首页 > 最新文献

Neurourology and Urodynamics最新文献

英文 中文
Potential for Misdiagnosis of Detrusor Underactivity Due to Urodynamic Voiding Position and Seating Characteristics.
IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-27 DOI: 10.1002/nau.25650
Rachel Vancavage, Oyenike Ilaka, Shreya Patel, Rosalie Zurlo, Paul Feustel, Rebecca G Rogers, Elise J B De, Brittany L Roberts

Background: Detrusor underactivity (DUA) is a lower urinary tract (LUT) diagnosis that is diagnosed with multichannel urodynamic studies (UDS). The effect of voiding position and DUA detection is unclear.

Objectives: We investigated whether moving individuals from the UDS chair to their typical voiding position would more accurately assess detrusor function in cases of absent or nonrepresentative voiding. We hypothesized that patients unable to achieve a representative void while on the UDS chair may be misdiagnosed with DUA, and that changing position may reveal intact detrusor function.

Methods: We retrospectively studied patients who underwent UDS with a single provider over 2 years. Studies were included if a patient was moved to a new position after unsuccessful or unrepresentative void attempts on the UDS chair. Two neurourologists reanalyzed the studies and recorded: time spent attempting to void on UDS chair and after moving position, whether a bladder contraction occurred on UDS chair, pdet Q max and Q max when voiding occurred, presence of a bladder contraction in new position, and pdet Q max and Q max in new position, and Valsalva effort.

Results: 503 patients underwent UDS; 94/503 patients were moved to a new position and 81/94 studies were interpretable. 71% of patients without a bladder contraction on the UDS chair demonstrated contraction in new position.

Conclusion: UDS voiding position and surface can impact whether patients produce a bladder contraction and representative void during urodynamic testing. Positional change to more natural voiding positions and surfaces improves detection of intact detrusor function.

{"title":"Potential for Misdiagnosis of Detrusor Underactivity Due to Urodynamic Voiding Position and Seating Characteristics.","authors":"Rachel Vancavage, Oyenike Ilaka, Shreya Patel, Rosalie Zurlo, Paul Feustel, Rebecca G Rogers, Elise J B De, Brittany L Roberts","doi":"10.1002/nau.25650","DOIUrl":"https://doi.org/10.1002/nau.25650","url":null,"abstract":"<p><strong>Background: </strong>Detrusor underactivity (DUA) is a lower urinary tract (LUT) diagnosis that is diagnosed with multichannel urodynamic studies (UDS). The effect of voiding position and DUA detection is unclear.</p><p><strong>Objectives: </strong>We investigated whether moving individuals from the UDS chair to their typical voiding position would more accurately assess detrusor function in cases of absent or nonrepresentative voiding. We hypothesized that patients unable to achieve a representative void while on the UDS chair may be misdiagnosed with DUA, and that changing position may reveal intact detrusor function.</p><p><strong>Methods: </strong>We retrospectively studied patients who underwent UDS with a single provider over 2 years. Studies were included if a patient was moved to a new position after unsuccessful or unrepresentative void attempts on the UDS chair. Two neurourologists reanalyzed the studies and recorded: time spent attempting to void on UDS chair and after moving position, whether a bladder contraction occurred on UDS chair, pdet Q max and Q max when voiding occurred, presence of a bladder contraction in new position, and pdet Q max and Q max in new position, and Valsalva effort.</p><p><strong>Results: </strong>503 patients underwent UDS; 94/503 patients were moved to a new position and 81/94 studies were interpretable. 71% of patients without a bladder contraction on the UDS chair demonstrated contraction in new position.</p><p><strong>Conclusion: </strong>UDS voiding position and surface can impact whether patients produce a bladder contraction and representative void during urodynamic testing. Positional change to more natural voiding positions and surfaces improves detection of intact detrusor function.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Nocturia Determinants Using a Novel Portable Urine-Measuring Device. 用一种新型便携式尿量仪分析夜尿症决定因素。
IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-20 DOI: 10.1002/nau.25667
Kotaro Yamasue, Tomohiko Kaneoka, Tomoyuki Tatenuma, Masanari Umemura

Aims: To investigate the relationship between nocturia and values measured using a novel multifunctional portable urine-measuring device.

Methods: Thirty-five older men with nocturia and/or high-normal or high blood pressure were enrolled to record measurements on one full day (24 h) and two nights using the portable device during urination. Participants used a semi-conical cup with a small hole equipped with a conductivity sensor, temperature sensor, and timer to measure urine volume, salt content, urine temperature, and urination speed.

Results: Two participants were excluded owing to oliguria. The mean age of 33 participants was 75.2 ± 7.4 years (range: 55-85 years). The mean nocturnal urination frequency, including the first urination after waking, was 2.1 ± 0.6 times. Simple correlation analysis revealed that nocturnal urine frequency significantly increased with nocturnal urine volume (r = 0.65, p < 0.001) and salt content (r = 0.57, p < 0.001) but not with 24-h urine volume and salt content. Furthermore, the frequency significantly decreased with nocturnal urine temperature (r = -0.37, p < 0.05). No significant relationship was observed between morning blood pressure and nocturnal urination frequency. A high correlation was observed between nighttime urine volume and salt content (r = 0.73, p < 0.001).

