G. Mamardashvili, E. Kaigorodova, N. Mamardashvili, O. Koifman
{"title":"Self-assembly of the Sn(IV) and Сo(III) tetra(4-sulfophenyl)porphyrinates in aqueous and micellar-aqueous media","authors":"G. Mamardashvili, E. Kaigorodova, N. Mamardashvili, O. Koifman","doi":"10.6060/mhc234941m","DOIUrl":"https://doi.org/10.6060/mhc234941m","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71169650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. I. Koifman, S. S. Guseinov, N. Lebedeva, E. S. Yurina, M. O. Koifman, Y. Gubarev
A theoretical and experimental study of the interaction of the SARS-CoV-2 ORF10 protein with sulfosubstituted cobalt(II) and copper(II) phthalocyanines was carried out. The structures of the most probable complexes of metal phthalocyanines with the ORF10 protein were obtained by molecular docking methods. Cobalt(II) tetrasulfophthal ocyanine binds to the protein in the monomeric state, while the interaction ofORF1 0 with copper(II) tetrasulfophthalocyanine causes aggregation of the formed protein complexes, which was shown by the UV-Vis spectroscopy. Thermal denaturation of the ORF10 protein and its complexes with metal phthalocyanines was studied by differential scanning calorimetry. A joint analysis of the spectral and thermochemical data made it possible to propose a description of the mechanism of thermal denaturation ofthe ORF10 protein.
{"title":"DSC study of SARS-CoV-2 ORF10 protein and its complexes with water-soluble metal phthalocyanines","authors":"O. I. Koifman, S. S. Guseinov, N. Lebedeva, E. S. Yurina, M. O. Koifman, Y. Gubarev","doi":"10.6060/mhc224858g","DOIUrl":"https://doi.org/10.6060/mhc224858g","url":null,"abstract":"A theoretical and experimental study of the interaction of the SARS-CoV-2 ORF10 protein with sulfosubstituted cobalt(II) and copper(II) phthalocyanines was carried out. The structures of the most probable complexes of metal phthalocyanines with the ORF10 protein were obtained by molecular docking methods. Cobalt(II) tetrasulfophthal ocyanine binds to the protein in the monomeric state, while the interaction ofORF1 0 with copper(II) tetrasulfophthalocyanine causes aggregation of the formed protein complexes, which was shown by the UV-Vis spectroscopy. Thermal denaturation of the ORF10 protein and its complexes with metal phthalocyanines was studied by differential scanning calorimetry. A joint analysis of the spectral and thermochemical data made it possible to propose a description of the mechanism of thermal denaturation ofthe ORF10 protein.","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71169599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yana E. Kibireva, M. Islyaikin, M. Rodríguez‐Morgade, T. Torres
{"title":"Synthesis and Characterization of a Soluble Hemihexaphyrazine Derivative","authors":"Yana E. Kibireva, M. Islyaikin, M. Rodríguez‐Morgade, T. Torres","doi":"10.6060/mhc234968i","DOIUrl":"https://doi.org/10.6060/mhc234968i","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71169779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mg and Zn Complexes with Phosphonate Substituted β-Octaphenylporphyrin as Photocatalysts for Oxidation of Sulfides","authors":"E. Ermakova, A. Bessmertnykh-Lemeune","doi":"10.6060/mhc235119l","DOIUrl":"https://doi.org/10.6060/mhc235119l","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71170192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dyades of Coproporphyrin I with Pyropheophorbides Bound by Azine Bridge","authors":"A. O. Shkirdova, V. Tyurin, I. A. Zamilatskov","doi":"10.6060/mhc235051z","DOIUrl":"https://doi.org/10.6060/mhc235051z","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71170428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Sh. Lebedeva, E. S. Yurina, S. S. Guseinov, O. I. Koifman
{"title":"Interaction of Monoheteryl Substituted Cationic Porphyrins with Synthetic Nucleic Acids","authors":"N. Sh. Lebedeva, E. S. Yurina, S. S. Guseinov, O. I. Koifman","doi":"10.6060/mhc235287l","DOIUrl":"https://doi.org/10.6060/mhc235287l","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135103311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. K. Attatsi, Yuanyuan Qiu, Weihua Zhu, Long Zhao, Xu Liang
{"title":"meso-Expanded Co(III)triarylcorroles with One to Three Nitrophenyl Moieties: Synthesis, Characterization and Tunable Electrochemical Catalysis","authors":"I. K. Attatsi, Yuanyuan Qiu, Weihua Zhu, Long Zhao, Xu Liang","doi":"10.6060/mhc214017a","DOIUrl":"https://doi.org/10.6060/mhc214017a","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71167500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dmitrii Bukharin, L. Maiorova, A. Gromov, O. Koifman
{"title":"Octa-tert-butylsulfanyl Zinc Tetrapyrazinoporphyrazinate: Self-Assembled Nanostructures at the Air-Water Interface and Solid Solution in Thin Films","authors":"Dmitrii Bukharin, L. Maiorova, A. Gromov, O. Koifman","doi":"10.6060/mhc224808m","DOIUrl":"https://doi.org/10.6060/mhc224808m","url":null,"abstract":"","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71169159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Koifman, T. Ageeva, N. Kuzmina, V. F. Otvagin, A. Nyuchev, A. Fedorov, D. V. Belykh, N. S. Lebedeva, E. S. Yurina, S. Syrbu, M. O. Koifman, Yury A. Gubarev
This review presents a wide range of tetrapyrrole photosensitizers used for photodynamic therapy (PDT), antimicrobial photodynamic therapy, photoinactivation of pathogens. Methods of synthesis and design of new photosensitizers with greater selectivity of accumulation in tumor tissue and increased photoinduced antitumor activity are considered. The issues of studying the properties of new photosensitizers, their photoactivity, the ability to generate singlet oxygen, and the possibility of using targeted photodynamic therapy in clinical practice are discussed. The review examines the work on PDT by national and foreign researchers.
