Pub Date : 2021-01-11DOI: 10.23736/S0026-4725.20.05434-1
R. Razzolini, G. Iannaccone
{"title":"Systolic, mean and pulse pressure values in patients with acute coronary syndrome: worth keeping an eye on.","authors":"R. Razzolini, G. Iannaccone","doi":"10.23736/S0026-4725.20.05434-1","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05434-1","url":null,"abstract":"","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75023196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-11DOI: 10.23736/S0026-4725.20.05229-9
C. Musto, A. Nusca, G. Biondi‐Zoccai, F. De Felice, M. Scappaticci, M. Nazzaro, M. Viscusi, A. Ceccacci, F. Versaci
BACKGROUND The optimal management of patients with ST-elevation acute coronary syndromes and multivessel coronary artery disease is challenging. There is a growing body of evidence supporting invasive functional evaluation of multivessel disease with FFR or iFR has been added to the literature. In this regard, the WAVE study recently demonstrated the diagnostic accuracy of iFR functional assessment of non-culprit lesions in multivessel patients with STEMI. However, no studies have still verified the long-term clinical impact of an iFR-guided revascularization in this setting of patients. METHODS Patients undergoing primary PCI for STEMI and presenting multivessel disease will be enrolled. After the treatment of the culprit lesion, an iFR-guided functional assessment of non-culprit lesions will be done: if iFR ≤ 0.89 PCI will be performed during the index procedure or staged. Conversely, iFR> 0.89 will be direct the patient towards a conservative approach. RESULTS The study start date was May 1, 2018. The enrollement phase was completed on March 30, 2020. The primary endpoint is the occurrence of Target Lesion Failure (TLF), a composite of cardiovascular death, non-fatal myocardial infarction, and ischemia-driven revascularization of the vessel previously assessed with iFR. Secondary end points include MACE (Cardiovascular death, non-fatal MI, any revascularization). CONCLUSIONS The aim of the present study is to evaluate the long-term clinical impact of an iFR-guided revascularization of the non-culprit lesions in STEMI patients with multivessel coronary artery disease.
{"title":"Instantaneous wave-free ratio-guided revascularization of non-culprit lesion in patients with ST-segment elevation myocardial infarction and multivessel coronary disease: design and rationale of the WAVE registry.","authors":"C. Musto, A. Nusca, G. Biondi‐Zoccai, F. De Felice, M. Scappaticci, M. Nazzaro, M. Viscusi, A. Ceccacci, F. Versaci","doi":"10.23736/S0026-4725.20.05229-9","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05229-9","url":null,"abstract":"BACKGROUND\u0000The optimal management of patients with ST-elevation acute coronary syndromes and multivessel coronary artery disease is challenging. There is a growing body of evidence supporting invasive functional evaluation of multivessel disease with FFR or iFR has been added to the literature. In this regard, the WAVE study recently demonstrated the diagnostic accuracy of iFR functional assessment of non-culprit lesions in multivessel patients with STEMI. However, no studies have still verified the long-term clinical impact of an iFR-guided revascularization in this setting of patients.\u0000\u0000\u0000METHODS\u0000Patients undergoing primary PCI for STEMI and presenting multivessel disease will be enrolled. After the treatment of the culprit lesion, an iFR-guided functional assessment of non-culprit lesions will be done: if iFR ≤ 0.89 PCI will be performed during the index procedure or staged. Conversely, iFR> 0.89 will be direct the patient towards a conservative approach.\u0000\u0000\u0000RESULTS\u0000The study start date was May 1, 2018. The enrollement phase was completed on March 30, 2020. The primary endpoint is the occurrence of Target Lesion Failure (TLF), a composite of cardiovascular death, non-fatal myocardial infarction, and ischemia-driven revascularization of the vessel previously assessed with iFR. Secondary end points include MACE (Cardiovascular death, non-fatal MI, any revascularization).\u0000\u0000\u0000CONCLUSIONS\u0000The aim of the present study is to evaluate the long-term clinical impact of an iFR-guided revascularization of the non-culprit lesions in STEMI patients with multivessel coronary artery disease.","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75184625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.23736/S0026-4725.20.05456-0