Conclusions: Nocturnal urine volume, salt content, and urine temperature are significantly correlated with nocturia. The portable urine-measuring device could guide nocturia reduction through facilitation of the reduction of nocturnal urine volume and salt content, in addition to urine temperature monitoring.

目的:探讨一种新型多功能便携式尿量仪与夜尿症的关系。方法:选取35例夜尿症和/或高血压的老年男性,分别在一天(24小时)和两晚使用便携式装置记录排尿时的测量值。参与者使用一个带有小孔的半圆锥形杯子,杯子上装有导电性传感器、温度传感器和计时器来测量尿量、盐含量、尿温和排尿速度。结果:2名受试者因少尿被排除。33名参与者的平均年龄为75.2±7.4岁(55-85岁)。平均夜间排尿次数(包括醒后第一次排尿)为2.1±0.6次。简单相关分析显示,夜尿频率随夜尿量的增加而显著增高(r = 0.65, p)。结论:夜尿量、盐含量、尿温与夜尿症显著相关。便携式测尿仪除了监测尿温外,还可通过促进夜尿量和盐含量的降低来指导夜尿减少。
{"title":"Analysis of Nocturia Determinants Using a Novel Portable Urine-Measuring Device.","authors":"Kotaro Yamasue, Tomohiko Kaneoka, Tomoyuki Tatenuma, Masanari Umemura","doi":"10.1002/nau.25667","DOIUrl":"https://doi.org/10.1002/nau.25667","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the relationship between nocturia and values measured using a novel multifunctional portable urine-measuring device.</p><p><strong>Methods: </strong>Thirty-five older men with nocturia and/or high-normal or high blood pressure were enrolled to record measurements on one full day (24 h) and two nights using the portable device during urination. Participants used a semi-conical cup with a small hole equipped with a conductivity sensor, temperature sensor, and timer to measure urine volume, salt content, urine temperature, and urination speed.</p><p><strong>Results: </strong>Two participants were excluded owing to oliguria. The mean age of 33 participants was 75.2 ± 7.4 years (range: 55-85 years). The mean nocturnal urination frequency, including the first urination after waking, was 2.1 ± 0.6 times. Simple correlation analysis revealed that nocturnal urine frequency significantly increased with nocturnal urine volume (r = 0.65, p < 0.001) and salt content (r = 0.57, p < 0.001) but not with 24-h urine volume and salt content. Furthermore, the frequency significantly decreased with nocturnal urine temperature (r = -0.37, p < 0.05). No significant relationship was observed between morning blood pressure and nocturnal urination frequency. A high correlation was observed between nighttime urine volume and salt content (r = 0.73, p < 0.001).</p><p><strong>Conclusions: </strong>Nocturnal urine volume, salt content, and urine temperature are significantly correlated with nocturia. The portable urine-measuring device could guide nocturia reduction through facilitation of the reduction of nocturnal urine volume and salt content, in addition to urine temperature monitoring.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inspiration From Simplified Ligament Repair in Stress Urinary Incontinence. 简化韧带修复治疗压力性尿失禁的启示。
IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-16 DOI: 10.1002/nau.25668
Aybüke Tayarer, Filiz Dişçi
{"title":"Inspiration From Simplified Ligament Repair in Stress Urinary Incontinence.","authors":"Aybüke Tayarer, Filiz Dişçi","doi":"10.1002/nau.25668","DOIUrl":"https://doi.org/10.1002/nau.25668","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should We Be Treating Affective Symptoms, Like Anxiety and Depression Which May Be Related to LUTD in Patients With OAB? ICI-RS 2024. 我们是否应该治疗可能与OAB患者LUTD相关的情感症状,如焦虑和抑郁?ICI-RS 2024。
IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-16 DOI: 10.1002/nau.25662
Mauro Van den Ende, Apostolos Apostolidis, Sanjay Sinha, George Bou Kheir, Rayan Mohamed-Ahmed, Caroline Selai, Paul Abrams, Desiree Vrijens

Aims: To discuss the role of screening and treatment of affective symptoms, like anxiety and depression in patients with LUTD. A review of the literature regarding the bidirectional association and multidisciplinary approaches integrating psychometric assessments with personalized treatment plans to improve diagnostic accuracy and therapeutic outcomes of LUTD.

Methods: This review summarizes discussions and a narrative review of (recent) literature during an International Consultation on Incontinence-Research Society 2024 research proposal with respect to the role of screening for anxiety and depression, effect of mental health symptoms on treatment outcomes and future implications.

Results: Consensus recognized the importance to incorporate attention to anxiety and depression in relation to LUTD. The awareness of this association can lead to better outcomes. Future research projects are proposed to evaluate the bidirectional relationship.

Conclusion: The relationship between affective symptoms and LUTD underscores the need for integrated treatment approaches that address both psychological and urological dimensions. Further research is required to identify specific patient subgroups that would benefit most from these interventions, to develop standardized screening tools, and to refine treatment protocols. Multidisciplinary care, incorporating psychological assessment and personalized treatment strategies, could enhance outcomes for LUTD patients.

