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[End-of-life decision-making in patients with a ventricular assist device]. [使用心室辅助装置患者的临终决策]。
Q4 Medicine Pub Date : 2025-10-22
Sophie L Gerritse, Maaike van der Graaf, Jasper J Brugts, Olivier C Manintveld, C D van der Rijt, Eric C T Geijteman

In the Netherlands, approximately 240,000 patients suffer from chronic heart failure, and the incidence is expected to rise in the coming decades. A Left Ventricular Assist Device (LVAD), either temporary or permanent, is increasingly used to treat patients with advanced and end-stage chronic heart failure, with a five-year survival rate exceeding 50%. Healthcare providers in both primary and secondary care will encounter LVAD patients more frequently. Terminal care for LVAD patients requires a specialized approach, with proactive care planning being crucial.

在荷兰,大约有24万名患者患有慢性心力衰竭,预计未来几十年发病率还会上升。左心室辅助装置(LVAD),无论是临时的还是永久性的,越来越多地用于治疗晚期和终末期慢性心力衰竭患者,其5年生存率超过50%。初级和二级医疗保健提供者会更频繁地遇到LVAD患者。LVAD患者的临终护理需要专门的方法,积极的护理计划是至关重要的。
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引用次数: 0
[Catheter-related issues in primary health care]. [初级保健中与导管有关的问题]。
Q4 Medicine Pub Date : 2025-10-21
Laurie den Braber, Frank M J Martens, Paul W Veenboer

Urinary catheters are often used in primary health care, nursing facilities and in palliative care. Although often effective, the use of these catheters does come with certain risks and complications. In this paper we will answer 10 questions about catheter use in primary health care, with special attention for indications and treatment/prevention of complications.

导尿管常用于初级卫生保健、护理设施和姑息治疗。虽然通常有效,但使用这些导管也有一定的风险和并发症。在本文中,我们将回答关于导管在初级卫生保健中使用的10个问题,特别关注适应症和并发症的治疗/预防。
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引用次数: 0
[Ultra-low-dose CT versus chest X-ray in the emergency department: what are the differences in the (cost)effectiveness?] 急诊科超低剂量CT与胸部x线:在(成本)效益上有何差异?]
Q4 Medicine Pub Date : 2025-10-16
Maadrika M N P Kanglie, Inge A H van den Berk, Tjitske S R van Engelen

Objective: The enhanced diagnostic accuracy of ultra-low-dose chest CT (ULDCT) compared to chest X-ray (CXR) at a comparable radiation dose, makes ULDCT an appealing alternative at the emergency department (ED). Design We assessed the impact on health outcomes of replacing CXR with ULDCT in patients with suspected non-traumatic pulmonary disease at the ED. Results ULDCT is non-inferior in short-term functional health with minimal differences in hospital admissions, length of stay, mortality, and economic impact compared to CXR. There were more incidental findings, but less additional imaging procedures after 28 days with ULDCT. Pneumonia was more often correctly diagnosed with ULDCT. In patients with an atypical presentation of pneumonia ULDCT performed better than CXR. Conclusion The results of our trial do not support the unconditional use of ULDCT in the work-up of patients presenting with non-traumatic pulmonary disease at the ED. It is recommended to consider the use of ULDCT instead of CXR in vulnerable patients.

目的:超低剂量胸部CT (ULDCT)与同等放射剂量的胸部x线(CXR)相比,诊断准确性更高,使ULDCT成为急诊科(ED)的一种有吸引力的替代选择。我们评估了在急诊科疑似非创伤性肺病患者用ULDCT替代CXR对健康结果的影响。结果与CXR相比,ULDCT在短期功能健康方面不差,入院率、住院时间、死亡率和经济影响方面差异极小。使用ULDCT 28天后,有更多的偶然发现,但更少的额外影像学检查。ULDCT对肺炎的诊断准确率更高。在非典型肺炎患者中,ULDCT的表现优于CXR。结论本试验结果不支持在急诊科非创伤性肺部疾病患者的体检中无条件使用ULDCT,建议在易感患者中考虑使用ULDCT而不是CXR。
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引用次数: 0
[A mallet finger, and then?] [一个槌状手指,然后呢?]
Q4 Medicine Pub Date : 2025-10-14
Patrick Krastman, Mark de Vries, Jos Runhaar, Gerald Kraan

Mallet finger (hammer finger) predominantly results from trauma causing injury to the terminal extensor tendon at the level of the distal phalanx. It remains unclear whether radiography provides additional value in all patients with a mallet finger, which warrants further investigation. We recommend obtaining radiographs in primary care only for mallet fingers resulting from high-energy trauma. The purpose of radiography should not be to distinguish between tendinous and bony mallet fingers, but rather to assess whether surgical intervention may be indicated.

