI发现,即“ocarina征象”。在几种类型的部分mmprt中,ocarina征象是最常见的MRI发现。我们的研究结果表明,陶笛征可能有助于诊断未被注意到的部分mmprt。证据水平:IV,回顾性比较研究。
{"title":"A characteristic MRI finding to diagnose a partial tear of the medial meniscus posterior root: an ocarina sign.","authors":"Takayuki Furumatsu,&nbsp;Takaaki Hiranaka,&nbsp;Keisuke Kintaka,&nbsp;Yuki Okazaki,&nbsp;Naohiro Higashihara,&nbsp;Masanori Tamura,&nbsp;Toshifumi Ozaki","doi":"10.1186/s43019-021-00120-4","DOIUrl":"https://doi.org/10.1186/s43019-021-00120-4","url":null,"abstract":"<p><strong>Background: </strong>Diagnosing partial tears of the medial meniscus (MM) posterior root is difficult. The aim of this study was to evaluate diagnostic values involved in conventional magnetic resonance imaging (MRI) features of MM posterior root tears (MMPRTs) and find other MRI-based findings in patients with partial MMPRTs.</p><p><strong>Methods: </strong>Eighteen patients who had arthroscopically confirmed partial MMPRTs were included. As a control, 18 patients who underwent partial meniscectomy for other types of MM tears were evaluated. Isolated partial MMPRTs were classified into the following three types: type A, accurate partial stable tear (cleavage < 1/2 of root width); type B, bridged unstable root tear (cleavage ≥ 1/2 of root width); type C, complex horn tear expanded to the root. Conventional MRI-based findings of MMPRTs were evaluated between two groups (n = 23). Posterior root irregularity, bone marrow spot, and ocarina-like appearance showing several condensed circles in triangular meniscal horn (ocarina sign) were also evaluated.</p><p><strong>Results: </strong>Posterior root irregularity and bone marrow spot were frequently observed in the partial MMPRTs (47.8%), compared with the other MM tears (P = 0.007 and 0.023, respectively). The ocarina sign was detected in 69.6% of patients with partial MMPRTs. A significant difference between two groups was observed in a positive ratio of ocarina sign (P < 0.001). Types A, B, and C of the partial tear/damage were observed in three, eight, and seven patients, respectively. The ocarina sign was the most common MRI finding in each type of partial MMPRT.</p><p><strong>Conclusions: </strong>This study demonstrated that a characteristic MRI finding, \"ocarina sign,\" was frequently observed in patients with partial tear/damage of the MM posterior root. The ocarina sign was the most common MRI finding in several types of partial MMPRTs. Our results suggest that the ocarina sign may be useful to diagnose unnoticed partial MMPRTs.</p><p><strong>Level of evidence: </strong>IV, retrospective comparative study.</p>","PeriodicalId":17886,"journal":{"name":"Knee Surgery & Related Research","volume":"33 1","pages":"38"},"PeriodicalIF":3.1,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39501131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Surgery-related predictors of kneeling ability following total knee arthroplasty: a systematic review and meta-analysis. 全膝关节置换术后跪下能力的手术相关预测因素:系统回顾和荟萃分析。
IF 3.1 Q1 ORTHOPEDICS Pub Date : 2021-10-02 DOI: 10.1186/s43019-021-00117-z
Shaheer Nadeem, Raman Mundi, Harman Chaudhry

Purpose: Kneeling ability is among the poorest outcomes following total knee arthroplasty (TKA). The purpose of this meta-analysis was to: (1) quantify kneeling ability after TKA; (2) identify surgical approaches and prosthesis designs that improve kneeling ability following TKA; and (3) quantify the effectiveness of these approaches.

Methods: We performed a systematic review in accordance with the PRISMA guidelines of multiple medical databases. Data relating to demographics, TKA technique, prosthesis design, and kneeling-specific outcomes were extracted. Comparative outcomes data were pooled using a random effects model.

