Pub Date : 2025-12-01DOI: 10.1038/s41574-025-01214-9
Sun-Wei Guo
Whole-exome sequencing and single-cell technologies are providing unprecedented insights into adenomyosis, uncovering a complex phylogenetic relationship between eutopic and ectopic endometria and identifying prolactin signalling as a possible pathogenic factor. However, these advances contrast with the failure of a clinical trial for a DRD2 agonist, which underscores the formidable translational challenges.
{"title":"Cracking the enigma of adenomyosis: prospects and challenges","authors":"Sun-Wei Guo","doi":"10.1038/s41574-025-01214-9","DOIUrl":"10.1038/s41574-025-01214-9","url":null,"abstract":"Whole-exome sequencing and single-cell technologies are providing unprecedented insights into adenomyosis, uncovering a complex phylogenetic relationship between eutopic and ectopic endometria and identifying prolactin signalling as a possible pathogenic factor. However, these advances contrast with the failure of a clinical trial for a DRD2 agonist, which underscores the formidable translational challenges.","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"22 2","pages":"74-75"},"PeriodicalIF":40.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1038/s41574-025-01215-8
Maxine E. Whelan, Sathish Thirunavukkarasu, Karen Pearce, David W. Dunstan, Simon J. Griffin, Susan R. Davis, Annice Mukherjee, Robyn J. Tapp
{"title":"Midlife and the menopause transition in type 2 diabetes mellitus prevention","authors":"Maxine E. Whelan, Sathish Thirunavukkarasu, Karen Pearce, David W. Dunstan, Simon J. Griffin, Susan R. Davis, Annice Mukherjee, Robyn J. Tapp","doi":"10.1038/s41574-025-01215-8","DOIUrl":"https://doi.org/10.1038/s41574-025-01215-8","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"368 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-27DOI: 10.1038/s41574-025-01200-1
Lea Miquel, Benoit Testud, Frederique Albarel, Romain Appay, Thomas Graillon, Thomas Cuny, Henry Dufour, Mikael Ebbo, Thierry Brue, Pierre-André Jarrot, Nicolas Schleinitz, Frederic Castinetti
{"title":"An update on hypophysitis","authors":"Lea Miquel, Benoit Testud, Frederique Albarel, Romain Appay, Thomas Graillon, Thomas Cuny, Henry Dufour, Mikael Ebbo, Thierry Brue, Pierre-André Jarrot, Nicolas Schleinitz, Frederic Castinetti","doi":"10.1038/s41574-025-01200-1","DOIUrl":"https://doi.org/10.1038/s41574-025-01200-1","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"27 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145609177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metabolic control of feto–placental development and pregnancy outcomes","authors":"Yuanfeng Gao, Xin Yu, Yuefan Wang, Hongmei Wang, Yan-Ling Wang, Ng Shyh-Chang","doi":"10.1038/s41574-025-01206-9","DOIUrl":"https://doi.org/10.1038/s41574-025-01206-9","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"1 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145593725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1038/s41574-025-01203-y
Gabriela Brenta
{"title":"Kidney diseases and the thyroid: interactions and consequences","authors":"Gabriela Brenta","doi":"10.1038/s41574-025-01203-y","DOIUrl":"https://doi.org/10.1038/s41574-025-01203-y","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"146 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1038/s41574-025-01211-y
Subhajit Dutta
{"title":"CD38 as a driver of ageing","authors":"Subhajit Dutta","doi":"10.1038/s41574-025-01211-y","DOIUrl":"https://doi.org/10.1038/s41574-025-01211-y","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"1 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1038/s41574-025-01212-x
Manuel Tena-Sempere, Dimitrios-Dionyssios Koutsouris, George Dedoussis, Jeroen Lakerveld, Karl-Heinz Wagner, Itziar Tueros, Philippe Froguel, Torsten Bohn, Paulo J. Oliveira
{"title":"OBEClust: joining forces to prevent obesity","authors":"Manuel Tena-Sempere, Dimitrios-Dionyssios Koutsouris, George Dedoussis, Jeroen Lakerveld, Karl-Heinz Wagner, Itziar Tueros, Philippe Froguel, Torsten Bohn, Paulo J. Oliveira","doi":"10.1038/s41574-025-01212-x","DOIUrl":"https://doi.org/10.1038/s41574-025-01212-x","url":null,"abstract":"","PeriodicalId":18916,"journal":{"name":"Nature Reviews Endocrinology","volume":"169 1","pages":""},"PeriodicalIF":40.5,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：