K. Ravindra, M. D. Del Buono, J. Chiabrando, P. Westman, E. Bressi, D. Kadariya, C. Maehara, M. Dell, Liangsuo Ma, J. van Wezenbeek, F. Moeller, L. Keyser-Marcus, L. Keen, Tamas S. Gal, A. Abbate
BACKGROUND Takotsubo syndrome (TS) is an acute, reversible form of heart failure, often mimicking an acute coronary syndrome (ACS). Data regarding racial differences in TS are inconsistent. The aim is to assess clinical features associated with unfavorable in-hospital outcomes between African American (AA) and Caucasian (CAU) patients. METHODS A retrospective electronic health record query identified 44 AA patients and 110 CAU patients with a diagnosis of TS. Our primary outcome was a composite of death, stroke, and cardiogenic shock during hospitalization. Variables associated with an increased risk of the primary composite outcomes were included in a logistic regression model. RESULTS Compared to CAU patients, AA patients were a more comorbid population, and presented a higher prevalence of history of illicit drug use (27.3% vs 13.6% p=0.044). There were no significant differences regarding in-hospital complication rates between AA and CAU patients. In the logistic regression model, infection was associated with greater risk of developing the primary outcome in AA patients (OR=7.26 95% CI [1.22-43.17], p=0.029), whereas angina was a protective factor (OR=0.11 95% CI [0.02-0.65], p=0.015). In CAU patients, severely depressed ejection fraction and worse peak creatinine during hospitalization increased risk of developing the primary outcome (OR=5.88 95% CI [2.01-17.17], p<0.001 and OR=1.64 95% CI [1.15-2.58], p=0.031, respectively). Meanwhile, emotional stressors were protective (OR=0.16 95% CI [0.03-0.88], p=0.004). CONCLUSIONS Despite experiencing the same rate of in-hospital complications, the clinical profiles of AA patients are distinct from CAU patients admitted for TS, and clinical variables correlated with worse in-hospital outcomes also differ by race.
takotsubo综合征(TS)是一种急性、可逆的心力衰竭，通常与急性冠状动脉综合征(ACS)相似。关于TS的种族差异的数据不一致。目的是评估非裔美国人(AA)和高加索人(CAU)患者与不良住院结果相关的临床特征。方法回顾性电子健康记录查询了44例AA和110例CAU诊断为TS的患者，我们的主要结局是住院期间死亡、卒中和心源性休克的复合结局。与主要综合结果风险增加相关的变量被纳入逻辑回归模型。结果与CAU患者相比，AA患者是更多的合并症人群，并且存在更高的非法药物使用史(27.3% vs 13.6% p=0.044)。AA和CAU患者住院并发症发生率无显著差异。在logistic回归模型中，感染与AA患者发生主要结局的高风险相关(OR=7.26 95% CI [1.22-43.17]， p=0.029)，而心绞痛是一个保护因素(OR=0.11 95% CI [0.02-0.65]， p=0.015)。在CAU患者中，住院期间严重的低射血分数和较差的峰值肌酐增加了发生主要结局的风险(OR=5.88 95% CI [2.01-17.17]， p<0.001; OR=1.64 95% CI [1.15-2.58]， p=0.031)。同时，情绪应激源具有保护作用(OR=0.16, 95% CI [0.03-0.88]， p=0.004)。结论尽管AA患者的住院并发症发生率相同，但AA患者的临床特征与因TS入院的CAU患者不同，与住院预后较差相关的临床变量也因种族而异。
{"title":"Clinical features and outcomes between African American and Caucasian patients with Takotsubo Syndrome.","authors":"K. Ravindra, M. D. Del Buono, J. Chiabrando, P. Westman, E. Bressi, D. Kadariya, C. Maehara, M. Dell, Liangsuo Ma, J. van Wezenbeek, F. Moeller, L. Keyser-Marcus, L. Keen, Tamas S. Gal, A. Abbate","doi":"10.23736/S0026-4725.20.05456-0","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05456-0","url":null,"abstract":"BACKGROUND\u0000Takotsubo syndrome (TS) is an acute, reversible form of heart failure, often mimicking an acute coronary syndrome (ACS). Data regarding racial differences in TS are inconsistent. The aim is to assess clinical features associated with unfavorable in-hospital outcomes between African American (AA) and Caucasian (CAU) patients.\u0000\u0000\u0000METHODS\u0000A retrospective electronic health record query identified 44 AA patients and 110 CAU patients with a diagnosis of TS. Our primary outcome was a composite of death, stroke, and cardiogenic shock during hospitalization. Variables associated with an increased risk of the primary composite outcomes were included in a logistic regression model.\u0000\u0000\u0000RESULTS\u0000Compared to CAU patients, AA patients were a more comorbid population, and presented a higher prevalence of history of illicit drug use (27.3% vs 13.6% p=0.044). There were no significant differences regarding in-hospital complication rates between AA and CAU patients. In the logistic regression model, infection was associated with greater risk of developing the primary outcome in AA patients (OR=7.26 95% CI [1.22-43.17], p=0.029), whereas angina was a protective factor (OR=0.11 95% CI [0.02-0.65], p=0.015). In CAU patients, severely depressed ejection fraction and worse peak creatinine during hospitalization increased risk of developing the primary outcome (OR=5.88 95% CI [2.01-17.17], p<0.001 and OR=1.64 95% CI [1.15-2.58], p=0.031, respectively). Meanwhile, emotional stressors were protective (OR=0.16 95% CI [0.03-0.88], p=0.004).