首页 > 最新文献

Nature Reviews Disease Primers最新文献

英文 中文
Author Correction: Oesophageal atresia. 作者更正:食道闭锁。
IF 81.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-22 DOI: 10.1038/s41572-024-00513-1
Marinde van Lennep, Maartje M J Singendonk, Luigi Dall'Oglio, Fréderic Gottrand, Usha Krishnan, Suzanne W J Terheggen-Lagro, Taher I Omari, Marc A Benninga, Michiel P van Wijk
{"title":"Author Correction: Oesophageal atresia.","authors":"Marinde van Lennep, Maartje M J Singendonk, Luigi Dall'Oglio, Fréderic Gottrand, Usha Krishnan, Suzanne W J Terheggen-Lagro, Taher I Omari, Marc A Benninga, Michiel P van Wijk","doi":"10.1038/s41572-024-00513-1","DOIUrl":"https://doi.org/10.1038/s41572-024-00513-1","url":null,"abstract":"","PeriodicalId":18910,"journal":{"name":"Nature Reviews Disease Primers","volume":"10 1","pages":"24"},"PeriodicalIF":81.5,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive candidiasis. 侵袭性念珠菌病
IF 81.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-21 DOI: 10.1038/s41572-024-00503-3
Cornelia Lass-Flörl, Souha S Kanj, Nelesh P Govender, George R Thompson, Luis Ostrosky-Zeichner, Miriam Alisa Govrins

Invasive candidiasis is an important fungal disease caused by Candida albicans and, increasingly, non-albicans Candida pathogens. Invasive Candida infections originate most frequently from endogenous human reservoirs and are triggered by impaired host defences. Signs and symptoms of invasive candidiasis are non-specific; candidaemia is the most diagnosed manifestation, with disseminated candidiasis affecting single or multiple organs. Diagnosis poses many challenges, and conventional culture techniques are frequently supplemented by non-culture-based assays. The attributable mortality from candidaemia and disseminated infections is ~30%. Fluconazole resistance is a concern for Nakaseomyces glabratus, Candida parapsilosis, and Candida auris and less so in Candida tropicalis infection; acquired echinocandin resistance remains uncommon. The epidemiology of invasive candidiasis varies in different geographical areas and within various patient populations. Risk factors include intensive care unit stay, central venous catheter use, broad-spectrum antibiotics use, abdominal surgery and immune suppression. Early antifungal treatment and central venous catheter removal form the cornerstones to decrease mortality. The landscape of novel therapeutics is growing; however, the application of new drugs requires careful selection of eligible patients as the spectrum of activity is limited to a few fungal species. Unanswered questions and knowledge gaps define future research priorities and a personalized approach to diagnosis and treatment of invasive candidiasis is of paramount importance.