锤状指(锤状指)主要是由于创伤导致远端指骨水平的末段伸肌腱损伤。目前尚不清楚放射检查是否对所有槌状指患者都有额外的价值,这需要进一步的研究。我们建议在初级保健中仅对高能外伤造成的锤状指进行x线检查。x线摄影的目的不应该是区分腱状和骨性锤状指,而是评估是否需要手术干预。
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引用次数: 0
[Music on prescription]. [处方上的音乐]。
Q4 Medicine Pub Date : 2025-10-09
Antonia S Becker, Emy S vanderValkBouman, Hans J Jeekel, Markus Klimek

Listening to recorded music can alleviate pain, anxiety, and stress in different healthcare settings. However, it is not standardly offered to patients in clinical practice. This article discusses two patient cases in the Netherlands, providing examples with a focus on practical, social and individual factors. Previous research suggests that there is no universal music suitable for all patients in every situation, but that self-selected and/or preferred music yields the best results for pain management. Looking at individual perceptions, patients face various barriers to listening to (self-selected) music in clinical practice, such as not considering the option and social sensitivity within healthcare contexts. A proactive approach by healthcare professionals and autonomy of patients are essential to overcome these barriers. Practical advice is provided for integrating music into clinical practice, while considering patient perspectives.

在不同的医疗环境中,听录制的音乐可以减轻疼痛、焦虑和压力。然而,在临床实践中,它并没有被标准地提供给患者。本文讨论了在荷兰的两个病人的情况下,提供的例子,重点放在实际,社会和个人因素。先前的研究表明,没有一种通用的音乐适合所有病人的每一种情况,但自我选择和/或首选的音乐对疼痛管理产生了最好的效果。从个人的观点来看,在临床实践中,患者在听(自我选择)音乐时面临各种障碍,例如不考虑医疗保健背景下的选择和社会敏感性。医疗保健专业人员采取积极主动的方法和患者的自主是克服这些障碍的关键。在考虑患者观点的同时,提供了将音乐融入临床实践的实用建议。
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引用次数: 0
[A woman with a lytic bone lesion]. [有溶解性骨损伤的妇女]。
Q4 Medicine Pub Date : 2025-10-08
Hannah van Buggenum, Charlotte van Noord, Yorick Sandberg

A pathologic wrist fracture in a 63-year-old woman was caused by a Brown tumor, which is a rare, benign and focal lytic bone lesion, caused by rapid osteoclastic activity and peritrabecular fibrosis due to primary hyperparathyroidism attributed to a parathyroid adenoma. After removal of the adenoma the Brown tumor decreased.

一位63岁女性的病理性手腕骨折是由棕色肿瘤引起的,这是一种罕见的、良性的局灶性溶解性骨病变,由甲状旁腺腺瘤引起的原发性甲状旁腺功能亢进引起的快速破骨细胞活动和小梁周围纤维化引起。切除腺瘤后,褐色肿瘤缩小。
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引用次数: 0
[Molecular biomarkers of biological age; how we can use them, now and in the future]. 生物年龄的分子生物标志物;我们现在和将来如何使用它们。
Q4 Medicine Pub Date : 2025-09-30
P Eline Slagboom, Joris Deelen, Simon P Mooijaart

Chronological age is the most important risk factor for many age-related diseases, but is of limited value in distinguishing the risks of a single individual. In particular, older adults of the same chronological age vary greatly in terms of overall health, presence of diseases, vulnerability, and functional capacity. The underlying (patho)physiological state of the body is a reflection of biological age and may therefore differ from chronological age. However, there is currently no widely accepted definition of biological age. Novel molecular biomarkers are able to capture (part of) the (patho)physiological state of an individual. These biomarkers are becoming increasingly affordable and scalable, but still require validation for their intended application, i.e. reflecting an individual's vulnerability and risk of disease. In this article, we discuss the current state of research into applications of molecular biomarkers and what these developments mean for preventive healthcare and decision-making and treatment of vulnerable older adults.

实足年龄是许多年龄相关疾病最重要的危险因素,但在区分单个个体的风险方面价值有限。特别是,相同实足年龄的老年人在总体健康、疾病、脆弱性和功能能力方面差异很大。身体的潜在(病理)生理状态是生物年龄的反映,因此可能不同于实足年龄。然而,目前还没有一个被广泛接受的生物年龄的定义。新的分子生物标志物能够捕捉(部分)个体的(病理)生理状态。这些生物标志物正变得越来越便宜和可扩展,但仍需要对其预期应用进行验证,即反映个体的脆弱性和疾病风险。在这篇文章中,我们讨论了分子生物标志物应用的研究现状,以及这些发展对脆弱老年人的预防保健、决策和治疗的意义。
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引用次数: 0
[A not-so-typical ankle sprain]. [不太典型的脚踝扭伤]。
Q4 Medicine Pub Date : 2025-09-29
Jari Dahmen, Liam D A Paget, Frank F Smithuis, Sjoerd A S Stufkens, Gino M M J Kerkhoffs, Ronald A W Verhagen

Background: An estimated hundreds of thousands of patients are treated in the Netherlands every year for an ankle sprain. We describe two cases where the course of an ankle sprain differed from the usual presentation.