\u0000\u0000\u0000CONCLUSIONS\u0000Despite experiencing the same rate of in-hospital complications, the clinical profiles of AA patients are distinct from CAU patients admitted for TS, and clinical variables correlated with worse in-hospital outcomes also differ by race.","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76013512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.23736/S0026-4725.20.05571-1
E. Michos, P. Sabouret
{"title":"Racial differences in Takotsubo Cardiomyopathy: more alike than different?","authors":"E. Michos, P. Sabouret","doi":"10.23736/S0026-4725.20.05571-1","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05571-1","url":null,"abstract":"","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82115239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.23736/S0026-4725.20.05570-X
Simone Calcagno, V. Sucato, F. Versaci
{"title":"Stent Oversizing or not-oversizing? An unresolved dilemma.","authors":"Simone Calcagno, V. Sucato, F. Versaci","doi":"10.23736/S0026-4725.20.05570-X","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05570-X","url":null,"abstract":"","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82239348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.23736/S0026-4725.20.05602-9
G. Testino, P. Balbinot, R. Pellicano
{"title":"Cannabis, health and prevention.","authors":"G. Testino, P. Balbinot, R. Pellicano","doi":"10.23736/S0026-4725.20.05602-9","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05602-9","url":null,"abstract":"","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73368863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.23736/S0026-4725.20.05555-3
F. Piroli, A. Leone, Simone Calcagno
{"title":"The role of chronic obstructive pulmonary disease in acute coronary syndrome patients: a critical risk factor for lipid plaque burden?","authors":"F. Piroli, A. Leone, Simone Calcagno","doi":"10.23736/S0026-4725.20.05555-3","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05555-3","url":null,"abstract":"","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74678775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.23736/S0026-4725.20.05386-4
Gemma Reddin, Brian J. Forrestal, H. Garcia-Garcia, D. Medvedofsky, Manavotam Singh, F. Asch, H. Ribeiro, C. Campos
BACKGROUND Takotsubo Cardiomyopathy (TTC) is classified into 4 types dependent on anatomical area affected identified on gross visual assessment. We have sought to understand if it is feasible and advantageous to use left ventricular global longitudinal strain (LVGLS), LV segmental longitudinal strain and right ventricle free wall strain (RVFWS) to classify TTC. METHODS We conducted a retrospective observational study on twenty-five patients who meet the Modified Mayo Clinic Criteria for TTC [1]. Two independent reviewers performed strain analysis, they were both blinded to patient's diagnosed classification and outcomes. RESULTS Based on classification by traditional assessment the 92% (n=23) were diagnosed with typical TTC, indicating apical involvement. The entire LV was affected, 67% (n=16) had abnormal strain (STE>-18) in all three LV regions (base, mid ventricle and apex). 71% of patients (n=17) had abnormal LVGLS (>-18). Abnormal strain across all three LV regions was associated with higher prevalence (70%, n=8 Vs 30%, n=4 respectively) of composite cardiovascular events and longer length of hospital stay. There was a statistically significant difference in average length of hospital stay in those patients who had abnormal strain in all three region compared to those that did not have abnormal strain across all three regions (8 days compared to 3.44 days, p value 0.02). CONCLUSIONS A new classification of TCC based on strain analysis should be developed. The traditional model is arbitrary; it fails to recognize that in most patients the entire LV is affect, it does not have prognostic significance and the most prevalent typical variant indicates apical involvement. Our study suggests that the entire LV is affected, and strain analysis has prognostic significance.
