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Bioassay of p-cresidine for possible carcinogenicity. 对吖啶可能致癌性的生物测定。

A bioassay of p-cresidine for possible carcinogenicity was conducted using Fischer 344 rats and B6C3F1 mice. p-Cresidine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The dietary concentrations used in the chronic bioassay for low and high dose rats were 0.5 and 1.0 percent, respectively. The time-weighted average concentrations fed to low dose male, low dose female, high dose male and high dose female mice were 0.22, 0.22. 0.46, and 0.44 percent, respectively. All dosed animals, except for high dose male mice, were administered p-cresidine in the diet for 104 weeks and observed for an additional period of up to 2 weeks. All high dose male mice were dead by the end of week 92. For each species, 50 animals of each sex were placed on test as controls and fed only the basal laboratory diet. Mortality rates were dose-related for both sexes of both species. That incidences of certain tumors were higher in low dose than in high dose groups was probably due to accelerated mortality in the high dose group. In dosed rats of both sexes, statistically significant incidences of bladder carcinomas (combined incidences of papillary carcinomas, squamous-cell carcinomas, transitional-cell papillomas, transitional-cell carcinomas, and undifferentiated carcinomas) and olfactory neuroblastomas were observed. The combined incidence of neoplastic nodules of the liver, hepatocelular carcinomas, or mixed hepato/cholangio carcinomas was also significant in low dose male rats. In both male and female dosed mice, the incidence of bladder carcinomas (combined incidence of carcinomas NOS, squamous-cell carcinomas, and transitional carcinomas) was significant. The incidence of hepatocellular carcinomas was also significant in dosed female mice. Under the conditions of this bioassay, p-cresidine was carcinogenic to Fischer 344 rats, causing increased incidences of carcinomas and of papillomas of the urinary bladder in both sexes, increased incidences of olfactory neuroblastomas in both sexes, and of liver tumors in males. p-Cresidine was also carcinogenic in B6C3F1 mice, causing carcinomas of the urinary bladders in both sexes and hepatocellular carcinomas in females.

以Fischer 344大鼠和B6C3F1小鼠为实验对象,进行了对哌替啶可能致癌性的生物测定。在饲料中以两种浓度中的任意一种给药,每组50只雄性和50只雌性动物。低剂量和高剂量大鼠慢性生物测定中使用的膳食浓度分别为0.5%和1.0%。低剂量雄鼠、低剂量雌鼠、高剂量雄鼠、高剂量雌鼠的时间加权平均浓度分别为0.22、0.22。分别为0.46%和0.44%。除高剂量雄性小鼠外,所有给药的动物都在饮食中给予对克参啶104周,并观察长达2周的额外时间。所有高剂量雄性小鼠在第92周结束时死亡。对每个物种,雌雄各50只作为对照,只饲喂基础实验室饲料。两种动物的两性死亡率均与剂量有关。某些肿瘤在低剂量组的发生率高于高剂量组,这可能是由于高剂量组的死亡率加快。在给药的雌雄大鼠中,膀胱癌(乳头状癌、鳞状细胞癌、移行细胞乳头状瘤、移行细胞癌和未分化癌的合并发病率)和嗅觉神经母细胞瘤的发病率均有统计学意义。在低剂量雄性大鼠中,肝脏肿瘤结节、肝细胞癌或肝/胆管混合癌的合并发病率也很显著。在雄性和雌性给药小鼠中,膀胱癌(NOS癌、鳞状细胞癌和移行性癌的联合发病率)的发生率均显著。在给药的雌性小鼠中,肝细胞癌的发生率也很高。在本生物试验条件下,对克雷辛对Fischer 344大鼠具有致癌性,导致两性大鼠的癌和膀胱乳头状瘤的发病率增加,两性大鼠的嗅觉神经母细胞瘤的发病率增加,雄性大鼠的肝脏肿瘤发病率增加。对cresidine在B6C3F1小鼠中也具有致癌性,可导致两性膀胱癌和雌性肝细胞癌。
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引用次数: 0
Bioassay of 6-nitrobenzimidazole for possible carcinogenicity (CAS No. 94-52-0). 6-硝基苯并咪唑可能致癌性的生物测定(CAS No. 94-52-0)。

