P. L. M. D. Chico, V. Giorgi, R. Ferriani, P. Navarro
{"title":"Evaluation of a new transdermal testosterone dosage used for 60 days prior to controlled ovarian stimulation in poor responders: preliminary results","authors":"P. L. M. D. Chico, V. Giorgi, R. Ferriani, P. Navarro","doi":"10.4322/hra.000222","DOIUrl":"https://doi.org/10.4322/hra.000222","url":null,"abstract":"","PeriodicalId":179585,"journal":{"name":"Human Reproduction Archives","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130106379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Review the literature on the relationship between religion and the practices and positions of professionals and students of sexual and reproductive health in relation to induced abortion. Method: Systematic review in SciELO, and LILACS databases, from January 2010 to May 2021, using the descriptors (“Abortion, Induced” [Mesh]) AND “Religion” [Mesh]. Two authors separately evaluated the articles, selecting those that met the eligibility criteria. Disagreements were submitted to the opinion of the third author. 270 articles were identified and 31 articles were selected for qualitative metasynthesis. Study exempted from submission to the Ethics and Research Committee. Results: 23 articles (74.2%) used quantitative designs, six (19.3%) qualitative methods, one (3.2%) case report, and one (3.2%) intervention design. Students and resident physicians were approached in 15 articles (48.4%), physicians in 14 (45.1%), midwives in four (12.9%), and nurses in two (6.5%). In all articles analyzed, the strongest link with religious beliefs showed influence in positions and practices that oppose or restrict induced abortion. Conclusion: Conservative and fundamentalist religious positions on induced abortion persist, which negatively influence students and health professionals, hampering women’s human rights and reproductive rights.
{"title":"Religious implications in the positioning and practice of health professionals and students about induced abortion: systematic review","authors":"J. Drezett, Renato José de Oliveira, M. Puccia","doi":"10.4322/hra.000421","DOIUrl":"https://doi.org/10.4322/hra.000421","url":null,"abstract":"Objective: Review the literature on the relationship between religion and the practices and positions of professionals and students of sexual and reproductive health in relation to induced abortion. Method: Systematic review in SciELO, and LILACS databases, from January 2010 to May 2021, using the descriptors (“Abortion, Induced” [Mesh]) AND “Religion” [Mesh]. Two authors separately evaluated the articles, selecting those that met the eligibility criteria. Disagreements were submitted to the opinion of the third author. 270 articles were identified and 31 articles were selected for qualitative metasynthesis. Study exempted from submission to the Ethics and Research Committee. Results: 23 articles (74.2%) used quantitative designs, six (19.3%) qualitative methods, one (3.2%) case report, and one (3.2%) intervention design. Students and resident physicians were approached in 15 articles (48.4%), physicians in 14 (45.1%), midwives in four (12.9%), and nurses in two (6.5%). In all articles analyzed, the strongest link with religious beliefs showed influence in positions and practices that oppose or restrict induced abortion. Conclusion: Conservative and fundamentalist religious positions on induced abortion persist, which negatively influence students and health professionals, hampering women’s human rights and reproductive rights.","PeriodicalId":179585,"journal":{"name":"Human Reproduction Archives","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133974513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernanda M Lafraia, Ana Luisa Dias Barbosa, Luisa Abreu Zorzanelli, L. R. Morais, Fernanda Parciapese Dittmer, C. A. F. Guazzelli
,
，
