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Impact of Donor, Host, and Surgical Parameters on High Endothelial Cell Density More Than 5 Years after Penetrating Keratoplasty. 供体、宿主和手术参数对穿透性角膜移植术后 5 年以上高内皮细胞密度的影响
IF 0.8 4区 医学 Q4 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1055/a-2349-0770
Albéric Sneyers, Loay Daas, Elena Zemova, Adrien Quintin, Cristian Munteanu, Berthold Seitz

Objectives: To investigate the correlation between postoperative endothelial cell loss (ECL) and donor, host, and surgical parameters, and to assess the clinical impact of maintaining a high endothelial cell density (ECD) of ≥ 1500 cells/mm2 5 years after penetrating keratoplasty (PKP).

Methods: This retrospective cohort study included 216 eyes with 5 years of follow-up, of which 94 had annual visits, and who underwent normal-risk elective PKP for noninfectious indications by one corneal microsurgeon (B. S.) between 2009 and 2016.

Results: Among the 216 eyes, ECL (39.1%) over 5 years postoperative exhibited weak positive correlations with storage solution time (p = 0.024) and postmortem time (p = 0.028), and moderately positively correlations with the preoperative ECD (p < 0.001). The 5-year postoperative ECL differed significantly between in domo-prepared (36.8%) and ex domo donor corneas (46.3%; p = 0.001). In the 94 eyes, no significant differences were found between the two groups for central pupil pachymetry (CCT) and BCVA (p > 0.074). However, CCT increased significantly between 1 and 4 years (p = 0.034) and 1 and 5 years postoperatively (p = 0.012), respectively. BCVA improved significantly at 1 year postoperatively and continued to improve until 2 years postoperatively (p < 0.001).

Conclusion: The Lions corneal bank Saar-Lor-Lux achieved a significantly reduced ECL (36.8%) over 5 years compared to ex domo donor corneas (46.3%). A weak positive correlation was found between ECL with the storage solution time and the postmortem time, as well as a moderate positive correlation with the preoperative ECD. Although CCT increased significantly over 5 years, BCVA improved significantly from the first to the second postoperative year and remained stable thereafter.

目的研究术后内皮细胞丢失(ECL)与供体、宿主和手术参数之间的相关性,评估穿透性角膜移植术(PKP)5年后维持≥1500个细胞/mm2的高内皮细胞密度(ECD)的临床影响:这项回顾性队列研究纳入了随访5年的216只眼睛,其中94只眼睛每年就诊一次,这些眼睛在2009年至2016年期间因非感染性适应症接受了由一名角膜显微外科医生(B. S.)实施的正常风险选择性PKP手术:在这 216 只眼睛中,术后 5 年的 ECL(39.1%)与储存溶液时间(p = 0.024)和死后时间(p = 0.028)呈弱正相关,与术前 ECD 呈中度正相关(p 0.074)。然而,CCT 分别在术后 1 至 4 年(p = 0.034)和 1 至 5 年(p = 0.012)明显增加。BCVA 在术后 1 年明显改善,并在术后 2 年前持续改善(p 结论:BCVA 在术后 1 年明显改善,并在术后 2 年前持续改善:与外部供体角膜(46.3%)相比,Lions 角膜库 Saar-Lor-Lux 5 年内的 ECL(36.8%)明显降低。研究发现,ECL 与储存液时间和尸检时间呈弱正相关,与术前 ECD 呈中度正相关。虽然CCT在5年内明显增加,但BCVA在术后第一年到第二年明显改善,此后保持稳定。
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引用次数: 0
Celebrating 25 Years of Optical Biometry: A Milestone in Ophthalmology. 庆祝光学生物测量 25 周年:眼科学的里程碑。
IF 0.8 4区 医学 Q4 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-10-01 DOI: 10.1055/a-2428-8007
Sibylle Katharina Scholtz, Achim Langenbucher, Oliver Stachs

