Pub Date : 2024-05-11DOI: 10.33667/2078-5631-2024-8-53-56
D. V. Moskvichev, R. S. Frantsev, A. Strachuk, E. Korovyakova, A. V. Kuchuk, E. A. Presnova
{"title":"Normozoospermia. Is it always the norm?","authors":"D. V. Moskvichev, R. S. Frantsev, A. Strachuk, E. Korovyakova, A. V. Kuchuk, E. A. Presnova","doi":"10.33667/2078-5631-2024-8-53-56","DOIUrl":"https://doi.org/10.33667/2078-5631-2024-8-53-56","url":null,"abstract":"","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140988612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-11DOI: 10.33667/2078-5631-2024-8-48-53
E. E. Chernaya, E. I. Kutefa, A. Kasparova, E. N. Vasilkovskaya, L. A. Chegus, S. Semenchenko
{"title":"Pregnancy, labor, postpartum and neonatal outcomes in women with new coronavirus infection and preterm labor","authors":"E. E. Chernaya, E. I. Kutefa, A. Kasparova, E. N. Vasilkovskaya, L. A. Chegus, S. Semenchenko","doi":"10.33667/2078-5631-2024-8-48-53","DOIUrl":"https://doi.org/10.33667/2078-5631-2024-8-48-53","url":null,"abstract":"","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140988640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-11DOI: 10.33667/2078-5631-2024-11-7-13
O. O. Yanushevich, N. I. Krikheli, I. Maev, A. V. Zaborovsky, O. Levchenko, Yu. S. Galeeva, E. V. Starikova, D. N. Andreev, P. A. Bely, F. S. Sokolov, A. K. Fomenko, S. V. Tsaregorodtsev, N. G. Andreev, V. V. Evdokimov, M. K. Devkota, A. L. Kebina, E. N. Ilyina, V. M. Govorun, O. V. Rudneva
Relevance. The COVID-19 pandemic caused by the SARS-CoV-2 virus has demonstrated the critical importance of understanding the mechanisms of transmission and finding effective methods of prevention. Particular attention has been paid to the role of oral hygiene, as the oral cavity serves as a major route of transmission. Studies show that the composition of the oral microbiota can influence the course and outcome of COVID-19 disease. Therefore, there is a need to study the effects of oral antiseptics on the microbiome, which may offer new opportunities for the prevention and treatment of this disease.Objective. The aim of this study is to evaluate the effectiveness of the oral cleansing foam «Parodontol PROF» in reducing the pathogenic microflora of the oral cavity in patients with COVID-19 and to assess its effect on the risk of secondary infections.Materials and methods. The study was conducted on the basis of the Clinical Medical Centre «Kuskovo» of Russian University of Medicine. It included 450 patients with a confirmed diagnosis of COVID-19. The participants were divided into two groups: the test group used oral cleansing foam, while the control group used no additional oral hygiene. Comparative analyses of the taxonomic composition of the oropharyngeal microbiota and dental plaque before and after the use of the cleansing foam were performed.Results. The study showed that patients who regularly used the cleansing foam «Parodontol PROF» had a significant decrease in the representation of pathogens, including Mycoplasma, and an increase in the number of beneficial commensals such as Lactococcus and Lactobacillus. These changes indicate the potential efficacy of this product to improve oral hygiene and reduce the risk of secondary infections.Conclusion. The study supports the hypothesis that improving oral hygiene with specialised antiseptic agents, such as a cleansing foam, may help to reduce pathogenic microflora in the oral cavity in patients with COVID-19. This, in turn, may reduce the risk of pathogen migration into the lower respiratory tract and the development of secondary infections. The findings emphasise the importance of further research in this area and the development of comprehensive approaches to oral hygiene management in the context of infectious diseases.
