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Fetal Macrosomia at a Tertiary Care Centre in Lagos, Nigeria. 尼日利亚拉各斯一家三级保健中心的巨大胎儿症。
Omololu Adegbola, Fatimah Murtazha Habeebu-Adeyemi

Background: Large babies have attracted immense attention as they present obstetric problems with associated increase in perinatal morbidity and mortality. The major risk of fetal macrosomia is trauma to the fetus and mother during vaginal delivery.

Objective: To compare the outcome of macrosomic babies with babies of normal birth weights.

Methods: This was a retrospective comparative study of deliveries over a period of two years from 1 "August 2005 to 31st July 2007.

Results: There were 198 macrosomic babies (6.9%) out of a total of 2,879 deliveries that occurred within the study period. Majority of the mothers were multiparous; para 2 to 4 (47.5% in the study group and 33.7% in the control group). Emergency Caesarean Section (EMCS) rate in the study group was 44.4% while it was 25.3% in the control group and this was statistically significant (p value <0.001). In this study the maternal injuries in the study group were not significantly higher than the control group. The fetal morbidity and mortality in the study group was significantly higher than the control group both with p values <0.001.

Conclusion: Fetal macrosomia is associated with high morbidity and mortality in this centre, there is a need to identify pregnant women at risk as well as adequate counseling of possible interventions and outcomes.