A bioassay for possible carcinogenicity of 6-nitrobenzimidazole was conducted using Fischer 344 rats and B6C3F1 mice. 6-Nitrobenzimidazole was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species. The dietary concentrations used in the chronic bioassay were 0.5 and 0.12 percent for the high and low dose rats, respectively, and 0.24 and 0.12 percent for the high and low dose mice, respectively. After a 78-week period of compound administration, observation of the rats continued for up to an additional 29 weeks and observation of the mice continued for an additional 18 weeks. For each species and each dosed group, 49 or 50 animals of each sex were placed on test as controls. There were no significant positive associations between the administered dietary concentrations of 6-nitrobenzimidazole and mortality in either sex of rats or mice. In all groups adequate numbers of animals survived sufficiently long to be at risk from late-developing tumors. Among both male and female mice, the incidences of hepatocellular carcinomas in high dose groups were statistically significant relative to controls. Among rats of both sexes, nonneoplastic lesions of the eyes and of the Harderian glands appeared to be associated with administration of 6-nitrobenzimidazole. No neoplasms, however, were attributed to compound administration. Under the conditions of this bioassay, dietary administration of 6-nitrobenzimidazole was not carcinogenic to Fischer 344 rats; however, the compound was carcinogenic to B6C3F1 mice, causing hepatocellular carcinomas in both sexes.

采用Fischer 344大鼠和B6C3F1小鼠对6-硝基苯并咪唑的致癌性进行了生物测定。将6-硝基苯并咪唑以两种浓度中的任意一种添加到饲料中,每组50只雄性和50只雌性动物。在慢性生物测定中,高剂量和低剂量大鼠的饮食浓度分别为0.5%和0.12%,高剂量和低剂量小鼠的饮食浓度分别为0.24%和0.12%。在78周的复合给药期后,对大鼠的观察持续了29周,对小鼠的观察持续了18周。对于每个物种和每个剂量组,每个性别的49或50只动物作为对照进行试验。饲粮中6-硝基苯并咪唑的浓度与大鼠和小鼠的死亡率均无显著正相关。在所有组中,有足够数量的动物存活足够长的时间,从而有可能罹患晚期肿瘤。在雄性和雌性小鼠中,高剂量组的肝细胞癌发生率相对于对照组有统计学意义。在雌雄大鼠中,眼睛和哈德氏腺的非肿瘤性病变似乎与6-硝基苯并咪唑的施用有关。然而,没有肿瘤归因于复合给药。在本实验条件下,6-硝基苯并咪唑对Fischer 344大鼠无致癌性;然而,该化合物对B6C3F1小鼠具有致癌性,在两性中均可引起肝细胞癌。
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引用次数: 0
Bioassay of aldicarb for possible carcinogenicity. 涕灭威可能致癌性的生物测定。

A bioassay of aldicarb for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats and 50 mice of each sex were administered aldicarb at one of two doses, either 2 or 6 ppm, for 103 weeks and then observed for an additional 0 to 2 weeks. Matched controls consisted of 25 untreated rats and 25 untreated mice of each sex. All surviving animals were killed at weeks 103 to 105. Mean body weights of the dosed male and female rats were essentially the same as those of the corresponding controls. Mean body weights of the dosed male and female mice also were essentially the same as those of corresponding controls. Hyperactivity was noted in the dosed groups of mice. Survival was not affected significantly in dosed groups of either the rats or the mice and was 72% or greater in all dosed or control groups at week 90. Sufficient numbers of animals were at risk for the development of late-appearing tumors. No tumors occurred in either the rats or mice at incidences that could clearly be related to administration of the test chemical. In both rats and mice, however, there was no indication either through weight depression or early mortality that maximum tolerated dose levels were used. Therefore, the studies may not have been conducted using maximum sensitivity for the assessment of the possible carcinogenicity of aldicarb. It is concluded that under the conditions of this bioassay, technical-grade aldicarb was not carcinogenic for F344 rats or B6C3F1 mice of either sex.