{"title":"Evaluation of the dynamics of oral pathogenic microbiota in COVID-19 patients by genomic sequencing after application of foam with antimicrobial action","authors":"O. O. Yanushevich, N. I. Krikheli, I. Maev, A. V. Zaborovsky, O. Levchenko, Yu. S. Galeeva, E. V. Starikova, D. N. Andreev, P. A. Bely, F. S. Sokolov, A. K. Fomenko, S. V. Tsaregorodtsev, N. G. Andreev, V. V. Evdokimov, M. K. Devkota, A. L. Kebina, E. N. Ilyina, V. M. Govorun, O. V. Rudneva","doi":"10.33667/2078-5631-2024-11-7-13","DOIUrl":"https://doi.org/10.33667/2078-5631-2024-11-7-13","url":null,"abstract":"Relevance. The COVID-19 pandemic caused by the SARS-CoV-2 virus has demonstrated the critical importance of understanding the mechanisms of transmission and finding effective methods of prevention. Particular attention has been paid to the role of oral hygiene, as the oral cavity serves as a major route of transmission. Studies show that the composition of the oral microbiota can influence the course and outcome of COVID-19 disease. Therefore, there is a need to study the effects of oral antiseptics on the microbiome, which may offer new opportunities for the prevention and treatment of this disease.Objective. The aim of this study is to evaluate the effectiveness of the oral cleansing foam «Parodontol PROF» in reducing the pathogenic microflora of the oral cavity in patients with COVID-19 and to assess its effect on the risk of secondary infections.Materials and methods. The study was conducted on the basis of the Clinical Medical Centre «Kuskovo» of Russian University of Medicine. It included 450 patients with a confirmed diagnosis of COVID-19. The participants were divided into two groups: the test group used oral cleansing foam, while the control group used no additional oral hygiene. Comparative analyses of the taxonomic composition of the oropharyngeal microbiota and dental plaque before and after the use of the cleansing foam were performed.Results. The study showed that patients who regularly used the cleansing foam «Parodontol PROF» had a significant decrease in the representation of pathogens, including Mycoplasma, and an increase in the number of beneficial commensals such as Lactococcus and Lactobacillus. These changes indicate the potential efficacy of this product to improve oral hygiene and reduce the risk of secondary infections.Conclusion. The study supports the hypothesis that improving oral hygiene with specialised antiseptic agents, such as a cleansing foam, may help to reduce pathogenic microflora in the oral cavity in patients with COVID-19. This, in turn, may reduce the risk of pathogen migration into the lower respiratory tract and the development of secondary infections. The findings emphasise the importance of further research in this area and the development of comprehensive approaches to oral hygiene management in the context of infectious diseases.","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":"112 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140987741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-11DOI: 10.33667/2078-5631-2024-8-57-61
N. V. Buzovskaya, A. Morozov, T. Sorokovikova, S. Naumova
{"title":"Human papillomavirus as a predictor of cervical cancer in women of reproductive age (literature review)","authors":"N. V. Buzovskaya, A. Morozov, T. Sorokovikova, S. Naumova","doi":"10.33667/2078-5631-2024-8-57-61","DOIUrl":"https://doi.org/10.33667/2078-5631-2024-8-57-61","url":null,"abstract":"","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140988142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.33667/2078-5631-2024-8-36-40
A. A. Grigoryants, N. Burova, V. Avrutskaya, I. Krukier
{"title":"Changes in the level of anti-inflammatory and pro-inflammatory cytokines in patients with external genital endometriosis (literature review)","authors":"A. A. Grigoryants, N. Burova, V. Avrutskaya, I. Krukier","doi":"10.33667/2078-5631-2024-8-36-40","DOIUrl":"https://doi.org/10.33667/2078-5631-2024-8-36-40","url":null,"abstract":"","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":" 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140990748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.33667/2078-5631-2024-8-25-31
M. V. Labzina, S. V. Abramova, A. S. Nechaykin, D. Y. Shubin, M. I. Kechemaykina
{"title":"Vegetative innervation of the human reproductive system in embryogenesis","authors":"M. V. Labzina, S. V. Abramova, A. S. Nechaykin, D. Y. Shubin, M. I. Kechemaykina","doi":"10.33667/2078-5631-2024-8-25-31","DOIUrl":"https://doi.org/10.33667/2078-5631-2024-8-25-31","url":null,"abstract":"","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":" 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140991471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.33667/2078-5631-2024-8-16-21
A. V. Ledina, S. I. Rogovskaya, I. P. Shabalova, N. N. Bayandina