侵袭性念珠菌病是由白色念珠菌以及越来越多的非白色念珠菌病原体引起的一种重要真菌疾病。侵袭性念珠菌感染最常见于人类内源性储库,由宿主防御功能受损引发。侵袭性念珠菌病的体征和症状无特异性;念珠菌血症是最常见的诊断表现,播散性念珠菌病会影响单个或多个器官。诊断面临许多挑战,传统的培养技术经常辅以非培养检测。念珠菌血症和播散性感染造成的死亡率约为 30%。氟康唑耐药性是光滑中色酵母菌、副荚膜念珠菌和无荚膜念珠菌感染的一个问题,热带念珠菌感染的耐药性则较少;获得性棘白菌素耐药性仍不常见。侵袭性念珠菌病的流行病学在不同的地理区域和不同的患者人群中各不相同。风险因素包括入住重症监护室、使用中心静脉导管、使用广谱抗生素、腹部手术和免疫抑制。早期抗真菌治疗和移除中心静脉导管是降低死亡率的基础。新型疗法的应用范围正在不断扩大;然而,由于新药的作用范围仅限于少数真菌种类,因此需要对符合条件的患者进行仔细筛选。悬而未决的问题和知识空白决定了未来研究的重点,而对侵袭性念珠菌病进行个性化诊断和治疗至关重要。
{"title":"Invasive candidiasis.","authors":"Cornelia Lass-Flörl, Souha S Kanj, Nelesh P Govender, George R Thompson, Luis Ostrosky-Zeichner, Miriam Alisa Govrins","doi":"10.1038/s41572-024-00503-3","DOIUrl":"10.1038/s41572-024-00503-3","url":null,"abstract":"<p><p>Invasive candidiasis is an important fungal disease caused by Candida albicans and, increasingly, non-albicans Candida pathogens. Invasive Candida infections originate most frequently from endogenous human reservoirs and are triggered by impaired host defences. Signs and symptoms of invasive candidiasis are non-specific; candidaemia is the most diagnosed manifestation, with disseminated candidiasis affecting single or multiple organs. Diagnosis poses many challenges, and conventional culture techniques are frequently supplemented by non-culture-based assays. The attributable mortality from candidaemia and disseminated infections is ~30%. Fluconazole resistance is a concern for Nakaseomyces glabratus, Candida parapsilosis, and Candida auris and less so in Candida tropicalis infection; acquired echinocandin resistance remains uncommon. The epidemiology of invasive candidiasis varies in different geographical areas and within various patient populations. Risk factors include intensive care unit stay, central venous catheter use, broad-spectrum antibiotics use, abdominal surgery and immune suppression. Early antifungal treatment and central venous catheter removal form the cornerstones to decrease mortality. The landscape of novel therapeutics is growing; however, the application of new drugs requires careful selection of eligible patients as the spectrum of activity is limited to a few fungal species. Unanswered questions and knowledge gaps define future research priorities and a personalized approach to diagnosis and treatment of invasive candidiasis is of paramount importance.</p>","PeriodicalId":18910,"journal":{"name":"Nature Reviews Disease Primers","volume":"10 1","pages":"20"},"PeriodicalIF":81.5,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive candidiasis. 侵袭性念珠菌病
IF 81.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-21 DOI: 10.1038/s41572-024-00510-4
{"title":"Invasive candidiasis.","authors":"","doi":"10.1038/s41572-024-00510-4","DOIUrl":"10.1038/s41572-024-00510-4","url":null,"abstract":"","PeriodicalId":18910,"journal":{"name":"Nature Reviews Disease Primers","volume":"10 1","pages":"21"},"PeriodicalIF":81.5,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140184991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal detachment. 视网膜脱落
IF 81.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-14 DOI: 10.1038/s41572-024-00501-5
Jonathan B Lin, Raja Narayanan, Elise Philippakis, Yoshihiro Yonekawa, Rajendra S Apte

Retinal detachment (RD) occurs when the neurosensory retina, the neurovascular tissue responsible for phototransduction, is separated from the underlying retinal pigment epithelium (RPE). Given the importance of the RPE for optimal retinal function, RD invariably leads to decreased vision. There are three main types of RD: rhegmatogenous, tractional and exudative (also termed serous) RD. In rhegmatogenous RD, one or more retinal breaks enable vitreous fluid to enter the subretinal space and separate the neurosensory retina from the RPE. In tractional RD, preretinal, intraretinal or subretinal membranes contract and exert tangential forces and elevate the retina from the underlying RPE. Finally, in exudative RD, an underlying inflammatory condition, vascular abnormality or the presence of a tumour causes exudative fluid to accumulate in the subretinal space, exceeding the osmotic pump function of the RPE. The surgical management of RD usually involves pars plana vitrectomy, scleral buckling or pneumatic retinopexy. The approach taken often depends on patient characteristics as well as on practitioner experience and clinical judgement. Advances in surgical technology and continued innovation have improved outcomes for many patients. However, even if retinal re-attachment is achieved, some patients still experience decreased vision or other visual symptoms, such as metamorphopsia, that diminish their quality of life. Continued research in the areas of neuroprotection and retinal biology as well as continued surgical innovation are necessary to enhance therapeutic options and outcomes for these patients.