通过给F344大鼠和B6C3F1小鼠喂食饲料,对涕灭威可能的致癌性进行了生物测定。每组各50只大鼠和50只小鼠,按两种剂量(2 ppm或6 ppm)中的一种给药103周,然后再观察0至2周。配对的对照组由25只未治疗的大鼠和25只未治疗的小鼠组成。所有幸存的动物在第103周至第105周被杀死。给药的雄性和雌性大鼠的平均体重与相应的对照组基本相同。给药的雄性和雌性小鼠的平均体重也与相应的对照组基本相同。在给药组的小鼠中发现了多动症。大鼠和小鼠的存活率在给药组中都没有受到显著影响,在第90周时,所有给药组和对照组的存活率都达到72%或更高。有足够数量的动物有发展为晚期肿瘤的风险。在大鼠和小鼠身上都没有发生肿瘤,其发生率显然与试验化学物质的施用有关。然而,在大鼠和小鼠中,无论是通过体重抑制还是早期死亡率,都没有迹象表明使用了最大耐受剂量水平。因此,这些研究可能没有使用最大灵敏度来评估涕灭威可能的致癌性。在本实验条件下,技术级灭蚊威对F344大鼠和B6C3F1小鼠均无致癌作用。
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引用次数: 0
Bioassay of butylated hydroxytoluene (BHT) for possible carcinogenicity. 丁基羟基甲苯(BHT)可能致癌性的生物测定。

A bioassay of BHT for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats and 50 mice of each sex were administered BHT at one of two doses, either 3,000 or 6,000 ppm; the rats for 105 weeks and the mice for 107 or 108 weeks. Matched controls consisted of 20 untreated rats and 20 untreated mice of each sex. All surviving animals were killed at the end of administration of the test chemical. Mean body weights of the dosed rats and mice were lower than those of the corresponding controls and were dose related throughout most of the bioassay. Survival was not affected significantly in the dosed groups of rats or mice, and the survival was 60% or greater in all dosed or control groups of rats and mice of each sex at the end of the bioassay. Sufficient number of animals were at risk for the development of late-appearing tumors. Alveolar/bronchiolar carcinomas or adenomas occurred in the female mice at a significant incidence in the low-dose group (P=0.009) but not in the high dose group, and the incidences were not significantly dose related (control 1/20, low-dose 16/46, high-dose 7/50). Thus, these lung tumors in the female cannot clearly be related to the administration of the BHT. No tumors occurred in either male or female rats at incidences that were significantly higher in dosed groups than in corresponding control groups. Nonneoplastic lesions that may have been related to the administration of the test chemical included focal alveolar histiocytosis at increased incidences in the dosed female rats and various lesions of the liver at increased incidences in the dosed male mice. It is concluded that under the conditions of this bioassay, BHT was not carcinogenic for F344 rats or B6C3F1 mice.

通过给F344大鼠和B6C3F1小鼠喂食饲料,对BHT可能的致癌性进行了生物测定。每组各50只大鼠和50只小鼠被注射了两种剂量中的一种,即3000或6000 ppm;大鼠105周,小鼠107或108周。配对的对照组包括20只未治疗的大鼠和20只未治疗的小鼠。所有幸存的动物都在施用试验化学品结束时被杀死。给药的大鼠和小鼠的平均体重低于相应的对照组,并且在大部分生物测定中都与剂量相关。在给药组的大鼠或小鼠中,存活率没有受到显著影响,在生物测定结束时,所有给药组或对照组的大鼠和小鼠的存活率均为60%或更高。有足够数量的动物有发展为晚期肿瘤的风险。低剂量组雌性小鼠肺泡/细支气管癌或腺瘤发生率显著(P=0.009),高剂量组发生率不显著,且与剂量无关(对照组1/20,低剂量组16/46,高剂量组7/50)。因此,这些女性肺部肿瘤不能明确地与给予BHT有关。雄性或雌性大鼠均未发生肿瘤,剂量组的发生率明显高于相应的对照组。非肿瘤性病变可能与试验化学物质的施用有关,包括局灶性肺泡组织细胞增生,在给药的雌性大鼠中发病率增加,在给药的雄性小鼠中肝脏的各种病变发病率增加。本实验条件下,BHT对F344大鼠和B6C3F1小鼠均无致癌性。
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引用次数: 0
Bioassay of N,N'-diethylthiourea for possible carcinogenicity. N,N'-二乙基硫脲可能致癌性的生物测定。

