Pub Date : 2025-11-17DOI: 10.1038/s41589-025-02088-8
Gene Chong
{"title":"Putting two and two together","authors":"Gene Chong","doi":"10.1038/s41589-025-02088-8","DOIUrl":"10.1038/s41589-025-02088-8","url":null,"abstract":"","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":"21 12","pages":"1831-1831"},"PeriodicalIF":13.7,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1038/s41589-025-02089-7
Yiyun Song
{"title":"It is the host Z-RNA at play","authors":"Yiyun Song","doi":"10.1038/s41589-025-02089-7","DOIUrl":"10.1038/s41589-025-02089-7","url":null,"abstract":"","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":"21 12","pages":"1831-1831"},"PeriodicalIF":13.7,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1038/s41589-025-02074-0
Zhengwei Liu, Yizhou Dong
mRNA has emerged as an important class of therapeutic molecules. Now, an artificial intelligence (AI)-driven framework, which can design mRNA sequences with enhanced stability and translational efficiency, has been reported. This method for designing mRNA sequences is known as ‘generative models for RNA’ (GEMORNA) and could help to design more effective mRNA-based treatments.
{"title":"AI-powered design accelerates the development of mRNA therapeutics","authors":"Zhengwei Liu, Yizhou Dong","doi":"10.1038/s41589-025-02074-0","DOIUrl":"10.1038/s41589-025-02074-0","url":null,"abstract":"mRNA has emerged as an important class of therapeutic molecules. Now, an artificial intelligence (AI)-driven framework, which can design mRNA sequences with enhanced stability and translational efficiency, has been reported. This method for designing mRNA sequences is known as ‘generative models for RNA’ (GEMORNA) and could help to design more effective mRNA-based treatments.","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":"22 1","pages":"15-16"},"PeriodicalIF":13.7,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145509110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1038/s41589-025-02071-3
Rosanne Schmachtenberg, Wilfried Weber
The construction and assembly of information-processing biomaterials are limited by the need for laborious assembly of various circuits. A new framework to assemble protein-based elements encoding complex Boolean operations enables user-defined release of biomolecules from these materials.
{"title":"Self-assembling information-processing biomaterial circuits","authors":"Rosanne Schmachtenberg, Wilfried Weber","doi":"10.1038/s41589-025-02071-3","DOIUrl":"10.1038/s41589-025-02071-3","url":null,"abstract":"The construction and assembly of information-processing biomaterials are limited by the need for laborious assembly of various circuits. A new framework to assemble protein-based elements encoding complex Boolean operations enables user-defined release of biomolecules from these materials.","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":"21 12","pages":"1839-1841"},"PeriodicalIF":13.7,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145509026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1038/s41589-025-02094-w
Tristan Yoder, Elizabeth A. Mills, Wan-Lin Lo
{"title":"Publisher Correction: Intrinsically disordered domains expand the CAR T cell toolbox","authors":"Tristan Yoder, Elizabeth A. Mills, Wan-Lin Lo","doi":"10.1038/s41589-025-02094-w","DOIUrl":"https://doi.org/10.1038/s41589-025-02094-w","url":null,"abstract":"","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":"22 1","pages":""},"PeriodicalIF":14.8,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145515827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1038/s41589-025-02056-2
Baiyun Wang, Ning Zheng
{"title":"Degrons and degradation signals beyond short linear motifs","authors":"Baiyun Wang, Ning Zheng","doi":"10.1038/s41589-025-02056-2","DOIUrl":"https://doi.org/10.1038/s41589-025-02056-2","url":null,"abstract":"","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":"90 1","pages":""},"PeriodicalIF":14.8,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145509027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1038/s41589-025-02070-4
Lucía Payá Tormo, Tu-Quynh Nguyen, Cameron Fyfe, Hind Basbous, Katarzyna Dobrzyńska, Carlos Echavarri-Erasun, Lydie Martin, Giorgio Caserta, Pierre Legrand, Andrea Thorn, Patricia Amara, Guy Schoehn, Mickaël V. Cherrier, Luis M. Rubio, Yvain Nicolet