Results: Thirty-six studies met the eligibility criteria. The proportion of patients able to kneel increased with longer follow-up (36.8% at a minimum of 1 year follow-up versus 47.6% after a minimum of 3 years follow-up, p < 0.001). The odds of kneeling were greater for patients undergoing an anterolateral incision compared with an anteromedial incision (OR 3.0, 95% CI 1.3-6.9, p = 0.02); a transverse incision compared with a longitudinal incision (OR 3.5, 95% CI 1.4-8.7, p = 0.008); and a shorter incision compared with a longer incision (OR 8.5, 95% CI 2.3-30.9, p = 0.001). The odds of kneeling were worse for a mobile prosthesis compared with a fixed platform design (OR 0.3, 95% CI 0.1-0.7, p = 0.005).

Conclusion: A large majority of patients are unable to kneel following TKA, although the ability to kneel improves over time. This evidence may facilitate preoperative patient counseling. Variations in choice of incision location and length may affect ability to kneel; however, high-quality randomized trials are needed to corroborate our findings.

目的:膝跪能力是全膝关节置换术(TKA)后最差的预后之一。本荟萃分析的目的是:(1)量化TKA后跪地能力;(2)确定手术入路和假体设计,以提高TKA后的跪下能力;(3)量化这些方法的有效性。方法:我们按照PRISMA指南对多个医学数据库进行了系统评价。提取与人口统计学、TKA技术、假体设计和膝关节特异性结果相关的数据。比较结果数据采用随机效应模型汇总。结果:36项研究符合入选标准。随着随访时间的延长,能够下跪的患者比例增加(至少1年随访时为36.8%,至少3年随访时为47.6%)。结论:绝大多数患者在TKA后无法下跪,尽管下跪能力随着时间的推移而改善。这一证据可能有助于术前患者咨询。选择不同的切口位置和长度可能会影响下跪的能力;然而,需要高质量的随机试验来证实我们的发现。
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引用次数: 5
Relationship between early physical activity after total knee arthroplasty and postoperative physical function: are these related? 全膝关节置换术后早期体力活动与术后身体功能的关系:两者是否相关?
IF 3.1 Q1 ORTHOPEDICS Pub Date : 2021-09-28 DOI: 10.1186/s43019-021-00118-y
Daisuke Takamura, Kentaro Iwata, Tatsuya Sueyoshi, Tadashi Yasuda, Hideki Moriyama

Background: Physical activity is associated with physical function; however, the relationship between early physical activity after total knee arthroplasty (TKA) and postoperative physical function remains unclear. The purpose of this study was to evaluate the association of early physical activity after TKA with postoperative physical function.

Methods: Timed Up and Go test (TUG) of 47 patients was assessed preoperatively and at 10 days, 3 months, and 6 months postoperatively. Physical activity from the second to the ninth day after TKA was measured with accelerometer, and the correlation with pre- and postoperative physical function was evaluated . A multiple linear regression was used to predict TUG at 6 months after TKA.

Results: Postoperative physical activity correlated with preoperative TUG (ρ = -0.485, p < 0.001), TUG at 10 days (ρ = -0.675, p < 0.001), 3 months (ρ = -0.441, p < 0.01), and 6 months (ρ = -0.368, p < 0.05) after surgery. Multiple linear regression indicated that only the preoperative TUG was associated with TUG at 6 months. Postoperative physical activity was not an independent factor predicting TUG at 6 months after TKA.

Conclusion: Our study demonstrated that patients with better physical function have higher physical activity in the early postoperative period, whereas it does not affect physical function at 6 months after TKA. In the early postoperative period, increasing physical activity may not always be necessary to improve postoperative physical function. We also confirmed that preoperative physical function affects postoperative physical function. These findings may be beneficial in improving rehabilitation programs in the early postoperative period.

