Pub Date : 2024-11-20DOI: 10.1038/s41583-024-00885-z
Anna K. Gillespie
In this Journal Club, Anna Gillespie discusses how the discovery of hippocampal replay during the awake state reshaped our understanding of its role in memory function.
{"title":"Ruminating on replay during the awake state","authors":"Anna K. Gillespie","doi":"10.1038/s41583-024-00885-z","DOIUrl":"https://doi.org/10.1038/s41583-024-00885-z","url":null,"abstract":"In this Journal Club, Anna Gillespie discusses how the discovery of hippocampal replay during the awake state reshaped our understanding of its role in memory function.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"8 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142673165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1038/s41583-024-00876-0
Clara Liao, Alisha N Dua, Cassandra Wojtasiewicz, Conor Liston, Alex C Kwan
A feature in the pathophysiology of major depressive disorder (MDD), a mood disorder, is the impairment of excitatory synapses in the prefrontal cortex. Intriguingly, different types of treatment with fairly rapid antidepressant effects (within days or a few weeks), such as ketamine, electroconvulsive therapy and non-invasive neurostimulation, seem to converge on enhancement of neural plasticity. However, the forms and mechanisms of plasticity that link antidepressant interventions to the restoration of excitatory synaptic function are still unknown. In this Review, we highlight preclinical research from the past 15 years showing that ketamine and psychedelic drugs can trigger the growth of dendritic spines in cortical pyramidal neurons. We compare the longitudinal effects of various psychoactive drugs on neuronal rewiring, and we highlight rapid onset and sustained time course as notable characteristics for putative rapid-acting antidepressant drugs. Furthermore, we consider gaps in the current understanding of drug-evoked in vivo structural plasticity. We also discuss the prospects of using synaptic remodelling to understand other antidepressant interventions, such as repetitive transcranial magnetic stimulation. Finally, we conclude that structural neural plasticity can provide unique insights into the neurobiological actions of psychoactive drugs and antidepressant interventions.
{"title":"Structural neural plasticity evoked by rapid-acting antidepressant interventions.","authors":"Clara Liao, Alisha N Dua, Cassandra Wojtasiewicz, Conor Liston, Alex C Kwan","doi":"10.1038/s41583-024-00876-0","DOIUrl":"10.1038/s41583-024-00876-0","url":null,"abstract":"<p><p>A feature in the pathophysiology of major depressive disorder (MDD), a mood disorder, is the impairment of excitatory synapses in the prefrontal cortex. Intriguingly, different types of treatment with fairly rapid antidepressant effects (within days or a few weeks), such as ketamine, electroconvulsive therapy and non-invasive neurostimulation, seem to converge on enhancement of neural plasticity. However, the forms and mechanisms of plasticity that link antidepressant interventions to the restoration of excitatory synaptic function are still unknown. In this Review, we highlight preclinical research from the past 15 years showing that ketamine and psychedelic drugs can trigger the growth of dendritic spines in cortical pyramidal neurons. We compare the longitudinal effects of various psychoactive drugs on neuronal rewiring, and we highlight rapid onset and sustained time course as notable characteristics for putative rapid-acting antidepressant drugs. Furthermore, we consider gaps in the current understanding of drug-evoked in vivo structural plasticity. We also discuss the prospects of using synaptic remodelling to understand other antidepressant interventions, such as repetitive transcranial magnetic stimulation. Finally, we conclude that structural neural plasticity can provide unique insights into the neurobiological actions of psychoactive drugs and antidepressant interventions.</p>","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":" ","pages":""},"PeriodicalIF":34.7,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1038/s41583-024-00887-x
Katherine Whalley
Innate lymphoid cells regulate inhibitory synapse formation in the mouse cortex during early postnatal life.
先天性淋巴细胞在小鼠出生后早期调节大脑皮层抑制性突触的形成
{"title":"Innate immune control of synapse development","authors":"Katherine Whalley","doi":"10.1038/s41583-024-00887-x","DOIUrl":"https://doi.org/10.1038/s41583-024-00887-x","url":null,"abstract":"Innate lymphoid cells regulate inhibitory synapse formation in the mouse cortex during early postnatal life.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"76 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-14DOI: 10.1038/s41583-024-00877-z
Adam Turnbull, Feng Vankee Lin, Zhengwu Zhang
{"title":"Issues of parcellation in the calculation of structure-function coupling.","authors":"Adam Turnbull, Feng Vankee Lin, Zhengwu Zhang","doi":"10.1038/s41583-024-00877-z","DOIUrl":"10.1038/s41583-024-00877-z","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":" ","pages":""},"PeriodicalIF":34.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-14DOI: 10.1038/s41583-024-00878-y
Panagiotis Fotiadis, Dani S Bassett
{"title":"Reply to 'Issues of parcellation in the calculation of structure-function coupling'.","authors":"Panagiotis Fotiadis, Dani S Bassett","doi":"10.1038/s41583-024-00878-y","DOIUrl":"10.1038/s41583-024-00878-y","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":" ","pages":""},"PeriodicalIF":34.7,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-13DOI: 10.1038/s41583-024-00884-0
Michael Attwaters
Tan et al. identify a population of leptin-responsive neurons that regulate food intake and body weight.
Tan 等人发现了一个瘦素反应神经元群体，它能调节食物摄入量和体重。
{"title":"A new target for leptin","authors":"Michael Attwaters","doi":"10.1038/s41583-024-00884-0","DOIUrl":"https://doi.org/10.1038/s41583-024-00884-0","url":null,"abstract":"Tan et al. identify a population of leptin-responsive neurons that regulate food intake and body weight.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"10 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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