目的:探讨焦虑、抑郁等情感性症状在LUTD患者中的筛查和治疗作用。关于双向关联和多学科方法整合心理测量评估与个性化治疗计划,以提高LUTD的诊断准确性和治疗效果的文献综述。方法:本综述总结了在失禁研究学会2024年国际咨询会上关于焦虑和抑郁筛查的作用、心理健康症状对治疗结果的影响以及未来影响的讨论和(最近)文献的叙述性回顾。结果:共识认识到将注意力纳入与LUTD相关的焦虑和抑郁的重要性。意识到这种关联可以带来更好的结果。提出了未来的研究项目,以评估双向关系。结论:情感性症状与LUTD之间的关系强调了需要综合治疗方法,解决心理和泌尿方面的问题。需要进一步的研究来确定从这些干预措施中获益最多的特定患者亚组,开发标准化的筛查工具,并完善治疗方案。多学科治疗,结合心理评估和个性化治疗策略,可以提高LUTD患者的预后。
{"title":"Should We Be Treating Affective Symptoms, Like Anxiety and Depression Which May Be Related to LUTD in Patients With OAB? ICI-RS 2024.","authors":"Mauro Van den Ende, Apostolos Apostolidis, Sanjay Sinha, George Bou Kheir, Rayan Mohamed-Ahmed, Caroline Selai, Paul Abrams, Desiree Vrijens","doi":"10.1002/nau.25662","DOIUrl":"https://doi.org/10.1002/nau.25662","url":null,"abstract":"<p><strong>Aims: </strong>To discuss the role of screening and treatment of affective symptoms, like anxiety and depression in patients with LUTD. A review of the literature regarding the bidirectional association and multidisciplinary approaches integrating psychometric assessments with personalized treatment plans to improve diagnostic accuracy and therapeutic outcomes of LUTD.</p><p><strong>Methods: </strong>This review summarizes discussions and a narrative review of (recent) literature during an International Consultation on Incontinence-Research Society 2024 research proposal with respect to the role of screening for anxiety and depression, effect of mental health symptoms on treatment outcomes and future implications.</p><p><strong>Results: </strong>Consensus recognized the importance to incorporate attention to anxiety and depression in relation to LUTD. The awareness of this association can lead to better outcomes. Future research projects are proposed to evaluate the bidirectional relationship.</p><p><strong>Conclusion: </strong>The relationship between affective symptoms and LUTD underscores the need for integrated treatment approaches that address both psychological and urological dimensions. Further research is required to identify specific patient subgroups that would benefit most from these interventions, to develop standardized screening tools, and to refine treatment protocols. Multidisciplinary care, incorporating psychological assessment and personalized treatment strategies, could enhance outcomes for LUTD patients.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do We Have Sufficient Evidence to Derive Innovative Approaches to Assessing Unmet Need, Delivering Education on Bladder and Bowel Continence Health, and Providing a Better Environment for Joint Decision-Making? ICI-RS 2024. 我们是否有足够的证据来获得创新的方法来评估未满足的需求,提供关于膀胱和肠道失禁健康的教育,并为联合决策提供更好的环境?ICI-RS 2024。
IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-13 DOI: 10.1002/nau.25654
Nikki Cotterill, Michael Samarinas, Angie Rantell, Caroline Selai, Salvador Arlandis, Kathryn Jones, Paul Abrams, D Robinson, Adrian Wagg

Context: Improved continence outcomes are reliant on identification of unmet need, education delivery, and shared decision-making. The evidence base on which to derive innovative approaches in these areas was unclear.

Methods: A debate held at the International Consultation on Incontinence-Research Society meeting, held in Bristol in June 2024, considered ways to improve research requirements to advance these areas.

Results and conclusion: Artificial intelligence solutions and digital approaches to healthcare are emerging at pace and offer possibilities to improve these three key areas but this must be driven by person-centered approaches. Care must be taken to avoid increasing inequality through digital exclusion and language barriers. Research questions are highlighted to derive innovation in these three key areas.