{"title":"Dynamics driving the precursor in NifEN scaffold during nitrogenase FeMo-cofactor assembly","authors":"Lucía Payá Tormo, Tu-Quynh Nguyen, Cameron Fyfe, Hind Basbous, Katarzyna Dobrzyńska, Carlos Echavarri-Erasun, Lydie Martin, Giorgio Caserta, Pierre Legrand, Andrea Thorn, Patricia Amara, Guy Schoehn, Mickaël V. Cherrier, Luis M. Rubio, Yvain Nicolet","doi":"10.1038/s41589-025-02070-4","DOIUrl":"https://doi.org/10.1038/s41589-025-02070-4","url":null,"abstract":"","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":"171 1","pages":""},"PeriodicalIF":14.8,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145509028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1038/s41589-025-02066-0
Maria Dell, Masato Kogawa, Alena B. Streiff, Taro Shiraishi, Alessandro Lotti, Christoph M. Meier, Michelle A. Schorn, Christopher Field, Jackson K. B. Cahn, Hiromi Yokoyama, Yuito Yamada, Eike Peters, Yoko Egami, Yu Nakashima, Karen Co Tan, Christian Rückert, Mohammad Alanjary, Jörn Kalinowski, Tomohisa Kuzuyama, Paco Cardenas, Shirley Pomponi, Detmer Sipkema, Amy Wright, Kentaro Takada, Ikuro Abe, Toshiyuki Wakimoto, Haruko Takeyama, Jörn Piel
Marine sponges are the source of numerous bioactive natural products that serve as chemical defenses and provide pharmaceutical leads for drug development. For some of the compounds, symbiotic bacteria have been established as the actual producers. Among the known sponge symbionts, ‘ Candidatus Entotheonella’ members stand out because of their abundant and variable biosynthetic gene clusters (BGCs). Here, to obtain broader insights into this producer taxon, we conduct a comparative analysis on eight sponges through metagenomic and single-bacterial sequencing and biochemical studies. The data suggest sets of biosynthetic genes that are largely unique in 14 ‘Entotheonella’ candidate species and a member of a sister lineage named ‘ Candidatus Proxinella’. Four biosynthetic loci were linked in silico or experimentally to cytotoxins, antibiotics and the terpene cembrene A from corals. The results support widespread and diverse bacterial roles in the chemistry of sponges and aid the development of sustainable production methods for sponge-derived therapeutics.
{"title":"Chemical richness and diversity of uncultivated ‘Entotheonella’ symbionts in marine sponges","authors":"Maria Dell, Masato Kogawa, Alena B. Streiff, Taro Shiraishi, Alessandro Lotti, Christoph M. Meier, Michelle A. Schorn, Christopher Field, Jackson K. B. Cahn, Hiromi Yokoyama, Yuito Yamada, Eike Peters, Yoko Egami, Yu Nakashima, Karen Co Tan, Christian Rückert, Mohammad Alanjary, Jörn Kalinowski, Tomohisa Kuzuyama, Paco Cardenas, Shirley Pomponi, Detmer Sipkema, Amy Wright, Kentaro Takada, Ikuro Abe, Toshiyuki Wakimoto, Haruko Takeyama, Jörn Piel","doi":"10.1038/s41589-025-02066-0","DOIUrl":"https://doi.org/10.1038/s41589-025-02066-0","url":null,"abstract":"Marine sponges are the source of numerous bioactive natural products that serve as chemical defenses and provide pharmaceutical leads for drug development. For some of the compounds, symbiotic bacteria have been established as the actual producers. Among the known sponge symbionts, ‘ <jats:italic>Candidatus</jats:italic> Entotheonella’ members stand out because of their abundant and variable biosynthetic gene clusters (BGCs). Here, to obtain broader insights into this producer taxon, we conduct a comparative analysis on eight sponges through metagenomic and single-bacterial sequencing and biochemical studies. The data suggest sets of biosynthetic genes that are largely unique in 14 ‘Entotheonella’ candidate species and a member of a sister lineage named ‘ <jats:italic>Candidatus</jats:italic> Proxinella’. Four biosynthetic loci were linked in silico or experimentally to cytotoxins, antibiotics and the terpene cembrene A from corals. The results support widespread and diverse bacterial roles in the chemistry of sponges and aid the development of sustainable production methods for sponge-derived therapeutics.","PeriodicalId":18832,"journal":{"name":"Nature chemical biology","volume":"13 1","pages":""},"PeriodicalIF":14.8,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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