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Development and Rasch Analysis of the Prior Knowledge of Chemistry Concepts Test for Pre-medical Students in the Philippines 菲律宾医学预科生化学概念先验知识测试的开发与拉希分析
Pub Date : 2024-01-08 DOI: 10.26534/kimika.v34i2.14-33
Jonathan Barcelo
Chemistry concepts are embedded in several contexts that are related to the future professional roles of pre-medical students. In the current academic landscape of pre-medical programs, an objective measurement of prior knowledge of chemistry concepts is necessary to promote students’ academic success. To address this issue, this study aimed to develop and validate the Prior Knowledge of Chemistry Concepts Test. This multiple-choice research instrument is designed to measure pre-medical students’ knowledge of essential chemistry concepts from pre-requisite chemistry courses in pre-medical programs in the Philippines. The final item pool, consisting of 26 general chemistry concepts and 21 general organic chemistry concepts was administered to 470 college students from four tertiary institutions in the Philippines. Item content validity indices (I-CVI) and kappa statistics guided initial revisions, while dichotomous Rasch analysis was utilized to determine the psychometric properties of the research instrument. The analysis provided evidence of adequate person and item reliability, item fit, local independence, and unidimensionality, although some items may be omitted in subsequent iterations. The application of the research instrument to assessment and evaluation was elaborated using the student ability and item difficulty logits along the person-item map. Suggestions for the improvement of the research instrument were also discussed.
化学概念蕴含在多个与医学预科学生未来职业角色相关的情境中。在当前医学预科课程的学术环境中,有必要对化学概念的先验知识进行客观测量,以促进学生的学业成功。为解决这一问题,本研究旨在开发和验证 "化学概念先验知识测试"。这一多项选择研究工具旨在测量菲律宾医科预科学生对医科预科化学先修课程中基本化学概念的了解程度。最终的项目库包括 26 个普通化学概念和 21 个普通有机化学概念,由来自菲律宾四所高等院校的 470 名大学生完成。项目内容效度指数(I-CVI)和卡帕统计数据指导了初步修订,而二分法 Rasch 分析则用于确定研究工具的心理测量特性。分析结果表明,尽管在随后的迭代中可能会省略某些项目,但该工具具有充分的人际可靠性和项目可靠性、项目拟合性、局部独立性和单维性。根据人-项图谱,利用学生能力和项目难度对数对研究工具在评估和评价中的应用进行了阐述。此外,还讨论了改进研究工具的建议。
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引用次数: 0
Feasibility of An Introductory Chemistry for Cultural Heritage E-course for Museum Professionals in the Philippines 菲律宾博物馆专业人员开设文化遗产化学入门电子课程的可行性
Pub Date : 2023-05-29 DOI: 10.26534/kimika.v34i1.15-20
Jan-Michael Cayme, Aniano Jr. Asor, E. Miranda
Chemistry knowledge is fundamental in preserving and comprehending the tangible nature of museum collections. Despite chemistry’s importance in cultural heritage, a gap exists between the chemist’s knowledge and the accepted competencies of museum workers. This paper describes an initial study on introducing museum professionals with no formal scientific training in basic chemical thinking and research. A two-hour online session was conceived, comprising two separate lectures emphasizing the concepts, instrumental techniques, and example of a case study of an application of chemical analysis on a local heritage material. An open discussion and exchange of ideas followed the lectures. Feedback from the participants was very positive, and they described the online course as informative and valuable for their museum work. The qualitative evaluations obtained from this paper can serve as baseline information for developing a more extensive e-course in the future.