A bioassay for the possible carcinogenicity of N,N'-diethylthiourea was conducted using Fischer 344 rats and B6C3F1 mice. N,N'-Diethylthiourea was administered in the feed, at either of two concentrations, to groups of 50 males and 50 females of each species. Twenty animals of each sex and species, except for 19 male mice, were placed on test as controls. The high and low dietary concentrations of N,N'-diethylthiourea were, respectively, 250 and 125 ppm for rats and 500 and 250 ppm for mice. The compound was administered in the diet for 103 weeks, followed by an observation period of 1 week for all dosed groups. There were no significant positive associations between the dosages of N,N'-diethylthiourea administered and mortality in rats or mice of either sex. Adequate numbers of animals in all dose groups survived sufficiently long to be at risk from late-developing tumors. Compound-related mean body weight depression was apparent among dosed male and female mice when compared to their respective controls,indicating that the concentrations of N,N'-diethylthiourea administered to mice may have approximated the maximum tolerated dosages. There were statistically significant elevated incidences of follicular-cell carcinomas of the thyroid in high dose male rats. In addition, there were statistically significant elevated incidences of a combination of thyroid follicular-cell carcinomas and follicular-cell adenomas in high dose male and female rats. Under the conditions of this bioassay, N,N'-diethylthiourea was carcinogenic to Fischer 344 rats, causing follicular-cell carcinomas of the thyroid in males and follicular-cell neoplasms of the thyroid in females. There was no evidence for the carcinogenicity of the compound in B6C3F1 mice.

采用Fischer 344大鼠和B6C3F1小鼠进行了N,N'-二乙基硫脲可能致癌性的生物测定。将N,N'-二乙基硫脲以两种浓度中的任意一种添加到饲料中,每组50只雄性和50只雌性。除19只雄性小鼠外,各性别、各物种各20只作为对照。大鼠饲粮N,N′-二乙基硫脲高、低浓度分别为250、125 ppm,小鼠饲粮N,N′-二乙基硫脲500、250 ppm。给药103周,各给药组观察1周。N,N'-二乙基硫脲给药剂量与大鼠或小鼠的死亡率无显著正相关。所有剂量组中都有足够数量的动物存活足够长的时间,从而有患晚期肿瘤的风险。与对照组相比,给药的雄性和雌性小鼠的平均体重明显下降,表明给药小鼠的N,N'-二乙基硫脲浓度可能接近最大耐受剂量。高剂量雄性大鼠甲状腺滤泡细胞癌的发生率有统计学意义。此外,在高剂量雄性和雌性大鼠中,甲状腺滤泡细胞癌和滤泡细胞腺瘤合并的发病率有统计学意义的显著升高。在本实验条件下,N,N'-二乙基硫脲对Fischer 344大鼠具有致癌性,可引起雄性甲状腺滤泡细胞癌和雌性甲状腺滤泡细胞瘤。没有证据表明该化合物在B6C3F1小鼠中具有致癌性。
{"title":"Bioassay of N,N'-diethylthiourea for possible carcinogenicity.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A bioassay for the possible carcinogenicity of N,N'-diethylthiourea was conducted using Fischer 344 rats and B6C3F1 mice. N,N'-Diethylthiourea was administered in the feed, at either of two concentrations, to groups of 50 males and 50 females of each species. Twenty animals of each sex and species, except for 19 male mice, were placed on test as controls. The high and low dietary concentrations of N,N'-diethylthiourea were, respectively, 250 and 125 ppm for rats and 500 and 250 ppm for mice. The compound was administered in the diet for 103 weeks, followed by an observation period of 1 week for all dosed groups. There were no significant positive associations between the dosages of N,N'-diethylthiourea administered and mortality in rats or mice of either sex. Adequate numbers of animals in all dose groups survived sufficiently long to be at risk from late-developing tumors. Compound-related mean body weight depression was apparent among dosed male and female mice when compared to their respective controls,indicating that the concentrations of N,N'-diethylthiourea administered to mice may have approximated the maximum tolerated dosages. There were statistically significant elevated incidences of follicular-cell carcinomas of the thyroid in high dose male rats. In addition, there were statistically significant elevated incidences of a combination of thyroid follicular-cell carcinomas and follicular-cell adenomas in high dose male and female rats. Under the conditions of this bioassay, N,N'-diethylthiourea was carcinogenic to Fischer 344 rats, causing follicular-cell carcinomas of the thyroid in males and follicular-cell neoplasms of the thyroid in females. There was no evidence for the carcinogenicity of the compound in B6C3F1 mice.</p>","PeriodicalId":18935,"journal":{"name":"National Cancer Institute carcinogenesis technical report series","volume":"149 ","pages":"1-103"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22431251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioassay of 2,4-diaminotoluene for possible carcinogenicity. 2,4-二氨基甲苯可能致癌性的生物测定。