背景:体力活动与身体功能有关;然而,全膝关节置换术(TKA)后早期体力活动与术后身体功能之间的关系尚不清楚。本研究的目的是评估TKA术后早期体力活动与术后身体功能的关系。方法:对47例患者进行术前、术后10天、3个月、6个月的TUG (Timed Up and Go test)测试。用加速度计测量TKA后第2 ~第9天的身体活动,并评估其与术前和术后身体功能的相关性。采用多元线性回归预测TKA后6个月的TUG。结果:术后体力活动与术前TUG相关(ρ = -0.485, p)。结论:我们的研究表明,身体功能较好的患者术后早期体力活动较高,而TKA术后6个月体力活动不影响身体功能。在术后早期,增加体力活动可能并不总是必要的,以改善术后的身体功能。我们也证实了术前身体功能对术后身体功能的影响。这些发现可能有助于改善术后早期的康复计划。
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引用次数: 10
Open reduction and internal fixation using multiple nonabsorbable suture materials in acute patella fracture: comparison of clinical and radiological outcome with tension band wiring. 使用多种不可吸收缝线材料切开复位内固定治疗急性髌骨骨折:张力带钢丝的临床和影像学结果比较。
IF 3.1 Q1 ORTHOPEDICS Pub Date : 2021-09-28 DOI: 10.1186/s43019-021-00116-0
Kwang Won Lee, Sang Beom Ma, Dae Suk Yang, Seung Hak Oh, Seong Ho Park

Background: For treating displaced patella fractures, tension band wiring is the most widely used technique. However, implant removal surgery is often necessary to alleviate discomfort caused by fixation materials. On the contrary, fixation using nonabsorbable suture materials is anticipated to result in comparable outcomes without need for further implant removal surgery. However, there is a lack of clinical studies comparing the two fixation techniques (wire and nonabsorbable suture materials) for acute patella fractures.

Methods: From 2014 to 2018, we retrospectively reviewed 60 patients who underwent open reduction with internal fixation for acute patella fracture. Thirty patients (group 1) who received surgery using tension band wiring and 30 patients (group 2) who received surgery using nonabsorbable suture materials were enrolled. The average follow-up period was more than 1 year after operation. Operation time, postoperative bone union time, range of motion (ROM) of the knee joint, postoperative clinical results, and complications were compared between the two groups.

Result: Operation time, clinical bone union, and radiologic bone union were not statistically different between groups 1 and 2. At 3 months postoperatively, flexion was 120.3 ± 9.4° in group 1 and 110.5 ± 7.7° in group 2, showing statistically significant difference (p = 0.037). At 6 and 12 months postoperatively, the ROM was similar in both groups. Hospital for special surgery score at 3 months postoperatively was 78.4 ± 8.2 in group 1 and 83.7 ± 8.7 in group 2, showing statistically significant differences (p = 0.032). However, at 6 and 12 months postoperatively, there were no statistical differences. Lysholm score at 3 months postoperatively was 73.5 ± 8.1 in group 1 and 80.4 ± 8.2 in group 2, showing statistically significant difference (p = 0.016), but at 6 and 12 months postoperatively, there were no statistical differences.

Conclusion: Fixation using multiple nonabsorbable suture materials can be an alternative surgical method in managing patella fractures, along with tension band wiring.