化学知识是保存和理解博物馆藏品有形性质的基础。尽管化学在文化遗产中很重要,但化学家的知识与博物馆工作人员公认的能力之间存在差距。本文介绍了一项关于引进未经正规化学基本思维和研究科学训练的博物馆专业人员的初步研究。一个两小时的在线课程被构思出来,包括两个独立的讲座,强调概念、仪器技术,以及在当地遗产材料上应用化学分析的案例研究实例。讲座结束后进行了公开讨论和思想交流。参与者的反馈非常积极,他们认为在线课程内容丰富,对他们的博物馆工作很有价值。本文所获得的定性评价可以作为今后开发更广泛的电子课程的基准信息。
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引用次数: 0
Improving the Least Mastered Competencies of Grade 11 Students in General Chemistry using Electronic Strategic Intervention Material (E-SIM) 利用电子策略干预材料(E-SIM)提高高二学生普通化学的最低掌握能力
Pub Date : 2022-12-30 DOI: 10.26534/kimika.v33i2.59-76
Gwyneth Rosal, Jhan Cromwell Aguinaldo, Lean Donnie Reyes, Gabriel Harold Casuat, Romalyn Balagtas, Erickson Del Mundo
Students perceive chemistry as a complex subject resulting in low academic performance. Education systems shall support students in bridging the gap between traditional learning and online set-up using technology-based materials. The Electronic Strategic Intervention Material (E-SIM) is a new learning method to help improve the learner’s performance in the least mastered competencies. This study focuses on determining how the E-SIM for “Ganyan Ang Bonding” (in English: Bonding Goes Like This) topic will improve the Grade 11 students’ knowledge about chemical bonding. The researchers used a one-group pretest-posttest control design. The population was pooled using simple random sampling and out of the randomly selected sections, twenty-two students were qualified after the voluntary response sampling. Pretest and posttest, which underwent validation, were given before and after the intervention respectively. The material was validated by experts prior to its utilization. The analysis showed a 0.01 normalized gain score, which is confirmed by the paired sample t-test with a result of -3.17 and p-value of 0.0023, hence presenting that there is a significant increase between the pretest and posttest scores. The student perception survey was used to further determine the efficiency of the material, which showed that the students perceived the E-SIM as an effective tool as review material.
学生认为化学是一门复杂的学科,导致学习成绩不佳。教育系统应支持学生利用基于技术的材料弥合传统学习和在线设置之间的差距。电子策略干预材料(E-SIM)是一种新的学习方法,旨在帮助学习者提高在最少掌握能力方面的表现。本研究的重点是确定“Ganyan Ang Bonding”(英语:Bonding Goes Like This)主题的E-SIM如何提高11年级学生对化学键的认识。研究人员采用了一组前测后测对照设计。总体采用简单随机抽样的方法,在随机选择的部分中,经过自愿抽样,有22名学生符合条件。干预前后分别进行前测和后测,并进行验证。该材料在使用前经专家验证。经分析,归一化增益得分为0.01,配对样本t检验结果为-3.17,p值为0.0023,证明前测与后测成绩有显著提高。通过学生感知调查进一步确定材料的有效性,结果表明学生认为E-SIM是一种有效的复习材料工具。
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引用次数: 0
Predicting The Toxicity of Emerging Pollutants via Molecular Docking: Interaction of Polyhalogenated Carbazoles with Human Androgen Receptor 通过分子对接预测新出现污染物的毒性:多卤代咔唑与人类雄激素受体的相互作用
Pub Date : 2022-11-03 DOI: 10.26534/kimika.v33i2.1-20
Ma. Juryst Chelsea Armas, D. Apodaca
Polyhalogenated carbazoles (PHCZs) are persistent chemical pollutants increasingly detected in different environmental matrices. They are structurally and chemically similar to other persistent organic pollutants (POPs), which are capable of disrupting the endocrine systems. However, PHCZs such as 3-chloro-9H-carbazole (3-CCZ), 3-bromo-9H-carbazole (3-BCZ), and 36-dibromo-9H-carbazole (36-BCZ) are rarely discussed in the context of their adverse effects on human health. Using molecular docking to investigate the potential toxicity of these PHCZs with the human androgen receptor (AR), this study finds that 36-dibromo-9H-carbazole and 3-bromo-9H-carbazole are potential AR antagonists, with the former being more toxic than the latter. This finding is on account of the presence of both Asn705 and Thr877 in the hydrophobic interaction of 36-BCZ, while only Thr877 is found in the hydrophobic interaction of 3-BCZ. Hence, PHCZs with higher bromine substitutions are more likely to be endocrine disruptors. Moreover, their binding sites with the human androgen receptor are similar to that of the androgen (agonist). Therefore, this study suggests that PHCZs may readily penetrate and disrupt the human androgen receptor (AR), providing the groundwork for future research studies and experimental validation on the molecular docking employed.