Optical biometry has fundamentally transformed cataract surgery, and 2024 marked 25 years since the introduction of the first optical biometer. In the early 1980 s, Fercher and colleagues pioneered the optical noncontact eye length measurement, leading to the first interferometric A-scan of the eye. This innovation, patented and later developed by Zeiss, culminated in the release of the IOLMaster in 1999, enabling more accurate and reproducible eye diagnostics. Over the years, optical biometry has evolved into advanced swept-source optical coherence tomography devices, accompanied by numerous formulas for calculating intraocular lens power. Today, this technology is crucial not only for cataract surgeries, especially in eyes previously treated with refractive surgery, but also in advancing our understanding of diseases across fields like cardiology and oncology.

光学生物计量从根本上改变了白内障手术,2024年是第一台光学生物计量仪问世25周年。在20世纪80年代早期,Fercher和他的同事开创了光学非接触式眼睛长度测量,导致了第一次眼睛的干涉测量a扫描。这项创新获得专利,后来由蔡司开发,最终于1999年发布了IOLMaster,实现了更准确和可重复的眼睛诊断。多年来,光学生物测量已经发展成为先进的扫描源光学相干断层扫描设备,伴随着许多计算人工晶状体功率的公式。今天,这项技术不仅对白内障手术至关重要,尤其是对以前接受过屈光手术的眼睛,而且对促进我们对心脏病学和肿瘤学等领域疾病的理解也至关重要。
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引用次数: 0
Systemic Treatment Kimmtrak for Metastatic Uveal Melanoma. 转移性葡萄膜黑色素瘤的全身治疗。
IF 0.8 4区 医学 Q4 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1055/a-2299-3941
Ludwig M Heindl, Wanlin Fan
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引用次数: 0
25 Jahre optische Biometrie, simulierte IOL-Implantation und künstliche Intelligenz in der Ophthalmologie – Innovationen und Entwicklungen 2024. 光学生物识别,模拟IOL植入和人工智能在眼科:创新和发展2024年。
IF 0.8 4区 医学 Q4 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1055/a-2439-4228
Oliver Stachs, Christian Mardin, Rudolf F Guthoff
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引用次数: 0
Artificial Intelligence: A Challenge to Scientific Communication. 人工智能:对科学传播的挑战。
IF 0.8 4区 医学 Q4 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1055/a-2418-5238
Charlotte Gauckler, Micha H Werner

Recent years have seen formidable advances in artificial intelligence. Developments include a large number of specialised systems either existing or planned for use in scientific research, data analysis, translation, text production and design with grammar checking and stylistic revision, plagiarism detection, and scientific review in addition to general-purpose AI systems for searching the internet and generative AI systems for texts, images, videos, and musical compositions. These systems promise more ease and simplicity in many aspects of work. Blind trust in AI systems with uncritical, careless use of AI results is dangerous, as these systems do not have any inherent understanding of the content they process or generate, but only simulate this understanding by reproducing statistical patterns extracted from training data. This article discusses the potential and risk of using AI in scientific communication and explores potential systemic consequences of widespread AI implementation in this context.

近年来,人工智能取得了惊人的进步。发展包括大量现有或计划用于科学研究,数据分析,翻译,文本制作和设计的语法检查和风格修改,抄袭检测和科学审查的专业系统,以及用于搜索互联网的通用人工智能系统和用于文本,图像,视频和音乐作品的生成人工智能系统。这些系统承诺在工作的许多方面更容易和简单。盲目信任人工智能系统,不加批判地、不小心地使用人工智能结果是危险的,因为这些系统对它们处理或生成的内容没有任何内在的理解,只是通过复制从训练数据中提取的统计模式来模拟这种理解。本文讨论了在科学传播中使用人工智能的潜力和风险,并探讨了在此背景下广泛实施人工智能的潜在系统性后果。
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引用次数: 0
Retrospective Analysis of Bicanalicular Lacrimal Silicone Tube Intubation in Patients with Congenital Nasolacrimal Duct Obstruction: A Long-term Follow-up Study. 先天性鼻泪管阻塞患者双侧泪囊硅胶管插管的回顾性分析:长期随访研究。
IF 0.8 4区 医学 Q4 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-04-26 DOI: 10.1055/a-2237-1139
Julian Alexander Zimmermann, Jens Julian Storp, Ralph-Laurent Merté, Larissa Lahme, Nicole Eter

