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Abstract 2506:Smarca4inactivation promotes lineage-specific transformation and early metastatic features in the lung 摘要:smarca4失活促进肺部谱系特异性转化和早期转移特征
Molecular and Cellular Biology / Genetics
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2506
Carla P. Concepcion, Sai Ma, Lindsay M. LaFave, A. Bhutkar, Manyuan Liu, L. DeAngelo, Jonathan Y. Kim, Isabella Del Priore, A. Schoenfeld, Vinay K. Kartha, Peter M. K. Westcott, Francisco J. Sánchez-Rivera, Kevin Meli, Manav Gupta, Gregory Riely, N. Rekhtman, C. Rudin, Carla F. Kim, A. Regev, Jason D. Buenrostro, T. Jacks
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引用次数: 0
Abstract 2183: Genomic profiling of small bowl adenocarcinoma reveals targetable mutations in multiple signaling pathways 2183:小碗腺癌的基因组分析揭示了多种信号通路中的靶向突变
Molecular and Cellular Biology / Genetics
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2183
Rong Liu, Xiaomo Li, Zhi-ming Zhao, T. Ma, Fei Wang, Si Liu
{"title":"Abstract 2183: Genomic profiling of small bowl adenocarcinoma reveals targetable mutations in multiple signaling pathways","authors":"Rong Liu, Xiaomo Li, Zhi-ming Zhao, T. Ma, Fei Wang, Si Liu","doi":"10.1158/1538-7445.AM2021-2183","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2183","url":null,"abstract":"","PeriodicalId":18754,"journal":{"name":"Molecular and Cellular Biology / Genetics","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80264980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2131: m6A demethylase ALKBH5 promote tumor growth through IGF2BPs' recognition of m6A modified CDKN1A in non-small lung cancer 摘要:在非小细胞肺癌中，m6A去甲基化酶ALKBH5通过igf2bp对m6A修饰CDKN1A的识别促进肿瘤生长
Molecular and Cellular Biology / Genetics
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2131
Kazuo Tsuchiya, Katsuhiro Yoshimura, Y. Inoue, Yuji Iwashita, T. Ohta, Hidetaka Yamada, Hirofumi Watanabe, H. Tao, A. Kawase, M. Tanahashi, H. Ogawa, K. Funai, K. Shinmura, T. Suda, H. Sugimura
{"title":"Abstract 2131: m6A demethylase ALKBH5 promote tumor growth through IGF2BPs' recognition of m6A modified CDKN1A in non-small lung cancer","authors":"Kazuo Tsuchiya, Katsuhiro Yoshimura, Y. Inoue, Yuji Iwashita, T. Ohta, Hidetaka Yamada, Hirofumi Watanabe, H. Tao, A. Kawase, M. Tanahashi, H. Ogawa, K. Funai, K. Shinmura, T. Suda, H. Sugimura","doi":"10.1158/1538-7445.AM2021-2131","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2131","url":null,"abstract":"","PeriodicalId":18754,"journal":{"name":"Molecular and Cellular Biology / Genetics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79007658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2288: Identification of gene fusions in soft tissue sarcoma improved by integrative DNA and RNA sequencing 2288: DNA和RNA整合测序技术改进了软组织肉瘤基因融合体的鉴定
Molecular and Cellular Biology / Genetics
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2288
Jiayong Liu, Shu Li, Tian Gao, Chunyang Wang, Qifan He, Xiaojuan Wang, T. Ma
{"title":"Abstract 2288: Identification of gene fusions in soft tissue sarcoma improved by integrative DNA and RNA sequencing","authors":"Jiayong Liu, Shu Li, Tian Gao, Chunyang Wang, Qifan He, Xiaojuan Wang, T. Ma","doi":"10.1158/1538-7445.AM2021-2288","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2288","url":null,"abstract":"","PeriodicalId":18754,"journal":{"name":"Molecular and Cellular Biology / Genetics","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79452298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2019: Drug repositioning to induce the synthetic lethality in cancer cells with GSH-depleting therapy 2019: gsh消耗疗法诱导肿瘤细胞合成致死的药物重新定位
Molecular and Cellular Biology / Genetics
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2019
Yuji Otsuki, O. Nagano, H. Saya
{"title":"Abstract 2019: Drug repositioning to induce the synthetic lethality in cancer cells with GSH-depleting therapy","authors":"Yuji Otsuki, O. Nagano, H. Saya","doi":"10.1158/1538-7445.AM2021-2019","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2019","url":null,"abstract":"","PeriodicalId":18754,"journal":{"name":"Molecular and Cellular Biology / Genetics","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81893265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2191: Clear cell renal cell carcinoma molecular differences between Hispanic Americans and European Americans 摘要2191:西班牙裔美国人和欧洲裔美国人肾透明细胞癌分子差异