{"title":"Chronic cervicitis: a gynecologist and cytologist’s view of the problem","authors":"A. V. Ledina, S. I. Rogovskaya, I. P. Shabalova, N. N. Bayandina","doi":"10.33667/2078-5631-2024-8-16-21","DOIUrl":"https://doi.org/10.33667/2078-5631-2024-8-16-21","url":null,"abstract":"","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":" 70","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140993267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.33667/2078-5631-2024-8-32-35
L. Tkachenko, O. Kurushina, I. A. Gritsenko, A. S. Justus
{"title":"Features of pain manifestations in women with premenstrual syndrome","authors":"L. Tkachenko, O. Kurushina, I. A. Gritsenko, A. S. Justus","doi":"10.33667/2078-5631-2024-8-32-35","DOIUrl":"https://doi.org/10.33667/2078-5631-2024-8-32-35","url":null,"abstract":"","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":" 85","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140991202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.33667/2078-5631-2024-7-46-54
M. S. Ruban, L. V. Bolotina, Yu. B. Karagodina, T. I. Deshkina, A. L. Kornietskaya, A. A. Fedenko
Currently, tumour tissue biopsy to determine RAS/BRAF gene alterations, assess microsatellite instability status, and determine HER‑2/neu gene amplification/hyperexpression is the gold standard of diagnosis and allows the selection of optimal molecularly targeted therapy when considering treatment strategies for patients with metastatic colorectal cancer. However, biopsy does not fully reflect the existing intratumoural heterogeneity and clonal evolution of tumour cells, which can often be the cause of therapeutic failures. In recent years, liquid biopsy has attracted increasing attention as an additional and potentially alternative non-invasive tool for molecular tumour profiling. Assessment of circulating tumour DNA allows changes in the genetic status of the tumour to be monitored and the «burden» of disease to be measured dynamically in real time. Advances in liquid biopsy technology have led to promising new strategies for the management of patients with metastatic colorectal cancer in late-line therapy. The standard drug arsenal in this group of patients is limited to either repeat administration of previously effective therapy or regorafenib and the combination of trifluridine/tipiracil with bevacizumab, which are characterized by limited clinical activity. However, thanks to the discovery of the NeoRAS wild-type phenomenon and the rechallenge strategy of anti-EGFR monoclonal antibodies based on the study of clonal selection and evolution of tumour cells, the administration of epidermal growth factor inhibitors in a molecularly selected by liquid biopsy population is accompanied by good tolerability and efficacy. Numerous clinical studies are ongoing to further understand the mechanisms of tumour resistance and to develop new evidence-based treatment approaches in order to realise the concept of personalised medicine.
目前，通过肿瘤组织活检确定 RAS/BRAF 基因改变、评估微卫星不稳定性状态和确定 HER-2/neu 基因扩增/高表达是诊断的黄金标准，在考虑转移性结直肠癌患者的治疗策略时可选择最佳的分子靶向治疗。然而，活检并不能完全反映肿瘤细胞现有的瘤内异质性和克隆进化，这往往是治疗失败的原因。近年来，液体活检作为一种额外的、潜在的非侵入性肿瘤分子图谱分析工具日益受到关注。通过对循环肿瘤 DNA 的评估，可以监测肿瘤基因状态的变化，并实时动态地测量疾病的 "负担"。液体活检技术的进步为晚期治疗转移性结直肠癌患者的管理带来了前景广阔的新策略。这类患者的标准药物库仅限于重复使用以前有效的疗法或瑞戈非尼（regorafenib）和三氟嘧啶/替吡拉西与贝伐珠单抗（bevacizumab）联合疗法，这些疗法的临床活性有限。然而，由于新RAS野生型现象的发现，以及基于肿瘤细胞克隆选择和进化研究的抗表皮生长因子受体单克隆抗体再挑战策略，在通过液体活检进行分子筛选的人群中使用表皮生长因子抑制剂具有良好的耐受性和疗效。目前正在进行大量临床研究，以进一步了解肿瘤抗药性的机制，并开发新的循证治疗方法，从而实现个性化医疗的概念。
{"title":"Circulating tumour DNA analysis and new uses of anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer","authors":"M. S. Ruban, L. V. Bolotina, Yu. B. Karagodina, T. I. Deshkina, A. L. Kornietskaya, A. A. Fedenko","doi":"10.33667/2078-5631-2024-7-46-54","DOIUrl":"https://doi.org/10.33667/2078-5631-2024-7-46-54","url":null,"abstract":"Currently, tumour tissue biopsy to determine RAS/BRAF gene alterations, assess microsatellite instability status, and determine HER‑2/neu gene amplification/hyperexpression is the gold standard of diagnosis and allows the selection of optimal molecularly targeted therapy when considering treatment strategies for patients with metastatic colorectal cancer. However, biopsy does not fully reflect the existing intratumoural heterogeneity and clonal evolution of tumour cells, which can often be the cause of therapeutic failures. In recent years, liquid biopsy has attracted increasing attention as an additional and potentially alternative non-invasive tool for molecular tumour profiling. Assessment of circulating tumour DNA allows changes in the genetic status of the tumour to be monitored and the «burden» of disease to be measured dynamically in real time. Advances in liquid biopsy technology have led to promising new strategies for the management of patients with metastatic colorectal cancer in late-line therapy. The standard drug arsenal in this group of patients is limited to either repeat administration of previously effective therapy or regorafenib and the combination of trifluridine/tipiracil with bevacizumab, which are characterized by limited clinical