{"title":"Ovary transmigration of a levonorgestrel-releasing intrauterine device and ectopic pregnancy: a case report","authors":"Fernanda M Lafraia, Ana Luisa Dias Barbosa, Luisa Abreu Zorzanelli, L. R. Morais, Fernanda Parciapese Dittmer, C. A. F. Guazzelli","doi":"10.4322/hra.000521","DOIUrl":"https://doi.org/10.4322/hra.000521","url":null,"abstract":",","PeriodicalId":179585,"journal":{"name":"Human Reproduction Archives","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127703806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. J. Sestari, B. F. Gamba, Francis Patrício França Ferreira, R. F. Curado, E. Castro, N. A. Bérgamo, L. Ribeiro-Bicudo
Objective : It is well established that inherited chromosomal alterations such as copy number variations (CNVs) are associated to miscarriage. However, most studies focus on evaluating CNVs only in products of conception. The aim of this systematic review was to highlight the importance of investigating CNVs in couples with a history of recurrent miscarriage as well as their role in pregnancy, filling part of the gap between studies of recurrent miscarriage. Methods : A search in PubMed, Scientific Electronic Library Online (SCIELO), Latin American and Caribbean Literature in Health Sciences (LILACS), and Portal de CAPES/MEC databases for relevant published articles was conducted using the following controlled search terms: “copy number variation”, “cnv”, “miscarriage”, “recurrent miscarriage”, “spontaneous abortion”, “loss pregnancy”, “couple”, “microarray analysis”, “comparative genomic array”, and “array CGH”. The Boolean operators AND and OR were used. The search captured studies published up to October 2020. Results : A total of five studies were extracted for the present analysis. Sixteen CNVs involving the PDZD2, GOLPH3, TIMP2, CTNNA3, STS, EGFL6, STX6, CETN2, CTDSPL, GSTT1, HLA, MSR1, NIPA1, NIPA2, CYFIP1 and TUBGCP5 genes on ten different chromosomes were considered at potential risk for pregnancy maintenance. Conclusion : The findings of the present study affirm the importance of investigating the role of CNVs in couples with recurrent miscarriage and not just products of conception, in addition contributing to more accurate medical diagnoses.
目的:遗传染色体改变如拷贝数变异(CNVs)与流产有关已被证实。然而，大多数研究都只关注于胚胎的CNVs评价。本系统综述的目的是强调在有复发性流产史的夫妇中调查CNVs及其在妊娠中的作用的重要性，填补复发性流产研究之间的部分空白。方法:在PubMed、science Electronic Library Online (SCIELO)、Latin American and Caribbean Literature in Health Sciences (LILACS)和Portal de CAPES/MEC数据库中检索相关已发表文章，检索词为:拷贝数变异、cnv、流产、复发性流产、自然流产、丢失妊娠、夫妇、微阵列分析、比较基因组阵列和CGH阵列。使用了布尔运算符AND和OR。该搜索收集了截至2020年10月发表的研究。结果:本分析共提取了5项研究。16个cnv涉及10条不同染色体上的PDZD2、GOLPH3、TIMP2、CTNNA3、STS、EGFL6、STX6、CETN2、CTDSPL、GSTT1、HLA、MSR1、NIPA1、NIPA2、CYFIP1和TUBGCP5基因，被认为存在妊娠维持的潜在风险。结论:本研究的结果肯定了研究CNVs在反复流产夫妇中的作用的重要性，而不仅仅是怀孕的产物，此外还有助于更准确的医学诊断。
{"title":"Copy number variations as a risk factor for couples with idiopathic recurrent miscarriage: A systematic review","authors":"S. J. Sestari, B. F. Gamba, Francis Patrício França Ferreira, R. F. Curado, E. Castro, N. A. Bérgamo, L. Ribeiro-Bicudo","doi":"10.4322/hra.000821","DOIUrl":"https://doi.org/10.4322/hra.000821","url":null,"abstract":"Objective : It is well established that inherited chromosomal alterations such as copy number variations (CNVs) are associated to miscarriage. However, most studies focus on evaluating CNVs only in products of conception. The aim of this systematic review was to highlight the importance of investigating CNVs in couples with a history of recurrent miscarriage as well as their role in pregnancy, filling part of the gap between studies of recurrent miscarriage. Methods : A search in PubMed, Scientific Electronic Library Online (SCIELO), Latin American and Caribbean Literature in Health Sciences (LILACS), and Portal de CAPES/MEC databases for relevant published articles was conducted using the following controlled search terms: “copy number variation”, “cnv”, “miscarriage”, “recurrent miscarriage”, “spontaneous abortion”, “loss pregnancy”, “couple”, “microarray analysis”, “comparative genomic array”, and “array CGH”. The Boolean operators AND and OR were used. The search captured studies published up to October 2020. Results : A total of five studies were extracted for the present