Journal of VitreoRetinal Diseases最新文献

Purpose: To report a rare case of sub-internal limiting membrane (sub-ILM) hemorrhage following femtosecond laser in situ keratomileusis, successfully managed conservatively. Methods: A single postoperative case was reviewed. Results: A 32-year-old woman presented with unilateral vision loss 1 month after femtosecond laser in situ keratomileusis. Clinical examination revealed a sub-ILM hemorrhage involving the macula, with an initial best-corrected visual acuity (BCVA) of 6/24. The patient underwent conservative management with serial follow-up examinations. Over the following months, the hemorrhage demonstrated progressive spontaneous resolution. At 4 months, the patient had a normal fundoscopic examination, and the BCVA improved to 6/6 without surgical intervention. Conclusions: Sub-ILM hemorrhage may occur as a rare posterior segment complication after laser in situ keratomileusis, even in otherwise healthy patients without known risk factors. Prompt diagnosis and close monitoring are crucial, and surgical intervention should be reserved for cases that fail to resolve spontaneously. To the best of our knowledge, this is the first documented case of sub-ILM hemorrhage following femtosecond laser in situ keratomileusis. Laser in situ keratomileusis. Further research is warranted to understand the effects of femtosecond laser in situ keratomileusis on intraocular pressure dynamics and retinal vasculature.

Purpose: To highlight the clinical utility of ultra-widefield swept-source optical coherence tomography angiography (SS-OCTA) in evaluating diabetic retinopathy (DR), particularly focusing on its ability to detect peripheral ischemia and neovascularization. Methods: Eyes of 5 participants with varying severity of DR were imaged with expanded-field 12 × 12-mm SS-OCTA scans and ultra-widefield SS-OCTA montages. Montages were created by stitching five 21 × 26-mm scans, offering up to a 200° field of view. Cases were assessed for areas of nonperfusion, intraretinal microvascular abnormalities, and neovascularization extending beyond the posterior pole. Results: Ultra-widefield SS-OCTA imaging demonstrated progressive mid-peripheral and peripheral nonperfusion, intraretinal microvascular abnormalities, and neovascularization in association with increasing DR severity. Peripheral nonperfusion and neovascular changes were detected beyond the scope of standard 12 × 12-mm scan areas. Conclusions: Ultra-widefield SS-OCTA is effective in noninvasively detecting peripheral retinal lesions such as ischemia and neovascularization. This technology offers potential to refine DR staging, improve risk stratification, and guide earlier clinical interventions.

Purpose: To describe a case of persistent visual distortion following clinical resolution of intracameral cefuroxime-induced cystoid macular edema (CME). Methods: A single case was evaluated. Results: A 68-year-old woman developed persistent visual distortion after cataract surgery with intracameral cefuroxime administration. Although optical coherence tomography (OCT) revealed only a small ellipsoid zone defect indicating near-complete recovery, adaptive optics scanning laser ophthalmoscopy (AOSLO) uncovered a pronounced fissure-like lesion coursing through the macular photoreceptor mosaic. This discrepancy demonstrated localized photoreceptor disruption that was not apparent on OCT. Conclusions: Intracameral cefuroxime-induced CME may result in lasting photoreceptor damage despite apparent anatomic recovery on OCT. This case underscores the limitations of current clinical imaging and highlights the potential of AOSLO to detect photoreceptor damage underlying persistent blurred vision after resolution of CME.

Purpose: To report the case of a 13-year-old boy who underwent immediate sequential bilateral retinal detachment surgery in the setting of Stickler syndrome and familial adenomatous polyposis syndrome. Methods: Retrospective chart review of a single case followed by descriptive analysis. Results: A 13-year-old boy with bilateral rhegmatogenous retinal detachment underwent immediate sequential bilateral vitreoretinal surgery because of socioeconomic limitations that restricted return visits. Intraoperatively, multiple areas of congenital hypertrophy of the retinal pigment epithelium were observed. The patient had a family history of Stickler syndrome and familial adenomatous polyposis. Genetic evaluation revealed pathogenic mutations in COL2A and APC. Conclusions: Complex genetic conditions such as Stickler syndrome and familial adenomatous polyposis require multidisciplinary management. This case underscores the challenges of managing a 13-year-old patient with Stickler syndrome and bilateral retinal detachment. Immediate sequential bilateral vitreoretinal surgery proved effective, highlighting the need for tailored approaches to Stickler syndrome management.