背景:张力带钢丝是治疗移位髌骨骨折最常用的技术。然而,为了减轻固定材料引起的不适,通常需要进行植入物移除手术。相反,使用不可吸收的缝线材料进行固定,预计不需要进一步的植入物移除手术就能获得类似的结果。然而,比较两种固定技术(金属丝和不可吸收缝线材料)治疗急性髌骨骨折的临床研究缺乏。方法:回顾性分析2014 - 2018年收治的60例急性髌骨骨折切开复位内固定患者。30例使用张力带钢丝的患者(第一组)和30例使用不可吸收缝合材料的患者(第二组)被纳入研究。术后平均随访1年以上。比较两组手术时间、术后骨愈合时间、膝关节活动度(ROM)、术后临床结果及并发症。结果:1、2组手术时间、临床骨愈合、影像学骨愈合差异无统计学意义。术后3个月,1组屈曲度为120.3±9.4°,2组为110.5±7.7°,差异有统计学意义(p = 0.037)。术后6个月和12个月,两组的ROM相似。术后3个月特外科住院评分1组为78.4±8.2,2组为83.7±8.7,差异有统计学意义(p = 0.032)。然而,在术后6个月和12个月,没有统计学差异。术后3个月Lysholm评分1组为73.5±8.1分,术后2组为80.4±8.2分,差异有统计学意义(p = 0.016),但术后6、12个月比较差异无统计学意义。结论:使用多种不可吸收缝线材料固定可作为治疗髌骨骨折的一种替代手术方法,并配合张力带钢丝。
{"title":"Open reduction and internal fixation using multiple nonabsorbable suture materials in acute patella fracture: comparison of clinical and radiological outcome with tension band wiring.","authors":"Kwang Won Lee,&nbsp;Sang Beom Ma,&nbsp;Dae Suk Yang,&nbsp;Seung Hak Oh,&nbsp;Seong Ho Park","doi":"10.1186/s43019-021-00116-0","DOIUrl":"https://doi.org/10.1186/s43019-021-00116-0","url":null,"abstract":"<p><strong>Background: </strong>For treating displaced patella fractures, tension band wiring is the most widely used technique. However, implant removal surgery is often necessary to alleviate discomfort caused by fixation materials. On the contrary, fixation using nonabsorbable suture materials is anticipated to result in comparable outcomes without need for further implant removal surgery. However, there is a lack of clinical studies comparing the two fixation techniques (wire and nonabsorbable suture materials) for acute patella fractures.</p><p><strong>Methods: </strong>From 2014 to 2018, we retrospectively reviewed 60 patients who underwent open reduction with internal fixation for acute patella fracture. Thirty patients (group 1) who received surgery using tension band wiring and 30 patients (group 2) who received surgery using nonabsorbable suture materials were enrolled. The average follow-up period was more than 1 year after operation. Operation time, postoperative bone union time, range of motion (ROM) of the knee joint, postoperative clinical results, and complications were compared between the two groups.</p><p><strong>Result: </strong>Operation time, clinical bone union, and radiologic bone union were not statistically different between groups 1 and 2. At 3 months postoperatively, flexion was 120.3 ± 9.4° in group 1 and 110.5 ± 7.7° in group 2, showing statistically significant difference (p = 0.037). At 6 and 12 months postoperatively, the ROM was similar in both groups. Hospital for special surgery score at 3 months postoperatively was 78.4 ± 8.2 in group 1 and 83.7 ± 8.7 in group 2, showing statistically significant differences (p = 0.032). However, at 6 and 12 months postoperatively, there were no statistical differences. Lysholm score at 3 months postoperatively was 73.5 ± 8.1 in group 1 and 80.4 ± 8.2 in group 2, showing statistically significant difference (p = 0.016), but at 6 and 12 months postoperatively, there were no statistical differences.</p><p><strong>Conclusion: </strong>Fixation using multiple nonabsorbable suture materials can be an alternative surgical method in managing patella fractures, along with tension band wiring.</p>","PeriodicalId":17886,"journal":{"name":"Knee Surgery & Related Research","volume":"33 1","pages":"34"},"PeriodicalIF":3.1,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8477530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39468532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Clinical outcomes of combined anterior cruciate ligament and anterolateral ligament reconstruction: a systematic review and meta-analysis. 前交叉韧带联合前外侧韧带重建的临床结果:系统回顾和荟萃分析。
IF 3.1 Q1 ORTHOPEDICS Pub Date : 2021-09-23 DOI: 10.1186/s43019-021-00115-1
Diego Ariel de Lima, Lana Lacerda de Lima, Nayara Gomes Reis de Souza, Rodrigo Amorim de Moraes Perez, Marcel Faraco Sobrado, Tales Mollica Guimarães, Camilo Partezani Helito

Objectives: To compare the clinical outcomes of isolated anterior cruciate ligament (ACL) reconstruction with combined reconstruction of the ACL and anterolateral ligament (ALL) of the knee.