analysis. Sixteen CNVs involving the PDZD2, GOLPH3, TIMP2, CTNNA3, STS, EGFL6, STX6, CETN2, CTDSPL, GSTT1, HLA, MSR1, NIPA1, NIPA2, CYFIP1 and TUBGCP5 genes on ten different chromosomes were considered at potential risk for pregnancy maintenance. Conclusion : The findings of the present study affirm the importance of investigating the role of CNVs in couples with recurrent miscarriage and not just products of conception, in addition contributing to more accurate medical diagnoses.","PeriodicalId":179585,"journal":{"name":"Human Reproduction Archives","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129619442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Nadai, E. Ferreira-Filho, J. Magalhães, J. Lubianca, I. C. E. Sorpreso, E. C. Baracat, J. M. Soares-Júnior
The efficacy of the contraceptive methods is high, and contraceptive effect is mainly due to progestogen, since it promotes inhibition of ovulation, thickening of the cervical mucus, and reduction in tubal motility. Therefore, one must reflect on the role of estrogen – is it time to abandon it? In this paper, we discuss the role of estrogen and progestogen in contraception
{"title":"Hormonal contraception: Is it time to abandon estrogen?","authors":"M. Nadai, E. Ferreira-Filho, J. Magalhães, J. Lubianca, I. C. E. Sorpreso, E. C. Baracat, J. M. Soares-Júnior","doi":"10.4322/hra.000123","DOIUrl":"https://doi.org/10.4322/hra.000123","url":null,"abstract":"The efficacy of the contraceptive methods is high, and contraceptive effect is mainly due to progestogen, since it promotes inhibition of ovulation, thickening of the cervical mucus, and reduction in tubal motility. Therefore, one must reflect on the role of estrogen – is it time to abandon it? In this paper, we discuss the role of estrogen and progestogen in contraception","PeriodicalId":179585,"journal":{"name":"Human Reproduction Archives","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115084898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elaine Cristina Fontes de Oliveira, M. S. Praça, G. P. Garcia, Ines Katerina Damasceno Cavallo
,
，
{"title":"Recurrent Pregnancy Loss: reviewing therapeutic approaches","authors":"Elaine Cristina Fontes de Oliveira, M. S. Praça, G. P. Garcia, Ines Katerina Damasceno Cavallo","doi":"10.4322/hra.000721","DOIUrl":"https://doi.org/10.4322/hra.000721","url":null,"abstract":",","PeriodicalId":179585,"journal":{"name":"Human Reproduction Archives","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122166025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Raupp, V. Piccinini, M. Hentschke, M. Dall'Agno, A. T. F. Kira, F. Seganfredo, N. Rossato, Á. Petracco, M. Badalotti
Introduction: Hereditary hemochromatosis (HH) is a genetic disease that causes systemic iron overload. The excess of iron accumulates in several organs, leading to organ dysfunction. Therefore, the excess of iron deposition might create an endocrine impairment, and can further lead to hypogonadism and, rarely, to amenorrhea. In this study, we aim to report a rare cause of HH and primary amenorrhea, with the help of clinical investigations. case Description: This study is based on a single patient who was diagnosed with amenorrhea. The patient had a previous history of HH, type I diabetes mellitus, and chronic liver disease. The physical and hormonal investigations were normal, and her karyotype was 46 XX. A magnetic resonance imaging (MRI) demonstrated a diffuse reduction of the pituitary tissue signal, which might resemble HH. Discussion: The diagnosis of HH is based on a biochemical and genetic evaluation. The treatment includes regular phlebotomies and the control of comorbidities. In most of the cases, the hypogonadotropic hypogonadism leads to amenorrhea due to a pituitary impairment. However, a rare appearance of amenorrhea without hypogonadism may also be possible. Hence, the investigation of HH should be suggested incases of primary amenorrhea. The early diagnosis of HH is crucial to prevent the morbidity and mortality in patients with these clinical features.