背景:大婴儿已经引起了极大的关注,因为他们提出的产科问题与围产期发病率和死亡率相关的增加。巨大胎儿的主要风险是阴道分娩时对胎儿和母亲的创伤。目的:比较巨体儿与正常出生体重儿的预后。方法:对2005年8月1日至2007年7月31日两年内分娩的产妇进行回顾性比较研究。结果:在研究期间共2879例分娩中,有198例巨大婴儿(6.9%)。大多数母亲是多胞胎;第2段至第4段(研究组47.5%,对照组33.7%)。研究组的急诊剖宫产率为44.4%,而对照组为25.3%,具有统计学意义(p值)。结论:该中心的巨大胎儿与高发病率和死亡率相关,有必要确定高危孕妇,并对可能的干预措施和结果进行充分的咨询。
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引用次数: 0
Antidiabetic effects of chitosan capsule on streptozotocin-induced diabetic rats and possible cardioprotective and β-cell regenerative effects 壳聚糖胶囊对链脲佐菌素诱导的糖尿病大鼠的降糖作用及其可能的心脏保护和β细胞再生作用
Pub Date : 2015-01-01 DOI: 10.4314/NQJHM.V25I4
I. Akande, D. O. Fasheun
Background: Chitosan capsule is manufactured by Green World Natural Solutions International Limited, U.S.A. as a food supplement; it is indicated in the management of obesity and hyperglycemia.Objective: To investigate the antidiabetic effects of Green World Chitosan capsuleTM in streptozotocin-induced diabetic rats.Methods: Twenty male Wistar albino rats (130-150 g) were divided into five groups comprising normal control, diabetic control and diabetic treated with 150 mg/kg body weight chitosan, 300 mg/kg body weight chitosan or 6 IU/kg body weight insulin. Diabetes was induced by a single intraperitonial injection of 65 mg/kg body weight streptozotocin prior to the commencement of treatment. After four weeks of treatment, the animals were sacrificed and their blood samples were collected for biochemical assays. The pancreas was harvested for histological assessments.Results: Treatment with the two doses of Chitosan significantly (p < 0.05) reduced the blood glucose level, total cholesterol, triglyceride, low density lipoprotein (LDL) cholesterol, and very low density lipoprotein (VLDL) cholesterol but significantly (p < 0.05) increased catalase activity compared to the diabetic control. Only the animals treated with the higher dose Chitosan (300 mg/kg body weight) showed a significant (p < 0.05) increase in high density lipoprotein (HDL) cholesterol with a significant decrease (p < 0.05) in malondialdehyde content, alanine amino transferase (ALT) activity, and alkaline phosphatase (ALP) activity. The aspartate amino transferase (AST) activity of the Chitosan treated groups was reduced but not significantly compared to the diabetic control. Histological examination of the pancreas of the diabetic rats treated with the two doses of Chitosan showed increased islet cells cluster compared with the diabetic control group.Conclusion: Green World Chitosan posseses hypoglycemic, hypolipidemic and antioxidant potentials, and could therefore be effective in the management of diabetes.Keywords: Chitosan capsule , Green World, Diabetes, Streptozotocin.
背景:壳聚糖胶囊是美国绿色世界天然解决方案国际有限公司生产的一种食品补充剂;它适用于肥胖和高血糖的治疗。目的:探讨绿世界壳聚糖胶囊对链脲佐菌素诱导的糖尿病大鼠的降糖作用。方法:雄性Wistar白化大鼠20只(130 ~ 150 g)分为正常对照组、糖尿病对照组和糖尿病组,分别给予150 mg/kg体重的壳聚糖、300 mg/kg体重的壳聚糖和6 IU/kg体重的胰岛素治疗。在开始治疗前,单次腹腔注射链脲佐菌素65 mg/kg体重诱导糖尿病。治疗四周后,处死动物,采集血液样本进行生化分析。摘取胰腺进行组织学评估。结果:与糖尿病对照组相比,两剂量壳聚糖治疗显著(p < 0.05)降低了血糖水平、总胆固醇、甘油三酯、低密度脂蛋白(LDL)胆固醇和甚低密度脂蛋白(VLDL)胆固醇,显著(p < 0.05)提高了过氧化氢酶活性。只有高剂量壳聚糖(300 mg/kg体重)处理的动物高密度脂蛋白(HDL)胆固醇显著(p < 0.05)升高,丙二醛含量、丙氨酸氨基转移酶(ALT)活性和碱性磷酸酶(ALP)活性显著(p < 0.05)降低。与糖尿病对照组相比,壳聚糖处理组的谷草氨酸氨基转移酶(AST)活性降低但不显著。两剂量壳聚糖处理的糖尿病大鼠胰腺组织学检查显示,与糖尿病对照组相比,胰岛细胞簇增加。结论:绿世界壳聚糖具有降血糖、降血脂和抗氧化作用,可有效治疗糖尿病。关键词:壳聚糖胶囊,绿色世界,糖尿病,链脲佐菌素
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引用次数: 1
The frequency of suicidal ideation in asthma and the relationship to asthma control and depression 哮喘患者自杀意念频率及其与哮喘控制和抑郁的关系
Pub Date : 2015-01-01 DOI: 10.4314/NQJHM.V25I1
R. Ogbolu, O. Ozoh, O. Aina, B. Fadipe, N. Okubadejo
Background: There is considerable evidence from clinical and epidemiological studies linking asthma to an increased risk of suicide.Objective: To provide preliminary data among Nigerians on the frequency and characteristics of suicidal ideation in asthma.Methods: A cross-sectional study among consecutively consenting asthma patients attending the respiratory clinic of the Lagos University Teaching Hospital in Lagos, Nigeria, over a six month period. Level of asthma control was assessed using the Asthma Control Test (ACT). The Beck Scale for Suicidal Ideation (BSI) and the Suicide items of Beck's Depressive Inventory (BDI) were used to obtain data on suicidal ideation and the risk of depression respectively. Correlation and regression analysis were performed.Results: Eighty one (66.7% women) adult asthma patients participated. Their mean age was 46.3±13.0 years, mean ACT score was 18.7±4.3 (maximum score 25) and mean BDI score was 3.6 ± 4.0 (maximum score 63). There was a significant negative relationship between the ACT score and the BDI score (p 1). The mean BDI score was