当负责光传导的神经血管组织--神经感觉视网膜与底层视网膜色素上皮(RPE)分离时,就会发生视网膜脱离(RD)。鉴于视网膜色素上皮对视网膜最佳功能的重要性,RD 必然会导致视力下降。RD 主要有三种类型:流变性、牵引性和渗出性(也称浆液性)RD。在流变性 RD 中,一个或多个视网膜断裂使玻璃体液进入视网膜下间隙,将神经感觉视网膜与 RPE 分离。在牵引性 RD 中,视网膜前膜、视网膜内膜或视网膜下膜收缩并产生切向力,使视网膜从底层 RPE 上抬起。最后,在渗出性 RD 中,潜在的炎症状况、血管异常或肿瘤的存在导致渗出性液体积聚在视网膜下间隙,超过了 RPE 的渗透泵功能。RD 的手术治疗通常包括玻璃体旁切除术、巩膜扣锁术或气动视网膜整形术。采取哪种方法通常取决于患者的特征以及医生的经验和临床判断。手术技术的进步和不断创新改善了许多患者的治疗效果。然而,即使实现了视网膜再粘连,一些患者仍会出现视力下降或其他视觉症状,如偏盲,从而降低了他们的生活质量。有必要在神经保护和视网膜生物学领域继续开展研究,并不断进行手术创新,以提高这些患者的治疗选择和疗效。
{"title":"Retinal detachment.","authors":"Jonathan B Lin, Raja Narayanan, Elise Philippakis, Yoshihiro Yonekawa, Rajendra S Apte","doi":"10.1038/s41572-024-00501-5","DOIUrl":"10.1038/s41572-024-00501-5","url":null,"abstract":"<p><p>Retinal detachment (RD) occurs when the neurosensory retina, the neurovascular tissue responsible for phototransduction, is separated from the underlying retinal pigment epithelium (RPE). Given the importance of the RPE for optimal retinal function, RD invariably leads to decreased vision. There are three main types of RD: rhegmatogenous, tractional and exudative (also termed serous) RD. In rhegmatogenous RD, one or more retinal breaks enable vitreous fluid to enter the subretinal space and separate the neurosensory retina from the RPE. In tractional RD, preretinal, intraretinal or subretinal membranes contract and exert tangential forces and elevate the retina from the underlying RPE. Finally, in exudative RD, an underlying inflammatory condition, vascular abnormality or the presence of a tumour causes exudative fluid to accumulate in the subretinal space, exceeding the osmotic pump function of the RPE. The surgical management of RD usually involves pars plana vitrectomy, scleral buckling or pneumatic retinopexy. The approach taken often depends on patient characteristics as well as on practitioner experience and clinical judgement. Advances in surgical technology and continued innovation have improved outcomes for many patients. However, even if retinal re-attachment is achieved, some patients still experience decreased vision or other visual symptoms, such as metamorphopsia, that diminish their quality of life. Continued research in the areas of neuroprotection and retinal biology as well as continued surgical innovation are necessary to enhance therapeutic options and outcomes for these patients.</p>","PeriodicalId":18910,"journal":{"name":"Nature Reviews Disease Primers","volume":"10 1","pages":"18"},"PeriodicalIF":81.5,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal detachment. 视网膜脱落
IF 81.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-03-14 DOI: 10.1038/s41572-024-00509-x
{"title":"Retinal detachment.","authors":"","doi":"10.1038/s41572-024-00509-x","DOIUrl":"10.1038/s41572-024-00509-x","url":null,"abstract":"","PeriodicalId":18910,"journal":{"name":"Nature Reviews Disease Primers","volume":"10 1","pages":"19"},"PeriodicalIF":81.5,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140132128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare diseases: challenges and opportunities for research and public health. 罕见疾病:研究和公共卫生的挑战与机遇。
IF 81.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-02-29 DOI: 10.1038/s41572-024-00505-1
Domenica Taruscio, William A Gahl
{"title":"Rare diseases: challenges and opportunities for research and public health.","authors":"Domenica Taruscio, William A Gahl","doi":"10.1038/s41572-024-00505-1","DOIUrl":"10.1038/s41572-024-00505-1","url":null,"abstract":"","PeriodicalId":18910,"journal":{"name":"Nature Reviews Disease Primers","volume":"10 1","pages":"13"},"PeriodicalIF":81.5,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creutzfeldt-Jakob Disease and other prion diseases. 克雅氏病和其他朊病毒疾病。
IF 81.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-02-29 DOI: 10.1038/s41572-024-00506-0
{"title":"Creutzfeldt-Jakob Disease and other prion diseases.","authors":"","doi":"10.1038/s41572-024-00506-0","DOIUrl":"10.1038/s41572-024-00506-0","url":null,"abstract":"","PeriodicalId":18910,"journal":{"name":"Nature Reviews Disease Primers","volume":"10 1","pages":"15"},"PeriodicalIF":81.5,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creutzfeldt-Jakob disease and other prion diseases. 克雅氏病和其他朊病毒疾病。
IF 81.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-02-29 DOI: 10.1038/s41572-024-00497-y
Inga Zerr, Anna Ladogana, Simon Mead, Peter Hermann, Gianluigi Forloni, Brian S Appleby