{"title":"Hemochromatosis as a cause of central primary Amenorrhea: A literature review and case report","authors":"G. Raupp, V. Piccinini, M. Hentschke, M. Dall'Agno, A. T. F. Kira, F. Seganfredo, N. Rossato, Á. Petracco, M. Badalotti","doi":"10.4322/hra.001519","DOIUrl":"https://doi.org/10.4322/hra.001519","url":null,"abstract":"Introduction: Hereditary hemochromatosis (HH) is a genetic disease that causes systemic iron overload. The excess of iron accumulates in several organs, leading to organ dysfunction. Therefore, the excess of iron deposition might create an endocrine impairment, and can further lead to hypogonadism and, rarely, to amenorrhea. In this study, we aim to report a rare cause of HH and primary amenorrhea, with the help of clinical investigations. case Description: This study is based on a single patient who was diagnosed with amenorrhea. The patient had a previous history of HH, type I diabetes mellitus, and chronic liver disease. The physical and hormonal investigations were normal, and her karyotype was 46 XX. A magnetic resonance imaging (MRI) demonstrated a diffuse reduction of the pituitary tissue signal, which might resemble HH. Discussion: The diagnosis of HH is based on a biochemical and genetic evaluation. The treatment includes regular phlebotomies and the control of comorbidities. In most of the cases, the hypogonadotropic hypogonadism leads to amenorrhea due to a pituitary impairment. However, a rare appearance of amenorrhea without hypogonadism may also be possible. Hence, the investigation of HH should be suggested incases of primary amenorrhea. The early diagnosis of HH is crucial to prevent the morbidity and mortality in patients with these clinical features.","PeriodicalId":179585,"journal":{"name":"Human Reproduction Archives","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126613196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. F. Curado, B. F. Gamba, Lucilene Arilho Ribeiro Bicudo, Manoel de Araújo Rocha, M. S. Approbato, W. Amaral, N. A. Bérgamo
Universidade Federal de Goiás, Goiânia, Goiás, Brasil Abstract Objective: To investigate the presence of chromosomal abnormalities in infertile men with azoospermia or oligozoospermia evaluated at the Human Reproduction Laboratory of the Hospital das Clinicas (LabRep -HC) of the Federal University of Goias (UFG), Goiania, Goias, Brazil, in the period 2012-2014. Methods: Metaphases were analyzed by GTG banding obtained from the culture of lymphocytes of 33 men with idiopathic infertility. Results: The patients’ ages ranged from 24-59 years and they had been attempting to conceive for an average of 5 (± 4,59) years. In 4 cases (12%) have been Klinefelter syndrome (KS) karyotype 47,XXY, was observed in three of these subjects and the fourth showed mosaicism 47,XXY[9]/46,XY[2]. The remaining 29/33 had normal karyotype. Conclusions: KS affects approximately 5 to 10% of infertile men, according to the literature. In this study, 12% of subjects were observed to have chromosomal abnormalities and sex chromosome aneuploidies were the only abnormality to be observed in the samples. Genetic testing can help identify which patients would benefit from technical reproduction. As well as contributing to unraveling the etiology of male infertility in patients treated at LabRep-HC-UFG, this study is relevant because assisted reproduction techniques ignore the process of natural selection and some classic chromosomal abnormalities or deleterious mutations could be inherited. Thus, counseling based on genetic assessments may prevent the inheritance of primary and secondary congenital defects in was slightly higher (5%). In our study, no individuals in the oligozoospermic group were found to have KS. All four KS cases were in the azoospermic group, which corresponds to 25% (4/16) of the azoospermic men. In the present study, 12% were diagnosed three with karyotype 47,XXY and one had amosaic 47XXY/46,XY karyotype.