significantly higher among participants with suicidal ideation compared to those without suicidal ideation (6.8±5.2 versus 3.4±3.8, p=0.04). Among the participants with suicidal ideation, the BDI score and ACT score were negatively and insignificantly correlated to the BSI score (Pearson's correlation= -0.26, p=0.62), (Pearson's correlation=-0.03, p=0.96) respectively.Conclusion: The frequency of suicidal ideation among patients with asthma is modest. Participants with suicidal ideation were more symptomatic for depression and most had poor asthma control. This highlights the need for increased recognition and treatment of co-morbid psychiatric illness among asthma patients.Keywords: Asthma, suicide, Nigeria, comorbidity, depressio
背景:临床和流行病学研究有大量证据表明哮喘与自杀风险增加有关。目的:为尼日利亚人哮喘患者自杀意念的频率和特征提供初步资料。方法:对在尼日利亚拉各斯拉各斯大学教学医院呼吸内科就诊的连续同意哮喘患者进行为期6个月的横断面研究。采用哮喘控制试验(ACT)评估哮喘控制水平。采用贝克自杀意念量表(BSI)和贝克抑郁量表(BDI)自杀条目分别获得自杀意念和抑郁风险的数据。进行相关分析和回归分析。结果:81例成人哮喘患者参与调查,其中女性占66.7%。平均年龄46.3±13.0岁,ACT平均评分18.7±4.3分(最高评分25分),BDI平均评分3.6±4.0分(最高评分63分)。ACT得分与BDI得分呈显著负相关(p < 1)。有自杀意念者BDI得分均值显著高于无自杀意念者(6.8±5.2比3.4±3.8,p=0.04)。在有自杀意念的被试中,BDI评分、ACT评分与BSI评分分别呈负相关且不显著(Pearson相关= -0.26,p=0.62)、(Pearson相关=-0.03,p=0.96)。结论:哮喘患者自杀意念发生率不高。有自杀念头的参与者更有抑郁症状,而且大多数人哮喘控制不佳。这突出了对哮喘患者共病性精神疾病的认识和治疗的必要性。关键词:哮喘,自杀,尼日利亚,共病,抑郁症
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引用次数: 0
In Vitro inhibition of Leishmaniadonavoni by extracts and column fractions of five selected endemic medicinal plants in Nigeria 5种尼日利亚特有药用植物提取物和柱状提取物对利什曼多纳沃尼的体外抑制作用
Pub Date : 2014-01-01 DOI: 10.4314/NQJHM.V24I2
A. Falodun, O. Erharuyi, V. Imieje, J. E. Falodun, Joy Ahomafor, T. Onyekaba, D. Cox, M. Abaldry, M. Hamann
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引用次数: 0
Congenital inclusion cysts of the subgaleal space 先天性盖骨下间隙包涵性囊肿
Pub Date : 2014-01-01 DOI: 10.4314/NQJHM.V24I1
O. Bankole, M. O. Nnadi, S. O. Arigbabu
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引用次数: 0
Factors contributing to dissatisfaction in complete denture wearers. 导致全口义齿佩戴者不满意的因素。
Pub Date : 2014-01-01 DOI: 10.4314/NQJHM.V24I3
B. Akinboboye, H. Oderinu, P. Akeredolu, O. Shaba
Background: Cisplatin (Cis-diamminedichloroplatinum II, CP) is an important chemotherapeutic agent, useful in the treatment of cancer, but with several side effects such as nephrotoxicity.Objective: The present study investigated the effect of Aloe vera gel (AVG) and selenium on Cisplatin induced oxidative stress on the kidneys and livers of male and female Wistar albino rats.Methods: Male and female Wistar albino rats were injected with a single dose of cisplatin (7mg CP/kg b.m., i.p.), selenium (6mg Se/kg b.m, as Na2SeO3 , i.p.) and Aloe vera (6mg Se/kg b.m), alone or in combination.Results: The result showed that CP increased lipid peroxidation (LPO) and decreased reduced glutathione (GSH) concentrations were significantly higher in male wistar albino rats than in female wistar albino rats when treated with Aloe vera, suggesting male wistar albino rats were more susceptible to CP- induced oxidative stress than female wistar albino rats; Aloe vera served as a potent antilipidemic source and boosted immunity; reversed CPinduced kidney and liver damage in both male and female rats. Pre-treatment with selenium and Aloe vera limited CPinduced alterations of antioxidant enzyme activities and significantly prevented CP-induced kidney and liver damage. The levels of pretreated groups had a lower activity of these enzymes with the Aloe vera group having the lowest activities of these enzymes. Histological studies on the kidneys and livers of male and female Wistar albino rats showed significant damage.Conclusion: The nutritional Aloe vera possessed antioxidant components which prevented and ameliorated oxidative stress and loss of cellular antioxidants induced by Cisplatin in rats.Keywords: Cisplatin; selenium; nephrotoxicity; lipid peroxidation; antioxidant defense system, rat
背景:广泛牙缺失的修复被认为可以改善咀嚼,但仍有一部分全口义齿佩戴者对其义齿不满意。目的:本研究旨在确定导致全口义齿佩戴者不满意的因素。方法:采用问卷调查的方式,对某教学医院24例患者进行全口义齿配装后的社会人口学、义齿使用情况及满意度调查。数据分析采用SPSS version 16。O视窗统计软件。结果:24例受试者遵守研究方案。受试者的平均年龄为63.30岁±标准差17.67。男性17例(70.8%),女性7例(29.2%)。8名患者(33.3%)对义齿不满意。5名受试者对下义齿不满意,3名受试者对上义齿不满意。不满意的主要原因是咀嚼问题(62.5%)。义齿种类与满意度有统计学意义(P =0.02)。那些认为假牙很好的病人仍然对他们的假牙不满意。饮食类型与感知满意度有显著相关(P=0.003)。结论:单口常规全口义齿佩戴者普遍存在感知不满。主要的限制是咀嚼问题。关键词:修复,全口义齿,满意度
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引用次数: 1
Pathway to Independence: Implications for Developing A Sustainable MIS Program in low Resource settings. 独立之路:在低资源环境下发展可持续管理信息系统项目的意义。
Oludara Mobolaji, Nwariaku Fiemu, Ibrahim Akanmu, Pursnani Kish, Williams Omolara, Omodele Foluso, Osuoji Roland, Ikuerowo Stephen, Aderounmu Adebimpe

