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Global genomic diversity for All of Us 我们所有人的全球基因组多样性
IF 42.7 1区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-03-20 DOI: 10.1038/s41576-024-00727-9
Linda Koch
A publication in Nature reports the data release of around 245,000 clinical-grade whole-genome sequences as part of the NIH’s All of Us Research Programme. Several companion papers highlight the value of better capturing global genomic diversity.
自然》(Nature)杂志发表的一篇文章报道了作为美国国立卫生研究院(NIH)"我们所有人 "研究计划(All of Us Research Programme)一部分的约 245,000 个临床级全基因组序列的数据发布情况。几篇相关论文强调了更好地捕捉全球基因组多样性的价值。
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引用次数: 0
The evolution of modifier genes 修饰基因的演变
IF 42.7 1区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-03-19 DOI: 10.1038/s41576-024-00724-y
Yoav Ram
In this Journal Club, Yoav Ram recalls how he reconciled results from his own research with the reduction principle through the help of a paper published in PNAS by Altenberg et al.
在本期 "期刊俱乐部 "中,Yoav Ram 回顾了他是如何通过 Altenberg 等人发表在《美国科学院院刊》上的一篇论文,将自己的研究成果与还原原理相协调的。
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引用次数: 0
Dynamics of ER stress-induced gene regulation in plants 植物中ER胁迫诱导的基因调控动态。
IF 42.7 1区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-03-18 DOI: 10.1038/s41576-024-00710-4
Dae Kwan Ko, Federica Brandizzi
Endoplasmic reticulum (ER) stress is a potentially lethal condition that is induced by the abnormal accumulation of unfolded or misfolded secretory proteins in the ER. In eukaryotes, ER stress is managed by the unfolded protein response (UPR) through a tightly regulated, yet highly dynamic, reprogramming of gene transcription. Although the core principles of the UPR are similar across eukaryotes, unique features of the plant UPR reflect the adaptability of plants to their ever-changing environments and the need to balance the demands of growth and development with the response to environmental stressors. The past decades have seen notable progress in understanding the mechanisms underlying ER stress sensing and signalling transduction pathways, implicating the UPR in the effects of physiological and induced ER stress on plant growth and crop yield. Facilitated by sequencing technologies and advances in genetic and genomic resources, recent efforts have driven the discovery of transcriptional regulators and elucidated the mechanisms that mediate the dynamic and precise gene regulation in response to ER stress at the systems level. Plants have uniquely adapted to manage endoplasmic reticulum stress triggered by protein misfolding. The authors review the dynamics of gene expression regulation underlying the unfolded protein response in plants, highlighting recent insights provided by systems-level approaches and omics data.
内质网(ER)应激是由ER中未折叠或折叠错误的分泌蛋白的异常积累诱发的一种潜在致死状态。在真核生物中,ER 应激由未折叠蛋白反应(UPR)通过严格调控但高度动态的基因转录重编程来管理。虽然 UPR 的核心原理与真核生物相似,但植物 UPR 的独特性反映了植物对不断变化的环境的适应性,以及平衡生长和发育需求与环境胁迫响应的需要。过去几十年来,人们在了解ER胁迫感应和信号转导途径的基本机制方面取得了显著进展,UPR与生理性和诱导性ER胁迫对植物生长和作物产量的影响有关。在测序技术以及基因和基因组资源进步的推动下,最近的研究工作推动了转录调控因子的发现,并阐明了在系统水平上介导响应 ER 胁迫的动态和精确基因调控的机制。
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引用次数: 0
Competition between sites of meiotic recombination in snakes 蛇类减数分裂重组位点之间的竞争。
IF 42.7 1区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-03-12 DOI: 10.1038/s41576-024-00722-0
Kirsty Minton
A study in Science reports that corn snakes use both PRDM9 and promoter-like features to direct meiotic recombination, indicating that these are not mutually exclusive.
科学》杂志上的一项研究报告说,玉米蛇同时使用 PRDM9 和启动子样特征来指导减数分裂重组,这表明这两者并不相互排斥。
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引用次数: 0
The regulatory landscape of chromatin accessibility 染色质可及性的调控格局
IF 42.7 1区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-03-11 DOI: 10.1038/s41576-024-00719-9
Henry Ertl
A study in Nature Genetics identifies many regulators of genome-wide chromatin accessibility and then reports the mechanistic underpinnings for one of the identified transcription factors.
自然-遗传学》(Nature Genetics)杂志上的一项研究确定了全基因组染色质可及性的许多调节因子,然后报告了其中一个已确定转录因子的机制基础。
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引用次数: 0
Sequence composition changes in short tandem repeats: heterogeneity, detection, mechanisms and clinical implications 短串联重复序列的序列组成变化:异质性、检测、机制和临床意义
IF 42.7 1区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-03-11 DOI: 10.1038/s41576-024-00696-z
Indhu-Shree Rajan-Babu, Egor Dolzhenko, Michael A. Eberle, Jan M. Friedman
Short tandem repeats (STRs) are a class of repetitive elements, composed of tandem arrays of 1–6 base pair sequence motifs, that comprise a substantial fraction of the human genome. STR expansions can cause a wide range of neurological and neuromuscular conditions, known as repeat expansion disorders, whose age of onset, severity, penetrance and/or clinical phenotype are influenced by the length of the repeats and their sequence composition. The presence of non-canonical motifs, depending on the type, frequency and position within the repeat tract, can alter clinical outcomes by modifying somatic and intergenerational repeat stability, gene expression and mutant transcript-mediated and/or protein-mediated toxicities. Here, we review the diverse structural conformations of repeat expansions, technological advances for the characterization of changes in sequence composition, their clinical correlations and the impact on disease mechanisms. This Review highlights the diversity in sequence composition of disease-related short tandem repeats. The authors discuss how to detect non-canonical motifs in repeat sequences from sequencing data and review the molecular and clinical consequences of sequence composition changes.