Purpose: To describe a case of severe Valsalva retinopathy secondary to habitual ear popping in the setting of chronic Eustachian tube dysfunction. Methods: A retrospective chart and literature review were conducted. Results: A 40-year-old woman with chronic Eustachian tube dysfunction developed sudden loss of vision in the left eye (to 20/400) following habitual ear popping. Examination demonstrated features consistent with Valsalva retinopathy, including vitreous, subhyaloid, sub-internal limiting membrane, and retinal hemorrhages. Following an initial observation period of 6 months, she underwent pars plana vitrectomy, which improved her vision to 20/20. Conclusions: Habitual ear popping can lead to severe Valsalva retinopathy and significant vision loss, particularly in individuals with underlying Eustachian tube dysfunction. Given the prevalence of Eustachian tube dysfunction, clinicians should be aware of the association between habitual ear popping and Valsalva retinopathy to ensure timely diagnosis and management.

Purpose: Diabetes and its microvascular complications have significant social and economic impact, and targeted prevention strategies are paramount. Wearable technology may play an important role in personalized diabetes management. This study assesses the association between physical activity measured by wearable activity trackers and the presence of diabetic retinopathy (DR) in individuals with diabetes. Methods: Retrospective chart review of accelerometer data obtained on personal fitness (Fitbit) trackers from adults with diabetes who had >1 month of linked activity tracking data registered in the All of Us Research Program Registered Tier dataset (version 7). Binary logistic regression models were used to assess adjusted associations between presence of DR and physical activity measures of mean number of daily steps and mean number of daily minutes spent on moderate-to-vigorous activities. Results: Of the 668 participants, 63% were female and 37% were male, 80% were non-Hispanic White, and 42.5% had a history of smoking. Mean age was 64.3 years (range, 25-91 years). A unit increase of 1000 daily steps walked by participants was significantly associated with a 45% reduction in the odds of having DR (odds ratio [OR] 0.55, 95% CI 0.33-0.91). A 1-minute unit increase in the mean number of daily minutes spent on moderate-to-vigorous activity was significantly associated with a 24% reduction in the odds of having DR (OR 0.76, 95% CI 0.63-0.92). Conclusions: These findings demonstrate that increased physical activity, as measured through objective quantification of both daily steps and minutes of activity, is inversely correlated with the presence of DR. This may indicate a role for wearable technology in personalizing diabetes management.

Purpose: To describe a rare case of spontaneous resolution and subsequent recurrence of subretinal fluid (SRF) associated with circumscribed choroidal hemangioma. Methods: A single case was reviewed. Results: A 67-year-old woman presented with a circumscribed choroidal hemangioma and visually significant SRF. Three weeks after initial presentation and before planned treatment, the patient's vision returned to baseline, and imaging confirmed complete resolution of SRF. She was observed without intervention. Two months later, the SRF recurred, and the patient was successfully treated with photodynamic therapy, achieving complete resolution. Conclusions: Spontaneous resolution of SRF secondary to circumscribed choroidal hemangioma can occur, albeit rarely. At the time of treatment planning, reassessment of symptoms and repeat imaging may help identify such spontaneous improvement. If resolution occurs, patients should be closely followed up for the possibility of fluid recurrence.

Purpose: Stargardt disease is an inherited form of retinal degeneration characterized by early-onset central vision loss. This report describes the long-term retinal histologic characteristics of a patient with Stargardt disease after human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) transplantation. Methods: Eyes were obtained postmortem from an 80-year-old legally blind male patient with Stargardt disease. The patient had previously undergone hESC-RPE transplantation of his left eye, and the right eye (untransplanted) served as a control. Fluorescence lifetime imaging microscopy was used to study retinal structure and metabolic activity. Staining of the retina for lipofuscin was performed using the Armed Forces Institute of Pathology method. Results: Metabolic analysis showed that the macular area had more oxidative phosphorylation relative to the mid-peripheral retina, in both the transplanted and untransplanted eye. Melanin-laden RPE cells were detected in the transplanted eye, which correlated with a pigment band present on fundus images post-hESC-RPE transplantation. Conclusions: This case description illustrates the long-term survival of subretinal hESC-RPE cells post-transplantation in a patient with Stargardt disease.