Methods: A search was conducted on the PubMed, Medline, Google Scholar, EMBASE, and Cochrane library databases, in line with the PRISMA protocol. The indexation terms used were "anterior cruciate ligament" OR "acl" AND "anterolateral ligament" AND "reconstruction." Articles that compared patients submitted to combined ACL and ALL reconstruction with those submitted to isolated reconstruction of the ACL, with levels of evidence I, II, and III, were included. Studies with follow-up of less than 2 years and articles that did not use "anatomical" techniques for ALL reconstruction, such as extraarticular tenodesis, were excluded. A meta-analysis with R software was conducted, with a random effects model, presented as risk ratio (RR) or mean difference (MD), with a 95% confidence level (CI) and statistically significant at p < 0.05.

Results: Ten articles were selected, with a total of 1495 patients, most of whom were men, of whom 674 submitted to ACL and ALL reconstruction and 821 to isolated ACL reconstruction. Combined ACL and ALL reconstruction exhibited a statistically significant advantage in residual pivot shift (RR 0.34, 95% CI 0.24-0.47, I2 = 0%, p < 0.01), rerupture rate (RR 0.34, 95% CI 0.19-0.62, I2 = 0%, p < 0.01), Lachman test (RR 0.59, 95% CI 0.40-0.86, I2 = 21%, p < 0.01), and postoperative Lysholm score (MD 2.28, CI 95% 0.75-3.81, I2 = 73%, p < 0.01).

Conclusions: Combined ACL and ALL reconstruction obtained better postoperative clinical outcomes when compared with isolated ACL reconstruction, especially in reducing residual pivot shift and rerupture rate.

目的:比较单纯前交叉韧带(ACL)重建与联合前交叉韧带(ALL)重建的临床效果。方法:检索PubMed、Medline、Google Scholar、EMBASE和Cochrane图书馆数据库,按照PRISMA协议进行检索。使用的索引术语是“前交叉韧带”或“acl”和“前外侧韧带”和“重建”。比较联合ACL和ALL重建患者与单独ACL重建患者的文章,证据等级为I、II和III。随访时间少于2年的研究和未使用“解剖学”技术进行ALL重建(如关节外肌腱固定术)的文章被排除在外。采用R软件进行meta分析,采用随机效应模型,以风险比(RR)或平均差(MD)表示,95%置信水平(CI), p有统计学意义。结果:选择10篇文章,共1495例患者,其中大部分为男性,其中674例行ACL和ALL重建,821例行孤立ACL重建。ACL联合ALL重建在残余支点移位方面具有统计学意义(RR 0.34, 95% CI 0.24-0.47, I2 = 0%, p 2 = 0%, p 2 = 21%, p 2 = 73%, p)结论:ACL联合ALL重建与单独ACL重建相比,术后临床效果更好,特别是在减少残余支点移位和再破裂率方面。
{"title":"Clinical outcomes of combined anterior cruciate ligament and anterolateral ligament reconstruction: a systematic review and meta-analysis.","authors":"Diego Ariel de Lima,&nbsp;Lana Lacerda de Lima,&nbsp;Nayara Gomes Reis de Souza,&nbsp;Rodrigo Amorim de Moraes Perez,&nbsp;Marcel Faraco Sobrado,&nbsp;Tales Mollica Guimarães,&nbsp;Camilo Partezani Helito","doi":"10.1186/s43019-021-00115-1","DOIUrl":"https://doi.org/10.1186/s43019-021-00115-1","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the clinical outcomes of isolated anterior cruciate ligament (ACL) reconstruction with combined reconstruction of the ACL and anterolateral ligament (ALL) of the knee.</p><p><strong>Methods: </strong>A search was conducted on the PubMed, Medline, Google Scholar, EMBASE, and Cochrane library databases, in line with the PRISMA protocol. The indexation terms used were \"anterior cruciate ligament\" OR \"acl\" AND \"anterolateral ligament\" AND \"reconstruction.\" Articles that compared patients submitted to combined ACL and ALL reconstruction with those submitted to isolated reconstruction of the ACL, with levels of evidence I, II, and III, were included. Studies with follow-up of less than 2 years and articles that did not use \"anatomical\" techniques for ALL reconstruction, such as extraarticular tenodesis, were excluded. A meta-analysis with R software was conducted, with a random effects model, presented as risk ratio (RR) or mean difference (MD), with a 95% confidence level (CI) and statistically significant at p < 0.05.</p><p><strong>Results: </strong>Ten articles were selected, with a total of 1495 patients, most of whom were men, of whom 674 submitted to ACL and ALL reconstruction and 821 to isolated ACL reconstruction. Combined ACL and ALL reconstruction exhibited a statistically significant advantage in residual pivot shift (RR 0.34, 95% CI 0.24-0.47, I<sup>2</sup> = 0%, p < 0.01), rerupture rate (RR 0.34, 95% CI 0.19-0.62, I<sup>2</sup> = 0%, p < 0.01), Lachman test (RR 0.59, 95% CI 0.40-0.86, I<sup>2</sup> = 21%, p < 0.01), and postoperative Lysholm score (MD 2.28, CI 95% 0.75-3.81, I<sup>2</sup> = 73%, p < 0.01).</p><p><strong>Conclusions: </strong>Combined ACL and ALL reconstruction obtained better postoperative clinical outcomes when compared with isolated ACL reconstruction, especially in reducing residual pivot shift and rerupture rate.</p>","PeriodicalId":17886,"journal":{"name":"Knee Surgery & Related Research","volume":"33 1","pages":"33"},"PeriodicalIF":3.1,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39443044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Outcomes of human umbilical cord blood-derived mesenchymal stem cells in enhancing tendon-graft healing in anterior cruciate ligament reconstruction: an exploratory study. 人脐带血间充质干细胞促进前交叉韧带重建肌腱移植物愈合的结果:一项探索性研究。
IF 3.1 Q1 ORTHOPEDICS Pub Date : 2021-09-16 DOI: 10.1186/s43019-021-00104-4
Sang Won Moon, Sinhyung Park, Minkyung Oh, Joon Ho Wang