A bioassay of 2,4-diaminotoluene for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats of each sex were administered 2,4-diaminotoluene at one of two doses, initially either 125 or 250 ppm, for 40 weeks. Because of excessive depression in the amount of mean body weight gained in both low- and high-dose groups, doses were then reduced to 50 and 100 ppm, respectively. Administration of 50 ppm to the low-dose groups was continued for 63 weeks, and surviving animals in these groups were then killed. Surviving animals in the high-dose males and females administered 100 ppm were killed at the end of 39 and 44 weeks, respectively, due to morbidity. The time-weighted average dose was 79 ppm for the low-dose male and females for 103 weeks, 176 ppm for the high-dose males for 79 weeks, and 171 ppm for the high-dose females for 84 weeks. Matched controls consisted of 20 untreated rats of each sex. Groups of 50 mice of each sex were administered 2,4-diaminotoluene at one of two doses, either 100 or 200 ppm, for 101 weeks. Matched controls consisted of 20 untreated mice of each sex. Surviving mice were killed at the end of administration of the test chemical. Mean body weights of dosed male and female rats and mice were lower than those of corresponding controls and were dose related except for the low-dose male mice, for which mean body weights were only slightly lower than those of controls. Mortality was not dose related in either the male or female mice, but was dose related in both the male and female rats. Survival was decreased and lesions of hepatonephrotoxicity were observed in the animals administered the 2,4-diaminotoluene. In the rats, hepatocellular carcinomas or neoplastic nodules occurred at incidences that were dose related in both the males (P=0.014) and the females (P=0.008). In direct comparisons of incidences of the tumors in control and dosed groups, the incidence in the high-dose male group had a P value of 0.026 (males: controls 0/20, low-dose 5/49, high-dose 10/50; females: controls 0/20; low-dose 0/50, high-dose 6/49). The significance of the occurrence of these tumors in both the male and female rats was supported by the high incidences of associated nonneoplastic lesions of the liver in the dosed groups and by low incidences of liver tumors in historical-control male or female F344 rats at the same laboratory. In addition, carcinomas or adenomas of the mammary gland occurred in the female rats at incidences that were dose related (P=0.002) and in direct comparisons were higher in the dosed groups (P<0.001) than in the control group (control 1/20; low-dose 38/50, high-dose 41/50). In male rats, fibromas of the subcutaneous tissue occurred at incidences that were dose related (P=0.004) and in direct comparisons were higher in the dosed groups (P

通过给F344大鼠和B6C3F1小鼠喂食饲料,对2,4-二氨基甲苯进行了可能致癌性的生物测定。每组50只雌雄老鼠分别以两种剂量中的一种注射2,4-二氨基甲苯,初始剂量为125 ppm或250 ppm,持续40周。由于低剂量组和高剂量组的平均体重增加量过度下降,因此剂量分别减少到50 ppm和100 ppm。对低剂量组持续给予50ppm,持续63周,然后杀死这些组中存活的动物。给予100 ppm高剂量雄性和雌性的存活动物分别在39周和44周结束时因发病率而死亡。低剂量男性和女性的时间加权平均剂量为79 ppm,高剂量男性为176 ppm,持续79周,高剂量女性为171 ppm,持续84周。配对的对照组包括20只未治疗的大鼠,雌雄各一只。每组各50只雌雄老鼠,以两种剂量(100或200 ppm)中的一种注射2,4-二氨基甲苯,持续101周。配对的对照组由雌雄各20只未经治疗的老鼠组成。在给药结束后,幸存的老鼠被杀死。除低剂量雄性小鼠的平均体重仅略低于对照组外,给药雄性和雌性大鼠和小鼠的平均体重均低于相应的对照组,且与剂量有关。雄性和雌性小鼠的死亡率与剂量无关,但雄性和雌性大鼠的死亡率都与剂量有关。在给予2,4-二氨基甲苯的动物中,观察到存活率降低和肝肾毒性病变。在雄性和雌性大鼠中,肝细胞癌或肿瘤结节的发生率均与剂量相关(P=0.014)。在直接比较对照组和给药组肿瘤发病率时,高剂量组男性发病率P值为0.026(男性:对照组0/20,低剂量5/49,高剂量10/50;女性:控制0/20;低剂量0/50,高剂量6/49)。这些肿瘤在雄性和雌性大鼠中发生的重要性,在同一实验室中,剂量组中相关的非肿瘤性肝脏病变的发生率很高,而在历史对照的雄性或雌性F344大鼠中肝脏肿瘤的发生率很低,这一点得到了支持。此外,雌性大鼠发生乳腺癌或腺瘤的发生率与剂量相关(P=0.002),并且在直接比较中,剂量组较高(P=0.002)
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引用次数: 0
Bioassay of parathion for possible carcinogenicity. 对硫磷可能致癌性的生物测定。