{"title":"Synthesis Strategy of Tetrapyrrolic Photosensitizers for Their Practical Application in Photodynamic Therapy","authors":"O. Koifman, T. Ageeva, N. Kuzmina, V. F. Otvagin, A. Nyuchev, A. Fedorov, D. V. Belykh, N. S. Lebedeva, E. S. Yurina, S. Syrbu, M. O. Koifman, Yury A. Gubarev","doi":"10.6060/mhc224870k","DOIUrl":"https://doi.org/10.6060/mhc224870k","url":null,"abstract":"This review presents a wide range of tetrapyrrole photosensitizers used for photodynamic therapy (PDT), antimicrobial photodynamic therapy, photoinactivation of pathogens. Methods of synthesis and design of new photosensitizers with greater selectivity of accumulation in tumor tissue and increased photoinduced antitumor activity are considered. The issues of studying the properties of new photosensitizers, their photoactivity, the ability to generate singlet oxygen, and the possibility of using targeted photodynamic therapy in clinical practice are discussed. The review examines the work on PDT by national and foreign researchers.","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71169794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Gafiatullin, Ilya V. Paskevich, V. Burilov, S. Solovieva, I. Antipin
The possibility of one-pot synthesis of mono-substituted quaternized derivatives of p-tert-butylthiacalix[4]arene was demonstrated for the first time by the reaction of distally di-bromopropyl substituted p-tert-butyl thiacalix[4]arene with several nitrogen-containing nucleophiles. The structure and composition of the reaction products were analyzed by modern physical methods, including two-dimensional NMR spectroscopy and high-resolution mass spectrometry. A detailed analysis of the reaction mixtures made it possible to reveal the dealkylation mechanism, which consists in the nucleophilic attack of the bromide ion on the O-CH 2 carbon atom, followed by the formation of a bromine-containing adduct, detected by mass spectrometry. Dealkylation does not occur when the classical di-bromopropyl substituted p-tert-butyl calix[4]arene is used as a substrate - the bis-quaternized imidazolium calix[4]arene salt is formed in a high yield. Such a difference in the reactivity of two macrocycles is associated with the difference in the sizes of the macrocycles: in the case of di-substituted thiacalixarene, which has a large size, two unsubstituted hydroxyl groups form a hydrogen bond with only one alkoxy group, while in the classical calix[4]arene, two paired hydrogen bonds are formed. As a result, one of the two alkoxy groups of the thiacalixarene is more accessible for nucleophilic attack; formed thereafter thiacalixarene nucleofuge-anion is stabilized by two hydrogen bonds at once.
{"title":"One-pot Synthesis of Mono-substituted Quaternized p-tert- Butylthiacalix[4]arenes","authors":"B. Gafiatullin, Ilya V. Paskevich, V. Burilov, S. Solovieva, I. Antipin","doi":"10.6060/mhc214097b","DOIUrl":"https://doi.org/10.6060/mhc214097b","url":null,"abstract":"The possibility of one-pot synthesis of mono-substituted quaternized derivatives of p-tert-butylthiacalix[4]arene was demonstrated for the first time by the reaction of distally di-bromopropyl substituted p-tert-butyl thiacalix[4]arene with several nitrogen-containing nucleophiles. The structure and composition of the reaction products were analyzed by modern physical methods, including two-dimensional NMR spectroscopy and high-resolution mass spectrometry. A detailed analysis of the reaction mixtures made it possible to reveal the dealkylation mechanism, which consists in the nucleophilic attack of the bromide ion on the O-CH 2 carbon atom, followed by the formation of a bromine-containing adduct, detected by mass spectrometry. Dealkylation does not occur when the classical di-bromopropyl substituted p-tert-butyl calix[4]arene is used as a substrate - the bis-quaternized imidazolium calix[4]arene salt is formed in a high yield. Such a difference in the reactivity of two macrocycles is associated with the difference in the sizes of the macrocycles: in the case of di-substituted thiacalixarene, which has a large size, two unsubstituted hydroxyl groups form a hydrogen bond with only one alkoxy group, while in the classical calix[4]arene, two paired hydrogen bonds are formed. As a result, one of the two alkoxy groups of the thiacalixarene is more accessible for nucleophilic attack; formed thereafter thiacalixarene nucleofuge-anion is stabilized by two hydrogen bonds at once.","PeriodicalId":18090,"journal":{"name":"Macroheterocycles","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71167542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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