Prion diseases share common clinical and pathological characteristics such as spongiform neuronal degeneration and deposition of an abnormal form of a host-derived protein, termed prion protein. The characteristic features of prion diseases are long incubation times, short clinical courses, extreme resistance of the transmissible agent to degradation and lack of nucleic acid involvement. Sporadic and genetic forms of prion diseases occur worldwide, of which genetic forms are associated with mutations in PRNP. Human to human transmission of these diseases has occurred due to iatrogenic exposure, and zoonotic forms of prion diseases are linked to bovine disease. Significant progress has been made in the diagnosis of these disorders. Clinical tools for diagnosis comprise brain imaging and cerebrospinal fluid tests. Aggregation assays for detection of the abnormally folded prion protein have a clear potential to diagnose the disease in peripherally accessible biofluids. After decades of therapeutic nihilism, new treatment strategies and clinical trials are on the horizon. Although prion diseases are relatively rare disorders, understanding their pathogenesis and mechanisms of prion protein misfolding has significantly enhanced the field in research of neurodegenerative diseases.

朊病毒疾病具有共同的临床和病理特征,如海绵状神经元变性和宿主衍生蛋白(称为朊病毒蛋白)的异常沉积。朊病毒病的特点是潜伏期长、临床病程短、传染性病原体极难被降解以及缺乏核酸参与。世界各地都有零星和遗传形式的朊病毒病,其中遗传形式的朊病毒病与 PRNP 的突变有关。这些疾病在人与人之间的传播是由先天性接触引起的,而人畜共患形式的朊病毒病则与牛病有关。这些疾病的诊断已取得重大进展。临床诊断工具包括脑成像和脑脊液检测。检测异常折叠的朊病毒蛋白的聚集检测法显然有可能诊断外周生物流体中的疾病。在经历了数十年的治疗虚无主义之后,新的治疗策略和临床试验即将问世。虽然朊病毒病是一种相对罕见的疾病,但对其发病机制和朊病毒蛋白错误折叠机制的了解极大地促进了神经退行性疾病研究领域的发展。
{"title":"Creutzfeldt-Jakob disease and other prion diseases.","authors":"Inga Zerr, Anna Ladogana, Simon Mead, Peter Hermann, Gianluigi Forloni, Brian S Appleby","doi":"10.1038/s41572-024-00497-y","DOIUrl":"10.1038/s41572-024-00497-y","url":null,"abstract":"<p><p>Prion diseases share common clinical and pathological characteristics such as spongiform neuronal degeneration and deposition of an abnormal form of a host-derived protein, termed prion protein. The characteristic features of prion diseases are long incubation times, short clinical courses, extreme resistance of the transmissible agent to degradation and lack of nucleic acid involvement. Sporadic and genetic forms of prion diseases occur worldwide, of which genetic forms are associated with mutations in PRNP. Human to human transmission of these diseases has occurred due to iatrogenic exposure, and zoonotic forms of prion diseases are linked to bovine disease. Significant progress has been made in the diagnosis of these disorders. Clinical tools for diagnosis comprise brain imaging and cerebrospinal fluid tests. Aggregation assays for detection of the abnormally folded prion protein have a clear potential to diagnose the disease in peripherally accessible biofluids. After decades of therapeutic nihilism, new treatment strategies and clinical trials are on the horizon. Although prion diseases are relatively rare disorders, understanding their pathogenesis and mechanisms of prion protein misfolding has significantly enhanced the field in research of neurodegenerative diseases.</p>","PeriodicalId":18910,"journal":{"name":"Nature Reviews Disease Primers","volume":"10 1","pages":"14"},"PeriodicalIF":81.5,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attention-deficit/hyperactivity disorder. 注意力缺陷/多动症。
IF 81.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-02-22 DOI: 10.1038/s41572-024-00495-0
Stephen V Faraone, Mark A Bellgrove, Isabell Brikell, Samuele Cortese, Catharina A Hartman, Chris Hollis, Jeffrey H Newcorn, Alexandra Philipsen, Guilherme V Polanczyk, Katya Rubia, Margaret H Sibley, Jan K Buitelaar

