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[Genetic analysis of multifactorial cardiac diseases: idiopathic dilated cardiomyopathy and myocardial infarction]. [多因素心脏病的遗传分析:特发性扩张型心肌病和心肌梗死]。
Pub Date : 1999-10-01 DOI: 10.1272/jnms.66.332
A Kimura
備考 原因遺伝子 原因遺伝子座 遺伝形式 心筋αアクチン 15q14 AD 不整脈を伴う 不明 CMD1A (CDCD1) 1p11 q11 不明 CMD1B (CMPD1) 9q13 q22 不明 CMD1C (CMPD3) 10q21 q22 不明 CMD1D (CMPD2) 1q32 不整脈を伴う 不明 CMD1E (CDCD2) 3p22 p25 不整脈と筋症状を伴う 不明 CMD1F 6q23 不明(タイチン?) CMD1G 2q31 筋症状のないもの ディストロフィン XLDCM Xq21.2 XR Barth 症候群(白血球減少を伴う乳児DCM) タファジン Xq28 筋症状を伴う乳児DCM CPTase 1p32 AR ミトコンドリア病 tRNA, rRNA ミトコンドリアDNA M #常染色体性優性遺伝(AD),常染色体劣性遺伝(AR),伴性劣性遺伝(XR),母系遺伝(M) はじめに
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引用次数: 1
[Perspective of clinical genetics]. [临床遗传学观点]。
Pub Date : 1999-10-01 DOI: 10.1272/jnms.66.340
A Watanabe, M Migita, Y Watanabe, T Shimada
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引用次数: 1
[Kallmann syndrome: a failure of GnRH neuronal migration]. [Kallmann综合征:GnRH神经元迁移失败]。
Pub Date : 1999-08-01 DOI: 10.1272/jnms.66.220
I S Parhar, Y Sakuma
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引用次数: 0
[Autoimmune fatigue syndrome and fibromyalgia syndrome]. 自身免疫疲劳综合征和纤维肌痛综合征。
Pub Date : 1999-08-01 DOI: 10.1272/jnms.66.239
Y Itoh, T Igarashi, N Tatsuma, T Imai, J Yoshida, M Tsuchiya, M Murakami, Y Fukunaga

We have encounted two patients with fibromyalgia (FM) initially diagnosed as having autoimmune fatigue syndrome (AIFS). To investigate the relationship between AIFS and FM, the distribution of the tender points in patients with AIFS was assessed according to the ACR criteria for FM. It was revealed that AIFS patients had 5.6 tender points on averages. Patients with headaches, digestive problems, or difficulty going to school had more tender points than patients without. Patients with ANA titers < 1: 160 had more tender points than patients with ANA > or = 1: 160. Anti-Sa negative patients had more tender points than positive patients. These results suggest a relationship between AIFS and FM in terms of the pathophysiologic mechanisms of the numerous tender points. In other words, ANA-positive FM patients could be one form of AIFS, as well as ANA-positive chronic fatigue syndrome patients. Thus, autoimmunity could explain the controversial disease entities of FM and/or CFS.

我们遇到了两例纤维肌痛(FM)患者,最初诊断为自身免疫性疲劳综合征(AIFS)。为了研究AIFS与FM之间的关系,根据FM的ACR标准评估AIFS患者压痛点的分布。结果显示,AIFS患者平均有5.6个压痛点。有头痛、消化问题或上学困难的患者比没有头痛的患者有更多的压痛点。ANA滴度< 1:16 0的患者比ANA滴度>或= 1:16 0的患者有更多的压痛点。抗- sa阴性患者的压痛点多于阳性患者。这些结果表明,AIFS和FM之间的关系在众多压痛点的病理生理机制方面。也就是说,ana阳性的FM患者可能是AIFS的一种,ana阳性的慢性疲劳综合征患者也可能是AIFS的一种。因此,自身免疫可以解释FM和/或CFS有争议的疾病实体。
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引用次数: 1
[Effects of bright light on cognitive disturbances in Alzheimer-type dementia]. [强光对阿尔茨海默型痴呆患者认知障碍的影响]。
Pub Date : 1999-08-01 DOI: 10.1272/jnms.66.229
T Ito, H Yamadera, R Ito, S Endo

We investigated the effectiveness of bright light therapy on cognitive disturbances and its effect on circadian (sleep-wake) rhythm in Alzheimer-type dementia (ATD). Twenty-seven patients with ATD were treated with bright light therapy in the morning for 4 consecutive weeks. We evaluated the cognitive functions and circadian rhythms of the patients as a whale, and as members of two groups (one: questionable and mild dementia: the other: moderate and severe dementia; both groups classified by the severity criteria of Clinical Dementia Rating). We assessed circadian rhythms by actigraphy and cognitive states by Mini-Mental-State Examination (MMSE) and Alzheimer's Disease Assessment Scale (ADAS) before and after light therapy. Bright light therapy improved circadian rhythm. Although bright light therapy had no Significant effect on the Severity of dementia, it improved the MMSE scores, cognitive functions of ADAS scores (memory > language) and non-cognitive functions of ADAS scores (behavior = mood), especially in the questionable and mild dementia group. These results suggest that bright light therapy improves cognitive functions with the modification of circadian rhythm, especially in the early stages of ATD.