Molecular and Cellular Biology / Genetics
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2191
Yuliang Chen, Karleen M. Meiklejohn, N. Ellis, E. Bracamonte, Benjamin R. Lee, Ken Batai
{"title":"Abstract 2191: Clear cell renal cell carcinoma molecular differences between Hispanic Americans and European Americans","authors":"Yuliang Chen, Karleen M. Meiklejohn, N. Ellis, E. Bracamonte, Benjamin R. Lee, Ken Batai","doi":"10.1158/1538-7445.AM2021-2191","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2191","url":null,"abstract":"","PeriodicalId":18754,"journal":{"name":"Molecular and Cellular Biology / Genetics","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84406468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2502: Co-existing P53 and ARID1A mutations promote metastatic endometrial tumorigenesis 共存的P53和ARID1A突变促进转移性子宫内膜肿瘤的发生
Molecular and Cellular Biology / Genetics
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2502
Jake J. Reske, M. Wilson, Jeanne Holladay, J. Risinger, R. Chandler
{"title":"Abstract 2502: Co-existing P53 and ARID1A mutations promote metastatic endometrial tumorigenesis","authors":"Jake J. Reske, M. Wilson, Jeanne Holladay, J. Risinger, R. Chandler","doi":"10.1158/1538-7445.AM2021-2502","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2502","url":null,"abstract":"","PeriodicalId":18754,"journal":{"name":"Molecular and Cellular Biology / Genetics","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84870329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2061: Investigation ofPALB2mutation & correlation with immunotherapy biomarker in Chinese non-small cell lung cancer patients 2061:中国非小细胞肺癌患者palb2基因突变及其与免疫治疗生物标志物的相关性研究
Molecular and Cellular Biology / Genetics
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2061
Xiangyang Cheng, Yating Zheng, W. Xie, Mengli Huang
{"title":"Abstract 2061: Investigation ofPALB2mutation & correlation with immunotherapy biomarker in Chinese non-small cell lung cancer patients","authors":"Xiangyang Cheng, Yating Zheng, W. Xie, Mengli Huang","doi":"10.1158/1538-7445.AM2021-2061","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2061","url":null,"abstract":"","PeriodicalId":18754,"journal":{"name":"Molecular and Cellular Biology / Genetics","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84924376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract 2230: Integrative genomic analysis of refractory metastatic cancer 摘要2230:难治性转移癌的整合基因组分析
Molecular and Cellular Biology / Genetics
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-2230
J. Viot, Yoann Pradat, Ismael Padioleau, A. Yurchenko, Loic Verlingues, R. Clodion, S. Michiels, M. Deloger, Gerome Jules-Clement, Y. Loriot, B. Besse, F. André, Paul-Henry Cournedes, D. Gautheret, S. Nikolaev
{"title":"Abstract 2230: Integrative genomic analysis of refractory metastatic cancer","authors":"J. Viot, Yoann Pradat, Ismael Padioleau, A. Yurchenko, Loic Verlingues, R. Clodion, S. Michiels, M. Deloger, Gerome Jules-Clement, Y. Loriot, B. Besse, F. André, Paul-Henry Cournedes, D. Gautheret, S. Nikolaev","doi":"10.1158/1538-7445.AM2021-2230","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-2230","url":null,"abstract":"","PeriodicalId":18754,"journal":{"name":"Molecular and Cellular Biology / Genetics","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85376537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract LB185: BBX and PLK1 feedback mechanisms regulate mitotic entry & exit 摘要:LB185: BBX和PLK1反馈机制调节有丝分裂的进入和退出
Molecular and Cellular Biology / Genetics
Pub Date : 2021-07-01 DOI: 10.1158/1538-7445.AM2021-LB185
Gaiyun Li, M. Gillison
{"title":"Abstract LB185: BBX and PLK1 feedback mechanisms regulate mitotic entry & exit","authors":"Gaiyun Li, M. Gillison","doi":"10.1158/1538-7445.AM2021-LB185","DOIUrl":"https://doi.org/10.1158/1538-7445.AM2021-LB185","url":null,"abstract":"","PeriodicalId":18754,"journal":{"name":"Molecular and Cellular Biology / Genetics","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80930252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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