背景:改善尿失禁的结果依赖于未满足需求的识别、教育的提供和共同决策。在这些领域派生创新方法的证据基础尚不清楚。方法:2024年6月在布里斯托尔举行的国际失禁研究学会会议上举行的一场辩论,考虑了改善研究要求以推进这些领域的方法。结果和结论:医疗保健的人工智能解决方案和数字方法正在迅速涌现,并为改善这三个关键领域提供了可能性,但这必须以人为本的方法为驱动。必须注意避免因数字排斥和语言障碍而加剧不平等。研究问题突出,以获得在这三个关键领域的创新。
{"title":"Do We Have Sufficient Evidence to Derive Innovative Approaches to Assessing Unmet Need, Delivering Education on Bladder and Bowel Continence Health, and Providing a Better Environment for Joint Decision-Making? ICI-RS 2024.","authors":"Nikki Cotterill, Michael Samarinas, Angie Rantell, Caroline Selai, Salvador Arlandis, Kathryn Jones, Paul Abrams, D Robinson, Adrian Wagg","doi":"10.1002/nau.25654","DOIUrl":"https://doi.org/10.1002/nau.25654","url":null,"abstract":"<p><strong>Context: </strong>Improved continence outcomes are reliant on identification of unmet need, education delivery, and shared decision-making. The evidence base on which to derive innovative approaches in these areas was unclear.</p><p><strong>Methods: </strong>A debate held at the International Consultation on Incontinence-Research Society meeting, held in Bristol in June 2024, considered ways to improve research requirements to advance these areas.</p><p><strong>Results and conclusion: </strong>Artificial intelligence solutions and digital approaches to healthcare are emerging at pace and offer possibilities to improve these three key areas but this must be driven by person-centered approaches. Care must be taken to avoid increasing inequality through digital exclusion and language barriers. Research questions are highlighted to derive innovation in these three key areas.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Should the BCI and BOOI Index be Correctly Applied in Patients With Low-Compliance Bladder? 低顺应性膀胱患者如何正确应用BCI和BOOI指数?
IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-08 DOI: 10.1002/nau.25663
Xiao Zeng, Ting Kang, WenJiao Huang, Tao Jin
{"title":"How Should the BCI and BOOI Index be Correctly Applied in Patients With Low-Compliance Bladder?","authors":"Xiao Zeng, Ting Kang, WenJiao Huang, Tao Jin","doi":"10.1002/nau.25663","DOIUrl":"https://doi.org/10.1002/nau.25663","url":null,"abstract":"","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unilateral and Bilateral Transcutaneous Tibial Nerve Stimulation in Women With Overactive Bladder Syndrome: A Randomized Controlled Study (UBTTNS-OAB Study). 单侧和双侧经皮胫神经刺激治疗女性膀胱过度活动综合征:随机对照研究(UBTTNS-OAB 研究)。
IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 Epub Date: 2024-10-25 DOI: 10.1002/nau.25608
Letícia Martinelli Galhardo, Geovanna Volta Giorgenon, Marina Rótoli, Camila Carvalho de Araújo, Luiz G O Brito, Cássia R T Juliato

Introduction: The efficacy of unilateral versus bilateral Transcutaneous Tibial Nerve Stimulation (TTNS) for women with Overactive Bladder Syndrome (OAB) remains uncertain.

Objective: To compare the efficacy of unilateral and bilateral TTNS in the tibial region in women with OAB.

Methods: This randomized, controlled, triple-blind clinical trial included women with OAB or urgency-predominant urinary incontinence (UUI). Participants were randomized (1:1) into the Unilateral Tibial Group or Bilateral Tibial Group. Before treatment, they underwent a pre-assessment including peripheral sensitivity examination and completion of sociodemographic data and seven validated questionnaires on urinary symptoms, quality of life, sleep, and psycho-emotional aspects. TTNS interventions were administered twice weekly (12 sessions, 30 min each). Posttreatment, participants underwent another physical examination and completed the same questionnaires, with a 30-day follow-up. Categorical variables were analyzed using Chi-square or Fisher's Exact Test, while numerical variables were assessed with the Mann-Whitney test. Group comparisons over time utilized intention-to-treat ANOVA (p < 0.05).

Results: Thirty-five women participated: 17 in the unilateral group and 18 in the bilateral group. Mean ages were 55.1 (±14.7) years and 52.7 (±12.6) years, respectively (p = 0.680). Initial OAB severity (ICIQ-OAB) did not differ significantly between groups (p = 0.561). Both groups showed significant improvement in ICIQ-OAB scores: unilateral group from 10.1 (±3.4) to 5.8 (±3.4) (p < 0.001), bilateral group from 9.3 (±3.3) to 5.1 (±4) (p < 0.001), with no intergroup difference (p = 0.395). Improvement in UUI symptoms was observed: unilateral group from 2.2 (±1.4) to 0.7 (±1.5), bilateral group from 1.5 (±1.9) to 0.2 (±0.5), without significant intergroup difference (p = 0.645). Quality of life scores improved similarly between groups (p = 0.055).

Conclusion: TTNS appears to be effective in improving bladder storage and UUI symptoms in women with OAB, with no difference between unilateral and bilateral applications.

Clinical trial registration: Brazilian Registry of Clinical Trials (REBEC) (RBR: 96f2fgkn).