takotsubo心肌病(TTC)根据大体视觉评估确定的受影响解剖区域分为4种类型。我们试图了解左室整体纵向应变(LVGLS)、左室节段纵向应变(LVGLS)和右心室自由壁应变(RVFWS)对TTC的分类是否可行和有利。方法我们对25例符合修改的梅奥临床TTC标准的患者进行回顾性观察研究[1]。两名独立的审稿人进行了应变分析，他们都对患者的诊断分类和结果一无所知。结果92% (n=23)的患者在传统评估分类的基础上诊断为典型TTC，提示根尖受累。整个左室受到影响，67% (n=16)的左室基底、中脑室和心尖三个区域均出现异常应变(STE>-18)。71%的患者(n=17) LVGLS异常(>-18)。所有三个左室区域的异常应变与复合心血管事件的较高患病率(分别为70%，n=8 Vs 30%， n=4)和较长的住院时间相关。在所有三个区域中有异常应变的患者与在所有三个区域中没有异常应变的患者的平均住院时间有统计学意义上的差异(8天对3.44天，p值0.02)。结论应建立一种基于应变分析的TCC分类新方法。传统的模式是武断的;它没有认识到在大多数患者中整个左室都受到影响，它没有预后意义，最普遍的典型变异表明心尖受累。我们的研究表明整个左室受到影响，应变分析具有预后意义。
{"title":"Left ventricular global longitudinal strain assessment in patients with Takotsubo Cardiomyopathy: a call for an echocardiography-based classification.","authors":"Gemma Reddin, Brian J. Forrestal, H. Garcia-Garcia, D. Medvedofsky, Manavotam Singh, F. Asch, H. Ribeiro, C. Campos","doi":"10.23736/S0026-4725.20.05386-4","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05386-4","url":null,"abstract":"BACKGROUND\u0000Takotsubo Cardiomyopathy (TTC) is classified into 4 types dependent on anatomical area affected identified on gross visual assessment. We have sought to understand if it is feasible and advantageous to use left ventricular global longitudinal strain (LVGLS), LV segmental longitudinal strain and right ventricle free wall strain (RVFWS) to classify TTC.\u0000\u0000\u0000METHODS\u0000We conducted a retrospective observational study on twenty-five patients who meet the Modified Mayo Clinic Criteria for TTC [1]. Two independent reviewers performed strain analysis, they were both blinded to patient's diagnosed classification and outcomes.\u0000\u0000\u0000RESULTS\u0000Based on classification by traditional assessment the 92% (n=23) were diagnosed with typical TTC, indicating apical involvement. The entire LV was affected, 67% (n=16) had abnormal strain (STE>-18) in all three LV regions (base, mid ventricle and apex). 71% of patients (n=17) had abnormal LVGLS (>-18). Abnormal strain across all three LV regions was associated with higher prevalence (70%, n=8 Vs 30%, n=4 respectively) of composite cardiovascular events and longer length of hospital stay. There was a statistically significant difference in average length of hospital stay in those patients who had abnormal strain in all three region compared to those that did not have abnormal strain across all three regions (8 days compared to 3.44 days, p value 0.02).\u0000\u0000\u0000CONCLUSIONS\u0000A new classification of TCC based on strain analysis should be developed. The traditional model is arbitrary; it fails to recognize that in most patients the entire LV is affect, it does not have prognostic significance and the most prevalent typical variant indicates apical involvement. Our study suggests that the entire LV is affected, and strain analysis has prognostic significance.","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"428 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75906940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.23736/S0026-4725.20.05454-7
E. Elia, S. Ministrini, F. Carbone, F. Montecucco