多卤代咔唑(phcz)是一种持久性化学污染物,在不同的环境基质中越来越多地被检测到。它们在结构和化学上与其他能够破坏内分泌系统的持久性有机污染物(POPs)相似。然而,诸如3-氯- 9h -咔唑(3-CCZ)、3-溴- 9h -咔唑(3-BCZ)和36-二溴- 9h -咔唑(36-BCZ)等phcz对人体健康的不良影响很少被讨论。通过分子对接研究这些phcz对人雄激素受体(AR)的潜在毒性,本研究发现36-二溴- 9h -咔唑和3-溴- 9h -咔唑是潜在的AR拮抗剂,前者的毒性大于后者。这是因为36-BCZ的疏水相互作用中同时存在Asn705和Thr877,而3-BCZ的疏水相互作用中只存在Thr877。因此,具有较高溴取代的phcz更有可能是内分泌干扰物。此外,它们与人类雄激素受体的结合位点与雄激素(激动剂)相似。因此,本研究提示phcz可能很容易穿透和破坏人雄激素受体(AR),为今后的研究和分子对接的实验验证提供了基础。
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引用次数: 0
A New Pentacyclic Triterpenoid from Albizia lebbekoides (DC) Benth (Leguminosae) 豆科Albizia lebbekoides (DC) Benth中一个新的五环三萜
Pub Date : 2021-10-07 DOI: 10.26534/kimika.v32i2.41-46
Yohannes Woldemariam, I. Villaseñor
Albizia lebbekoides (DC) Benth is one of the five species of the genus Albizia found in the Philippines. Not much is known about the chemistry and potential uses of this species. Solvent partition followed by sequential and repeated liquid chromatographic purification over silica led to the isolation of a compound from the hexane extract of A. lebbekoides leaves. A review of related literature and spectral analyses showed that the isolated compound is a new pentacyclic triterpenoid with an oleanane skeleton. Its structure was determined as 3β, 16α-dihydroxyolean-6(7),12(13)-dien-28-oic acid.
Albizia lebbekoides (DC) Benth是在菲律宾发现的Albizia属的五种之一。人们对这种植物的化学成分和潜在用途知之甚少。溶剂分割后,连续和重复液相色谱纯化的二氧化硅导致分离化合物从小檗叶的己烷提取物。文献复习和光谱分析表明,分离得到的化合物是一种新的齐墩烷骨架的五环三萜化合物。其结构为3β, 16α-二羟基齐墩酸-6(7),12(13)-二烯-28-酸。
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引用次数: 0
Feasibility of Modifying Existing Chemistry Demonstrations by Using Substitute Materials 用替代材料修饰现有化学演示的可行性
Pub Date : 2020-09-11 DOI: 10.26534/kimika.v31i2.55-61
Dane Mykel M. Quiambao, A. Guidote, Rhodora F. Nicdao
This study aimed to reiterate the use of Chemistry demonstrations as effective teaching tools to students while addressing some of its drawbacks, which discourages teachers from doing them such as cost and safety. Four chosen existing Chemistry demonstrations (Blue Bottle Experiment, Copper Sulfate Experiment, Blown Away, Dancing Flames) were modified by using substitute reagents, which are more accessible, relatively safer, and at lower cost. These demonstrations were chosen based on how easily the substitute reagents will be obtained. Afterwards, with the permission of a private junior high school, they were presented to a group of Grade 9 students of their choosing. The students were asked to evaluate each demonstration using a Likert scale-based questionnaire. This questionnaire rates each demonstration in terms of aesthetics, the materials and procedure done, effectiveness to explain certain Chemistry topics, safety, and the students’ overall judgment regarding the use of demonstrations as teaching tools. By converting their evaluation to quantitative values, the demonstrations scored high in all major categories. With this, it is highly recommended to explore other Chemistry demonstrations for possible modifications, which can be integrated in lecture classes.