Congenital nasolacrimal duct obstruction (CNLDO) is the most common cause of epiphora in the first year of life. In addition to conservative therapy, there are several invasive methods available. The aim of this retrospective study was to conduct a long-term follow-up of bicanalicular lacrimal duct intubation as the primary intervention in a large cohort of patients with CNLDO. The electronic medical records of 487 patients with CNLDO who underwent bicanalicular tube intubation were reviewed. To determine the long-term outcomes, a telephone interview was conducted. A total of 328 eyes of 235 patients were included in the study. The median average follow-up period was 6.67 (5.58 - 8.67) years. At the time of the survey, 218 patients (92.8%) were symptom free. Mean patient satisfaction with surgical outcome was 10/10. To our knowledge, this study provides the longest follow-up of the largest patient cohort in the literature consisting of patients who underwent probing with bicanalicular lacrimal silicone tube intubation as a primary intervention for CNLDO. This study showed a high long-term postoperative success rate, with high postoperative satisfaction, few complications, and a low need for reintervention.

先天性鼻泪管阻塞(CNLDO)是导致婴儿出生后第一年内出现眼睑外翻的最常见原因。除保守治疗外,还有多种侵入性方法可供选择。这项回顾性研究的目的是对一大批 CNLDO 患者进行长期随访,将双耳泪道插管作为主要干预措施。研究人员查阅了 487 名接受双泪管插管的 CNLDO 患者的电子病历。为了确定长期疗效,还进行了电话访谈。研究共纳入了 235 名患者的 328 只眼睛。平均随访时间中位数为 6.67(5.58 - 8.67)年。调查期间,218 名患者(92.8%)无症状。患者对手术结果的平均满意度为 10/10。据我们所知,这项研究提供了文献中最大患者群的最长随访时间,这些患者都接受过双耳泪道硅胶管插管探查术,作为 CNLDO 的主要干预措施。该研究显示,术后长期成功率高,术后满意度高,并发症少,再次干预的需求低。
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引用次数: 0
[Minimally invasive therapy for nasolacrimal duct obstructions]. [鼻泪管阻塞的微创疗法]。
IF 0.8 4区 医学 Q4 OPHTHALMOLOGY Pub Date : 2024-12-01 Epub Date: 2024-09-10 DOI: 10.1055/a-2375-0128
Karl-Heinz Emmerich, Monica Lang, Hans Meyer-Rüsenberg

Today, microendoscopic minimally invasive therapy techniques, such as laser dacryoplasty (LDP) for complete stenosis and microdrill dacryoplasty (MDP) for incomplete stenoses are therapeutic options for PANDO (primary acquired nasolacrimal duct obstructions). Due to excellent prognosis, external DCR is still "gold standard" especially for patients with complex problems.