Attention-deficit/hyperactivity disorder (ADHD; also known as hyperkinetic disorder) is a common neurodevelopmental condition that affects children and adults worldwide. ADHD has a predominantly genetic aetiology that involves common and rare genetic variants. Some environmental correlates of the disorder have been discovered but causation has been difficult to establish. The heterogeneity of the condition is evident in the diverse presentation of symptoms and levels of impairment, the numerous co-occurring mental and physical conditions, the various domains of neurocognitive impairment, and extensive minor structural and functional brain differences. The diagnosis of ADHD is reliable and valid when evaluated with standard diagnostic criteria. Curative treatments for ADHD do not exist but evidence-based treatments substantially reduce symptoms and/or functional impairment. Medications are effective for core symptoms and are usually well tolerated. Some non-pharmacological treatments are valuable, especially for improving adaptive functioning. Clinical and neurobiological research is ongoing and could lead to the creation of personalized diagnostic and therapeutic approaches for this disorder.

注意力缺陷/多动障碍(ADHD,又称运动过动症)是一种常见的神经发育疾病,影响着全世界的儿童和成年人。多动症的病因主要是遗传,涉及常见和罕见的遗传变异。目前已发现该疾病与环境有关,但很难确定其因果关系。该病的异质性表现在症状表现和损害程度的多样性、多种并发的精神和身体疾病、不同领域的神经认知障碍以及广泛的轻微脑结构和功能差异。根据标准诊断标准进行评估,多动症的诊断是可靠和有效的。目前尚无根治多动症的方法,但循证治疗可大大减轻症状和/或功能障碍。药物治疗对主要症状有效,而且通常耐受性良好。一些非药物治疗方法也很有价值,尤其是在改善适应功能方面。临床和神经生物学研究正在进行中,这些研究可能会为这一疾病提供个性化的诊断和治疗方法。
{"title":"Attention-deficit/hyperactivity disorder.","authors":"Stephen V Faraone, Mark A Bellgrove, Isabell Brikell, Samuele Cortese, Catharina A Hartman, Chris Hollis, Jeffrey H Newcorn, Alexandra Philipsen, Guilherme V Polanczyk, Katya Rubia, Margaret H Sibley, Jan K Buitelaar","doi":"10.1038/s41572-024-00495-0","DOIUrl":"10.1038/s41572-024-00495-0","url":null,"abstract":"<p><p>Attention-deficit/hyperactivity disorder (ADHD; also known as hyperkinetic disorder) is a common neurodevelopmental condition that affects children and adults worldwide. ADHD has a predominantly genetic aetiology that involves common and rare genetic variants. Some environmental correlates of the disorder have been discovered but causation has been difficult to establish. The heterogeneity of the condition is evident in the diverse presentation of symptoms and levels of impairment, the numerous co-occurring mental and physical conditions, the various domains of neurocognitive impairment, and extensive minor structural and functional brain differences. The diagnosis of ADHD is reliable and valid when evaluated with standard diagnostic criteria. Curative treatments for ADHD do not exist but evidence-based treatments substantially reduce symptoms and/or functional impairment. Medications are effective for core symptoms and are usually well tolerated. Some non-pharmacological treatments are valuable, especially for improving adaptive functioning. Clinical and neurobiological research is ongoing and could lead to the creation of personalized diagnostic and therapeutic approaches for this disorder.</p>","PeriodicalId":18910,"journal":{"name":"Nature Reviews Disease Primers","volume":"10 1","pages":"11"},"PeriodicalIF":81.5,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139932043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Hepatocellular carcinoma. 作者更正:肝细胞癌。
IF 81.5 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-02-12 DOI: 10.1038/s41572-024-00500-6
Josep M Llovet, Robin Kate Kelley, Augusto Villanueva, Amit G Singal, Eli Pikarsky, Sasan Roayaie, Riccardo Lencioni, Kazuhiko Koike, Jessica Zucman-Rossi, Richard S Finn
{"title":"Author Correction: Hepatocellular carcinoma.","authors":"Josep M Llovet, Robin Kate Kelley, Augusto Villanueva, Amit G Singal, Eli Pikarsky, Sasan Roayaie, Riccardo Lencioni, Kazuhiko Koike, Jessica Zucman-Rossi, Richard S Finn","doi":"10.1038/s41572-024-00500-6","DOIUrl":"https://doi.org/10.1038/s41572-024-00500-6","url":null,"abstract":"","PeriodicalId":18910,"journal":{"name":"Nature Reviews Disease Primers","volume":"10 1","pages":"10"},"PeriodicalIF":81.5,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Nature Reviews Disease Primers
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1