activity. However, thanks to the discovery of the NeoRAS wild-type phenomenon and the rechallenge strategy of anti-EGFR monoclonal antibodies based on the study of clonal selection and evolution of tumour cells, the administration of epidermal growth factor inhibitors in a molecularly selected by liquid biopsy population is accompanied by good tolerability and efficacy. Numerous clinical studies are ongoing to further understand the mechanisms of tumour resistance and to develop new evidence-based treatment approaches in order to realise the concept of personalised medicine.","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":" 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140991133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-10DOI: 10.33667/2078-5631-2024-7-41-45
E. I. Kuznetsova, D. D. Tsyrenov
Currently, special attention of researchers is attracted to the problem of diagnosing postoperative brain damage and cognitive impairment in patients with cardiovascular pathology after cardiac surgery without/under conditions of artificial circulation (AC). The main method of assessing the functional state of the brain is quantitative electroencephalography (EEG). Because of cardiovascular and oncological pathology could persist in one patient it is actual simultaneous cardial and oncological surgery under EEG monitoring.Objective: based on the literature data, to find out the role of EEG in diagnosis of cerebral complications in patients with cardiovascular pathology after cardiac surgery without /under conditions of AC.Methods. We found and analyzed data in specialized medical data base Pubmed, Scopus, Web of Science about EEG methods in patients after heart bypass with/without AC from 1980 to 2023 years.Results. The quantitative EEG is very important for early diagnosis and prognosis for cerebral ischemia, epileptiform activity, postoperative cognitive dysfunction in patients with coronary heart disease (CHD) after coronary artery bypass with/without AC. However, the studies did not included patients with oncopathology, people over 70 years of age. It opens possibilities for early diagnosis of central nervous system functional condition in patients with lung cancer and cardiovascular disorders in simultaneous (concomitant heart and lung with/without AC) surgery. It will help a correction of complications in time and a development of guided rehabilitation
目前，研究人员特别关注在无人工循环（AC）条件下诊断心血管病变患者术后脑损伤和认知障碍的问题。评估大脑功能状态的主要方法是定量脑电图（EEG）。目的：根据文献资料，找出脑电图在无/有人工循环条件下心脏手术后心血管病变患者脑并发症诊断中的作用。我们在专业医学数据库Pubmed、Scopus、Web of Science中查找并分析了1980年至2023年间有/无AC心脏搭桥术后患者的脑电图方法。定量脑电图对于冠状动脉搭桥术（有/无 AC）后冠心病（CHD）患者脑缺血、癫痫样活动、术后认知功能障碍的早期诊断和预后非常重要。然而，这些研究并不包括肿瘤患者和 70 岁以上的老人。该研究为早期诊断肺癌和心血管疾病患者的中枢神经系统功能状况提供了可能性。这将有助于及时纠正并发症和开展有指导的康复治疗。
{"title":"The role of quantitative electroencephalography in the diagnosis of postoperative cerebral consequences in patients with cardiovascular pathology who underwent cardiac surgery using artificial circulation. Importance for oncology (literature review)","authors":"E. I. Kuznetsova, D. D. Tsyrenov","doi":"10.33667/2078-5631-2024-7-41-45","DOIUrl":"https://doi.org/10.33667/2078-5631-2024-7-41-45","url":null,"abstract":"Currently, special attention of researchers is attracted to the problem of diagnosing postoperative brain damage and cognitive impairment in patients with cardiovascular pathology after cardiac surgery without/under conditions of artificial circulation (AC). The main method of assessing the functional state of the brain is quantitative electroencephalography (EEG). Because of cardiovascular and oncological pathology could persist in one patient it is actual simultaneous cardial and oncological surgery under EEG monitoring.Objective: based on the literature data, to find out the role of EEG in diagnosis of cerebral complications in patients with cardiovascular pathology after cardiac surgery without /under conditions of AC.Methods. We found and analyzed data in specialized medical data base Pubmed, Scopus, Web of Science about EEG methods in patients after heart bypass with/without AC from 1980 to 2023 years.Results. The quantitative EEG is very important for early diagnosis and prognosis for cerebral ischemia, epileptiform activity, postoperative cognitive dysfunction in patients with coronary heart disease (CHD) after coronary artery bypass with/without AC. However, the studies did not included patients with oncopathology, people over 70 years of age. It opens possibilities for early diagnosis of central nervous system functional condition in patients with lung cancer and cardiovascular disorders in simultaneous (concomitant heart and lung with/without AC) surgery. It will help a correction of complications in time and a development of guided rehabilitation","PeriodicalId":18337,"journal":{"name":"Medical alphabet","volume":" 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140990950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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