A bioassay for possible carcinogenicity of technical-grade parathion was conducted by administering the test chemical in the diet to Osborne-Mendel rats and B6C3F1 mice. Groups of 50 rats of each sex were administered parathion at one of two doses for 80 weeks, then observed for 32 or 33 weeks. Time-weighted average doses for males were 32 or 63 ppm; for females, they were 23 or 45 ppm. All surviving rats were killed at 112 or 113 weeks. Groups of 50 mice of each sex were administered parathion at one of two doses, either 80 or 160 ppm. The low-dose males were administered parathion for 71 weeks; the high-dose males for 62 weeks; and the low- and high-dose females for 80 weeks. The animals were then maintained for observation and all surviving mice were killed at 89 or 90 weeks. Matched controls consisted of groups of 10 untreated rats or mice of each sex; pooled controls of rats or mice taken from similar bioassays of other test chemicals were also used. Mean body weights of high-dose male and female rats and of high- and low-dose male mice were generally lower than those of the matched controls during the period of administration of the chemical. Mean body weights of the other groups of dosed rats and mice did not differ appreciably from those of the matched controls. Since body weights and survival of the female mice were not affected, female mice may have been able to tolerate a higher dose. Sufficient numbers of male and female animals of both species were at risk for the development of late-appearing tumors. In both male and female rats, the incidences of cortical adenomas or carcinomas of the adrenal showed dose-related trends (P<0.001) using pooled controls and, in direct comparisons, were higher in the high-dose groups (P<0.001) than in the pooled controls (males: pooled controls 3/80, matched controls 0/9, low-dose 7/49, high-dose 11/46; females: pooled controls 4/78, matched controls 1/10, low-dose 6/47, high-dose 13/42). Most of the tumors were adenomas. When the matched controls were used, dose-related trends in incidences of the adrenal tumors were significant (males, P=0.048; females, P=0.028); in direct comparisons, however, the incidences of the tumors in the individual groups did not differ significantly from those in corresponding matched controls. The incidences of the tumors in the dosed male and female rats were higher than those in corresponding historical controls (males 8/148, females 5/180). In mice, no tumors occurred in either sex at incidences that were significantly higher in the dosed groups than in the corresponding control groups. It is concluded that under the conditions of this bioassay, parathion was not carcinogenic to B6C3F1 mice. In the male and female Osborne-Mendel rats receiving parathion in their diet, there was a higher incidence of cortical tumors of the adrenal than in pooled or historical controls, suggesting that parathion is carcinogenic to this strain of rat.

通过给奥斯本-孟德尔大鼠和B6C3F1小鼠喂食试验化学物质,对技术级对硫磷可能的致癌性进行了生物测定。每组50只,雌雄各别,给予对硫磷两种剂量中的一种,持续80周,然后观察32周或33周。男性的时间加权平均剂量为32或63 ppm;对于女性来说,它们是23或45 ppm。在112周或113周时杀死所有存活的大鼠。每组50只雌雄老鼠被注射两种剂量的对硫磷,浓度分别为80或160 ppm。低剂量雄鼠给予对硫磷71周;高剂量雄鼠62周;低剂量和高剂量的雌性老鼠持续80周。然后将这些小鼠饲养观察,并在89或90周时杀死所有存活的小鼠。配对的对照组包括每组10只未经治疗的大鼠或雌雄小鼠;还使用了从其他测试化学品的类似生物测定中提取的大鼠或小鼠的混合对照。在给药期间,高剂量雄性和雌性大鼠以及高剂量和低剂量雄性小鼠的平均体重普遍低于匹配的对照组。其他剂量组的大鼠和小鼠的平均体重与匹配的对照组没有明显差异。由于雌性小鼠的体重和存活率没有受到影响,因此雌性小鼠可能能够耐受更高剂量。两种动物中有足够数量的雄性和雌性动物都有发生晚期肿瘤的风险。在雄性和雌性大鼠中,肾上腺皮质腺瘤或癌的发病率呈剂量相关趋势(P
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引用次数: 0
Bioassay of malaoxon for possible carcinogenicity. 丙氧胂可能致癌性的生物测定。