我们研究了强光治疗阿尔茨海默型痴呆(ATD)认知障碍的有效性及其对昼夜节律(睡眠-觉醒)节律的影响。对27例ATD患者进行连续4周的晨光治疗。我们将患者的认知功能和昼夜节律作为鲸鱼进行评估,并作为两组成员(一组:可疑和轻度痴呆;另一组:中度和重度痴呆;两组均按临床痴呆评分的严重程度标准进行分类)。我们在光疗前后通过活动记录仪评估昼夜节律,通过迷你精神状态检查(MMSE)和阿尔茨海默病评估量表(ADAS)评估认知状态。强光疗法改善了昼夜节律。虽然强光疗法对痴呆的严重程度没有显著影响,但它改善了MMSE评分、ADAS评分的认知功能(记忆>语言)和ADAS评分的非认知功能(行为=情绪),尤其是在可疑和轻度痴呆组。这些结果表明,强光疗法通过改变昼夜节律来改善认知功能,特别是在ATD的早期阶段。
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引用次数: 14
[Diagnosis and treatment of atopic dermatitis]. 【特应性皮炎的诊断与治疗】。
Pub Date : 1999-08-01 DOI: 10.1272/jnms.66.279
S Kawana
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引用次数: 12
[Clinical study of Helicobacter pylori infection]. 幽门螺杆菌感染的临床研究
Pub Date : 1999-08-01 DOI: 10.1272/jnms.66.222
T Matsuhisa, N Yamada
{"title":"[Clinical study of Helicobacter pylori infection].","authors":"T Matsuhisa,&nbsp;N Yamada","doi":"10.1272/jnms.66.222","DOIUrl":"https://doi.org/10.1272/jnms.66.222","url":null,"abstract":"","PeriodicalId":19192,"journal":{"name":"Nihon Ika Daigaku zasshi","volume":"66 4","pages":"222-8"},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21330144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal diagnosis of acute massive fetomaternal hemorrhage. 急性大出血的产前诊断。
Pub Date : 1999-08-01 DOI: 10.1272/jnms.66.266
T Ohshita, S Suzuki, R Sawa, Y Yoneyama, H Asakura, T Araki

We present here 2 cases of acute and 2 cases of chronic massive fetomaternal hemorrhage. A sinusoidal fetal heart rate pattern may indicate chronic fetomaternal hemorrhage, but, when increased variability is observed in fetal monitoring, maternal hemoglobin F should be measured to exclude acute fetomaternal hemorrhage.

我们在此报告2例急性和2例慢性大出血。胎儿心率呈正弦型可能提示慢性胎母出血,但是,当胎儿监测中观察到变异性增加时,应测量母体血红蛋白F以排除急性胎母出血。
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引用次数: 9
Value of magnetization transfer contrast as a sensitive technique to reflect histopathological changes in the white matter adjacent to the frontal horns of lateral ventricles. 磁化转移造影剂作为反映侧脑室额角附近白质组织病理变化的敏感技术的价值。
Pub Date : 1999-08-01 DOI: 10.1272/jnms.66.245
M Nakahara, H Hayashi, T Kumazaki, O Mori

The purpose of this study is to evaluate the usefulness of magnetization transfer contrast (MTC) as a technique to reflect histopathological changes in the white matter adjacent to the frontal horns of the lateral ventricles. Radiological-pathological correlation was performed in six patients who underwent Magnetic Resonance (MR) examination prior to death and in whom postmortem examinations of the brain were obtained. The extent and the severity of degeneration in the white matter adjacent to the frontal horns were evaluated histopathologically, and compared with those observed on the conventional proton density (PD) weighted MR images (Group 1). Changes in the white matter of another 35 patients were classified into three types according to the pattern of high signals adjacent to the frontal horns on conventional PD weighted MR images, and magnetization transfer ratio (MTR) in the white matter adjacent to the frontal horns was calculated from multi-slice and single-slice FSE images (Group 2). The relationship between signal intensities and MTR in the white matter adjacent to the frontal horns was evaluated. The extent of degeneration in the white matter adjacent to the frontal horns was classified into mild, moderate and severe types on the basis of stainin for myelins, axons and astrocytes. In Group 1, histopathological findings indicated a difference in severity of degeneration in the white matter adjacent to the frontal horns among the three types, while no significant differences were noted in the signals on PD weighted MR images. In Group 2, MTR showed significant differences in the signal intensities in the white matter adjacent to the frontal horns (p < 0.01) between the three types, while conventional PD weighted MR images failed to differentiate between them. In conclusion, MT imaging is a sensitive technique to evaluate the histopathological changes in the white matter adjacent to the frontal horns that cannot be detected by conventional MR imaging.