导言:单侧和双侧经皮胫神经刺激(TTNS)对膀胱过度活动综合征(OAB)女性患者的疗效仍不确定:比较单侧和双侧经皮胫神经刺激术对膀胱过度活动症女性患者的疗效:这项随机对照三盲临床试验的参与者包括患有尿失禁(OAB)或急迫性尿失禁(UUI)的女性。参与者被随机(1:1)分为单侧胫骨组或双侧胫骨组。在治疗前,他们接受了预评估,包括外周敏感度检查、社会人口学数据填写以及关于排尿症状、生活质量、睡眠和心理情感方面的七份有效问卷。TTNS 干预每周进行两次(12 次,每次 30 分钟)。治疗后,参与者再次接受身体检查,填写相同的问卷,并进行为期 30 天的随访。分类变量采用卡方检验(Chi-square)或费雪精确检验(Fisher's Exact Test)进行分析,数字变量采用曼惠尼检验(Mann-Whitney Test)进行评估。不同时间段的组间比较采用意向治疗方差分析(P 结果:35 名妇女参加了治疗:单侧组 17 人,双侧组 18 人。平均年龄分别为 55.1 (±14.7) 岁和 52.7 (±12.6) 岁(p = 0.680)。两组患者最初的 OAB 严重程度(ICIQ-OAB)无显著差异(p = 0.561)。两组患者的 ICIQ-OAB 评分均有明显改善:单侧组从 10.1(±3.4)分降至 5.8(±3.4)分(p 结论:TTNS 似乎能有效治疗 OAB:TTNS似乎能有效改善OAB女性患者的膀胱储尿和尿失禁症状,单侧和双侧应用之间没有差异:临床试验注册:巴西临床试验注册中心(REBEC)(RBR:96f2fgkn)。
{"title":"Unilateral and Bilateral Transcutaneous Tibial Nerve Stimulation in Women With Overactive Bladder Syndrome: A Randomized Controlled Study (UBTTNS-OAB Study).","authors":"Letícia Martinelli Galhardo, Geovanna Volta Giorgenon, Marina Rótoli, Camila Carvalho de Araújo, Luiz G O Brito, Cássia R T Juliato","doi":"10.1002/nau.25608","DOIUrl":"10.1002/nau.25608","url":null,"abstract":"<p><strong>Introduction: </strong>The efficacy of unilateral versus bilateral Transcutaneous Tibial Nerve Stimulation (TTNS) for women with Overactive Bladder Syndrome (OAB) remains uncertain.</p><p><strong>Objective: </strong>To compare the efficacy of unilateral and bilateral TTNS in the tibial region in women with OAB.</p><p><strong>Methods: </strong>This randomized, controlled, triple-blind clinical trial included women with OAB or urgency-predominant urinary incontinence (UUI). Participants were randomized (1:1) into the Unilateral Tibial Group or Bilateral Tibial Group. Before treatment, they underwent a pre-assessment including peripheral sensitivity examination and completion of sociodemographic data and seven validated questionnaires on urinary symptoms, quality of life, sleep, and psycho-emotional aspects. TTNS interventions were administered twice weekly (12 sessions, 30 min each). Posttreatment, participants underwent another physical examination and completed the same questionnaires, with a 30-day follow-up. Categorical variables were analyzed using Chi-square or Fisher's Exact Test, while numerical variables were assessed with the Mann-Whitney test. Group comparisons over time utilized intention-to-treat ANOVA (p < 0.05).</p><p><strong>Results: </strong>Thirty-five women participated: 17 in the unilateral group and 18 in the bilateral group. Mean ages were 55.1 (±14.7) years and 52.7 (±12.6) years, respectively (p = 0.680). Initial OAB severity (ICIQ-OAB) did not differ significantly between groups (p = 0.561). Both groups showed significant improvement in ICIQ-OAB scores: unilateral group from 10.1 (±3.4) to 5.8 (±3.4) (p < 0.001), bilateral group from 9.3 (±3.3) to 5.1 (±4) (p < 0.001), with no intergroup difference (p = 0.395). Improvement in UUI symptoms was observed: unilateral group from 2.2 (±1.4) to 0.7 (±1.5), bilateral group from 1.5 (±1.9) to 0.2 (±0.5), without significant intergroup difference (p = 0.645). Quality of life scores improved similarly between groups (p = 0.055).</p><p><strong>Conclusion: </strong>TTNS appears to be effective in improving bladder storage and UUI symptoms in women with OAB, with no difference between unilateral and bilateral applications.</p><p><strong>Clinical trial registration: </strong>Brazilian Registry of Clinical Trials (REBEC) (RBR: 96f2fgkn).</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"125-135"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prediction Value of Bladder Deformity Index for Upper Urinary Tract Damage in Patients With Neurogenic Bladder. 膀胱畸形指数对神经源性膀胱患者上尿路损伤的预测价值
IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 Epub Date: 2024-11-11 DOI: 10.1002/nau.25610
Ran Chang, Limin Liao, Huafang Jing, Yi Gao, Siyu Zhang, Yue Wang, Juan Wu

Aim: This study aimed to assess the predictive value of the Bladder Deformity Index (BDI) in determining upper urinary tract (UUT) damage among patients with neurogenic bladder (NB).

Methods: Clinical data of 132 NB patients admitted to the China Rehabilitation Research Center between January 2018 and December 2023 were retrospectively analyzed. Patients were categorized into UUT damage and normal UUT function groups based on the MRU and ultrasound grading systems for hydronephrosis, patients with the grade greater than or equal to I degree were considered to have UUTD. Patient demographics, biochemical parameters, and video-urodynamics (VUDS) findings were collected, and BDI was calculated. Independent sample t tests were employed to compare general characteristics and VUDS parameters between groups. Receiver operating characteristic (ROC) curves were utilized to evaluate the predictive capability of UUT damage.

Results: The study comprised 132 patients (86 males and 46 females) with an average NB duration of 7.37 ± 9.37 years (range: 0.2-44 years). UUT damage was present in 40.91% (n = 54) of patients. Significant differences (p < 0.05) were observed between the UUT damage and normal groups in terms of the duration of LUTS (9.98 ± 10.52 vs. 4.83 ± 7.32 years), creatinine levels (135.58 ± 110.51 vs. 57.66 ± 12.26 μmol/L), and BDI (103.28 ± 71.6 vs. 19.23 ± 15.03%). No significant differences were noted in age, bladder volume, or residual urine between the groups (p > 0.05). The AUC for the duration of LUTS, creatinine, and BDI were 0.691, 0.786, and 0.908, respectively, with a BDI Yoden index of 77%.