Background: The study investigated whether allogeneic human umbilical cord blood-derived MSCs (hUCB-MSCs) could be safely used without treatment-related adverse events, reducing tunnel enlargement, and improve clinical results in human anterior cruciate ligament (ACL) reconstruction.

Methods: Thirty patients were enrolled consecutively. They were divided into three groups by randomization. In the negative control group, ACL reconstruction surgery without additional treatment was performed. In the experimental group, a hUCB-MSC and hyaluronic acid mixture was applied to the tendon-bone interface of the femoral tunnels during ACL reconstruction surgery. In the positive control group, only hyaluronic acid was applied. Finally, 27 patients were analyzed after the exclusion of three patients. The incidence of treatment-related adverse events, clinical outcomes, including second-look arthroscopic findings, and the amount of tunnel enlargement, were evaluated.

Results: There were no treatment-related adverse events in the treatment groups. Tunnel enlargement in the experimental group (579.74 ± 389.85 mm3) was not significantly different from those in the negative (641.97 ± 455.84 mm3) and positive control (421.96 ± 274.83 mm3) groups (p = 0.6468). There were no significant differences between the groups in clinical outcomes such as KT-2000 measurement (p = 0.793), pivot shift test (p = 0.9245), International Knee Documentation Committee subjective score (p = 0.9195), Tegner activity level (p = 0.9927), and second-look arthroscopic findings (synovial coverage of the graft, p = 0.7984; condition of the graft, p = 0.8402).

Conclusions: Allogeneic hUCB-MSCs were used safely for ACL reconstruction without treatment-related adverse event in a 2-year follow-up. However, our study did not suggest any evidence to show clinical advantage such as the prevention of tunnel enlargement postoperatively and a decrease in knee laxity or improvement of clinical outcomes.

Trial registration: CRIS, Registration Number: KCT0000917. Registered on 12 November 2013; https://cris.nih.go.kr/cris/index.jsp.