Background: Gastrointestinal surgery has been at the forefront of advances in minimally invasive surgery (MIS). In the low resource settings of the developing countries, despite the benefits of MIS, its uptake in sub-Saharan African countries has been slow.

Objective: The present study reports the process of developing a minimally-invasive surgery service line as well as surgical outcomes in LASUTH. METHODS. We reviewed medical records of all patients who underwent minimally invasive surgery at LASUTH between March 2011 and March 2012. During each of three training missions in LASUTH patients with Gastrointestinal and gynaecological surgical conditions were carefully selected, and prepared for surgery. All patients were admitted a day prior to surgery. A description of the surgical technique and the skills training used is also presented.

Results: A total of 24 laparoscopic procedures were performed between March 2011 and March 2012. There were more females 17(70.8%) than males 7(29.2%), with a female to male ratio of 2.5:1. The age range was from 18 yrs to 75 yrs with a peak in the age group between 21-30 yrs. The chief complaints were right hypochondrial pain in 9 cases (37.5%) and right iliac fossa pain in 6 cases (25%) whilst others were right groin swelling, dysphagia, infertility and intersex state.

Conclusion: The results presented in respect of conversion rate, length of post operative stay and complications rate are similar to the pattern in more established centers. The use of team training as done in LASUTH helps to accelerate the rate of learning and ensures sustainability.