{"title":"Karyotype Analysis in Infertile Men from the Center Western Brazil","authors":"R. F. Curado, B. F. Gamba, Lucilene Arilho Ribeiro Bicudo, Manoel de Araújo Rocha, M. S. Approbato, W. Amaral, N. A. Bérgamo","doi":"10.4322/hra.001018","DOIUrl":"https://doi.org/10.4322/hra.001018","url":null,"abstract":"Universidade Federal de Goiás, Goiânia, Goiás, Brasil Abstract Objective: To investigate the presence of chromosomal abnormalities in infertile men with azoospermia or oligozoospermia evaluated at the Human Reproduction Laboratory of the Hospital das Clinicas (LabRep -HC) of the Federal University of Goias (UFG), Goiania, Goias, Brazil, in the period 2012-2014. Methods: Metaphases were analyzed by GTG banding obtained from the culture of lymphocytes of 33 men with idiopathic infertility. Results: The patients’ ages ranged from 24-59 years and they had been attempting to conceive for an average of 5 (± 4,59) years. In 4 cases (12%) have been Klinefelter syndrome (KS) karyotype 47,XXY, was observed in three of these subjects and the fourth showed mosaicism 47,XXY[9]/46,XY[2]. The remaining 29/33 had normal karyotype. Conclusions: KS affects approximately 5 to 10% of infertile men, according to the literature. In this study, 12% of subjects were observed to have chromosomal abnormalities and sex chromosome aneuploidies were the only abnormality to be observed in the samples. Genetic testing can help identify which patients would benefit from technical reproduction. As well as contributing to unraveling the etiology of male infertility in patients treated at LabRep-HC-UFG, this study is relevant because assisted reproduction techniques ignore the process of natural selection and some classic chromosomal abnormalities or deleterious mutations could be inherited. Thus, counseling based on genetic assessments may prevent the inheritance of primary and secondary congenital defects in was slightly higher (5%). In our study, no individuals in the oligozoospermic group were found to have KS. All four KS cases were in the azoospermic group, which corresponds to 25% (4/16) of the azoospermic men. In the present study, 12% were diagnosed three with karyotype 47,XXY and one had amosaic 47XXY/46,XY karyotype.","PeriodicalId":179585,"journal":{"name":"Human Reproduction Archives","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128603630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The aim of the current article was to review data already published in the literature on Polycystic Ovarian Syndrome associated with infertility. Methods: Search for scientific articles in the databases: Lilacs, SciELO, Medline, Pubmed, Elsevier and Virtual Health Library, from 2001 to 2017, as well as bibliographies present at Potiguar University. Results: Polycystic Ovarian Syndrome is a hormonal disorder that affects a large part of the female population of reproductive age. The main cause of this disorder is hyperandrogenism, which together with oligoanovulation adds more characteristic factors for the diagnosis of this pathology. Hyperandrogenism is characterized by an excessive production of androgen hormones, with this production being discerned by a marked synthesis of testosterone, which is stimulated by the luteinizing hormone and intensified by insulin or by the intrinsic elevation of the secretion of these androgens. Although this pathology is recognized mainly by androgenic elevation, its hormonal action is still unknown. However, studies indicate that the high catabolism of cortisol and the intense response of adrenal androgens to normal adrenocorticotrophic hormone levels are related. Assisted human reproduction (AHR) has been an option to treat infertility due to Polycystic Ovarian Syndrome (PCOS); however it presents, mixed results. Due to the importance of this subject and the absence of recent articles relevant to the topic, the aim of this article was to review the published data on the PCOS associated with infertility. conclusions: In vitro fertilization is an option to achieve pregnancy in women refractory to treatment with ovulation stimulants. Despite few studies linking Polycystic Ovarian Syndrome with in vitro fertilization, it was found that this biotechnology provides significant results, however it may present subsequent disorders.