Conclusion: Long-term LUTS, elevated creatinine levels, and high BDI are associated with UUT damage. BDI demonstrates high sensitivity and specificity in diagnosing UUT damage, outperforming creatinine levels and NB duration. Patients with BDI values exceeding 77% are at a heightened risk of UUT damage. BDI facilitates quantitative evaluation of cystography and preliminary evaluation upper and lower urinary tract function in NB patients. Further research is warranted to validate BDI's feasibility in quantifying cystography and diagnosing UUT damage.

Trial registration: This study is retrospective and does not require clinical trial registration.

目的:本研究旨在评估膀胱畸形指数(BDI)在判断神经源性膀胱(NB)患者上尿路(UUT)损伤方面的预测价值:回顾性分析2018年1月至2023年12月期间中国康复研究中心收治的132例NB患者的临床数据。根据MRU和超声肾积水分级系统将患者分为UUT损伤组和UUT功能正常组,分级大于或等于I度的患者被认为患有UUTD。收集患者的人口统计学资料、生化参数和视频尿动力学(VUDS)检查结果,并计算 BDI。采用独立样本 t 检验比较组间一般特征和 VUDS 参数。利用受体操作特征曲线(ROC)评估 UUT 损伤的预测能力:该研究包括 132 名患者(86 名男性和 46 名女性),平均 NB 病程为 7.37 ± 9.37 年(范围:0.2-44 年)。40.91%的患者(n = 54)存在 UUT 损伤。差异显著(P 0.05)。LUTS持续时间、肌酐和BDI的AUC分别为0.691、0.786和0.908,BDI约登指数为77%:结论:长期尿失禁、肌酐水平升高和 BDI 偏高与 UUT 损伤有关。BDI 在诊断 UUT 损伤方面具有较高的灵敏度和特异性,优于肌酐水平和 NB 持续时间。BDI 值超过 77% 的患者发生 UUT 损伤的风险较高。BDI 有助于对膀胱造影进行定量评估,并初步评估 NB 患者的上下尿路功能。需要进一步研究验证 BDI 在量化膀胱造影和诊断 UUT 损伤方面的可行性:本研究为回顾性研究,无需进行临床试验注册。
{"title":"Prediction Value of Bladder Deformity Index for Upper Urinary Tract Damage in Patients With Neurogenic Bladder.","authors":"Ran Chang, Limin Liao, Huafang Jing, Yi Gao, Siyu Zhang, Yue Wang, Juan Wu","doi":"10.1002/nau.25610","DOIUrl":"10.1002/nau.25610","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to assess the predictive value of the Bladder Deformity Index (BDI) in determining upper urinary tract (UUT) damage among patients with neurogenic bladder (NB).</p><p><strong>Methods: </strong>Clinical data of 132 NB patients admitted to the China Rehabilitation Research Center between January 2018 and December 2023 were retrospectively analyzed. Patients were categorized into UUT damage and normal UUT function groups based on the MRU and ultrasound grading systems for hydronephrosis, patients with the grade greater than or equal to I degree were considered to have UUTD. Patient demographics, biochemical parameters, and video-urodynamics (VUDS) findings were collected, and BDI was calculated. Independent sample t tests were employed to compare general characteristics and VUDS parameters between groups. Receiver operating characteristic (ROC) curves were utilized to evaluate the predictive capability of UUT damage.</p><p><strong>Results: </strong>The study comprised 132 patients (86 males and 46 females) with an average NB duration of 7.37 ± 9.37 years (range: 0.2-44 years). UUT damage was present in 40.91% (n = 54) of patients. Significant differences (p < 0.05) were observed between the UUT damage and normal groups in terms of the duration of LUTS (9.98 ± 10.52 vs. 4.83 ± 7.32 years), creatinine levels (135.58 ± 110.51 vs. 57.66 ± 12.26 μmol/L), and BDI (103.28 ± 71.6 vs. 19.23 ± 15.03%). No significant differences were noted in age, bladder volume, or residual urine between the groups (p > 0.05). The AUC for the duration of LUTS, creatinine, and BDI were 0.691, 0.786, and 0.908, respectively, with a BDI Yoden index of 77%.</p><p><strong>Conclusion: </strong>Long-term LUTS, elevated creatinine levels, and high BDI are associated with UUT damage. BDI demonstrates high sensitivity and specificity in diagnosing UUT damage, outperforming creatinine levels and NB duration. Patients with BDI values exceeding 77% are at a heightened risk of UUT damage. BDI facilitates quantitative evaluation of cystography and preliminary evaluation upper and lower urinary tract function in NB patients. Further research is warranted to validate BDI's feasibility in quantifying cystography and diagnosing UUT damage.</p><p><strong>Trial registration: </strong>This study is retrospective and does not require clinical trial registration.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"103-108"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Biofeedback Therapy for Giggle Incontinence in Children: How Many Sessions Are Required? 生物反馈疗法对儿童咯咯失禁的疗效:需要进行多少次治疗?
IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 Epub Date: 2024-10-20 DOI: 10.1002/nau.25605
Furkan Adem Canbaz, Gonca Gerçel, Sefa Sağ

Introduction: Giggle incontinence (GI) is characterized by the sudden and involuntary expulsion of urine coinciding with episodes of laughter. The underlying pathophysiology of this condition remains unclear, and various treatment approaches are employed. The objective of this study is to assess the effectiveness of biofeedback (BF) therapy in treating GI and ascertain the requisite number of therapy sessions needed for efficacy.