背景:胃肠道手术一直处于微创手术(MIS)的前沿。在发展中国家资源匮乏的情况下,尽管管理信息系统有好处,但撒哈拉以南非洲国家对它的吸收速度很慢。目的:本研究报道LASUTH微创手术服务线的发展过程及手术效果。方法。我们回顾了2011年3月至2012年3月期间在LASUTH接受微创手术的所有患者的医疗记录。在LASUTH的三次培训任务中,每次都精心挑选患有胃肠道和妇科外科疾病的患者,并为手术做准备。所有患者均在手术前一天入院。对手术技术和所使用的技能训练也进行了描述。结果:2011年3月至2012年3月共进行24例腹腔镜手术。女性17人(70.8%)多于男性7人(29.2%),男女比例为2.5:1。年龄范围从18岁到75岁,高峰期在21-30岁之间。主诉为右肋下痛9例(37.5%)、右髂窝痛6例(25%),其余为右腹股沟肿胀、吞咽困难、不孕、双性状态。结论:本院在转换率、术后住院时间、并发症发生率等方面与国内比较成熟的医院基本一致。LASUTH采用小组训练有助于加快学习速度并确保可持续性。
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引用次数: 0
Therapeutic Effects of Exercise Training On Selected Cardio-Pulmonary Parameters and Body Composition of Nigerians with Chronic Heart Failure (A Preliminary Study). 运动训练对尼日利亚慢性心力衰竭患者选定的心肺参数和身体成分的治疗作用(初步研究)
O A Ajiboye, C N Anigbogu, J N Ajuluchukwu, S I Jaja

Background: The use of exercise training in the management of individuals with chronic heart failure has not been widely accepted by health care providers especially in Sub-Saharan Africa because of the possibility that the failing hearts may have a negative response to the increased workload and stress of exercise.

Objective: The study aimed to evaluate the effects of exercise training (ET) on selected cardio-respiratory and body composition variables of Nigerians with chronic heart failure (CHF).

Methods: Thirty two Nigerians with CHF (male - 17), aged 30 to 71 years, mean age 54.2 ± 1.9 years and New York Heart Association Functional Class (NYHA) II-III recruited from Cardiology Clinic of Lagos University Teaching Hospital Nigeria participated in the study. They were randomized into exercise (EG) and control groups (CG). Exercise group performed 12-weeks of aerobic and resistance training for 60 minutes, three sessions per week. Selected cardio-respiratory and body composition variables were measured pre and post intervention in both groups. Data was analyzed using SPSS-17 package. Level of significance was set at 0.05.

Results: There was no significant difference in the measured variables between the groups at baseline (p > 0.05). Significant improvement was seen in EG in all the measured variables except the systolic (p = 0.29) and diastolic blood pressure (p = 0.45). No adverse effect was observed during the exercise training. No significant improvement was observed in the control group (p > 0.05).

Conclusion: Exercise training may improve cardiorespiratory and body composition variables in patients with chronic heart failure.