本研究旨在重申化学演示作为有效的教学工具对学生的使用,同时解决其一些缺点,如成本和安全等阻碍教师这样做。选择现有的四个化学演示(蓝瓶实验、硫酸铜实验、吹散实验、舞动的火焰实验),通过使用替代试剂进行修饰,替代试剂更容易获得,相对更安全,成本更低。这些示范的选择是基于如何容易获得替代试剂。之后,在一所私立初中的允许下,他们被介绍给一群他们选择的九年级学生。学生们被要求使用李克特量表评估每个演示。该问卷从美学、材料和程序、解释某些化学主题的有效性、安全性以及学生对使用演示作为教学工具的总体判断等方面对每个演示进行评分。通过将其评价转换为定量值,这些示范在所有主要类别中得分都很高。在此基础上,强烈建议探索其他化学演示以进行可能的修改,这些演示可以整合到课堂中。
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引用次数: 0
Teaching college chemistry in the time of COVID-19 pandemic: A personal account of teaching in the old normal vs. the new normal 新冠肺炎大流行时期的大学化学教学——新常态与旧常态下的教学体会
Pub Date : 2020-06-25 DOI: 10.26534/kimika.v31i1.70-75
Jr. M. Guidote Armando
The SARS CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2), cause of COVID-19 (CoronaVirus Disease 2019) has afflicted close to 10 million people all over the world resulting to almost half a million deaths.  This disease is severely contagious and necessitates social or physical distancing between persons. As such, traditional face-to-face learning is not advised and teachers need to shift to online teaching.  There are challenges to online teaching and learning for students, teachers, and the higher education institute, e.g. hardware, bandwidth, and software issues. These will be difficult but these can be overcome eventually.  This work is a personal account of the old normal or traditional way of teaching Organic Chemistry and the transition to the new normal of teaching on-line.  On-line teaching can be as effective as traditional teaching but everyone has to put in effort and participate in training to get used to this. In the end, it is the teacher’s being a true teacher that matters, that the teacher teaches to the best of his or her ability even during this time of the COVID-19 pandemic.
COVID-19(2019冠状病毒病)的病因SARS CoV-2(严重急性呼吸系统综合征冠状病毒2)已经折磨了全世界近1000万人,造成近50万人死亡。这种疾病具有严重传染性,人与人之间必须保持社交或身体距离。因此,不建议传统的面对面学习,教师需要转向在线教学。对于学生、教师和高等教育机构来说,在线教学面临着挑战,例如硬件、带宽和软件问题。这些都是困难的,但最终是可以克服的。本文是对有机化学传统教学方式的旧常态和向网络教学新常态过渡的个人叙述。在线教学可以像传统教学一样有效,但每个人都必须付出努力,参加培训,以适应这一点。最后,重要的是教师是一名真正的教师,即使在COVID-19大流行期间,教师也要尽其所能进行教学。
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引用次数: 4
The Bond-Valence Substituent Index for Predicting the Boiling Temperatures of Aliphatic Hydrocarbons 预测脂肪烃沸腾温度的键价取代基指数
Pub Date : 2020-06-18 DOI: 10.26534/kimika.v31i1.38-55
F. Sumera, Stephani Jacutin, Jan Michael Aficial, Aileen Filipino
A simple molecular descriptor based on molecular structure for predicting the boiling temperature (BT) of alkanes was developed in this paper. This topological index was used to correlate the boiling temperature of aliphatic hydrocarbons with their bond-valence substituent structure instead of by atom-to-atom branching framework. The predictive power of the bond-valence substituent index (BVSI) was evaluated by comparing it with the popular predictor in literature, the Randic index and the more recently proposed index, the Fi of Manso et al. (2012). The model developed through a second order regression of the plot of the alkane’s boiling temperature versus the BVSI index proved successful in its predictive power such that the method was also applied to a combination of aliphatic hydrocarbons, the alkanes, alkenes, alkynes and cycloalkanes. This topological index provided higher correlation with small deviations compared to the topological index used for comparison. A further study of the BVSI index can be explored for other organic compounds with different functional groups and other physical properties besides their boiling temperatures in the future.