目的:本文的目的是回顾已经发表的关于多囊卵巢综合征与不孕症相关的文献数据。方法:检索2001年至2017年Lilacs、SciELO、Medline、Pubmed、Elsevier和Virtual Health Library数据库中的科学论文，以及Potiguar大学现有的参考书目。结果:多囊卵巢综合征是一种影响大部分育龄女性的激素紊乱。这种疾病的主要原因是高雄激素症，它与低排卵一起为这种病理的诊断增加了更多的特征因素。高雄激素症的特点是雄激素分泌过多，这种分泌可以通过睾酮的显著合成来识别，睾酮受促黄体激素的刺激，并因胰岛素或这些雄激素分泌的内在升高而加剧。虽然这种病理主要由雄激素升高引起，但其激素作用尚不清楚。然而，研究表明，皮质醇的高分解代谢与肾上腺雄激素对正常促肾上腺皮质激素水平的强烈反应是相关的。辅助人类生殖(AHR)已经成为治疗多囊卵巢综合征(PCOS)导致的不孕症的一种选择;然而，结果喜忧参半。由于这一主题的重要性和近期相关文章的缺失，本文的目的是回顾已发表的关于多囊卵巢综合征与不孕症相关的数据。结论:体外受精是对促排卵药物治疗难治性的妇女实现妊娠的一种选择。尽管很少有研究将多囊卵巢综合征与体外受精联系起来，但人们发现这种生物技术提供了显著的结果，然而它可能带来随后的疾病。
{"title":"The influence of polycystic ovarian syndrome on in vitro fertilization","authors":"V. A. P. Lopes, D. Alves, D. M. Magalhães-Padilha","doi":"10.4322/hra.001919","DOIUrl":"https://doi.org/10.4322/hra.001919","url":null,"abstract":"Objectives: The aim of the current article was to review data already published in the literature on Polycystic Ovarian Syndrome associated with infertility. Methods: Search for scientific articles in the databases: Lilacs, SciELO, Medline, Pubmed, Elsevier and Virtual Health Library, from 2001 to 2017, as well as bibliographies present at Potiguar University. Results: Polycystic Ovarian Syndrome is a hormonal disorder that affects a large part of the female population of reproductive age. The main cause of this disorder is hyperandrogenism, which together with oligoanovulation adds more characteristic factors for the diagnosis of this pathology. Hyperandrogenism is characterized by an excessive production of androgen hormones, with this production being discerned by a marked synthesis of testosterone, which is stimulated by the luteinizing hormone and intensified by insulin or by the intrinsic elevation of the secretion of these androgens. Although this pathology is recognized mainly by androgenic elevation, its hormonal action is still unknown. However, studies indicate that the high catabolism of cortisol and the intense response of adrenal androgens to normal adrenocorticotrophic hormone levels are related. Assisted human reproduction (AHR) has been an option to treat infertility due to Polycystic Ovarian Syndrome (PCOS); however it presents, mixed results. Due to the importance of this subject and the absence of recent articles relevant to the topic, the aim of this article was to review the published data on the PCOS associated with infertility. conclusions: In vitro fertilization is an option to achieve pregnancy in women refractory to treatment with ovulation stimulants. Despite few studies linking Polycystic Ovarian Syndrome with in vitro fertilization, it was found that this biotechnology provides significant results, however it may present subsequent disorders.","PeriodicalId":179585,"journal":{"name":"Human Reproduction Archives","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126902412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. L. Moraes, N. A. Bérgamo, N. Melo, R. F. Curado, W. Amaral
Objectives: To Describe the complete trisomy of chromosome 9 and morphological changes of the newborn. Methods: This case report described 47XX+9 in newborn of 19 year-old healthy primigesta, in Goiania, Brazil. Ultrasound was used in the 20th week of gestation to analyze multiple fetal malformations. Cytogenetic analysis (Bandage G) was used to identify the karyotype of the newborn and parents. Results: The cytogenetic analysis (G banding), showed that the fetus was female and had a 47,XX,+9 karyotype. The delivery was carried out by cesarean section at the 34th week. The evolution was unfavorable, baby survived for approximately 65 minutes and showed neonatal ocular hypertelorism, micrognathia, low ear implantation with pavilion auricle anomaly, ambiguous genitalia, spina bifida, and clubfoot. The analysis performed by chromosomal banding technique with umbilical cord lymphocytes culture showed of 47XX+9 karyotype in all 20 surveyed cells. Karyotyping of peripheral blood parents was realized but both not showed chromosomal changes. Conclusions: According to our knowledge, this is the second case of 47XX + 9 in Brazil and the detection of morphological changes caused by rare syndromes during pregnancy may help in diagnosis and appropriate clinical management because they direct families to genetic tests that can essential for the future of gestation. dismorphism (small ears, microphthalmia, bulbous nose, small mouth, high palate), central nervous system abnormalities (hydrocephalus, malformation, Dandy-Walker syndrome, holoprosencephaly), congenital heart disease (most commonly ventricular septal defects), genitourinary anomalies (genital hypoplasia, cryptorchidism, cystic kidneys, hydronephrosis), and skeletal anomalies (dislocations, deformities). 