A bioassay of malaoxon, the oxygen analogue of malathion (an organophosphate insecticide), for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats and 50 mice of each sex were fed diets containing 500 or 1,000-ppm malaoxon for 103 weeks and were then observed for up to an additional 2 weeks. Matched controls consisted of groups of 50 untreated rats and 50 untreated mice of each sex. All surviving animals were killed at 103 to 105 weeks. The only effects that could be related to administration of malaoxon at the doses used were increased mortality among male mice, decreased mean body weights of female mice, gastric ulcers in male and female rats, and possibly C-cell adenomas or carcinomas of the thyroid among treated female rats. The incidence of C-cell adenomas or carcinomas among historical controls, however, precluded relating the incidence of these tumors to administration of the chemical. It was concluded that under the conditions of this bioassay malaoxon was not carcinogenic for F344 rats or B6C3F1 mice.

malaoxon是马拉硫磷(一种有机磷杀虫剂)的氧类似物,通过给F344大鼠和B6C3F1小鼠喂食饲料,对其可能的致癌性进行了生物测定。每组50只大鼠和50只小鼠,雌雄各别,喂食含有500或1000 ppm的丙氧胂的饮食103周,然后再观察长达2周。配对的对照组由各性别50只未治疗的大鼠和50只未治疗的小鼠组成。所有幸存的动物在103至105周时被杀死。唯一可能与使用的剂量有关的影响是雄性小鼠的死亡率增加,雌性小鼠的平均体重下降,雄性和雌性大鼠的胃溃疡,并且可能在治疗的雌性大鼠中出现c细胞腺瘤或甲状腺癌。然而,历史对照中c细胞腺瘤或癌的发病率排除了这些肿瘤的发病率与化学药物的使用有关。在本实验条件下,对F344大鼠和B6C3F1小鼠均无致癌性。
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引用次数: 0
Bioassay of C.I. vat yellow 4 for possible carcinogenicity. C.I.大黄4可能致癌性的生物测定。

A bioassay of C.I. vat yellow 4, a commercial formulation containing dibenzo(b, def) chrysene-7,14-dione, for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer 344 rats and B6C3F1 mice. Groups of 50 rats of each sex and 50 mice of each sex were administered C.I. vat yellow 4 in the diet at one of two doses, either 3,500 or 7,000 ppm for the rats, either 25,000 or 50,000 ppm for male mice, and either 12,500 or 25,000 ppm for the female mice. The rats were administered the test chemical for 104 weeks; the mice, for 106 weeks. Matched controls consisted of 20 untreated rats and 20 untreated mice of each sex. All surviving animals were killed at the end of the period of administration of the test chemical. Mean body weights of the dosed rats were lower than those of corresponding controls throughout the bioassay, but the differences in weights were slight for the males. Mean body weights of the dosed mice were not affected by the test chemical. Survival of the rats and mice were not affected adversely by the chemical, and sufficient numbers of dosed and control rats and mice of each sex were at risk for the development of late-appearing tumors. In the male and female rats and the female mice, no tumors occurred at incidences that were significantly higher in dosed groups than in control groups. In the male mice, lymphomas occurred at incidences that were dose related (P=0.002) and, in a direct comparison, the incidence of the tumor in the high-dose group was significantly higher (P=0.019) than that in the control group (controls 3/20, or 15%; low-dose 7/47, or 15%; high-dose 22/50, or 44%). The incidence of lymphomas and leukemias in historical-control male B6C3F1 mice, at this laboratory was 38/323 (12%). It is concluded that under the conditions of this bioassay, the formulated product containing C.I. vat yellow 4 was not carcinogenic for male or female Fischer 344 rats or for female B6C3F1 mice, but was carcinogenic for male B6C3F1 mice, causing an increased incidence of lymphomas.