提出了一种基于分子结构预测烷烃沸腾温度的简单分子描述符。该拓扑指数用于将脂肪烃的沸点温度与其键价取代基结构联系起来,而不是用原子-原子分支框架。通过将键价取代基指数(BVSI)与文献中流行的预测指标Randic指数和最近提出的指数Manso et al.(2012)的Fi进行比较,评估了BVSI的预测能力。该模型通过对烷烃沸腾温度与BVSI指数的二阶回归图开发,证明其预测能力是成功的,因此该方法也适用于脂肪烃、烷烃、烯烃、炔烃和环烷烃的组合。与用于比较的拓扑指数相比,该拓扑指数与小偏差的相关性更高。BVSI指数的进一步研究可以在未来探索其他具有不同官能团和其他物理性质的有机化合物的沸点温度。
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引用次数: 1
Isolation, Purification and Structure Elucidation of a Xanthone from the Pericarp of Kamandiis (Garcinia rubra Merr.) 金雀花(Garcinia rubra Merr.)果皮中一种山酮的分离纯化及结构分析
Pub Date : 2019-06-28 DOI: 10.26534/kimika.v30i1.40-44
C. M. Ravidas, T. Villar, L. O. Namuco, H. Hernandez
The pericarp of Garcinia rubra, an endemic Garcinia species in the Philippines was extracted with dichloromethane. An isolate of the extract was acetylated giving monoacetyl and diacetyl derivatives. Analysis of these derivatives led to the elucidation of the xanthone 1,3,7-trihydroxy-2,4-bis(3-methylbut-2-enyl)-9H-xanthen-9-one. The compound was isolated and characterized through column chromatography, acetylation, FTIR, NMR and LCMS analyses.
用二氯甲烷提取菲律宾特有藤黄属植物Garcinia rubra的果皮。提取物的分离物乙酰化,得到单乙酰和双乙酰衍生物。对这些衍生物进行分析,得到了1,3,7-三羟基-2,4-双(3-甲基-2-烯基)- 9h -xanthen-9- 1。通过柱层析、乙酰化、FTIR、NMR和LCMS等方法对化合物进行了分离和表征。
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引用次数: 0
Indicators of Asian Achievement in Chemistry: Implications to the Philippine Setting 亚洲人化学成绩的指标:对菲律宾环境的影响
Pub Date : 2019-06-11 DOI: 10.26534/kimika.v30i1.18-30
Joje Mar Perino Sanchez
This paper aimed to determine the indicators, which could contribute to the Chemistry achievement of selected Asian countries according to the data set provided by the 2015 Trends in Mathematics and Science Survey results. Educational data mining was employed to capture patterns, comparison and correlation among selected Asian countries (Hong Kong, Japan, Malaysia, Singapore, South Korea, Taiwan and Thailand) using TIMSS results in Chemistry and other Science domains achievements, learning resources, school climate, instructional considerations, and student affective aspects. This study found out that the average Chemistry achievement of the Asian countries was significantly higher than the world achievement. Through exploratory analysis, it was revealed that high achievers among the Asian countries have moderate to high perspective towards school climate, instructional considerations and student affective aspects, while those average or low achievers had high perspective towards the said factors. The study concluded that, out of the 15 factors included in the study, nine had positive correlation yet only prior achievement in Science, home educational resources, Science laboratory resources, computer use and prevalence of bullying could significantly determine the achievement of learners in Chemistry. Implications on spiral progression, resource allocation, safe, orderly and harmonious environments, and inspiring stories in instruction were derived for application in the Philippine context to maximize and enhance learning in Chemistry.
本文旨在根据2015年数学和科学趋势调查结果提供的数据集,确定有助于亚洲国家化学成就的指标。利用TIMSS在化学和其他科学领域的成果、学习资源、学校氛围、教学考虑和学生情感方面的结果,采用教育数据挖掘来捕捉模式、比较和相关性在选定的亚洲国家(香港、日本、马来西亚、新加坡、韩国、台湾和泰国)之间。研究发现,亚洲国家的平均化学成绩明显高于世界水平。通过探索性分析发现,亚洲国家的高成就学生对学校氛围、教学考虑和学生情感方面的看法是中至高的,而平均或低成就学生对上述因素的看法是高的。研究发现,在15个因素中,有9个因素与化学成绩呈正相关,但只有科学成绩、家庭教育资源、科学实验室资源、计算机使用和欺凌发生率对化学成绩有显著影响。在菲律宾的背景下,对螺旋发展、资源分配、安全、有序和和谐的环境以及教学中的鼓舞人心的故事的启示得到了应用,以最大限度地提高化学学习。
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引用次数: 2
期刊
KIMIKA
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