背景:在慢性心力衰竭患者的管理中使用运动训练尚未被卫生保健提供者广泛接受,特别是在撒哈拉以南非洲,因为心力衰竭可能会对增加的工作量和运动压力产生负面反应。目的:本研究旨在评估运动训练(ET)对尼日利亚慢性心力衰竭(CHF)患者心肺和身体组成变量的影响。方法:从尼日利亚拉各斯大学教学医院心脏科诊所招募32名尼日利亚CHF患者(男- 17岁),年龄30 ~ 71岁,平均年龄54.2±1.9岁,纽约心脏协会功能分级(NYHA) II-III级。随机分为运动组(EG)和对照组(CG)。运动组进行为期12周的有氧和阻力训练,每次60分钟,每周三次。在两组患者干预前和干预后测量选定的心肺和身体组成变量。数据分析采用SPSS-17软件包。显著性水平设为0.05。结果:两组在基线时各项指标比较,差异均无统计学意义(p > 0.05)。除收缩压(p = 0.29)和舒张压(p = 0.45)外,所有测量变量的EG均有显著改善。在运动训练期间未观察到不良反应。对照组无明显改善(p > 0.05)。结论:运动训练可以改善慢性心力衰竭患者的心肺和身体成分变量。
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引用次数: 0
Cytokines, Type 2 DM and the Metabolic Syndrome. 细胞因子,2型糖尿病和代谢综合征。
Pub Date : 2013-10-01 DOI: 10.4314/NQJHM.V23I4
A. Ogbera, A. Azenabor, O. Ogundahunsi, A. Ekun, E. Adejumo
BACKGROUNDInflammatory markers have been widely implicated in Diabetes Mellitus (DM) and the metabolic syndrome (Mets). Data on the association of cytokines (pro inflammatory mediators) and components of the Mets are sparse in sub Saharan Africa.OBJECTIVEWe sought to document the pattern of distribution of cytokines in Nigerian subjects with type 2 DM and compare cytokine levels between DM subjects with and without the Mets.METHODS200 subjects with type 2 DM and 100 healthy sex and aged matched Controls were studied. Anthropometric indices, lipid parameters and cytokine levels, which included interleukin 10 (IL-10), tumour necrosis factor-alpha (TNF-α), interferon gamma (IFN-γ) and C reactive protein (CRP) were determined. Continuous variables were compared between subjects with type 2 DM and the controls and also between DM subjects with and without the Mets.RESULTSThe mean levels of all studied cytokines were significantly higher in the subjects with type 2 DM than the Control subjects, save for IFN-γ which was significantly lower in type 2 DM. The mean cytokine levels were comparable in the DM subjects with and without the Mets and also comparable in obese DM and non obese DM subjects. Of the Mets defining criteria, waist circumference (WC) and Triglyceride (TG) were found to be significantly associated with only two of the studied cytokines. The correlation coefficient and p values of these findings are as follows: WC vs TNF-α (r = 0.16, p = 0.001) and TG vs CRP (r = 0.15, p = 0.03). Multiple regression analyses showed that the cytokines were linearly associated with each other but not with other clinical and biochemical variables. The cytokines were found to be interrelated. IL-10 with a beta value of 0.14 predicted the presence of INF-γ with a 95% confidence interval of 0.000 - 0.109 and a p value of 0.05. TNF-α with a beta value of 0.17 predicted the presence of IL-10 with a 95% confidence interval of 0.004 - 0.034 and a p value of 0.01. IL-10 with a beta value of 0.17 predicted the presence of TNF-α with a 95% confidence interval of 0.3-0.590 and a p value of 0.01.CONCLUSIONCytokine levels are higher in DM than non DM subjects; however, the cytokine levels are not strongly associated with the Mets. Limited correlations were found between each of the cytokines and the parameters of the Mets. Further studies on this entity amongst Africans should be carried out to ascertain if these results are peculiar to DM subjects in sub- Saharan Africa.
背景:炎性标志物在糖尿病(DM)和代谢综合征(Mets)中有广泛的关联。在撒哈拉以南非洲,关于细胞因子(促炎介质)和met成分的关联数据很少。目的:我们试图记录尼日利亚2型糖尿病患者细胞因子的分布模式,并比较有和没有Mets的糖尿病患者的细胞因子水平。方法选取200例2型糖尿病患者和100例性别、年龄相匹配的健康对照。测定人体测量指标、血脂参数和细胞因子水平,包括白细胞介素10 (IL-10)、肿瘤坏死因子α (TNF-α)、干扰素γ (IFN-γ)和C反应蛋白(CRP)。连续变量在2型糖尿病患者和对照组之间进行比较,也在有和没有Mets的糖尿病患者之间进行比较。结果2型糖尿病患者所有细胞因子的平均水平均显著高于对照组,但IFN-γ在2型糖尿病患者中显著低于对照组。有和没有Mets的糖尿病患者的平均细胞因子水平具有可比性,肥胖型糖尿病患者和非肥胖型糖尿病患者的平均细胞因子水平具有可比性。在Mets的定义标准中,腰围(WC)和甘油三酯(TG)被发现与所研究的两种细胞因子显著相关。相关系数和p值分别为:WC与TNF-α (r = 0.16, p = 0.001)、TG与CRP (r = 0.15, p = 0.03)。多元回归分析表明,细胞因子与其他临床和生化变量之间呈线性相关,而与其他临床和生化变量之间无线性相关。细胞因子被发现是相互关联的。IL-10 β值为0.14,预测INF-γ存在,95%置信区间为0.000 ~ 0.109,p值为0.05。TNF-α β值为0.17,预测IL-10的存在,95%可信区间为0.004 ~ 0.034,p值为0.01。IL-10 β值为0.17,预测TNF-α存在的95%置信区间为0.3 ~ 0.590,p值为0.01。结论糖尿病患者细胞因子水平高于非糖尿病患者;然而,细胞因子水平与大都会没有很强的联系。在每一种细胞因子和代谢参数之间发现了有限的相关性。应该在非洲人中对这一实体进行进一步研究,以确定这些结果是否是撒哈拉以南非洲DM受试者所特有的。
