Pub Date : 2026-01-23DOI: 10.1038/s41583-025-01021-1
M. Natasha Rajah, Roger A. Dixon, Gillian Einstein, Yaakov Stern, , Amanpreet Badhwar, Rachel Buckley, Karen Campbell, Keita Christophe, Jason Deska, Audrey Duarte, Liisa Galea, Maiya Geddes, Yasser Iturria-Medina, Inbal Itzhak, Robert-Paul Juster, Jim Mann, Bratislav Misic, Michael Rugg, Madeleine Sharp, Prashanthi Vemuri
{"title":"A roadmap for conducting more inclusive research on brain resilience in ageing and dementia","authors":"M. Natasha Rajah, Roger A. Dixon, Gillian Einstein, Yaakov Stern, , Amanpreet Badhwar, Rachel Buckley, Karen Campbell, Keita Christophe, Jason Deska, Audrey Duarte, Liisa Galea, Maiya Geddes, Yasser Iturria-Medina, Inbal Itzhak, Robert-Paul Juster, Jim Mann, Bratislav Misic, Michael Rugg, Madeleine Sharp, Prashanthi Vemuri","doi":"10.1038/s41583-025-01021-1","DOIUrl":"https://doi.org/10.1038/s41583-025-01021-1","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"70 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146033215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1038/s41583-026-01022-8
Arjen J Boender
{"title":"Behaviour without synapses: peptidergic signalling as a mode of behavioural coordination.","authors":"Arjen J Boender","doi":"10.1038/s41583-026-01022-8","DOIUrl":"https://doi.org/10.1038/s41583-026-01022-8","url":null,"abstract":"","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"29 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-13DOI: 10.1038/s41583-025-01016-y
Lia G Carvalhais,Koen Kole,Marijn Kuijpers
Neurons are structurally complex and highly compartmentalized, placing unique demands on organelles to adapt locally and support communication across long distances. The endoplasmic reticulum (ER) meets this challenge through a dynamic and versatile architecture that spans the entire neuron. While specialized ER structures in axons, dendrites and synapses have been recognized for some time, recent work has uncovered new insights into their local functions and interactions with other membranes. In this Review, we highlight how neuronal ER morphology is established in different subcellular domains, including somato-dendritic regions, axons, and presynaptic and postsynaptic sites. These distinct ER structures enable localized functions in Ca2+ signalling, biosynthesis, excitability, regeneration, synaptic transmission and plasticity. We also discuss how perturbations in the ER contribute to neurodegenerative diseases.
{"title":"The diverse forms and roles of the neuronal endoplasmic reticulum.","authors":"Lia G Carvalhais,Koen Kole,Marijn Kuijpers","doi":"10.1038/s41583-025-01016-y","DOIUrl":"https://doi.org/10.1038/s41583-025-01016-y","url":null,"abstract":"Neurons are structurally complex and highly compartmentalized, placing unique demands on organelles to adapt locally and support communication across long distances. The endoplasmic reticulum (ER) meets this challenge through a dynamic and versatile architecture that spans the entire neuron. While specialized ER structures in axons, dendrites and synapses have been recognized for some time, recent work has uncovered new insights into their local functions and interactions with other membranes. In this Review, we highlight how neuronal ER morphology is established in different subcellular domains, including somato-dendritic regions, axons, and presynaptic and postsynaptic sites. These distinct ER structures enable localized functions in Ca2+ signalling, biosynthesis, excitability, regeneration, synaptic transmission and plasticity. We also discuss how perturbations in the ER contribute to neurodegenerative diseases.","PeriodicalId":19082,"journal":{"name":"Nature Reviews Neuroscience","volume":"35 1","pages":""},"PeriodicalIF":34.7,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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