1,3,4 in metaphase for chromosome into modifications. After processing the culture the GTG banding following the protocol of 6 with modifications. An average of 20 metaphase cells were analyzed for determination of the patient’s karyotype. For confirmation of chromosomal disorder, the chromosomes of the umbilical cord lymphocytes were cultured and analyzed by banding technique. Results showed a nonmosaic constitution of trisomy 9 (47,XX,+9) in all 20 surveyed cells, confirming the cytogenetic analysis of amniotic fluid. Who asked karyotyping of peripheral blood progenitors, but both had karyotypes with no chromosomal changes.
{"title":"Complete trisomy of chromosome 9: karyotyping and morphological alterations in newborn","authors":"C. L. Moraes, N. A. Bérgamo, N. Melo, R. F. Curado, W. Amaral","doi":"10.4322/hra.001719","DOIUrl":"https://doi.org/10.4322/hra.001719","url":null,"abstract":"Objectives: To Describe the complete trisomy of chromosome 9 and morphological changes of the newborn. Methods: This case report described 47XX+9 in newborn of 19 year-old healthy primigesta, in Goiania, Brazil. Ultrasound was used in the 20th week of gestation to analyze multiple fetal malformations. Cytogenetic analysis (Bandage G) was used to identify the karyotype of the newborn and parents. Results: The cytogenetic analysis (G banding), showed that the fetus was female and had a 47,XX,+9 karyotype. The delivery was carried out by cesarean section at the 34th week. The evolution was unfavorable, baby survived for approximately 65 minutes and showed neonatal ocular hypertelorism, micrognathia, low ear implantation with pavilion auricle anomaly, ambiguous genitalia, spina bifida, and clubfoot. The analysis performed by chromosomal banding technique with umbilical cord lymphocytes culture showed of 47XX+9 karyotype in all 20 surveyed cells. Karyotyping of peripheral blood parents was realized but both not showed chromosomal changes. Conclusions: According to our knowledge, this is the second case of 47XX + 9 in Brazil and the detection of morphological changes caused by rare syndromes during pregnancy may help in diagnosis and appropriate clinical management because they direct families to genetic tests that can essential for the future of gestation. dismorphism (small ears, microphthalmia, bulbous nose, small mouth, high palate), central nervous system abnormalities (hydrocephalus, malformation, Dandy-Walker syndrome, holoprosencephaly), congenital heart disease (most commonly ventricular septal defects), genitourinary anomalies (genital hypoplasia, cryptorchidism, cystic kidneys, hydronephrosis), and skeletal anomalies (dislocations, deformities). 1,3,4 in metaphase for chromosome into modifications. After processing the culture the GTG banding following the protocol of 6 with modifications. An average of 20 metaphase cells were analyzed for determination of the patient’s karyotype. For confirmation of chromosomal disorder, the chromosomes of the umbilical cord lymphocytes were cultured and analyzed by banding technique. Results showed a nonmosaic constitution of trisomy 9 (47,XX,+9) in all 20 surveyed cells, confirming the cytogenetic analysis of amniotic fluid. Who asked karyotyping of peripheral blood progenitors, but both had karyotypes with no chromosomal changes.","PeriodicalId":179585,"journal":{"name":"Human Reproduction Archives","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125376190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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