本研究的目的是评估磁化转移造影剂(MTC)作为一种反映侧脑室额角附近白质组织病理学变化的技术的实用性。对6例在死亡前接受磁共振(MR)检查并在死后进行脑检查的患者进行放射学-病理学相关性分析。组织病理学评估额角附近白质变性的程度和严重程度,并与常规质子密度(PD)加权MR图像观察结果进行比较(1组)。另外35例患者的白质改变根据常规PD加权MR图像上额角附近高信号的模式分为三种类型。从多层和单层FSE图像(组2)计算前角附近白质的磁化传递比(MTR)。评估信号强度与前角附近白质的MTR之间的关系。根据髓鞘、轴突和星形胶质细胞的染色,将额角附近白质的变性程度分为轻度、中度和重度。在第1组中,组织病理学结果显示,三种类型的额角附近白质退行性变的严重程度不同,而PD加权MR图像上的信号无显著差异。在第二组中,MTR显示三种类型在额角附近白质的信号强度上有显著差异(p < 0.01),而常规PD加权MR图像无法区分它们。总之,MT成像是一种敏感的技术,可以评估常规MR成像无法检测到的额角附近白质的组织病理学变化。
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引用次数: 5
Two types of peritoneal dissemination of pancreatic cancer cells in a hamster model. 两种类型的胰腺癌细胞在仓鼠模型腹膜播散。
Pub Date : 1999-08-01 DOI: 10.1272/jnms.66.253
S Yamamura, M Onda, E Uchida

Peritoneal dissemination has an unfavorable impact on the prognosis of pancreatic cancer, and a peritoneal dissemination model was created in hamsters by using an experimental pancreatic cancer to clarify its pathological characteristics. PGHAM-1, a cancer cell line we established from BOP induced pancreatic cancer in Syrian golden hamsters, was inoculated into the abdominal cavity of Syrian golden hamsters. After inoculation, sequential changes in the diaphragm, omentum, and parietal peritoneum, and the metastatic patterns of the PGHAM-1 cells were morphologically investigated by macroscopical, microscopical, and ultrastructural observation. The cancer cells were easily absorbed at the stomata in the diaphragm and milky spots in the omentum, which were absorptive lymphatic structures, and lymphatic metastasis occurred 4 days after inoculation. In the parietal peritoneum, however, the cancer cells attached to and proliferated on the parietal peritoneum where mesothelial cells had exfoliated and the basement membrane was exposed. This process was comparatively time-consuming, and metastasis occurred in the parietal peritoneum at 7 days after inoculation. This study suggested that there might be two patterns of peritoneal dissemination of hamster pancreatic cancer. One route is lymphatic metastasis via stomata in the diaphragm and milky spots in the omentum, and the other is direct metastasis on the parietal peritoneum; each metastasis forms independently.

腹膜播散对胰腺癌的预后有不利影响,我们利用实验性胰腺癌在仓鼠体内建立腹膜播散模型,阐明其病理特征。将BOP诱导的叙利亚金仓鼠胰腺癌细胞系PGHAM-1接种于叙利亚金仓鼠腹腔。接种后,通过宏观、显微镜和超微结构观察,观察膈膜、大网膜和腹膜顶膜的顺序变化及PGHAM-1细胞的转移模式。肿瘤细胞在横膈膜的气孔和大网膜的乳状斑点处容易被吸收,为吸收性淋巴结构,接种后4 d发生淋巴转移。然而,在腹膜壁层,癌细胞附着并在腹膜壁层上增殖,其中间皮细胞脱落,基底膜暴露。这个过程比较耗时,接种后7天在腹膜顶骨发生转移。本研究提示仓鼠胰腺癌可能有两种腹膜传播模式。一种途径是经横膈膜气孔和网膜乳白色斑点的淋巴转移,另一种途径是直接转移到腹膜壁层;每种转移都是独立形成的。
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引用次数: 12
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Nihon Ika Daigaku zasshi
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