Case presentation: Case 1: A 22-year-old male presented to the Emergency Department following an inversion sprain to the ankle. The pain and swelling were localized around the subtalar joint rather than the lateral ankle ligament(s), with limited range of motion in the subtalar joint. Imaging revealed a fracture through a tarsal coalition. The patient was treated with cast immobilization. Case 2: A 50-year-old male presented to the outpatient clinic with ankle pain after a previous ankle sprain. The symptoms involved pain and swelling around the talocrural joint with limited inversion and eversion. Imaging revealed a chronically fractured tarsal coalition. The patient was treated conservatively.

Conclusion: Not every ankle sprain resulting from an inversion injury is a typical lateral ankle sprain. Physicians should maintain clinical awareness for exceptional cases where a fractured tarsal coalition may mimic the symptoms of a lateral ankle sprain.

背景:据估计,荷兰每年有数十万患者因踝关节扭伤而接受治疗。我们描述了两个病例的过程中,脚踝扭伤不同于通常的介绍。病例介绍:病例1:一名22岁男性因踝关节内翻扭伤而被送往急诊室。疼痛和肿胀局限于距下关节周围,而不是外侧踝关节韧带,距下关节活动范围有限。影像学显示跗骨联合骨折。患者采用石膏固定治疗。病例2:一名50岁男性因踝关节扭伤后踝关节疼痛来到门诊。症状包括距胫关节周围疼痛和肿胀,内翻和外翻有限。影像学显示慢性跗骨联合骨折。病人接受保守治疗。结论:并非所有由内翻损伤引起的踝关节扭伤都是典型的外侧踝关节扭伤。医生应保持临床意识的特殊情况下,骨折的跗骨联盟可能模仿的症状外侧踝关节扭伤。
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引用次数: 0
[Sustainable use of IV bags: lessons from the IV bag crisis]. 静脉注射袋的可持续使用:静脉注射袋危机的教训。
Q4 Medicine Pub Date : 2025-09-25
Tom G Jacobs, Loes J M van Herpen-Meeuwissen, Patricia M L A van den Bemt, Nicole G M Hunfeld, Milly E Attema-de Jonge

Medication substantially contributes to global CO₂ emission of healthcare. IV bags and associated materials are an important source of pollution. During the IV bag crisis, caused by the closure of a factory in the US due to Hurricane Helena, emergency measures were implemented to reduce IV bag use. These measures addressed the acute problem and created an opportunity for more sustainable use of IV bags and medication. We discuss four measures to achieve sustainable reduction in usage of IV bags: (1) switching from intravenous to oral medication administration where possible, (2) optimizing intravenous administration through bolus injection or injection port, (3) extending the administration time of unmanipulated IV bags to a maximum of 7 days, and (4) reducing flow rates to 2 ml/h for maintenance of venous access. These measures reduce waste, CO₂ emissions, and costs without compromising patient safety. Environmental sustainability in healthcare requires ongoing awareness and multidisciplinary collaboration.

药物对全球医疗保健的二氧化碳排放有很大贡献。IV袋及其相关材料是一个重要的污染源。在静脉输液袋危机期间,由于飓风海伦娜导致美国一家工厂关闭,采取了紧急措施减少静脉输液袋的使用。这些措施解决了这一严重问题,并为更可持续地使用静脉输液袋和药物创造了机会。我们讨论了实现持续减少静脉输液袋使用的四项措施:(1)在可能的情况下从静脉注射转向口服给药;(2)通过丸状注射或注射口优化静脉给药;(3)将未经操作的静脉输液袋的给药时间延长至最多7天;(4)将流速降低至2ml /h以维持静脉通路。这些措施在不影响患者安全的情况下减少了浪费、二氧化碳排放和成本。医疗保健中的环境可持续性需要持续的意识和多学科合作。
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引用次数: 0
[Tuberculosis: from compulsory admission to compulsory treatment]. 【结核病:从强制入院到强制治疗】。
Q4 Medicine Pub Date : 2025-09-25

Tuberculosis is still considered to be a threat to public health in the Netherlands. The Dutch Public Health Act enables the mandatory isolation of contagious patients who are not willing to be treated. However, this act does not mean that patients can be treated against their will. Another act, the Dutch Medical Treatment Act, regulates the contract between doctor and patient. According to this act, only patients who are mentally incompetent can be treated against their will. We describe two patients with contagious tuberculosis who are mentally incompetent. This article explains the steps which, in accordance with both acts, must be followed before starting appropriate treatment.

在荷兰,结核病仍然被认为是对公共卫生的威胁。《荷兰公共卫生法》规定对不愿接受治疗的传染性病人进行强制隔离。然而,这一行为并不意味着病人可以违背自己的意愿接受治疗。另一项法案《荷兰医疗法》规定了医生和病人之间的合同。根据该法案,只有精神不健全的病人才可以接受违背其意愿的治疗。我们描述了两个精神不健全的传染性肺结核患者。本条解释了根据这两项法令在开始适当治疗之前必须遵循的步骤。
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引用次数: 0
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Nederlands tijdschrift voor geneeskunde
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