{"title":"Cytokines, Type 2 DM and the Metabolic Syndrome.","authors":"A. Ogbera, A. Azenabor, O. Ogundahunsi, A. Ekun, E. Adejumo","doi":"10.4314/NQJHM.V23I4","DOIUrl":"https://doi.org/10.4314/NQJHM.V23I4","url":null,"abstract":"BACKGROUND\u0000Inflammatory markers have been widely implicated in Diabetes Mellitus (DM) and the metabolic syndrome (Mets). Data on the association of cytokines (pro inflammatory mediators) and components of the Mets are sparse in sub Saharan Africa.\u0000\u0000\u0000OBJECTIVE\u0000We sought to document the pattern of distribution of cytokines in Nigerian subjects with type 2 DM and compare cytokine levels between DM subjects with and without the Mets.\u0000\u0000\u0000METHODS\u0000200 subjects with type 2 DM and 100 healthy sex and aged matched Controls were studied. Anthropometric indices, lipid parameters and cytokine levels, which included interleukin 10 (IL-10), tumour necrosis factor-alpha (TNF-α), interferon gamma (IFN-γ) and C reactive protein (CRP) were determined. Continuous variables were compared between subjects with type 2 DM and the controls and also between DM subjects with and without the Mets.\u0000\u0000\u0000RESULTS\u0000The mean levels of all studied cytokines were significantly higher in the subjects with type 2 DM than the Control subjects, save for IFN-γ which was significantly lower in type 2 DM. The mean cytokine levels were comparable in the DM subjects with and without the Mets and also comparable in obese DM and non obese DM subjects. Of the Mets defining criteria, waist circumference (WC) and Triglyceride (TG) were found to be significantly associated with only two of the studied cytokines. The correlation coefficient and p values of these findings are as follows: WC vs TNF-α (r = 0.16, p = 0.001) and TG vs CRP (r = 0.15, p = 0.03). Multiple regression analyses showed that the cytokines were linearly associated with each other but not with other clinical and biochemical variables. The cytokines were found to be interrelated. IL-10 with a beta value of 0.14 predicted the presence of INF-γ with a 95% confidence interval of 0.000 - 0.109 and a p value of 0.05. TNF-α with a beta value of 0.17 predicted the presence of IL-10 with a 95% confidence interval of 0.004 - 0.034 and a p value of 0.01. IL-10 with a beta value of 0.17 predicted the presence of TNF-α with a 95% confidence interval of 0.3-0.590 and a p value of 0.01.\u0000\u0000\u0000CONCLUSION\u0000Cytokine levels are higher in DM than non DM subjects; however, the cytokine levels are not strongly associated with the Mets. Limited correlations were found between each of the cytokines and the parameters of the Mets. Further studies on this entity amongst Africans should be carried out to ascertain if these results are peculiar to DM subjects in sub- Saharan Africa.","PeriodicalId":19202,"journal":{"name":"Nigerian quarterly journal of hospital medicine","volume":"27 1","pages":"318-22"},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73145615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Undergraduate Students' Knowledge and Practice of Gonorrhea and other Sexually Transmitted Infections. 大学生淋病及其他性传播疾病的知识与实践。
A E Joda, F Tayo, B A Aina