短串联重复序列(STR)是一类重复元件,由 1-6 个碱基对序列图案的串联阵列组成,占人类基因组的很大一部分。这些疾病的发病年龄、严重程度、渗透性和/或临床表型受重复序列的长度及其序列组成的影响。根据重复序列的类型、频率和位置,非规范基序的存在可通过改变体细胞和代际重复的稳定性、基因表达以及突变转录本介导和/或蛋白质介导的毒性来改变临床结果。在此,我们回顾了重复扩增的各种结构构象、表征序列组成变化的技术进展、其临床相关性以及对疾病机制的影响。
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引用次数: 0
Short tandem repeats — how microsatellites became the currency of forensic genetics 短串联重复序列--微卫星如何成为法医遗传学的通行证
IF 42.7 1区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-03-11 DOI: 10.1038/s41576-024-00721-1
Bruce Budowle, Antti Sajantila
Short tandem repeats (STRs), also known as microsatellites, are the primary markers of forensic genetics for developing investigative leads in criminal cases and humanitarian efforts. Their variation in length and sequence provides genetic information even in samples of low quantity and quality, enabling high resolution for identification and attribution purposes, and culminating in the development of national DNA databases. Bruce Budowle and Antti Sajantila reflect on how short tandem repeats (STRs) became the primary markers of forensic genetics, including for developing investigative leads in criminal cases and humanitarian efforts.
短串联重复序列(STR),又称微卫星,是法医遗传学的主要标记,用于开发刑事案件和人道主义工作的调查线索。即使样本数量少、质量差,它们在长度和序列上的变化也能提供遗传信息,从而实现高分辨率的身份识别和归属目的,并最终促成了国家 DNA 数据库的开发。布鲁斯-布道尔(Bruce Budowle)和安蒂-萨扬蒂拉(Antti Sajantila)探讨了短串联重复序列 (STR) 如何成为法医遗传学的主要标记,包括用于开发刑事案件和人道主义工作的调查线索。
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引用次数: 0
Genetics of chronic respiratory disease 慢性呼吸系统疾病的遗传学。
IF 39.1 1区 生物学 Q1 GENETICS & HEREDITY Pub Date : 2024-03-06 DOI: 10.1038/s41576-024-00695-0
Ian Sayers, Catherine John, Jing Chen, Ian P. Hall
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and interstitial lung diseases are frequently occurring disorders with a polygenic basis that account for a large global burden of morbidity and mortality. Recent large-scale genetic epidemiology studies have identified associations between genetic variation and individual respiratory diseases and linked specific genetic variants to quantitative traits related to lung function. These associations have improved our understanding of the genetic basis and mechanisms underlying common lung diseases. Moreover, examining the overlap between genetic associations of different respiratory conditions, along with evidence for gene–environment interactions, has yielded additional biological insights into affected molecular pathways. This genetic information could inform the assessment of respiratory disease risk and contribute to stratified treatment approaches. In this Review, Sayers et al. summarize findings from recent large-scale genetic epidemiology studies on the genetic underpinnings of chronic respiratory diseases. Furthermore, they outline how insights gained from such studies can improve treatment approaches.
慢性呼吸道疾病,如慢性阻塞性肺病(COPD)、哮喘和间质性肺病,是一种多发病,具有多基因基础,在全球范围内造成了巨大的发病和死亡负担。最近的大规模遗传流行病学研究发现了遗传变异与个别呼吸系统疾病之间的关联,并将特定的遗传变异与肺功能相关的定量特征联系起来。这些关联增进了我们对常见肺部疾病的遗传基础和机制的了解。此外,研究不同呼吸系统疾病的遗传关联之间的重叠,以及基因与环境之间相互作用的证据,也让我们对受影响的分子途径有了更多的生物学认识。这些遗传信息可为呼吸系统疾病风险评估提供依据,并有助于采取分层治疗方法。
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引用次数: 0
How ancient genes form animal body plans 远古基因如何形成动物身体结构
IF 42.7 1区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-03-04 DOI: 10.1038/s41576-024-00717-x
Hajk-Georg Drost
Hajk-Georg Drost recalls a 2010 publication that used a phylotranscriptomic approach to estimate the age of genes that contribute to the developmental transcriptome across animal species and inspired a subsequent study on the embryonic hourglass in plants.
哈伊克-乔治-德罗斯特(Hajk-Georg Drost)回顾了 2010 年发表的一篇论文,该论文利用系统转录组学方法估算了对动物物种发育转录组有贡献的基因的年龄,并启发了随后对植物胚胎沙漏的研究。
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引用次数: 0
Changes in cell-cycle rate drive diverging cell fates 细胞周期速率的变化驱动着细胞命运的分化。
IF 42.7 1区 生物学 Q1 Biochemistry, Genetics and Molecular Biology Pub Date : 2024-03-01 DOI: 10.1038/s41576-024-00714-0
Kate E. Galloway
Kate Galloway highlights a paper by Kueh et al., who showed that the cell cycle indirectly influences concentrations of the transcription factor PU.1 to stabilize cell-fate trajectories in mice.
凯特-加洛韦重点介绍了 Kueh 等人的一篇论文,他们的研究表明,细胞周期会间接影响转录因子 PU.1 的浓度,从而稳定小鼠的细胞命运轨迹。
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引用次数: 0
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