Pub Date : 1900-01-01DOI: 10.51152/jbarbiomed.v5i1.25
Jayendra Jha, V. Malhotra, O. Jha, Shivani Gupta
Introduction Alterations in the lipid metabolism have been reported in the subject of diabetes mellitus. They may be influenced by the presence of hypertension. Aims The present study was undertaken to estimate the serum lipids profiles of diabetics with and without hypertension. Study design The study design is experimental with comparative study method, Methodology The sample size taken is 80 which is divided into four groups as A group of 20 healthy individuals of age 20-70 years, other B group of 20 diabetic patients without Hypertension, other C group of 20 hypertensive patients without diabetes and the rest 20 diabetic patients along with hypertension of age 20-70 years of D group. They were matched with respect to various lipid parameters such as total cholesterol, Triglycerides, lipoprotein ratio etc. with control group A. Place and duration of study: the study took place at Santosh group of institutions between August 2013 to August 2016. Result The serum cholesterol levels were significantly higher in hypertensives without diabetics and in diabetics with hypertension as compared to normal controls. No significant difference in the serum triglyceride level was observed among various groups in this study. The ?: ? lipoprotein ratio was found to be affected in all the groups as compared to controls with maximum ratio in diabetics without hypertension and in hypertension without diabetes. Patients who were suffering from diabetes and hypertension were at a maximum risk of developing atherosclerosisand its complications such as coronary artery disease. Diabetics with hypertension had significant higher levels of cholesterol as compared to that of without hypertension. The diabetics with hypertension had lipid abnormalities because of diabetic element in them rather than the hypertension. All the groups studied except the controls were found to be increasingly susceptible to the risk of atherosclerosis and its complications. This risk was found to be maximum in diabetics with hypertension rather than diabetics or hypertensive’s alone. Conclusion The need for right balanced diet, regular exercise and a stress free life is essential for prevention and management of diabetes and hypertension.
{"title":"Study of Lipid Profile in Diabetes Mellitus with and without Hypertension","authors":"Jayendra Jha, V. Malhotra, O. Jha, Shivani Gupta","doi":"10.51152/jbarbiomed.v5i1.25","DOIUrl":"https://doi.org/10.51152/jbarbiomed.v5i1.25","url":null,"abstract":"Introduction Alterations in the lipid metabolism have been reported in the subject of diabetes mellitus. They may be influenced by the presence of hypertension. Aims The present study was undertaken to estimate the serum lipids profiles of diabetics with and without hypertension. Study design The study design is experimental with comparative study method, Methodology The sample size taken is 80 which is divided into four groups as A group of 20 healthy individuals of age 20-70 years, other B group of 20 diabetic patients without Hypertension, other C group of 20 hypertensive patients without diabetes and the rest 20 diabetic patients along with hypertension of age 20-70 years of D group. They were matched with respect to various lipid parameters such as total cholesterol, Triglycerides, lipoprotein ratio etc. with control group A. Place and duration of study: the study took place at Santosh group of institutions between August 2013 to August 2016. Result The serum cholesterol levels were significantly higher in hypertensives without diabetics and in diabetics with hypertension as compared to normal controls. No significant difference in the serum triglyceride level was observed among various groups in this study. The ?: ? lipoprotein ratio was found to be affected in all the groups as compared to controls with maximum ratio in diabetics without hypertension and in hypertension without diabetes. Patients who were suffering from diabetes and hypertension were at a maximum risk of developing atherosclerosisand its complications such as coronary artery disease. Diabetics with hypertension had significant higher levels of cholesterol as compared to that of without hypertension. The diabetics with hypertension had lipid abnormalities because of diabetic element in them rather than the hypertension. All the groups studied except the controls were found to be increasingly susceptible to the risk of atherosclerosis and its complications. This risk was found to be maximum in diabetics with hypertension rather than diabetics or hypertensive’s alone. Conclusion The need for right balanced diet, regular exercise and a stress free life is essential for prevention and management of diabetes and hypertension. ","PeriodicalId":179698,"journal":{"name":"Journal of Basic and Applied Research in Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127366027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51152/jbarbiomed.v5i1.20
J. Hamilton-Ekeke, J. B. Moses
The purpose of the study is to ascertain if school variable (peer group pressure) and home variables (family history of alcohol consumption, socio-economic status of the family, attitude of parent towards alcohol drinking and cultural norms/festivity) lead to alcohol consumption among adolescents and proffer solution to the social menace of alcohol consumption among secondary school children. The study was a descriptive research design with mixed methods of data collection involving questionnaire and interview schedule. A sample of 100 students out of a population of 130 students and 180 students each of the mid-class (SS 2 and JS 2) of the senior and basic secondary schools respectively were involved in the study. Four hypotheses were posited and tested using Chi-square and statistical decisions made. The instruments for the study were questionnaire and interview schedule with a reliability coefficient of 0.78 using Pearson Moment Correlation Coefficient. It was found that parents are the major source of alcohol supply for many young Nigerians and children are often first introduced to alcohol in the family - home. Parents who drink alcohol are more likely to exhibit permissiveness towards alcohol use in their adolescent children. Based on the findings from this study, it could be concluded that children aged 10-16 years in Yenagoa metropolis of Nigeria, indulged in alcohol consumption regularly and in high quantity which is not good for their health. It is necessary that parents should present themselves as suitable role models in – order to guide their children against anti-social behaviours.