如今,微内窥镜微创治疗技术,如治疗完全性狭窄的激光泪道成形术(LDP)和治疗不完全性狭窄的微钻泪道成形术(MDP),已成为 PANDO(原发性获得性鼻泪管阻塞)的治疗选择。由于预后极佳,外部 DCR 仍是 "金标准",尤其是对于问题复杂的患者。
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引用次数: 0
Case Report: Periocular Steroid Injection Combined Vemurafenib Therapy in the Long-term Management of Orbital Involvement of Erdheim-Chester Disease. 病例报告:眼周类固醇注射联合维米福尼疗法用于埃尔德海姆-切斯特病眼眶受累的长期治疗。
IF 0.8 4区 医学 Q4 OPHTHALMOLOGY Pub Date : 2024-11-14 DOI: 10.1055/a-2405-7040
Fatma Selin Kaya, Hatem Hakan Selçuk, Seyhan Ordekçi, Bengi Demirayak, Sibel Zirtiloglu
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引用次数: 0
An Unusual Presentation of Persistent Cloquet's Canal with Detached Mittendorf Dot: A Case Report. 持续性 Cloquet 管伴有 Mittendorf 点阵脱落的不寻常表现:病例报告。
IF 0.8 4区 医学 Q4 OPHTHALMOLOGY Pub Date : 2024-11-14 DOI: 10.1055/a-2433-1630
Asli Giriftinoglu, Faik Gelisken, Daniel A Wenzel, Ben Klopfer, Caroline J Gassel
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引用次数: 0
[Electronic Documentation of Findings in Visual Impairment Counselling Using FIDUS Software]. [使用 FIDUS 软件对视障咨询结果进行电子记录]。
IF 0.8 4区 医学 Q4 OPHTHALMOLOGY Pub Date : 2024-11-14 DOI: 10.1055/a-2410-9320
Kerstin Hornig, Ulrich Schiefer, Judith Ungewiss

Background: The increasing use of electronic documentation extends to consultation for the visually impaired. The aim of this project was to develop a set of forms and electronic patient records specifically for low vision care, giving equal consideration to ophthalmological, orthoptic, and optometric specialities, as well as teaching aspects.

Patients and methods: FIDUS software (FIDUS Arztservice Wente GmbH, Darmstadt, Germany) is a well-established tool in ophthalmology practices and clinics. The software was used as a basis to develop digital entry forms with features such as auto-fill, selection recommendations, and inventory management for visual aids. The aim of the project was to maximise clarity and ease of use while also saving time during consultation with visually impaired patients.

Results: This article presents the implementation of these criteria using the electronic FIDUS record card with the corresponding electronic forms for electronic patient records taken during consultation with visually impaired patients. The index card visualises the patient's most important data and findings at a glance. Specifically designed for low vision consultation, the examination form documents visual aids prescribed to the patient in detail while also saving time. Other forms enable direct printing of prescription recommendations, test reports, and certificates. Entry forms can also be printed out for conventional handwritten records.

Conclusions: We have achieved an electronic patient record system specifically geared to ophthalmological and optical care requirements including local inventory for visually impaired patients. Determining the level of acceptance on the part of examiners, patients, and students and optimising the software will require follow-up studies.

背景:电子文档的使用越来越广泛,视障人士的咨询也是如此。本项目的目的是开发一套专门用于低视力护理的表格和电子病历,同时兼顾眼科、矫形科、视光科以及教学方面:FIDUS 软件(FIDUS Arztservice Wente GmbH,德国达姆施塔特)是眼科实践和诊所的成熟工具。我们以该软件为基础,开发了具有自动填写、选择建议和视觉辅助工具库存管理等功能的数字输入表格。该项目的目的是最大限度地提高清晰度和易用性,同时节省视障患者的就诊时间:结果:本文介绍了这些标准的实施情况,即在为视力受损患者问诊时,使用电子 FIDUS 记录卡和相应的电子病历表。该索引卡可以一目了然地显示患者最重要的数据和检查结果。专为低视力患者问诊设计的检查表可详细记录为患者开具的助视器处方,同时节省时间。其他表格可直接打印处方建议、测试报告和证书。输入表格也可以打印出来,用于传统的手写记录:我们已经开发出一套电子病历系统,专门用于满足眼科和光学护理要求,包括视障患者的本地库存。要确定检查人员、患者和学生的接受程度,并对软件进行优化,还需要进行后续研究。
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引用次数: 0
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Klinische Monatsblatter fur Augenheilkunde
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