Methods: Medical records of children treated with BF therapy for GI between November 2022 and November 2023 were retrospectively analyzed. The success of treatment was assessed after four and eight sessions, as well as following three maintenance sessions. Treatment outcomes were evaluated using the scoring system recommended by the International Children's Continence Society (ICCS), which categorizes responses into three levels: no response (Score 0), partial response (Score 1), and complete response (Score 2).

Results: Thirteen patients were initially diagnosed with GI. Of these, 10 patients were included in the study as three discontinued treatments. The cohort comprised an equal gender distribution with five females (50.0%) and five males (50.0%). The mean age of patients was 8.9 ± 3.3 (range 5-16) years. Two out of ten patients had a history of previous treatment for overactive bladder, while three had received treatment for primary monosymptomatic nocturnal enuresis. Following the completion of all BF sessions, the rate of complete response was observed at 80.0% (n = 8), while the partial response rate accounted for 10.0% (n = 1). Statistical analysis revealed significant differences in response scores after four and eight sessions (p < 0.01) as well as between the results after eight sessions and the completion of maintenance sessions (p < 0.01).

Conclusion: BF therapy demonstrates a high success rate in managing GI. Completion of at least eight BF therapy sessions enhances the probability of a successful outcome in the treatment of GI. Additionally, it has been observed that maintenance sessions contribute to the increased efficacy of the treatment.

简介傻笑性尿失禁(GI)的特点是在大笑时突然不自主地排出尿液。该病症的病理生理学尚不清楚,因此采用了多种治疗方法。本研究的目的是评估生物反馈疗法(BF)治疗遗尿症的效果,并确定疗效所需的治疗次数:方法: 对2022年11月至2023年11月期间接受生物反馈疗法治疗消化道疾病的儿童病历进行回顾性分析。在四次和八次治疗后,以及三次维持治疗后,对治疗的成功率进行了评估。治疗结果采用国际儿童尿失禁协会(ICCS)推荐的评分系统进行评估,该系统将反应分为三个等级:无反应(0 分)、部分反应(1 分)和完全反应(2 分):13名患者最初被诊断为消化道疾病。结果:13 名患者最初被诊断为消化道疾病,其中 10 名患者被纳入研究,因为有 3 名患者中断了治疗。患者性别分布均衡,其中女性 5 人(50.0%),男性 5 人(50.0%)。患者的平均年龄为 8.9 ± 3.3(5-16 岁)岁。十名患者中有两名曾接受过膀胱过度活动症治疗,三名曾接受过原发性单症状夜间遗尿症治疗。在完成所有膀胱过度活动治疗后,观察到完全应答率为 80.0%(8 人),部分应答率为 10.0%(1 人)。统计分析显示,四次治疗和八次治疗后的反应评分有明显差异(P 结论:BF 疗法对患者的成功率很高:BF 疗法在控制消化道疾病方面具有很高的成功率。完成至少八个 BF 治疗疗程可提高胃肠病治疗成功的概率。此外,据观察,维持疗程有助于提高疗效。
{"title":"Efficacy of Biofeedback Therapy for Giggle Incontinence in Children: How Many Sessions Are Required?","authors":"Furkan Adem Canbaz, Gonca Gerçel, Sefa Sağ","doi":"10.1002/nau.25605","DOIUrl":"10.1002/nau.25605","url":null,"abstract":"<p><strong>Introduction: </strong>Giggle incontinence (GI) is characterized by the sudden and involuntary expulsion of urine coinciding with episodes of laughter. The underlying pathophysiology of this condition remains unclear, and various treatment approaches are employed. The objective of this study is to assess the effectiveness of biofeedback (BF) therapy in treating GI and ascertain the requisite number of therapy sessions needed for efficacy.</p><p><strong>Methods: </strong>Medical records of children treated with BF therapy for GI between November 2022 and November 2023 were retrospectively analyzed. The success of treatment was assessed after four and eight sessions, as well as following three maintenance sessions. Treatment outcomes were evaluated using the scoring system recommended by the International Children's Continence Society (ICCS), which categorizes responses into three levels: no response (Score 0), partial response (Score 1), and complete response (Score 2).</p><p><strong>Results: </strong>Thirteen patients were initially diagnosed with GI. Of these, 10 patients were included in the study as three discontinued treatments. The cohort comprised an equal gender distribution with five females (50.0%) and five males (50.0%). The mean age of patients was 8.9 ± 3.3 (range 5-16) years. Two out of ten patients had a history of previous treatment for overactive bladder, while three had received treatment for primary monosymptomatic nocturnal enuresis. Following the completion of all BF sessions, the rate of complete response was observed at 80.0% (n = 8), while the partial response rate accounted for 10.0% (n = 1). Statistical analysis revealed significant differences in response scores after four and eight sessions (p < 0.01) as well as between the results after eight sessions and the completion of maintenance sessions (p < 0.01).</p><p><strong>Conclusion: </strong>BF therapy demonstrates a high success rate in managing GI. Completion of at least eight BF therapy sessions enhances the probability of a successful outcome in the treatment of GI. Additionally, it has been observed that maintenance sessions contribute to the increased efficacy of the treatment.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"207-211"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association Between Urinary Incontinence With Pelvic Pain and Sensory-Motor Function in Older Women With Stroke. 中风老年妇女尿失禁与骨盆疼痛和感觉运动功能之间的关系
IF 1.8 3区 医学 Q3 UROLOGY & NEPHROLOGY Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.1002/nau.25613
Fatih Özden, Yalcin Golcuk, Özgür Nadiye Karaman, Mehmet Özkeskin

Purpose: The study aimed to investigate the association between urinary incontinence (UI) severity, pelvic pain, and sensory-motor function in older women with stroke.