Diabetes mellitus is emerging as a major risk factor for heart failure. Diabetic cardiomyopathy is defined as a myocardial dysfunction that is not caused by underlying hypertension or coronary artery disease. Studies about clinical features, natural history and outcomes of the disease are few and often conflicting, because a universally accepted operative definition of diabetic cardiomyopathy is still lacking. Hyperglycemia and related metabolic and endocrine disorders are the triggering factors of myocardial damage in diabetic cardiomyopathy through multiple mechanisms. Among these mechanisms, inflammation has a relevant role, similar to other chronic myocardial disease, such as hypertensive or ischemic heart disease. A balance between inflammatory damage and healing processes is fundamental for homeostasis of myocardial tissue, whereas diabetes mellitus produces an imbalance, promoting inflammation and delaying healing. Therefore, diabetes-related chronic inflammatory state can produce a progressive qualitative deterioration of myocardial tissue, which reflects on progressive left ventricular functional impairment, which can be either diastolic, with prevalent myocardial hypertrophy, or systolic, with prevalent myocardial fibrosis. The aim of this narrative review is to summarize the existing evidence about the role of inflammation in diabetic cardiomyopathy onset and development. Ultimately, potential pharmacological strategies targeting inflammatory response will be reviewed and discussed.
{"title":"Diabetic cardiomyopathy and inflammation: development of hostile microenvironment resulting in cardiac damage.","authors":"E. Elia, S. Ministrini, F. Carbone, F. Montecucco","doi":"10.23736/S0026-4725.20.05454-7","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05454-7","url":null,"abstract":"Diabetes mellitus is emerging as a major risk factor for heart failure. Diabetic cardiomyopathy is defined as a myocardial dysfunction that is not caused by underlying hypertension or coronary artery disease. Studies about clinical features, natural history and outcomes of the disease are few and often conflicting, because a universally accepted operative definition of diabetic cardiomyopathy is still lacking. Hyperglycemia and related metabolic and endocrine disorders are the triggering factors of myocardial damage in diabetic cardiomyopathy through multiple mechanisms. Among these mechanisms, inflammation has a relevant role, similar to other chronic myocardial disease, such as hypertensive or ischemic heart disease. A balance between inflammatory damage and healing processes is fundamental for homeostasis of myocardial tissue, whereas diabetes mellitus produces an imbalance, promoting inflammation and delaying healing. Therefore, diabetes-related chronic inflammatory state can produce a progressive qualitative deterioration of myocardial tissue, which reflects on progressive left ventricular functional impairment, which can be either diastolic, with prevalent myocardial hypertrophy, or systolic, with prevalent myocardial fibrosis. The aim of this narrative review is to summarize the existing evidence about the role of inflammation in diabetic cardiomyopathy onset and development. Ultimately, potential pharmacological strategies targeting inflammatory response will be reviewed and discussed.","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90432651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.23736/S0026-4725.20.05442-0
J. Chiabrando, M. Feola
{"title":"Exercise and adverse ventricular remodeling. The cornerstone of heart failure.","authors":"J. Chiabrando, M. Feola","doi":"10.23736/S0026-4725.20.05442-0","DOIUrl":"https://doi.org/10.23736/S0026-4725.20.05442-0","url":null,"abstract":"","PeriodicalId":18565,"journal":{"name":"Minerva cardioangiologica","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85061310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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