通过给Fischer 344大鼠和B6C3F1小鼠喂食饲料中的试验化学品,对含有二苯并(b, def) chrysen7,14-dione的商业配方C.I. vat yellow 4进行了可能致癌性的生物测定。每组50只雌雄老鼠和50只雌雄老鼠,分别以两种剂量中的一种给老鼠喂食C.I.黄4,大鼠为3500或7000 ppm,雄性老鼠为25000或50000 ppm,雌性老鼠为12500或25000 ppm。给大鼠服用试验化学物质104周;小鼠,106周。配对的对照组包括20只未治疗的大鼠和20只未治疗的小鼠。所有幸存的动物都在试验化学品施用期结束时被杀死。在整个生物测定过程中,给药大鼠的平均体重低于相应的对照组,但雄性的体重差异很小。给药小鼠的平均体重没有受到试验化学物质的影响。大鼠和小鼠的生存没有受到化学物质的不利影响,并且有足够数量的剂量和对照大鼠和雌雄小鼠都有患晚期肿瘤的风险。在雄性、雌性大鼠和雌性小鼠中,没有肿瘤发生,剂量组的发生率明显高于对照组。在雄性小鼠中,淋巴瘤的发生率与剂量相关(P=0.002),在直接比较中,高剂量组的肿瘤发生率显著高于对照组(对照3/20,即15%;低剂量7/47,或15%;高剂量22/50,或44%)。本实验室历史对照雄性B6C3F1小鼠淋巴瘤和白血病的发生率为38/323(12%)。由此可见,在本生物试验条件下,含有C.I.缸黄4的制剂对雄性、雌性Fischer 344大鼠和雌性B6C3F1小鼠均无致癌性,但对雄性B6C3F1小鼠有致癌性,引起淋巴瘤发生率增高。
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引用次数: 0
Bioassay of sodium diethyldithiocarbamate for possible carcinogenicity. 二乙基二硫代氨基甲酸钠可能致癌性的生物测定。

A bioassay of sodium diethyldithiocarbamate for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats of each sex were administered sodium diethyldithiocarbamate at one of two doses, either 1,250 or 2,500 ppm, for 104 weeks. Groups of 50 mice of each sex were administered sodium diethyldithiocarbamate at one of two doses, either 500 or 4,000 ppm, for 108 or 109 weeks. Matched controls consisted of 16 untreated male rats, 20 untreated female rats and 20 untreated mice of each sex. All surviving rats and mice were killed at the end of administration of the test chemical. Mean body weights of all dosed groups of rats and mice were lower that those of corresponding controls and were dose related throughout the bioassay except those of the low-dose male rats, which were essentially unaffected by administration of the test chemical. Survivals of the rat and mice were unaffected, and no other clinical signs could be related to administration of the test chemical; thus, the animals may have been able to tolerate higher doses. Sufficient numbers of dosed and control animals of each species and sex were at risk for the development of late-appearing tumors. No tumors occurred in the rats or mice of either sex at incidences that were significantly higher in the dosed groups than in the control groups. It is concluded that under the conditions of this bioassay, sodium diethyldithiocarbamate was not carcinogenic for F344 rats or B6C3F1 mice of either sex.

通过在饲料中添加二乙基二硫代氨基甲酸钠,对F344大鼠和B6C3F1小鼠进行了可能致癌性的生物测定。每组50只大鼠,每只雌雄,以两种剂量(1,250或2,500 ppm)中的一种注射二乙基二硫代氨基甲酸钠,持续104周。每组50只雌雄老鼠被注射两种剂量的二乙基二硫代氨基甲酸钠,浓度分别为500或4000 ppm,持续108或109周。配对的对照组包括16只未治疗的雄性大鼠,20只未治疗的雌性大鼠和20只未治疗的雌雄小鼠。所有幸存的大鼠和小鼠在给药结束时被杀死。除低剂量雄性大鼠外,所有给药组的大鼠和小鼠的平均体重都低于相应的对照组,并且在整个生物测定过程中都与剂量相关,它们基本上不受给药的影响。大鼠和小鼠的存活率未受影响,并且没有其他临床症状与试验化学品的施用有关;因此,这些动物可能能够耐受更高的剂量。每个物种和性别的足够数量的剂量和对照动物都有发生迟发性肿瘤的风险。在大鼠或小鼠中,无论雌雄,均未发生肿瘤,但剂量组的发生率明显高于对照组。在本实验条件下,二乙基二硫代氨基甲酸钠对F344大鼠和B6C3F1小鼠均无致癌性。
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引用次数: 0
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National Cancer Institute carcinogenesis technical report series
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