Methods: A cross-sectional prospective study was carried out with 102 older women individuals with stroke. Barthel Index (BI), Incontinence Impact Questionnaire Short Form (IIQ-7), Urogenital Distress Inventory (UDI-6), Pelvic Pain Impact Questionnaire (PPIQ), Somatosensory Amplification Scale (SASS), and Somatic Sensitivity Scale (SeSS) were used for clinical measurements.

Results: Partial correlational analyses with age, stroke duration, and BMI as covariates revealed a moderate positive correlation between SASS and IIQ-7 (r = 0.315, p < 0.001) and UDI-6 (r = 0.376, p < 0.001). On the other hand, there was a strong positive correlation between SASS and PPIQ (r = 0.522, p < 0.001). SeSS had a low positive correlation with IIQ-7 (r = 0.198, p < 0.05) and UDI-6 (r = 0.203, p < 0.05). In addition, there was a positive and moderate correlation between SeSS and PPIQ (r = 0.384, p < 0.001). Multivariate linear regression analysis revealed causality of SASS (R2 = 0.381, p < 0.001) and SeSS (R2 = 0.167, p < 0.001) with PPIQ.

Conclusions: Increased abnormal sensory sensitivity is associated with increased pelvic pain levels in women with stroke. Clinicians should consider sensory abnormalities, especially pain, within the scope of UI in women with stroke. Our results provide preliminary essential data for sensory and pain awareness during pelvic rehabilitation in stroke patients.

目的:该研究旨在调查中风老年妇女尿失禁(UI)严重程度、骨盆疼痛和感觉运动功能之间的关系:对 102 名中风老年妇女进行了横断面前瞻性研究。临床测量采用巴特尔指数(BI)、尿失禁影响问卷简表(IIQ-7)、尿道窘迫量表(UDI-6)、盆腔疼痛影响问卷(PPIQ)、躯体感觉放大量表(SASS)和躯体敏感性量表(SeSS):结果:以年龄、卒中持续时间和体重指数为协变量的部分相关性分析显示,SASS 与 IIQ-7 之间存在中度正相关(r = 0.315,p 2 = 0.381,p 2 = 0.167,p 结论:感觉异常敏感度增加会导致患者的躯体疼痛和肢体麻木:感觉灵敏度异常的增加与中风女性骨盆疼痛程度的增加有关。临床医生应将感觉异常,尤其是疼痛纳入中风妇女的 UI 检查范围。我们的研究结果为中风患者骨盆康复期间的感觉和疼痛意识提供了初步的重要数据。
{"title":"The Association Between Urinary Incontinence With Pelvic Pain and Sensory-Motor Function in Older Women With Stroke.","authors":"Fatih Özden, Yalcin Golcuk, Özgür Nadiye Karaman, Mehmet Özkeskin","doi":"10.1002/nau.25613","DOIUrl":"10.1002/nau.25613","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to investigate the association between urinary incontinence (UI) severity, pelvic pain, and sensory-motor function in older women with stroke.</p><p><strong>Methods: </strong>A cross-sectional prospective study was carried out with 102 older women individuals with stroke. Barthel Index (BI), Incontinence Impact Questionnaire Short Form (IIQ-7), Urogenital Distress Inventory (UDI-6), Pelvic Pain Impact Questionnaire (PPIQ), Somatosensory Amplification Scale (SASS), and Somatic Sensitivity Scale (SeSS) were used for clinical measurements.</p><p><strong>Results: </strong>Partial correlational analyses with age, stroke duration, and BMI as covariates revealed a moderate positive correlation between SASS and IIQ-7 (r = 0.315, p < 0.001) and UDI-6 (r = 0.376, p < 0.001). On the other hand, there was a strong positive correlation between SASS and PPIQ (r = 0.522, p < 0.001). SeSS had a low positive correlation with IIQ-7 (r = 0.198, p < 0.05) and UDI-6 (r = 0.203, p < 0.05). In addition, there was a positive and moderate correlation between SeSS and PPIQ (r = 0.384, p < 0.001). Multivariate linear regression analysis revealed causality of SASS (R<sup>2</sup> = 0.381, p < 0.001) and SeSS (R<sup>2</sup> = 0.167, p < 0.001) with PPIQ.</p><p><strong>Conclusions: </strong>Increased abnormal sensory sensitivity is associated with increased pelvic pain levels in women with stroke. Clinicians should consider sensory abnormalities, especially pain, within the scope of UI in women with stroke. Our results provide preliminary essential data for sensory and pain awareness during pelvic rehabilitation in stroke patients.</p>","PeriodicalId":19200,"journal":{"name":"Neurourology and Urodynamics","volume":" ","pages":"165-170"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Neurourology and Urodynamics
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1