{"title":"School and Home Influence on Alcohol Consumption Among School Children in Nigeria","authors":"J. Hamilton-Ekeke, J. B. Moses","doi":"10.51152/jbarbiomed.v5i1.20","DOIUrl":"https://doi.org/10.51152/jbarbiomed.v5i1.20","url":null,"abstract":"The purpose of the study is to ascertain if school variable (peer group pressure) and home variables (family history of alcohol consumption, socio-economic status of the family, attitude of parent towards alcohol drinking and cultural norms/festivity) lead to alcohol consumption among adolescents and proffer solution to the social menace of alcohol consumption among secondary school children. The study was a descriptive research design with mixed methods of data collection involving questionnaire and interview schedule. A sample of 100 students out of a population of 130 students and 180 students each of the mid-class (SS 2 and JS 2) of the senior and basic secondary schools respectively were involved in the study. Four hypotheses were posited and tested using Chi-square and statistical decisions made. The instruments for the study were questionnaire and interview schedule with a reliability coefficient of 0.78 using Pearson Moment Correlation Coefficient. It was found that parents are the major source of alcohol supply for many young Nigerians and children are often first introduced to alcohol in the family - home. Parents who drink alcohol are more likely to exhibit permissiveness towards alcohol use in their adolescent children. Based on the findings from this study, it could be concluded that children aged 10-16 years in Yenagoa metropolis of Nigeria, indulged in alcohol consumption regularly and in high quantity which is not good for their health. It is necessary that parents should present themselves as suitable role models in – order to guide their children against anti-social behaviours.","PeriodicalId":179698,"journal":{"name":"Journal of Basic and Applied Research in Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124749389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.51152/jbarbiomed.v7i1.213
Sudipta Das, A. Samanta, Koushik Bankura, D. Roy, A. Nayak
The present work is focused on the preparation and in vitro release kinetics of liposomal formulation of Leuprolide Acetate. In this work, “Thin Lipid Film Hydration Method” was used for preparation of Leuprolide Acetate loaded liposomes. Prepared liposomal formulations of Leuprolide acetate was evaluated by drug entrapment study, in-vitro drug release kinetics and stability studies. The percentage drug entrapment of Leuprolide acetate for F1 and F2 formulations were found to be 78.14 ± 0.67 and 66.70 ± 0.81% respectively. In-vitro drug release study of liposomal formulations had shown zero order release pattern. Regression co-efficient (R2) value of Zero order kinetics for F1 and F2 formulations were 0.9912 and 0.9676 respectively. After storing formulations for 1 month, stability testing was done at 40C.It was found that all batches were stable. These liposomal formulations of Leuprolide acetate can be formulated for parenteral application to treat prostate cancer and in women, to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.
{"title":"Fabrication and Release Kinetics of Liposomes Containing Leuprolide Acetate","authors":"Sudipta Das, A. Samanta, Koushik Bankura, D. Roy, A. Nayak","doi":"10.51152/jbarbiomed.v7i1.213","DOIUrl":"https://doi.org/10.51152/jbarbiomed.v7i1.213","url":null,"abstract":"The present work is focused on the preparation and in vitro release kinetics of liposomal formulation of Leuprolide Acetate. In this work, “Thin Lipid Film Hydration Method” was used for preparation of Leuprolide Acetate loaded liposomes. Prepared liposomal formulations of Leuprolide acetate was evaluated by drug entrapment study, in-vitro drug release kinetics and stability studies. The percentage drug entrapment of Leuprolide acetate for F1 and F2 formulations were found to be 78.14 ± 0.67 and 66.70 ± 0.81% respectively. In-vitro drug release study of liposomal formulations had shown zero order release pattern. Regression co-efficient (R2) value of Zero order kinetics for F1 and F2 formulations were 0.9912 and 0.9676 respectively. After storing formulations for 1 month, stability testing was done at 40C.It was found that all batches were stable. These liposomal formulations of Leuprolide acetate can be formulated for parenteral application to treat prostate cancer and in women, to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.","PeriodicalId":179698,"journal":{"name":"Journal of Basic and Applied Research in Biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126520789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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