Pub Date : 2012-07-20DOI: 10.6084/M9.FIGSHARE.93088.V1
S. Jason, A. Heather, Brewer Michelle, Pickel Jim, Grigereit Laura
The function of adult neurogenesis remains unclear. While many tools for manipulating neurogenesis have been developed for mice, there are fewer tools for rats. Radiological and chemical strategies have been used to inhibit adult neurogenesis in rats but these methods may also have undesired side effects. Since rats have a larger brain and can perform complex behaviors, it would be useful to have additional rat models for studying neurogenesis. To address this gap we therefore developed a transgenic GFAP-TK rat in which adult neurogenesis can be specifically inhibited. Preliminary results suggest that, as in mice, reduced adult neurogenesis leads to anhedonia.
{"title":"A transgenic rat model for reducing adult neurogenesis","authors":"S. Jason, A. Heather, Brewer Michelle, Pickel Jim, Grigereit Laura","doi":"10.6084/M9.FIGSHARE.93088.V1","DOIUrl":"https://doi.org/10.6084/M9.FIGSHARE.93088.V1","url":null,"abstract":"The function of adult neurogenesis remains unclear. While many tools for manipulating neurogenesis have been developed for mice, there are fewer tools for rats. Radiological and chemical strategies have been used to inhibit adult neurogenesis in rats but these methods may also have undesired side effects. Since rats have a larger brain and can perform complex behaviors, it would be useful to have additional rat models for studying neurogenesis. To address this gap we therefore developed a transgenic GFAP-TK rat in which adult neurogenesis can be specifically inhibited. Preliminary results suggest that, as in mice, reduced adult neurogenesis leads to anhedonia.","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"29 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86849809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-04-04DOI: 10.1038/NPRE.2012.7149.1
Yan Liu
{"title":"Electron Transfer Pathways in Cell","authors":"Yan Liu","doi":"10.1038/NPRE.2012.7149.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7149.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"1 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85916784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-04-04DOI: 10.1038/NPRE.2012.7147.1
P. Singh, Pratyoosh Shukla
{"title":"A prelude report on molecular docking of HER2 protein towards comprehending anti-cancer properties of saponins from Solanum tuberosum","authors":"P. Singh, Pratyoosh Shukla","doi":"10.1038/NPRE.2012.7147.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7147.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"44 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87516063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-04-04DOI: 10.1038/NPRE.2012.7152.1
Samuel D. Dolzani, D. Cooper
{"title":"A novel apparatus/protocol designed for optogenetic manipulation and recording of individual neurons during a motivation and working memory task in the rodent","authors":"Samuel D. Dolzani, D. Cooper","doi":"10.1038/NPRE.2012.7152.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7152.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80598157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-04-04DOI: 10.1038/NPRE.2012.7153.1
D. Cooper, Melissa A. Fowler, Andrew L. Varnell, A. Dietrich, L. Birnbaumer
{"title":"Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine","authors":"D. Cooper, Melissa A. Fowler, Andrew L. Varnell, A. Dietrich, L. Birnbaumer","doi":"10.1038/NPRE.2012.7153.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7153.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82761898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-04-04DOI: 10.1038/NPRE.2012.7151.1
D. Cooper
{"title":"A call for disruptive innovation in science publishing with a new open data-sharing platform for the life sciences","authors":"D. Cooper","doi":"10.1038/NPRE.2012.7151.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7151.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"8 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80093700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-04-03DOI: 10.1038/NPRE.2012.7145.1
R. Kalathur, Kamesh R. Ayasolla, M. Futschik
{"title":"The Unfolded Protein Response and its potential role in Huntington's disease","authors":"R. Kalathur, Kamesh R. Ayasolla, M. Futschik","doi":"10.1038/NPRE.2012.7145.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7145.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"40 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75251450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-04-03DOI: 10.1038/NPRE.2012.7108.1
V. Kalmykov
{"title":"Generalized Theory of Life","authors":"V. Kalmykov","doi":"10.1038/NPRE.2012.7108.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7108.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"42 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86509353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-04-03DOI: 10.1038/NPRE.2012.7136.1
D. González, S. Giannerini, R. Rosa
{"title":"On the origin of the mitochondrial genetic code: Towards a unified mathematical framework for the management of genetic information","authors":"D. González, S. Giannerini, R. Rosa","doi":"10.1038/NPRE.2012.7136.1","DOIUrl":"https://doi.org/10.1038/NPRE.2012.7136.1","url":null,"abstract":"","PeriodicalId":18801,"journal":{"name":"Nature Precedings","volume":"17 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2012-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81742015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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