背景:本研究旨在探讨同种异体人脐带血来源的间充质干细胞(hUCB-MSCs)在人前交叉韧带(ACL)重建中是否可以安全使用而无治疗相关不良事件,减少隧道扩大,并改善临床结果。方法:30例患者连续入组。他们被随机分为三组。阴性对照组,行ACL重建手术,无需额外治疗。实验组在ACL重建手术中,将hub - msc和透明质酸混合物应用于股骨隧道的肌腱-骨界面。阳性对照组只应用透明质酸。最后,在排除3例患者后,对27例患者进行分析。评估治疗相关不良事件的发生率、临床结果(包括二次关节镜检查结果)和隧道扩大的数量。结果:各治疗组均未发生治疗相关不良事件。实验组隧道增大(579.74±389.85 mm3)与阴性组(641.97±455.84 mm3)和阳性对照组(421.96±274.83 mm3)比较差异无统计学意义(p = 0.6468)。两组临床结果无显著差异,如KT-2000测量(p = 0.793)、枢轴移位试验(p = 0.9245)、国际膝关节文献委员会主观评分(p = 0.9195)、Tegner活动水平(p = 0.9927)和二次关节镜检查结果(移骨滑膜覆盖率,p = 0.7984;移植物情况,p = 0.8402)。结论:同种异体hub - mscs用于ACL重建是安全的,在2年的随访中没有出现与治疗相关的不良事件。然而,我们的研究并没有提出任何临床优势的证据,如预防术后隧道扩大和减少膝关节松弛或改善临床结果。试验注册:CRIS,注册号:KCT0000917。注册于2013年11月12日;https://cris.nih.go.kr/cris/index.jsp。
{"title":"Outcomes of human umbilical cord blood-derived mesenchymal stem cells in enhancing tendon-graft healing in anterior cruciate ligament reconstruction: an exploratory study.","authors":"Sang Won Moon,&nbsp;Sinhyung Park,&nbsp;Minkyung Oh,&nbsp;Joon Ho Wang","doi":"10.1186/s43019-021-00104-4","DOIUrl":"https://doi.org/10.1186/s43019-021-00104-4","url":null,"abstract":"<p><strong>Background: </strong>The study investigated whether allogeneic human umbilical cord blood-derived MSCs (hUCB-MSCs) could be safely used without treatment-related adverse events, reducing tunnel enlargement, and improve clinical results in human anterior cruciate ligament (ACL) reconstruction.</p><p><strong>Methods: </strong>Thirty patients were enrolled consecutively. They were divided into three groups by randomization. In the negative control group, ACL reconstruction surgery without additional treatment was performed. In the experimental group, a hUCB-MSC and hyaluronic acid mixture was applied to the tendon-bone interface of the femoral tunnels during ACL reconstruction surgery. In the positive control group, only hyaluronic acid was applied. Finally, 27 patients were analyzed after the exclusion of three patients. The incidence of treatment-related adverse events, clinical outcomes, including second-look arthroscopic findings, and the amount of tunnel enlargement, were evaluated.</p><p><strong>Results: </strong>There were no treatment-related adverse events in the treatment groups. Tunnel enlargement in the experimental group (579.74 ± 389.85 mm<sup>3</sup>) was not significantly different from those in the negative (641.97 ± 455.84 mm<sup>3</sup>) and positive control (421.96 ± 274.83 mm<sup>3</sup>) groups (p = 0.6468). There were no significant differences between the groups in clinical outcomes such as KT-2000 measurement (p = 0.793), pivot shift test (p = 0.9245), International Knee Documentation Committee subjective score (p = 0.9195), Tegner activity level (p = 0.9927), and second-look arthroscopic findings (synovial coverage of the graft, p = 0.7984; condition of the graft, p = 0.8402).</p><p><strong>Conclusions: </strong>Allogeneic hUCB-MSCs were used safely for ACL reconstruction without treatment-related adverse event in a 2-year follow-up. However, our study did not suggest any evidence to show clinical advantage such as the prevention of tunnel enlargement postoperatively and a decrease in knee laxity or improvement of clinical outcomes.</p><p><strong>Trial registration: </strong>CRIS, Registration Number: KCT0000917. Registered on 12 November 2013; https://cris.nih.go.kr/cris/index.jsp.</p>","PeriodicalId":17886,"journal":{"name":"Knee Surgery & Related Research","volume":"33 1","pages":"32"},"PeriodicalIF":3.1,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39423348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
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Knee Surgery & Related Research
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