Molecular & Cellular Toxicology最新文献

{"title":"Targeting cathepsin L in the regulation of apoptosis in peripheral T-cell lymphoma","authors":"Rui Zhang, Yanjie Ruan, Yiming Zhao, Fengbo Jin, Mingzhen Yang, Zhimin Zhai","doi":"10.1007/s13273-023-00359-w","DOIUrl":"https://doi.org/10.1007/s13273-023-00359-w","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135100898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"YTHDC1 inhibits cell proliferation and angiogenesis in cervical cancer by regulating m6A modification of SOCS4 mRNA","authors":"Sihe Chen, Yongheng Chen, Lanting Yu, Xiangmei Hu","doi":"10.1007/s13273-023-00360-3","DOIUrl":"https://doi.org/10.1007/s13273-023-00360-3","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135642738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircSLCO3A1 depletion ameliorates lipopolysaccharide-induced inflammation and apoptosis of human pulmonary alveolar epithelial cells through the miR-424-5p/HMGB3 pathway.","authors":"Yan Li,&nbsp;Chunmei Zhang,&nbsp;Zhongyan Zhao","doi":"10.1007/s13273-023-00341-6","DOIUrl":"10.1007/s13273-023-00341-6","url":null,"abstract":"<p><strong>Background: </strong>Recent studies have shown the pathogenesis of acute lung injury (ALI) involves circular RNA (circRNA). However, there are no data on the role of circSLCO3A1 in ALI and the underlying mechanism.</p><p><strong>Objective: </strong>ALI-like cell injury was induced by stimulating human pulmonary alveolar epithelial cells (HPAEpiCs) using lipopolysaccharide (LPS). The expression of circSLCO3A1, miR-424-5p and high mobility group box 3 (HMGB3) was detected by quantitative real-time polymerase chain reaction. Cell viability and cell apoptosis were assessed by cell counting kit-8 (CCK-8) assay and flow cytometry analysis, respectively. Enzyme-linked immunosorbent assay was performed to determine the production of interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α) and monocyte chemotactic protein 1 (MCP-1). Caspase-3 activity was detected by caspase-3 activity assay. Protein expression of inducible NOS (iNOS), cyclooxygenase-2 (COX2), p-p65 and p65 was analyzed by Western blot. The interactions among circSLCO3A1, miR-424-5p and HMGB3 were identified by dual-luciferase reporter assay, RNA immunoprecipitation assay and RNA pull-down assay.</p><p><strong>Results: </strong>CircSLCO3A1 and HMGB3 expression were significantly increased, while miR-424-5p was decreased in LPS-treated HPAEpiCs and the serum of septic ALI patients in comparison with controls. CircSLCO3A1 knockdown assuaged LPS-induced HPAEpiC inflammation and apoptosis. Besides, circSLCO3A1 targeted miR-424-5p and regulated LPS-triggered HPAEpiC inflammation and apoptosis by binding to miR-424-5p. Under the treatment of LPS, miR-424-5p mediated HPAEpiC disorders by targeting HMGB3. Importantly, circSLCO3A1 modulated HMGB3 production by interacting with miR-424-5p.</p><p><strong>Conclusion: </strong>CircSLCO3A1 absence assuaged LPS-induced HPAEpiC inflammation and apoptosis through the miR-424-5p/HMGB3 axis.</p><p><strong>Highlights: </strong>CircSLCO3A1 expression was upregulated in LPS-induced HPAEpiCs and sepsis-induced ALI patients.CircSLCO3A1 depletion protected against LPS-induced HPAEpiC disorders.CircSLCO3A1 bound to miR-424-5p in HPAEpiCs.MiR-424-5p targeted HMGB3 in HPAEpiCs.CircSLCO3A1 regulated HMGB3 expression through miR-424-5p.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s13273-023-00341-6.</p>","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10211294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10091312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CircKLHL2 mitigates septic lung injury via circKLHL2-miR-338-3p-ATF6 ceRNA pathway","authors":"Chunmei Zhang, Ruoran Wu, Zhongyan Zhao","doi":"10.1007/s13273-023-00349-y","DOIUrl":"https://doi.org/10.1007/s13273-023-00349-y","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"1 1","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43031846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature ovarian insufficiency associated with environmental chemical exposure among Korean women: a study based on the Korean National Environmental Health Survey (2009–2012)","authors":"YunJeong Kim, Eunha Oh, Min-kyung Shin, D. Nam, So-Young Jeon, J. Yu, J. Song, Dohsik Minn, Eunil Lee","doi":"10.1007/s13273-023-00358-x","DOIUrl":"https://doi.org/10.1007/s13273-023-00358-x","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"1 1","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2023-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46252746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose-rate gamma radiation aggravates titanium dioxide nanoparticle-induced lung injury in mice","authors":"Sohi Kang, Hae-June Lee, Y. Son, M. Bae, W. Jo, J. Park, Sohee Jeong, Changjong Moon, I. Shin, C. Lee, J. Kim","doi":"10.1007/s13273-023-00353-2","DOIUrl":"https://doi.org/10.1007/s13273-023-00353-2","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2023-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44807748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FGD5-AS1 promotes growth and mobility of trophoblast cells by regulating IGF2 via sponging miR-16-5p in pre-eclampsia","authors":"Limei Quan, Yan Jin, Jianfang Wang, Xiwang Dai, Shuli Zhu, Zengwei Sheng","doi":"10.1007/s13273-023-00357-y","DOIUrl":"https://doi.org/10.1007/s13273-023-00357-y","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42039999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced cellular process and developmental process genotoxicity of polystyrene nanoplastics in zebrafish embryogenesis using Aurelia aurita proteins","authors":"In Hae Park, Sun Woo Geum, Min-Kyeong Yeo","doi":"10.1007/s13273-023-00356-z","DOIUrl":"https://doi.org/10.1007/s13273-023-00356-z","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":"1 1","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44439843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of Plantago asiatica L. water extract on lipid metabolism in a high-fat diet-induced obese C57BL/6 mice","authors":"M. Jung, Soyoung Kim, Yujin Kim, Mi Ryeo Kim","doi":"10.1007/s13273-023-00355-0","DOIUrl":"https://doi.org/10.1007/s13273-023-00355-0","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47374303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCSK9 regulates myocardial ischemia–reperfusion injury through parkin/pink1-mediated autophagy pathway","authors":"Guan-fen Huang, Hailong Bao, Peng-fei Zhan, Xiyang Lu, Zonggang Duan, Xinlin Xiong, Muzhi Lin, Bing Wang, Hongxin An, Luanda Xiahou, Haiyan Zhou, Zhenhua Luo, Wei Li","doi":"10.1007/s13273-023-00352-3","DOIUrl":"https://doi.org/10.1007/s13273-023-00352-3","url":null,"abstract":"","PeriodicalId":18683,"journal":{"name":"Molecular & Cellular Toxicology","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2023-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44926622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}