Background: Sexually transmitted infections (STIs) are a major public health issue. Adolescents and youth (15-24 years) are the age groups at the greater risk for acquiring them. Also a large percentage of new STIs occur in this age group with 7000 young people worldwide acquiring the infection every day. Sexually transmitted infections (STIs) are poorly recognized and inadequately treated in Nigeria despite the fact that they constitute a major risk factor for sexual transmission of HIV infection. The shortage of trained human resources is among the most important obstacles to strengthening health systems in low-income countries.

Objective: This study is to document the knowledge and practice of undergraduate students about gonorrhoea and other STIs as a baseline survey for future intervention work.

Methods: It was a questionnaire-based, cross sectional descriptive study of the knowledge and practice of STIs among students in the seven public tertiary academic institutions in Lagos State using list obtained from the Lagos State Ministry of Education. Thirty (30) students who agreed to be surveyed were conveniently selected from each school. Pre-tested, semi-structured, validated questionnaires were administered and collected back. Data was entered into Microsoft Excel and analysed using EPI Info, SPSS version 15 and Microsoft Excel. Results were considered to be statistically significant if p < 0.05.

Results: Majority of the respondents were of the 21 - 25 year age range (48%) and were mainly single (95%), Christian (61%) and Yoruba (81%). About 51% of the respondents had at least good knowledge of gonorrhoea and other STIs. Knowledge about symptoms and transmission was higher than knowledge of prevention, consequences and drugs. Among those that are sexually active 24% do not use condom while 10% reuse condom. Use of both modern and traditional medical practitioners (TMP) was documented among the students.

Conclusions: Awareness programs with key messages about gonorrhoea and other STIs should be developed and circulated widely in tertiary institutions in the state to improve students' practice. Also strategies to embrace TMP for STI management should be evolved.

背景:性传播感染(STIs)是一个重大的公共卫生问题。青少年和青年(15-24岁)是感染这些疾病风险最大的年龄组。此外,很大比例的新发性传播感染发生在这一年龄组,全世界每天有7000名年轻人感染。尽管性传播感染是艾滋病毒性传播感染的一个主要风险因素,但在尼日利亚,人们对性传播感染的认识和治疗都很差。缺乏训练有素的人力资源是加强低收入国家卫生系统的最重要障碍之一。目的:了解大学生淋病及其他性传播感染的知识和行为,为今后的干预工作提供基础调查。方法:采用问卷调查法,采用从拉各斯州教育部获得的名单,对拉各斯州7所公立高等教育机构学生的性传播感染知识和行为进行横断面描述性研究。同意接受调查的30名学生被方便地从每个学校中选出。预先测试的、半结构化的、有效的问卷被管理和收集回来。数据录入Microsoft Excel,使用EPI Info、SPSS version 15和Microsoft Excel进行分析。若p < 0.05,则认为结果有统计学意义。结果:大多数受访者年龄在21 - 25岁之间(48%),主要是单身(95%),基督徒(61%)和约鲁巴人(81%)。约51%的应答者至少对淋病和其他性传播感染有良好的了解。对症状和传播的了解高于对预防、后果和药物的了解。在性活跃人群中,24%的人不使用避孕套,10%的人重复使用避孕套。记录了学生使用现代和传统医生的情况。结论:应在州高等院校开展淋病及其他性传播感染关键信息的宣传活动,并广泛传播,以提高学生的实践水平。此外,应该发展将TMP纳入STI管理的战略。
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引用次数: 0
期刊
Nigerian quarterly journal of hospital medicine
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